Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -25.1 % | In vitro antiproliferative activity against HepG2 cell line (human liver tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -25.1 % | In vitro antiproliferative activity against HepG2 cell line (human liver tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -14.8 % | In vitro antiproliferative activity against MCF-7 cell line (human breast tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -14.8 % | In vitro antiproliferative activity against MCF-7 cell line (human breast tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -9.8 % | In vitro antiproliferative activity against MKN45 cell line (human stomach tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -9.8 % | In vitro antiproliferative activity against MKN45 cell line (human stomach tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -9.1 % | In vitro antiproliferative activity against A549 cell line (human lung tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Inhibition (functional) | = -9.1 % | In vitro antiproliferative activity against A549 cell line (human lung tumor) at 1 uM concentration | ChEMBL. | 15922597 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.