Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.082 | 0.4917 | 0.5902 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1316 | 0.8331 | 0.8454 |
Echinococcus granulosus | dihydrofolate reductase | 0.1316 | 0.8331 | 0.8331 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1316 | 0.8331 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1316 | 0.8331 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1316 | 0.8331 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0676 | 0.3926 | 0.5 |
Brugia malayi | Serotonin receptor | 0.1046 | 0.6471 | 0.7768 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.2155 | 0.2587 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1316 | 0.8331 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1316 | 0.8331 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0676 | 0.3926 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.1537 | 0.9854 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.082 | 0.4917 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0676 | 0.3926 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1316 | 0.8331 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1316 | 0.8331 | 1 |
Onchocerca volvulus | 0.0106 | 0 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1316 | 0.8331 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.082 | 0.4917 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.082 | 0.4917 | 0.5902 |
Leishmania major | C-8 sterol isomerase-like protein | 0.082 | 0.4917 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.3 M | Effective concentration required to protect CEM cells from Simian-Human immunodeficiency virus (SIV) infection | ChEMBL. | 15923115 |
EC50 (functional) | = 4.3 uM | Effective concentration required to protect CEM cells from Simian-Human immunodeficiency virus (SIV) infection | ChEMBL. | 15923115 |
TC50 (functional) | = 54 M | Toxic concentration (Cytotoxicity) of the compound in uninfected CEM cells | ChEMBL. | 15923115 |
TC50 (functional) | = 54 M | Toxic concentration (Cytotoxicity) of the compound in uninfected CEM cells | ChEMBL. | 15923115 |
TI (functional) | = 13 | Ratio of toxic concentration (TC50) to the effective concentration (EC50) of the compound (Therapeutic Index) in CEM cells | ChEMBL. | 15923115 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15923115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.