Detailed information for compound 33294

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 258.163 | Formula: C7H15O8P
  • H donors: 7 H acceptors: 8 LogP: -4.66 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC1C(CP(=O)(O)O)C(O)C(C(C1O)O)O
  • InChi: 1S/C7H15O8P/c8-3-2(1-16(13,14)15)4(9)6(11)7(12)5(3)10/h2-12H,1H2,(H2,13,14,15)
  • InChiKey: SPMGFBFPGVDAAD-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0035 0.0013 0.0021
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0053 0.1071
Loa Loa (eye worm) glutaminase 0.0533 0.0301 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0009 0.0236
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0247
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0004 0.0128
Echinococcus granulosus lamin dm0 0.0052 0.0023 0.1184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Schistosoma mansoni intermediate filament proteins 0.0052 0.0023 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0028 0.168
Onchocerca volvulus 0.0052 0.0023 0.0875
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0013 0.071
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0009 0.1297
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0012 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0012 0.0353
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0138
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0002 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0003 0.0109
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0532
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.8028 0.4641 1
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0117 0.006 0.1967
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0009 0.1256
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0002 0.0101
Treponema pallidum cysteinyl-tRNA synthetase 0.0117 0.006 0.122
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0009 0.1209
Echinococcus multilocularis cysteine protease 0.0016 0.0002 0.0033
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0018 0.1016
Leishmania major DNA polymerase eta, putative 0.003 0.001 0.0551
Schistosoma mansoni hypothetical protein 0.0328 0.0182 0.0181
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.0126 0.6909
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0013 0.0021
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.002
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0009 0.1297
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0053 0.2873
Echinococcus multilocularis lamin 0.0052 0.0023 0.1184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0012 0.1892
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0117 0.006 0.3258
Loa Loa (eye worm) ctsf protein 0.0016 0.0002 0.002
Loa Loa (eye worm) cysteine protease 0.0016 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0077
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0006 0.0272
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0009 0.0438
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0004 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0003 0.0296
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0013 0.0786
Loa Loa (eye worm) hypothetical protein 0.0117 0.006 0.1967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Echinococcus multilocularis dna polymerase eta 0.0043 0.0018 0.0898
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.0162 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0002 0.0033
Schistosoma mansoni hypothetical protein 0.0298 0.0165 0.0164
Schistosoma mansoni ap endonuclease 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0035 0.0013 0.0452
Entamoeba histolytica hypothetical protein 0.0023 0.0006 0.0643
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0023 0.0715
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0022 0.126
Brugia malayi phosphofructokinase 0.0105 0.0053 0.1734
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0004 0.0392
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0018 0.109
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0003 0.0001
Schistosoma mansoni lozenge 0.0054 0.0024 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0073 0.4444
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0002 0.0001
Leishmania major hypothetical protein, conserved 0.0035 0.0013 0.071
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0003 0.0126
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.3142 0.1812 0.1811
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Trypanosoma brucei unspecified product 0.0019 0.0003 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0009 0.0008
Brugia malayi follicle stimulating hormone receptor 0.0226 0.0123 0.4071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0013 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0053 0.1718
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.8028 0.4641 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0023 0.0715
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0003 0.0207
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0023 0.0715
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0003 0.0245
Leishmania major cathepsin L-like protease 0.0016 0.0002 0.0037
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0053 0.3248
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.0162 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0009 0.0438
Echinococcus multilocularis geminin 0.0328 0.0182 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0009 0.1343
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0009 0.0438
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0006 0.0125
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0009 0.1297
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0025 0.0024
Onchocerca volvulus 0.0047 0.002 0.0753
Schistosoma mansoni DNA polymerase eta 0.0043 0.0018 0.0016
Onchocerca volvulus 0.0035 0.0013 0.0452
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0013 0.0021
Schistosoma mansoni DNA helicase recq1 0.0019 0.0004 0.0002
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0053 0.0052
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0012 0.0372
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0006 0.0125
Schistosoma mansoni transcription factor btf3 0.0034 0.0012 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0025 0.0024
Plasmodium vivax vivapain-2 0.0016 0.0002 0.0101
Brugia malayi jmjC domain containing protein 0.0057 0.0025 0.0804
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0003 0.0096
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0002 0.0037
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0007 0.0321
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0009 0.0236
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0012 0.1892
Onchocerca volvulus 0.0229 0.0125 0.5165
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0013 0.0021
Leishmania major cathepsin L-like protease 0.0016 0.0002 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0025 0.0024
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0053 0.0108
Onchocerca volvulus 0.0035 0.0013 0.0452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0002 0.002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0003 0.0126
Brugia malayi intermediate filament protein 0.0052 0.0023 0.0715
Plasmodium vivax cysteine--tRNA ligase, putative 0.0117 0.006 1
Chlamydia trachomatis transglycolase/transpeptidase 0.0332 0.0185 0.4708
Schistosoma mansoni importin beta-1 0.0028 0.0009 0.0007
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0012 0.0697
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0168 0.009 0.0167
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0009 0.0236
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0009 0.0236
Leishmania major cathepsin L-like protease 0.0062 0.0028 0.168
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0175
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0121 0.0255
Loa Loa (eye worm) hypothetical protein 0.0231 0.0126 0.4171
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0003 0.0198
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0004 0.0128
Entamoeba histolytica Ran family GTPase 0.0021 0.0004 0.0436
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0002 0.0001
Giardia lamblia Cysteinyl-tRNA synthetase 0.0117 0.006 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.0162 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0013 0.0379
Brugia malayi beta-NAC-like protein 0.0034 0.0012 0.0372
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0004 0.0225
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0004 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0475 0.0268 0.8872
Schistosoma mansoni hypothetical protein 0.0328 0.0182 0.0181
Brugia malayi Pre-SET motif family protein 0.0029 0.0009 0.0264
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.001 0.1496
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0007 0.0321
Echinococcus granulosus leucyl tRNA synthetase 0.0117 0.006 0.3258
Mycobacterium ulcerans beta-lactamase 0.0035 0.0013 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.002 0.0618
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0117 0.006 0.0123
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0003 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0025 0.1332
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0053 0.0052
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0117 0.006 0.0059
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0002 0.0033
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0004 0.0532
Brugia malayi 6-phosphofructokinase 0.0105 0.0053 0.1734
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0168 0.009 0.0187
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0004 0.0099
Treponema pallidum hypothetical protein 0.0157 0.0083 0.171
Mycobacterium tuberculosis Conserved protein 0.0035 0.0013 0.0021
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0002 0.0101
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0004 0.0144
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0012 0.181
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0003 0.0039
Echinococcus multilocularis musashi 0.0052 0.0023 0.1184
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0009 0.0126
Onchocerca volvulus 0.0428 0.024 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0003 0.0067
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0475 0.0268 0.057
Mycobacterium ulcerans hypothetical protein 0.0154 0.0082 0.0169
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0028 0.168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0013 0.0021
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0002 0.0101
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0002 0.002
Schistosoma mansoni hypothetical protein 0.0047 0.002 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0105
Echinococcus granulosus intermediate filament protein 0.0052 0.0023 0.1184
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.0162 1
Schistosoma mansoni ap endonuclease 0.0018 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Leishmania major cathepsin L-like protease 0.0062 0.0028 0.168
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0009 0.1297
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0379
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0004 0.0392
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0009 0.0247
Entamoeba histolytica hypothetical protein 0.0034 0.0012 0.181
Mycobacterium ulcerans lipase LipD 0.0035 0.0013 0.0021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.0165 0.5466
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0117 0.006 0.1951
Leishmania major DNA polymerase eta, putative 0.0043 0.0018 0.1016
Echinococcus granulosus lamin 0.0052 0.0023 0.1184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0003 0.0109
Brugia malayi Importin beta-1 subunit 0.0028 0.0009 0.0247
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0004 0.0243
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0003 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0009 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0009 0.0008
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0025 0.1487
Mycobacterium tuberculosis Conserved protein 0.0035 0.0013 0.0021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0016 0.0935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0126
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0016 0.101
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0053 0.1718
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.0123 0.4071
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0157 0.0083 0.0173
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0003 0.0112
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0003 0.0058
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0004 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0003 0.0207
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0117 0.006 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0016 0.0935
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0013 0.0021
Echinococcus granulosus importin subunit beta 1 0.0028 0.0009 0.0409
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0023 0.0715
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0009 0.0247
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0053 0.1734
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0432 0.0243 0.0497
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0672 0.0382 0.0816
Loa Loa (eye worm) hypothetical protein 0.0428 0.024 0.7965
Echinococcus multilocularis transcription factor btf3 0.0034 0.0012 0.0616
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0138
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0472 0.0266 0.0567
Schistosoma mansoni DNA helicase recq5 0.0019 0.0004 0.0002
Toxoplasma gondii hypothetical protein 0.0047 0.002 0.3131
Trichomonas vaginalis esterase, putative 0.0035 0.0013 0.036
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0053 0.0108
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0001 0.0082
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0117 0.006 0.3684
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0003 0.0048
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0125 0.4112
Brugia malayi RNA, U transporter 1 0.0079 0.0039 0.1242
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0013 0.036
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0157 0.0083 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0126
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.0126 0.6909
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0379
Echinococcus multilocularis lamin dm0 0.0052 0.0023 0.1184
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0674 0.0383 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0002 0.0033
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0025 0.1332
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0013 0.036
Brugia malayi beta-lactamase family protein 0.0035 0.0013 0.0379
Plasmodium vivax SET domain protein, putative 0.0029 0.0009 0.1343
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0013 0.036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0009 0.0404
Brugia malayi hypothetical protein 0.0231 0.0126 0.4171
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0334 0.0186 0.0374
Echinococcus granulosus transcription factor btf3 0.0034 0.0012 0.0616
Giardia lamblia DINP protein human, muc B family 0.0019 0.0003 0.0048
Echinococcus granulosus bloom syndrome protein 0.0019 0.0004 0.0128
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0117 0.006 0.0059
Echinococcus multilocularis cysteine protease 0.0016 0.0002 0.0033
Brugia malayi hypothetical protein 0.0428 0.024 0.7965
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0009 0.1297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0009 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0003 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0053 0.1718
Toxoplasma gondii cathepsin CPL 0.0016 0.0002 0.0101
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0117 0.006 0.3736
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0003 0.019
Plasmodium falciparum cysteine--tRNA ligase 0.0117 0.006 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0002 0.0033
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.8028 0.4641 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Chlamydia trachomatis cysteine--tRNA ligase 0.0117 0.006 0.1374
Leishmania major cysteinyl-tRNA synthetase, putative 0.0117 0.006 0.3684
Plasmodium falciparum importin beta, putative 0.0028 0.0009 0.1256
Leishmania major GTP-binding protein, putative 0.0021 0.0004 0.0196
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0004 0.0057
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0009 0.0541
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0021 0.1203
Echinococcus multilocularis Protein lozenge 0.0054 0.0024 0.1232
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0053 0.8805
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0053 0.2873
Leishmania major cathepsin L-like protease 0.0062 0.0028 0.168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0013 0.0379
Loa Loa (eye worm) glutaminase 2 0.0533 0.0301 1
Echinococcus granulosus cathepsin l1 0.0016 0.0002 0.0033
Schistosoma mansoni ran 0.0021 0.0004 0.0003
Onchocerca volvulus 0.0117 0.006 0.245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0009 0.0008
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0053 0.3248
Schistosoma mansoni lamin 0.0052 0.0023 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0082 0.0169
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.002
Treponema pallidum penicillin-binding protein (pbp-1) 0.0674 0.0383 0.8086
Plasmodium vivax vivapain-2 0.0016 0.0002 0.0101
Onchocerca volvulus 0.0029 0.0009 0.0308
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0025 0.1332
Leishmania major cathepsin L-like protease 0.0016 0.0002 0.0037
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0004 0.0196
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0004 0.0077
Leishmania major importin beta-1 subunit, putative 0.0023 0.0006 0.0272
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0012 0.0697
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0004 0.0532
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0004 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0003 0.0112
Loa Loa (eye worm) fibroinase 0.0016 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0194
Echinococcus granulosus snurportin 1 0.0298 0.0165 0.9055
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0004 0.0294
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.001 0.0551
Brugia malayi beta-lactamase family protein 0.0035 0.0013 0.0379
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0003 0.0048
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0009 0.1297
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0003 0.0001
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0334 0.0186 0.0394
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0013 0.036
Loa Loa (eye worm) runx1 0.0054 0.0024 0.0743
Treponema pallidum penicillin-binding protein (pbp-3) 0.0829 0.0473 1
Plasmodium falciparum cysteine--tRNA ligase 0.0117 0.006 1
Leishmania major cathepsin L-like protease 0.0016 0.0002 0.0037
Onchocerca volvulus 0.0052 0.0023 0.0875
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0109 0.3588
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0117 0.006 1
Schistosoma mansoni glutaminase 0.0533 0.0301 0.03
Trichomonas vaginalis ran, putative 0.0021 0.0004 0.0085
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0334 0.0186 0.0394
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0472 0.0266 0.0547
Leishmania major basic transcription factor 3a, putative 0.0034 0.0012 0.0697
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0053 0.1734
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0003 0.0058
Mycobacterium ulcerans glutaminase 0.0533 0.0301 0.0643
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0379
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0004 0.0057
Schistosoma mansoni survival motor neuron protein 0.0047 0.002 0.0019
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0013 0.0628
Echinococcus granulosus dna polymerase kappa 0.0019 0.0003 0.0112
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0013 0.0021
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0009 0.1031
Brugia malayi 6-phosphofructokinase 0.0105 0.0053 0.1734
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0053 0.8805
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0025 0.0804
Brugia malayi Cathepsin L-like precursor 0.0016 0.0002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0053 0.1718
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0053 0.3304
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0013 0.1926
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0207
Leishmania major cathepsin L-like protease 0.0016 0.0002 0.0037
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0004 0.0196
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0053 0.8805
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0003 0.0096
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0013 0.0021
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0009 0.1297
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0016 0.0935
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0126
Mycobacterium ulcerans hypothetical protein 0.0035 0.0013 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0012 0.0353
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0025 0.1332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0475 0.0268 0.0551
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0004 0.0277
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0264
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0013 0.0628
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0004 0.0077
Loa Loa (eye worm) RecQ helicase 0.0019 0.0004 0.0077
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0002 0.0037
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0157 0.0083 0.0173
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0003 0.0067
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0002 0.0033
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0053 0.0088
Loa Loa (eye worm) beta-lactamase 0.0035 0.0013 0.0379
Treponema pallidum penicillin-binding protein (pbp-2) 0.0475 0.0268 0.5635
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0006 0.0125
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0013 0.036
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0009 0.0236
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0004 0.0144
Loa Loa (eye worm) hypothetical protein 0.0428 0.024 0.7965
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0175
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0003 0.0296
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0053 0.1734
Toxoplasma gondii exonuclease III APE 0.0018 0.0003 0.0296
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0117 0.006 0.1967
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0432 0.0243 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0013 0.071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0004 0.0392
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0542
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0003 0.0112
Brugia malayi beta-lactamase 0.0035 0.0013 0.0379
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0073 0.449
Schistosoma mansoni ran 0.0021 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0051 0.0022 0.0696
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.016 0.0085 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0018 0.0542
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0379
Schistosoma mansoni lamin 0.0052 0.0023 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0013 0.0011
Echinococcus granulosus geminin 0.0328 0.0182 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0004 0.0128
Toxoplasma gondii ABC1 family protein 0.0035 0.0013 0.1926
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0013 0.0011
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0012 0.1892
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0004 0.0128
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0004 0.0173
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0379
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0003 0.0207
Plasmodium vivax importin-beta 2, putative 0.0028 0.0009 0.1256
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0432 0.0243 0.0516
Echinococcus granulosus cysteinyl tRNA synthetase 0.0117 0.006 0.3258
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0009 0.0236
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0472 0.0266 0.0567
Echinococcus granulosus dna polymerase eta 0.0043 0.0018 0.0898
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0028 0.168
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0003 0.0109
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0004 0.0077
Echinococcus multilocularis snurportin 1 0.0298 0.0165 0.9055
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0073 0.4444
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0028 0.168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.1749
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0004 0.0392
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0009 0.0541
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0003 0.0001
Chlamydia trachomatis transglycolase/transpeptidase 0.0674 0.0383 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0013 0.0021
Trichomonas vaginalis glutaminase, putative 0.0533 0.0301 1
Brugia malayi Pre-SET motif family protein 0.0201 0.0109 0.3588
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0117 0.006 0.1508
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0117 0.006 0.3684
Brugia malayi jmjC domain containing protein 0.0057 0.0025 0.0804
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0009 0.0409
Brugia malayi glutaminase DH11.1 0.0533 0.0301 1
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0012 0.0774

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) 0 % Inhibitory activity against growth of vis-sis transformed NIH 3T3 cells at 1 mM; IA means inactive ChEMBL. No reference
Inhibition (functional) = 30 % Inhibitory activity against growth of wild type NIH 3T3 cells at 1 mM ChEMBL. No reference
Inhibition (functional) = 30 % Inhibitory activity against growth of wild type NIH 3T3 cells at 1 mM ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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