Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0024 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0024 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 92.5 % | Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as remaining activity measuring PGE2 formation from PGH2 at 10 uM after 15 mins by RP-HPLC analysis | ChEMBL. | 22992107 |
IC50 (binding) | Inhibition of 5-lipoxygenase in A23187-stimulated human neutrophils assessed as inhibition of enzyme product formation by RP-HPLC analysis | ChEMBL. | 22992107 | |
Inhibition (binding) | Inhibition of ovine COX1 assessed as inhibition of 12-HHT formation preincubated at 10 uM for 5 mins before arachidonic acid addition by HPLC analysis | ChEMBL. | 22992107 | |
Inhibition (functional) | = 43 % | Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 43 % | Inhibition of CXCL8-induced chemotaxis of human polymorphonuclear cells at 10e-8 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 70 % | Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M | ChEMBL. | 15974585 |
Inhibition (functional) | = 70 % | Inhibition of lipopolysaccharide-induced PGE-2 production at 10e-5 M | ChEMBL. | 15974585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.