Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Loa Loa (eye worm) | RNA binding protein | 0.0189 | 0.4885 | 0.4885 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.038 | 0.776 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.3458 | 0.3748 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1087 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.4885 | 0.5295 |
Echinococcus granulosus | geminin | 0.0331 | 0.9226 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0063 | 0.1003 | 0.2316 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.2316 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.2316 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0045 | 0.0465 | 0.1344 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Schistosoma mansoni | endoplasmin | 0.0045 | 0.0465 | 0.0504 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0063 | 0.1003 | 0.2162 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0063 | 0.1003 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.1347 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0042 | 0.038 | 0.282 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0045 | 0.0465 | 0.0465 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0074 | 0.1347 | 0.3111 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.0465 | 0.3452 |
Echinococcus granulosus | endoplasmin | 0.0042 | 0.038 | 0.0412 |
Schistosoma mansoni | heat shock protein | 0.0045 | 0.0465 | 0.0504 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Schistosoma mansoni | endoplasmin | 0.0045 | 0.0465 | 0.0504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.4885 | 0.5295 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Trichomonas vaginalis | heat shock protein, putative | 0.0045 | 0.0465 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0063 | 0.1003 | 0.7445 |
Echinococcus granulosus | heat shock protein | 0.0045 | 0.0465 | 0.0504 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.4885 | 0.5295 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0063 | 0.1003 | 0.7445 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0356 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0045 | 0.0465 | 0.3452 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1087 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1087 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0171 | 0.4329 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0189 | 0.4885 | 0.4885 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1347 | 0.1347 |
Brugia malayi | Isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1003 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Echinococcus multilocularis | heat shock protein | 0.0045 | 0.0465 | 0.0504 |
Brugia malayi | RNA binding protein | 0.0189 | 0.4885 | 0.4885 |
Plasmodium vivax | heat shock protein, putative | 0.0171 | 0.4329 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0042 | 0.038 | 0.5 |
Plasmodium vivax | heat shock protein 86, putative | 0.0045 | 0.0465 | 0.1074 |
Echinococcus multilocularis | tar DNA binding protein | 0.0189 | 0.4885 | 0.5295 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0097 | 0.0105 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1087 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0063 | 0.1003 | 0.7445 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0042 | 0.038 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.3458 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.3458 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.003 | 0 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0033 | 0.0097 | 0.0105 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0033 | 0.0097 | 0.0105 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1003 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Brugia malayi | Endoplasmin precursor | 0.0045 | 0.0465 | 0.0465 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0045 | 0.0465 | 0.1074 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0045 | 0.0465 | 0.1074 |
Brugia malayi | hypothetical protein | 0.0074 | 0.1347 | 0.1347 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0045 | 0.0465 | 0.1344 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0045 | 0.0465 | 0.3452 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0143 | 0.3458 | 0.3748 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0356 | 1 | 1 |
Giardia lamblia | Grp94/Hsp90 | 0.0042 | 0.038 | 0.5748 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.4885 | 0.5295 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0074 | 0.1347 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0063 | 0.1003 | 0.7445 |
Echinococcus multilocularis | endoplasmin | 0.0042 | 0.038 | 0.0412 |
Trichomonas vaginalis | heat shock protein, putative | 0.0039 | 0.0265 | 0.4732 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Treponema pallidum | heat shock protein 90 | 0.0042 | 0.038 | 0.5 |
Plasmodium vivax | endoplasmin, putative | 0.0045 | 0.0465 | 0.1074 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0039 | 0.0265 | 0.1966 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.3458 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0074 | 0.1347 | 0.2973 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0171 | 0.4329 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0074 | 0.1347 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Brugia malayi | heat shock protein 90 | 0.0045 | 0.0465 | 0.0465 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0189 | 0.4885 | 0.4885 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.9226 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0045 | 0.0465 | 0.3452 |
Echinococcus multilocularis | heat shock protein 90 | 0.0045 | 0.0465 | 0.0504 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0063 | 0.1003 | 0.1087 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1087 |
Brugia malayi | hypothetical protein | 0.0143 | 0.3458 | 0.3458 |
Entamoeba histolytica | hypothetical protein | 0.0143 | 0.3458 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0045 | 0.0465 | 0.0895 |
Loa Loa (eye worm) | endoplasmin | 0.0045 | 0.0465 | 0.0465 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0143 | 0.3458 | 0.3748 |
Loa Loa (eye worm) | TAR-binding protein | 0.0189 | 0.4885 | 0.4885 |
Leishmania major | heat shock protein 83-1 | 0.0045 | 0.0465 | 0.3452 |
Schistosoma mansoni | heat shock protein | 0.0045 | 0.0465 | 0.0504 |
Brugia malayi | isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1003 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0045 | 0.0465 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0045 | 0.0465 | 0.0504 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0039 | 0.0265 | 0.1966 |
Echinococcus multilocularis | geminin | 0.0331 | 0.9226 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0074 | 0.1347 | 1 |
Brugia malayi | TAR-binding protein | 0.0189 | 0.4885 | 0.4885 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0063 | 0.1003 | 0.7445 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0039 | 0.0265 | 0.0287 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0543 | 0.0543 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0143 | 0.3458 | 0.3748 |
Echinococcus multilocularis | heat shock protein 90 | 0.0039 | 0.0265 | 0.0287 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0042 | 0.038 | 0.5 |
Echinococcus granulosus | heat shock protein 90 | 0.0039 | 0.0265 | 0.0287 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.9226 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0189 | 0.4885 | 0.5295 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0074 | 0.1347 | 0.3111 |
Trichomonas vaginalis | heat shock protein, putative | 0.0042 | 0.038 | 0.776 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0063 | 0.1003 | 0.1087 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0074 | 0.1347 | 0.2973 |
Echinococcus granulosus | tar DNA binding protein | 0.0189 | 0.4885 | 0.5295 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0045 | 0.0465 | 0.3452 |
Trypanosoma brucei | heat shock protein, putative | 0.0045 | 0.0465 | 0.3452 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 75 mg kg-1 | Protection of mice infected with MRSA-32 cell suspension after oral administration of compound | ChEMBL. | 16078842 |
ED50 (functional) | > 75 mg kg-1 | Protection of mice infected with MRSA-32 cell suspension after oral administration of compound | ChEMBL. | 16078842 |
MIC (functional) | = 0.12 mg ml-1 | Minimum inhibitory concentration against methicillin susceptible Staphylococcus aureus after estarase action in rat serum | ChEMBL. | 16078842 |
MIC (functional) | = 0.5 mg ml-1 | Minimum inhibitory concentration against methicillin susceptible Staphylococcus aureus before estarase action in rat serum | ChEMBL. | 16078842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.