TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 298.724 | Formula: C16H11ClN2O2
H donors: 2 H acceptors: 3 LogP: 3.85 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)ncc(c2O)C(=O)Nc1ccccc1
InChi: 1S/C16H11ClN2O2/c17-10-6-7-12-14(8-10)18-9-13(15(12)20)16(21)19-11-4-2-1-3-5-11/h1-9H,(H,18,20)(H,19,21)
InChiKey: HPPDOHXODMXGOB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	High cysteine protein	0.0039	0.0447	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0039	0.0442	0.0903
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0031	0.0307	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Onchocerca volvulus		0.0039	0.0447	0.0628
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0014	0.0019	0.004
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0019	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.08	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0442	0.6137
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1599	0.3223
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0134	0.0271
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0039	0.0442	0.0903
Toxoplasma gondii	exonuclease III APE	0.0022	0.0146	0.162
Schistosoma mansoni	hypothetical protein	0.0303	0.4962	0.4962
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0442	0.6137
Echinococcus granulosus	thioredoxin glutathione reductase	0.0041	0.0477	0.0477
Schistosoma mansoni	peroxidasin	0.0213	0.3428	0.3428
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0509	0.1027
Brugia malayi	Animal haem peroxidase family protein	0.0213	0.3428	0.8059
Brugia malayi	Cadherin domain containing protein	0.0039	0.0447	0.105
Schistosoma mansoni	tyrosine kinase	0.0054	0.0696	0.0696
Echinococcus granulosus	protein jagged 1	0.0039	0.0447	0.0447
Brugia malayi	Latrophilin receptor protein 2	0.0014	0.001	0.0024
Schistosoma mansoni	tyrosine kinase	0.009	0.1322	0.1322
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0152	0.2101
Echinococcus multilocularis	lamin dm0	0.0031	0.0306	0.0306
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0146	0.2023
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.0515	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0306	0.0617
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0208	0.3343	1
Echinococcus granulosus	lamin dm0	0.0031	0.0306	0.0306
Echinococcus granulosus	epidermal growth factor receptor	0.009	0.1322	0.1322
Echinococcus multilocularis	epidermal growth factor receptor	0.009	0.1322	0.1322
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0146	0.2958
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Schistosoma mansoni	peroxidasin	0.0213	0.3428	0.3428
Brugia malayi	glutathione reductase	0.0041	0.0477	0.1122
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.0515	0.1038
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.08	0.2392
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.08	0.5087
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0054	0.0696	0.0696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0171	0.2366
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0019	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0306	0.4247
Echinococcus granulosus	neurogenic locus notch protein 4	0.0039	0.0447	0.0447
Echinococcus granulosus	fibropellin Ia	0.0039	0.0447	0.0447
Echinococcus granulosus	intermediate filament protein	0.0031	0.0306	0.0306
Loa Loa (eye worm)	animal heme peroxidase	0.0213	0.3428	0.6909
Echinococcus multilocularis	neurogenic locus protein delta	0.0039	0.0447	0.0447
Brugia malayi	Delta serrate ligand family protein	0.0039	0.0447	0.105
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0014	0.001	0.001
Trichomonas vaginalis	glutathione reductase, putative	0.0014	0.0019	0.027
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0039	0.0447	0.0447
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0039	0.0442	0.104
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0093	0.1375	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Brugia malayi	hypothetical protein	0.0261	0.4254	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.376	0.376
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0192	0.0386
Giardia lamblia	GTOR	0.0039	0.0442	0.9899
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0014	0.0019	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0223	0.3097
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0093	0.1375	0.8837
Echinococcus multilocularis	snurportin 1	0.0303	0.4962	0.4962
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0442	0.6137
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0477	1
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0039	0.0442	0.0442
Trichomonas vaginalis	chromobox protein, putative	0.0055	0.0721	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0262	0.0262
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0039	0.0442	1
Brugia malayi	Thioredoxin reductase	0.0041	0.0477	0.1122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0306	0.4247
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0477	0.0962
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0029	0.0272	0.3235
Schistosoma mansoni	cell polarity protein	0.0039	0.0447	0.0447
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0146	0.2023
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Echinococcus multilocularis		0.0052	0.0667	0.0667
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0039	0.0447	0.0447
Brugia malayi	Calcium binding EGF domain containing protein	0.0039	0.0447	0.105
Echinococcus multilocularis	microtubule associated protein 2	0.0597	1	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0134	0.0134
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0014	0.001	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0175	0.2421
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0589	0.1385
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0054	0.0696	0.0696
Brugia malayi	Animal haem peroxidase family protein	0.0213	0.3428	0.8059
Leishmania major	trypanothione reductase	0.0041	0.0477	0.1428
Schistosoma mansoni	hypothetical protein	0.0014	0.001	0.001
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0039	0.0447	0.105
Echinococcus multilocularis	fibropellin Ia	0.0039	0.0447	0.0447
Toxoplasma gondii	EGF family domain-containing protein	0.0039	0.0447	0.5478
Echinococcus multilocularis	lamin	0.0031	0.0306	0.0306
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0146	0.0298
Schistosoma mansoni	tyrosine kinase	0.0054	0.0696	0.0696
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0477	0.5867
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0282	0.0567
Brugia malayi	Furin-like cysteine rich region family protein	0.0168	0.2652	0.6235
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0134	0.2685
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0032	0.0032
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0104	0.1553	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0262	0.0536
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0306	0.4245
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0039	0.0442	0.1324
Onchocerca volvulus	Neurogenic locus notch homolog	0.0039	0.0447	0.0628
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0346	0.4802
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0016	0.0053	0.0109
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0696	0.1635
Brugia malayi	Animal haem peroxidase family protein	0.0213	0.3428	0.8059
Onchocerca volvulus		0.0039	0.0447	0.0628
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.009	0.1322	0.1322
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0146	0.0824
Brugia malayi	Cadherin domain containing protein	0.0039	0.0447	0.105
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0019	0.004
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0039	0.0447	0.0447
Leishmania major	C-8 sterol isomerase-like protein	0.0208	0.3343	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0032	0.0032
Brugia malayi	Calcium binding EGF domain containing protein	0.0039	0.0447	0.105
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0019	0.0019
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0039	0.0442	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0093	0.1375	0.8837
Echinococcus granulosus	tumor protein p63	0.0292	0.4783	0.4783
Brugia malayi	hypothetical protein	0.0022	0.015	0.0353
Loa Loa (eye worm)	phosphatidylinositol 3	0.0039	0.0442	0.0892
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Echinococcus multilocularis	musashi	0.0031	0.0306	0.0306
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0146	0.0146
Loa Loa (eye worm)	animal heme peroxidase	0.0213	0.3428	0.6909
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0146	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0033	0.0346	0.038
Schistosoma mansoni	ap endonuclease	0.0022	0.0146	0.0146
Onchocerca volvulus		0.0047	0.0589	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Loa Loa (eye worm)	Notch2	0.0039	0.0447	0.09
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0134	0.2507
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1889
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0039	0.0447	0.0628
Brugia malayi	Heterochromatin protein 1	0.0055	0.0721	0.1695
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.376	0.376
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0477	0.1428
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Onchocerca volvulus		0.0039	0.0447	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.08	0.08
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0306	0.072
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0306	0.4247
Onchocerca volvulus		0.0213	0.3428	0.7968
Echinococcus granulosus	peroxidasin	0.0213	0.3428	0.3428
Trypanosoma brucei	RNA helicase, putative	0.0299	0.4902	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0032	0.0065
Trypanosoma brucei	PAB1-binding protein , putative	0.0022	0.015	0.0306
Echinococcus multilocularis	neurogenic locus protein delta	0.0039	0.0447	0.0447
Onchocerca volvulus	Chorion peroxidase homolog	0.0213	0.3428	0.7968
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0039	0.0442	0.1324
Echinococcus multilocularis	neurogenic locus notch protein	0.0039	0.0447	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0306	0.4247
Schistosoma mansoni	laminin gamma-3 chain	0.0039	0.0447	0.0447
Onchocerca volvulus	Peroxidase homolog	0.0213	0.3428	0.7968
Trypanosoma brucei	trypanothione reductase	0.0041	0.0477	0.0974
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1882
Brugia malayi	latrophilin 2 splice variant baaae	0.0029	0.0282	0.0662
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.08	1
Brugia malayi	Blistered cuticle protein 3	0.0213	0.3428	0.8059
Loa Loa (eye worm)	hypothetical protein	0.0014	0.001	0.0021
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0019	0.0046
Onchocerca volvulus	Putative cubilin	0.0039	0.0447	0.0628
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0146	0.0436
Schistosoma mansoni	tyrosine kinase	0.0089	0.1305	0.1305
Echinococcus granulosus	chromobox protein 1	0.0055	0.0721	0.0721
Schistosoma mansoni	notch	0.0039	0.0447	0.0447
Schistosoma mansoni	hypothetical protein	0.0014	0.001	0.001
Schistosoma mansoni	slit	0.0039	0.0447	0.0447
Onchocerca volvulus		0.0039	0.0447	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1889
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0093	0.1375	0.8837
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0039	0.0442	0.0442
Schistosoma mansoni	lamin	0.0031	0.0306	0.0306
Schistosoma mansoni	ran	0.0021	0.0134	0.0134
Schistosoma mansoni	notch	0.0039	0.0447	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0175	0.2421
Echinococcus granulosus	epidermal growth factor receptor	0.0168	0.2652	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0171	0.2366
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0134	0.0402
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0019	0.0019
Onchocerca volvulus		0.0043	0.0509	0.0782
Brugia malayi	Peroxidasin	0.0213	0.3428	0.8059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0306	0.4247
Echinococcus granulosus	GPCR family 2	0.0014	0.001	0.001
Onchocerca volvulus	Peroxidasin homolog	0.0213	0.3428	0.7968
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0171	0.2366
Trichomonas vaginalis	chromobox protein, putative	0.0033	0.0346	0.4802
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0345	0.4787
Schistosoma mansoni	tyrosine kinase	0.0089	0.1305	0.1305
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.08	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0306	0.0617
Onchocerca volvulus	Peroxidasin homolog	0.0213	0.3428	0.7968
Schistosoma mansoni	ran	0.0021	0.0134	0.0134
Schistosoma mansoni	tyrosine kinase	0.0168	0.2652	0.2652
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Brugia malayi	hypothetical protein	0.0014	0.0018	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.4962	1
Echinococcus granulosus	protein jagged 2	0.0039	0.0447	0.0447
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0262	0.3115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1889
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.08	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0014	0.001	0.001
Loa Loa (eye worm)	animal heme peroxidase	0.0213	0.3428	0.6909
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0306	0.0306
Brugia malayi	hypothetical protein	0.0232	0.376	0.884
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0306	0.0617
Onchocerca volvulus	Slit protein homolog	0.0039	0.0447	0.0628
Echinococcus granulosus	chromobox protein 1	0.0055	0.0721	0.0721
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0014	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0146	0.0436
Echinococcus granulosus	delta-like protein 1	0.0039	0.0447	0.0447
Schistosoma mansoni	notch	0.0039	0.0447	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Mycobacterium tuberculosis	Probable oxidoreductase	0.0104	0.1553	1
Echinococcus granulosus	snurportin 1	0.0303	0.4962	0.4962
Echinococcus multilocularis	peroxidasin	0.0213	0.3428	0.3428
Onchocerca volvulus		0.0213	0.3428	0.7968
Loa Loa (eye worm)	hypothetical protein	0.0261	0.4254	0.8572
Brugia malayi	notch-like transmembrane receptor	0.0039	0.0447	0.105
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0039	0.0442	0.0442
Echinococcus multilocularis	protein jagged 2	0.0039	0.0447	0.0447
Schistosoma mansoni	importin beta-1	0.0028	0.0262	0.0262
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.015	0.0449
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.006	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0031	0.0307	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0208	0.3343	0.6736
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0041	0.0477	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Brugia malayi	GCC2 and GCC3 family protein	0.0039	0.0447	0.105
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0146	0.0343
Onchocerca volvulus		0.0039	0.0447	0.0628
Onchocerca volvulus		0.0031	0.0306	0.0282
Trypanosoma cruzi	target of rapamycin kinase 3	0.0031	0.0307	0.0918
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0146	0.2762
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0039	0.0442	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Brugia malayi	Animal haem peroxidase family protein	0.0213	0.3428	0.8059
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0014	0.001	0.0024
Echinococcus granulosus	slit 2 protein	0.0039	0.0447	0.0447
Echinococcus multilocularis	chromobox protein 1	0.0055	0.0721	0.0721
Entamoeba histolytica	hypothetical protein	0.0023	0.0171	0.118
Trypanosoma cruzi	PAB1-binding protein , putative	0.0022	0.015	0.0449
Toxoplasma gondii	LsmAD domain-containing protein	0.0022	0.015	0.1675
Echinococcus granulosus	notch	0.0039	0.0447	0.0447
Plasmodium falciparum	importin beta, putative	0.0028	0.0262	0.5309
Trichomonas vaginalis	mercuric reductase, putative	0.0014	0.0019	0.027
Schistosoma mansoni	tyrosine kinase	0.0089	0.1305	0.1305
Schistosoma mansoni	notch	0.0039	0.0447	0.0447
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.015	0.2855
Echinococcus multilocularis	slit 2 protein	0.0039	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Onchocerca volvulus	Peroxidase homolog	0.0213	0.3428	0.7968
Echinococcus multilocularis	protein jagged 1	0.0039	0.0447	0.0447
Schistosoma mansoni	hypothetical protein	0.0047	0.0589	0.0589
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0014	0.001	0.001
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0146	0.2762
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.006	0.0122
Echinococcus granulosus	insulin receptor	0.0054	0.0696	0.0696
Schistosoma mansoni	cellular tumor antigen P53	0.0043	0.0509	0.0509
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0262	0.0262
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0134	0.2507
Schistosoma mansoni	ap endonuclease	0.0022	0.0146	0.0146
Brugia malayi	Animal haem peroxidase family protein	0.0213	0.3428	0.8059
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0171	0.2366
Echinococcus multilocularis	neurogenic locus notch protein	0.0039	0.0447	0.0447
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0039	0.0442	0.1324
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Onchocerca volvulus		0.0031	0.0306	0.0282
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0171	0.2366
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0171	0.051
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1882
Schistosoma mansoni	notch	0.0039	0.0447	0.0447
Echinococcus multilocularis	insulin receptor	0.0054	0.0696	0.0696
Echinococcus granulosus	neural cadherin	0.0039	0.0447	0.0447
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0477	1
Trichomonas vaginalis	ran, putative	0.0021	0.0134	0.1862
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Plasmodium falciparum	glutathione reductase	0.0041	0.0477	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0039	0.0447	0.105
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0208	0.3343	0.7858
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0152	0.2101
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0262	0.0536
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0104	0.1553	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.08	0.08
Schistosoma mansoni	chromobox protein	0.0055	0.0721	0.0721
Brugia malayi	Muscle positioning protein 4	0.0039	0.0447	0.105
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0306	0.4245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0146	0.0436
Leishmania major	hypothetical protein, conserved	0.0022	0.015	0.0449
Loa Loa (eye worm)	animal heme peroxidase	0.0213	0.3428	0.6909
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0589	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Schistosoma mansoni	chromobox protein	0.0055	0.0721	0.0721
Schistosoma mansoni	septate junction protein	0.0039	0.0447	0.0447
Onchocerca volvulus		0.0261	0.4254	1
Echinococcus multilocularis	GPCR, family 2	0.0014	0.001	0.001
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0477	0.0962
Onchocerca volvulus	Dual oxidase homolog	0.0213	0.3428	0.7968
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0104	0.1553	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0175	0.2421
Schistosoma mansoni	hypothetical protein	0.0029	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0023	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0272	0.3771
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0146	0.162
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1889
Plasmodium vivax	ataxin-2 like protein, putative	0.0022	0.015	0.2855
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0014	0.0019	0.0058
Brugia malayi	hypothetical protein	0.0213	0.3428	0.8059
Echinococcus granulosus	neurogenic locus notch protein	0.0039	0.0447	0.0447
Echinococcus granulosus	neurogenic locus protein delta	0.0039	0.0447	0.0447
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Echinococcus granulosus	lamin	0.0031	0.0306	0.0306
Loa Loa (eye worm)	notch protein	0.0039	0.0447	0.09
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0146	0.0294
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0014	0.0019	0.004
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0262	0.5309
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0134	0.1471
Echinococcus multilocularis	epidermal growth factor receptor	0.0168	0.2652	0.2652
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.0477	0.2985
Echinococcus multilocularis	protein jagged 1	0.0039	0.0447	0.0447
Echinococcus multilocularis	neural cadherin	0.0039	0.0447	0.0447
Leishmania major	GTP-binding protein, putative	0.0021	0.0134	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0232	0.376	0.7578
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0529
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0146	0.0146
Schistosoma mansoni	tyrosine kinase	0.009	0.1322	0.1322
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0134	0.0134
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0134	0.0274
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0014	0.0019	0.004
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0014	0.001	0.001
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0208	0.3343	0.682
Schistosoma mansoni	microtubule-associated protein tau	0.0597	1	1
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.08	0.08
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0515	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0023	0.0045
Brugia malayi	intermediate filament protein	0.0031	0.0306	0.072
Mycobacterium tuberculosis	Probable dehydrogenase	0.0093	0.1375	0.8837
Onchocerca volvulus		0.0213	0.3428	0.7968
Loa Loa (eye worm)	blistered cuticle protein 3	0.0213	0.3428	0.6909
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0014	0.0019	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.0515	0.1211
Brugia malayi	EGF-like domain containing protein	0.0039	0.0447	0.105
Echinococcus multilocularis	chromobox protein 1	0.0055	0.0721	0.0721
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0136	0.1882
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0477	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0171	0.051
Loa Loa (eye worm)	heterochromatin protein 1	0.0055	0.0721	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Loa Loa (eye worm)	TK/INSR protein kinase	0.0054	0.0696	0.1402
Echinococcus multilocularis	notch	0.0039	0.0447	0.0447
Schistosoma mansoni	hypothetical protein	0.0014	0.001	0.001
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0306	0.0617
Brugia malayi	RNA, U transporter 1	0.0081	0.1158	0.2722
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0146	0.0378
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.08	0.08
Schistosoma mansoni	hypothetical protein	0.0299	0.4902	0.4902
Loa Loa (eye worm)	hypothetical protein	0.0022	0.015	0.0303
Echinococcus granulosus	protein jagged 1	0.0039	0.0447	0.0447
Echinococcus granulosus	neurogenic locus notch protein	0.0039	0.0447	0.0447
Plasmodium falciparum	ataxin-2 like protein, putative	0.0022	0.015	0.2855
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0209	0.2897
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Brugia malayi	Importin beta-1 subunit	0.0028	0.0262	0.0617
Trypanosoma cruzi	trypanothione reductase, putative	0.0014	0.0019	0.0058
Loa Loa (eye worm)	hypothetical protein	0.003	0.0296	0.0597
Echinococcus granulosus	protein jagged 2	0.0039	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0447	0.09
Schistosoma mansoni	lamin	0.0031	0.0306	0.0306
Trichomonas vaginalis	chromobox protein, putative	0.0055	0.0721	1
Mycobacterium tuberculosis	Probable reductase	0.0093	0.1375	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0168	0.2652	0.5345
Schistosoma mansoni	notch	0.0039	0.0447	0.0447
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0134	0.0316
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0134	0.0402
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Schistosoma mansoni	hypothetical protein	0.0039	0.0447	0.0447
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0018	0.0092	0.0187
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0014	0.0019	0.0058
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0031	0.0306	0.0282
Brugia malayi	chromobox protein homolog 3	0.0031	0.0306	0.072
Echinococcus multilocularis	tumor protein p63	0.0292	0.4783	0.4783
Loa Loa (eye worm)	hypothetical protein	0.0213	0.3428	0.6909

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -2.65 %	In vitro percent inhibition of LPS induced B-cell proliferation at the dose 1 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 10.4 %	In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 10 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 10.4 %	In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 10 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 10.5 %	In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 1 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 10.5 %	In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 1 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 12.3 %	In vitro percent inhibition of LPS induced B-cell proliferation at the dose 10 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 16.7 %	In vitro percent inhibition of ConA induced T-cell proliferation at the dose 1 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 22.3 %	In vitro percent inhibition of ConA induced T-cell proliferation at the dose 100 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 23.1 %	In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 100 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 23.1 %	In vitro percent inhibition of tumor necrosis factor, alpha secreted by macrophage at the dose 100 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 27.1 %	In vitro percent inhibition of LPS induced B-cell proliferation at the dose 100 ug/mL	ChEMBL.	15908212
Inhibition (functional)	= 32.6 %	In vitro percent inhibition of ConA induced T-cell proliferation at the dose 10 ug/mL	ChEMBL.	15908212

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL189737

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 333339