Detailed information for compound 333484

Basic information

Technical information
  • TDR Targets ID: 333484
  • Name: [(8R,9S,13S,14S,17S)-2-ethyl-17-hydroxy-13-me thyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclo penta[a]phenanthren-3-yl] sulfamate
  • MW: 379.514 | Formula: C20H29NO4S
  • H donors: 2 H acceptors: 3 LogP: 3.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc2[C@H]3CC[C@]4([C@H]([C@@H]3CCc2cc1OS(=O)(=O)N)CC[C@@H]4O)C
  • InChi: 1S/C20H29NO4S/c1-3-12-10-16-13(11-18(12)25-26(21,23)24)4-5-15-14(16)8-9-20(2)17(15)6-7-19(20)22/h10-11,14-15,17,19,22H,3-9H2,1-2H3,(H2,21,23,24)/t14-,15+,17-,19-,20-/m0/s1
  • InChiKey: POSDSPVRJAJSEI-SSGANFLRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • sulfamic acid [(8R,9S,13S,14S,17S)-2-ethyl-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens steroid sulfatase (microsomal), isozyme S Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi hypothetical protein Get druggable targets OG5_130476 All targets in OG5_130476
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans arylsulfatase AtsB steroid sulfatase (microsomal), isozyme S 583 aa 470 aa 23.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.0003
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0083 0.1268
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.1006 0.8317 0.8317
Echinococcus multilocularis 0.0018 0.0072 0.0117
Mycobacterium leprae Probable lipase LipE 0.0036 0.0221 0.124
Echinococcus multilocularis myoferlin 0.0018 0.0072 0.0117
Brugia malayi Synapse defective protein 1 0.0018 0.0072 0.0119
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0043 0.0275 0.0971
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0175 0.2667
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.1839 0.1839
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Schistosoma mansoni synaptic ras gtpase activating protein syngap 0.0018 0.0072 0.0117
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0218 0.074
Loa Loa (eye worm) hypothetical protein 0.0366 0.2978 0.2978
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0031
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0018 0.0072 0.0366
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus granulosus intersectin 2 0.0018 0.0072 0.0117
Trypanosoma brucei predicted C2 domain protein 0.0018 0.0072 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1216 0.1991
Schistosoma mansoni unc-13 (munc13) 0.0018 0.0072 0.0117
Schistosoma mansoni copine 0.0018 0.0072 0.0117
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0024 0.0039
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0175 0.2667
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0175 0.1091
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0117
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0155 0.1216 0.1216
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Echinococcus multilocularis protein kinase c eta type 0.0155 0.1216 0.1991
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0216 0.0354
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0043 0.0275 0.0971
Echinococcus granulosus protein kinase c iota type 0.0357 0.2899 0.4746
Echinococcus granulosus geminin 0.0337 0.2734 0.4475
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0292 0.4447
Schistosoma mansoni protein kinase C mu 0.016 0.1252 0.205
Mycobacterium tuberculosis Conserved protein 0.0036 0.0221 0.078
Plasmodium falciparum glutathione reductase 0.0031 0.0175 0.2667
Echinococcus multilocularis Protein son of sevenless 0.0013 0.0031 0.0051
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0043 0.0275 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Schistosoma mansoni cpg binding protein 0.0028 0.0156 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0218 0.0218
Toxoplasma gondii exonuclease III APE 0.0039 0.0242 0.1507
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0083 0.1268
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0201 0.1598 0.5635
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0018 0.0072 0.0117
Brugia malayi Protein kinase c protein 2 0.0544 0.4462 0.739
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0031 0.047
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0278
Brugia malayi beta-lactamase family protein 0.0036 0.0221 0.0367
Trichomonas vaginalis annexin VII, putative 0.0018 0.0072 0.0366
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0003 0.0048
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.1786 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Brugia malayi CXXC zinc finger family protein 0.0028 0.0156 0.0259
Brugia malayi Pre-SET motif family protein 0.0031 0.0181 0.03
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0083 0.0424
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0226 0.0375
Mycobacterium tuberculosis Possible hydrolase 0.001 0.0007 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Brugia malayi RhoGAP domain containing protein 0.0155 0.1216 0.2014
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0018 0.0072 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Trypanosoma cruzi cAMP binding protein, putative 0.0018 0.0072 0.1093
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0018 0.0072 0.0117
Echinococcus multilocularis intersectin 2 0.0018 0.0072 0.0117
Trichomonas vaginalis ras GTP exchange factor, putative 0.0013 0.0031 0.0159
Trypanosoma cruzi hypothetical protein 0.0013 0.0031 0.0474
Echinococcus granulosus raf serine:threonine protein kinase 0.0155 0.1216 0.1991
Entamoeba histolytica C2 domain protein, putative 0.0018 0.0072 0.0244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0297 0.0486
Brugia malayi beta-lactamase family protein 0.0036 0.0221 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0083 0.0519
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0218 0.036
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0024 0.0039
Brugia malayi Pleckstrin Homology Domain 0.0155 0.1216 0.2014
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0043 0.0275 0.0971
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0221 0.113
Mycobacterium ulcerans arylsulfatase AtsD 0.001 0.0007 0.0023
Echinococcus granulosus UNCoordinated family member unc 13 0.0018 0.0072 0.0117
Onchocerca volvulus Putative cc2d1b protein 0.0018 0.0072 0.008
Trichomonas vaginalis copine, putative 0.0018 0.0072 0.0366
Echinococcus granulosus N chimaerin 0.0155 0.1216 0.1991
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0018 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0226 0.1155
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0031 0.047
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0157
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.1786 0.6296
Echinococcus multilocularis protein piccolo 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0221 0.078
Plasmodium vivax ferlin, putative 0.0018 0.0072 0.1093
Toxoplasma gondii ABC1 family protein 0.0036 0.0221 0.1381
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0107 0.0178
Brugia malayi LD23056p 0.0018 0.0072 0.0119
Plasmodium vivax double C2-like domain-containing protein, putative 0.0018 0.0072 0.1093
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0292 1
Toxoplasma gondii Elicitor-responsive protein, putative 0.0018 0.0072 0.0447
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0741 0.6109 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0202 0.1603 0.2624
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0221 0.078
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0175 0.0617
Onchocerca volvulus 0.0155 0.1216 0.1352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0242 0.3684
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0083 0.0136
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.001 0.0000046615 0.0000076302
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0018 0.0072 0.0366
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0083 0.0519
Toxoplasma gondii diacylglycerol kinase, putative 0.0155 0.1216 0.7586
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0043 0.0275 0.0971
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.006 0.092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0181 0.0297
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0043 0.0275 0.1717
Giardia lamblia Hypothetical protein 0.001 0.0007 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0043 0.0275 0.0971
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1603 0.2624
Schistosoma mansoni synaptotagmin 0.0018 0.0072 0.0117
Echinococcus granulosus synaptotagmin protein 4 0.0018 0.0072 0.0117
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Schistosoma mansoni DNA helicase recq1 0.002 0.0083 0.0136
Brugia malayi Copine family protein 0.0018 0.0072 0.0119
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0018 0.0072 0.0366
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0175 0.2667
Leishmania major hypothetical protein, conserved 0.0036 0.0221 0.3376
Echinococcus multilocularis copine 9 0.0018 0.0072 0.0117
Loa Loa (eye worm) beta-lactamase 0.0036 0.0221 0.0221
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0175 0.2668
Loa Loa (eye worm) histone methyltransferase 0.001 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0072 0.0447
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0018 0.0072 0.0117
Brugia malayi hydrolase, alpha/beta fold family protein 0.0544 0.4465 0.7394
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.116 0.116
Brugia malayi Copine VIII 0.0018 0.0072 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0083 0.0138
Brugia malayi NEDD4.2 0.0018 0.0072 0.0119
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0018 0.0072 0.0117
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.016 0.1252 0.2074
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0043 0.0275 0.0971
Leishmania major phospholipase c-like protein 0.0018 0.0072 0.1093
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0656 0.2312
Brugia malayi phospholipase C homolog 0.0018 0.0072 0.0119
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0156 0.0156
Brugia malayi RasGEF domain containing protein 0.0013 0.0031 0.0051
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0181 0.1132
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0031 0.0192
Mycobacterium tuberculosis Probable dehydrogenase 0.0201 0.1598 0.5635
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0175 0.1091
Brugia malayi protein kinase C3,putative 0.016 0.1252 0.2074
Brugia malayi Synaptotagmin I 0.0018 0.0072 0.0119
Echinococcus multilocularis serine:threonine protein kinase N2 0.056 0.4591 0.7514
Schistosoma mansoni nedd-4-like E3 ubiquitin-protein ligase 0.0018 0.0072 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Plasmodium falciparum ferlin, putative 0.0018 0.0072 0.1093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0297 0.0491
Loa Loa (eye worm) C2 domain-containing protein 0.0018 0.0072 0.0072
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0218 0.1111
Loa Loa (eye worm) hypothetical protein 0.0147 0.1147 0.1147
Echinococcus granulosus RNA directed DNA polymerase 0.0366 0.2978 0.4875
Echinococcus multilocularis synaptotagmin 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0024 0.0123
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0431 0.0706
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0024 0.0039
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0018 0.0072 0.0366
Schistosoma mansoni alpha glucosidase 0.0036 0.0218 0.0356
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0218 0.1111
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0078 0.0575 0.2026
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.016 0.1252 0.205
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Plasmodium vivax alpha/beta hydrolase, putative 0.001 0.0000046615 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.066 0.1081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0242 0.0852
Loa Loa (eye worm) C2 domain-containing protein 0.0018 0.0072 0.0072
Schistosoma mansoni ras GTP exchange factor 0.0013 0.0031 0.0051
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0216 0.0358
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0242 0.0242
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0175 0.029
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Echinococcus multilocularis synaptotagmin 0.0018 0.0072 0.0117
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0175 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0043 0.0275 0.4198
Loa Loa (eye worm) hypothetical protein 0.0173 0.1368 0.1368
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0202 0.1603 0.1603
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0242 0.1233
Trichomonas vaginalis copine, putative 0.0018 0.0072 0.0366
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0024 0.0123
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0024 0.0367
Schistosoma mansoni diacylglycerol kinase theta 0.0155 0.1216 0.1991
Schistosoma mansoni cytochrome P450 0.0043 0.0275 0.0451
Entamoeba histolytica calcium-binding protein, putative 0.0018 0.0072 0.0244
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0226 0.037
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0043 0.0275 0.0971
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0226 0.0371
Schistosoma mansoni atypical protein kinase C 0.0357 0.2899 0.4746
Brugia malayi hypothetical protein 0.0161 0.1264 0.2093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0362 0.2944 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0197 0.1567 0.7998
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0321 0.0525
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0226 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0043 0.0275 0.0971
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0366 0.2978 0.4875
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1262 0.1262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Brugia malayi acetyltransferase, GNAT family protein 0.0165 0.1299 0.2151
Echinococcus granulosus otoferlin 0.0018 0.0072 0.0117
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0043 0.0275 0.0971
Echinococcus granulosus myotubularin protein 13 0.0155 0.1216 0.1991
Entamoeba histolytica hypothetical protein 0.0155 0.1216 0.4131
Echinococcus multilocularis raf serine:threonine protein kinase 0.0155 0.1216 0.1991
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0024 0.0123
Schistosoma mansoni serine/threonine kinase 0.0202 0.1603 0.2624
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0221 0.078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.126 0.2062
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0018 0.0072 0.0447
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0175 0.1091
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.001 0.0007 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0003 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Onchocerca volvulus 0.0012 0.0024 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0297 0.0486
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0325 0.0533
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0031 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0202 0.1603 0.2624
Echinococcus multilocularis tumor protein p63 0.0333 0.2702 0.4424
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0575 0.0575
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0221
Echinococcus granulosus synaptotagmin 0.0018 0.0072 0.0117
Schistosoma mansoni hydrolase 0.001 0.0000046615 0.0000076302
Echinococcus granulosus tumor protein p63 0.0333 0.2702 0.4424
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0043 0.0275 0.0971
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0031 0.0034
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0043 0.0275 0.0971
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0083 0.0136
Schistosoma mansoni ap endonuclease 0.0039 0.0242 0.0395
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0018 0.0072 0.0447
Onchocerca volvulus 0.0031 0.0181 0.0202
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0117
Echinococcus granulosus Protein kinase C brain isozyme 0.0741 0.6109 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0226 0.3451
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus multilocularis Diacylglycerol kinase theta 0.0155 0.1216 0.1991
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0242 0.3684
Trypanosoma brucei Coiled-coil and C2 domain-containing protein 0.0018 0.0072 0.0447
Brugia malayi hypothetical protein 0.001 0.0007 0.0011
Schistosoma mansoni diacylglycerol kinase theta 0.0155 0.1216 0.1991
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0043 0.0275 0.0971
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0155 0.1216 0.1216
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0218 0.1111
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0018 0.0072 0.0366
Echinococcus granulosus C2 calcium lipid binding region CaLB 0.0018 0.0072 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.016 0.1252 0.205
Entamoeba histolytica hypothetical protein 0.0018 0.0072 0.0244
Schistosoma mansoni ap endonuclease 0.0039 0.0242 0.0395
Brugia malayi Protein kinase domain containing protein 0.0202 0.1603 0.2655
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Echinococcus multilocularis extended synaptotagmin 2 0.0018 0.0072 0.0117
Trypanosoma brucei predicted C2 domain protein 0.0018 0.0072 0.0447
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0221 0.3376
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0031 0.0031
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0031 0.0051
Onchocerca volvulus 0.0018 0.0072 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0221 0.113
Plasmodium vivax hypothetical protein, conserved 0.001 0.0000046615 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0297 0.0486
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0221 0.078
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0123
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0031 0.0051
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0221 0.078
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Brugia malayi Sulfatase family protein 0.001 0.0007 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1712 0.1712
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0221 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0083 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Mycobacterium ulcerans sulfatase 0.001 0.0007 0.0023
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0175 0.2667
Mycobacterium tuberculosis Conserved protein 0.0036 0.0221 0.078
Trichomonas vaginalis ras GTP exchange factor, putative 0.0013 0.0031 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0202 0.1603 0.1603
Brugia malayi Cytochrome P450 family protein 0.0078 0.0575 0.0952
Echinococcus granulosus Protein son of sevenless 0.0013 0.0031 0.0051
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0031 0.0031
Brugia malayi RasGEF domain containing protein 0.0013 0.0031 0.0051
Mycobacterium ulcerans arylsulfatase AtsD 0.001 0.0007 0.0023
Onchocerca volvulus 0.0036 0.0221 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Brugia malayi diacylglycerol kinase 0.0155 0.1216 0.2014
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0072 0.0119
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0109
Brugia malayi RhoGAP domain containing protein 0.0155 0.1216 0.2014
Leishmania major trypanothione reductase 0.0088 0.0656 1
Echinococcus multilocularis 0.0043 0.0275 0.0451
Leishmania major c2 domain protein, putative 0.0018 0.0072 0.1093
Brugia malayi PAS domain containing protein 0.0048 0.0321 0.0531
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0157
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0018 0.0072 0.0366
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0325 0.1661
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.3288 0.5382
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0083 0.0424
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0226 0.7761
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0218 0.1358
Loa Loa (eye worm) glutathione reductase 0.0088 0.0656 0.0656
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.0072 0.0447
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0043 0.0275 0.0971
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0043 0.0275 0.0971
Schistosoma mansoni vav2 0.0155 0.1216 0.1991
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0226 0.0769
Echinococcus granulosus protein kinase c epsilon type 0.0733 0.6038 0.9884
Mycobacterium ulcerans beta-lactamase 0.0036 0.0221 0.078
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.016 0.1252 0.1252
Echinococcus granulosus protein piccolo 0.0018 0.0072 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0181 0.0297
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0181 0.0297
Echinococcus multilocularis synaptotagmin 2 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0043 0.0275 0.0971
Trypanosoma brucei C2 domain containing protein, putative 0.0018 0.0072 0.0447
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0201 0.1598 0.5635
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0013 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0043 0.0275 0.0971
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0181
Echinococcus granulosus synaptotagmin 15 0.0018 0.0072 0.0117
Mycobacterium ulcerans epoxide hydrolase EphA 0.0349 0.2836 1
Echinococcus granulosus synaptotagmin 0.0018 0.0072 0.0117
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0242 0.0395
Loa Loa (eye worm) AGC/NDR protein kinase 0.0202 0.1603 0.1603
Onchocerca volvulus 0.0049 0.0327 0.0364
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0043 0.0275 0.0971
Schistosoma mansoni synaptotagmin 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0242 0.0852
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0159
Brugia malayi N-terminal motif family protein 0.0013 0.0031 0.0051
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0226 0.1155
Trypanosoma cruzi C2 domain containing protein, putative 0.0018 0.0072 0.1093
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0013 0.0031 0.0051
Entamoeba histolytica hypothetical protein 0.0013 0.0031 0.0106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0242 0.0395
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Plasmodium falciparum double C2-like domain-containing protein 0.0018 0.0072 0.1093
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0218 0.3319
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0325 0.1661
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.001 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.016 0.1252 0.2074
Plasmodium vivax SET domain protein, putative 0.0031 0.0181 0.2767
Brugia malayi C1-like domain containing protein 0.016 0.1252 0.2074
Echinococcus multilocularis synaptotagmin 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0242 0.3684
Loa Loa (eye worm) raf kinase 0.0155 0.1216 0.1216
Echinococcus multilocularis synaptotagmin 0.0018 0.0072 0.0117
Brugia malayi WW domain containing protein 0.0018 0.0072 0.0119
Toxoplasma gondii hypothetical protein 0.0018 0.0072 0.0447
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0043 0.0275 0.0971
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0013 0.0031 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0221 0.113
Schistosoma mansoni protein kinase C 0.0173 0.1368 0.2239
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0024 0.0024
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1959 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0325 0.4963
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0325 0.203
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0031 0.0157
Trypanosoma brucei synaptotagmin, putative 0.0018 0.0072 0.0447
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Entamoeba histolytica hypothetical protein 0.0018 0.0072 0.0244
Loa Loa (eye worm) hypothetical protein 0.0161 0.1264 0.1264
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0201 0.1598 0.5635
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0221 0.0221
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Echinococcus granulosus dnaJ subfamily B 0.0403 0.3288 0.5382
Schistosoma mansoni alpha-glucosidase 0.0138 0.1075 0.1759
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0175 0.0893
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0221 0.0362
Onchocerca volvulus 0.0018 0.0072 0.008
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0024 0.0039
Brugia malayi Cytochrome P450 family protein 0.0078 0.0575 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus granulosus calpain 5 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.1786 0.6296
Schistosoma mansoni rac gtpase activating protein 0.0155 0.1216 0.1991
Schistosoma mansoni synaptotagmin 0.0018 0.0072 0.0117
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0155 0.1216 0.1991
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0175 0.2667
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0043 0.0275 0.0971
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0226 0.3451
Echinococcus multilocularis multiple C2 and transmembrane domain containing protein 0.0018 0.0072 0.0117
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0018 0.0072 0.1093
Echinococcus granulosus serine:threonine protein kinase N2 0.0362 0.2944 0.4818
Echinococcus granulosus neural cell expressed developmentally 0.0018 0.0072 0.0117
Echinococcus multilocularis N chimaerin 0.0155 0.1216 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0043 0.0275 0.0971
Trichomonas vaginalis copine, putative 0.0018 0.0072 0.0366
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0218 0.1111
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0031 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0078 0.0575 0.0575
Loa Loa (eye worm) hypothetical protein 0.1006 0.8317 0.8317
Loa Loa (eye worm) cytochrome P450 family protein 0.0099 0.0749 0.0749
Echinococcus multilocularis geminin 0.0337 0.2734 0.4475
Schistosoma mansoni hypothetical protein 0.0155 0.1216 0.1991
Echinococcus multilocularis UNCoordinated family member (unc 13) 0.0018 0.0072 0.0117
Entamoeba histolytica recQ family helicase, putative 0.002 0.0083 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0107 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0157
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1262 0.2089
Trypanosoma brucei predicted C2 domain protein 0.0018 0.0072 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0202 0.1603 0.2624
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0043 0.0275 0.0971
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Loa Loa (eye worm) Nedd4-PD 0.0018 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus granulosus cytochrome P450 2K1 0.0043 0.0275 0.0451
Onchocerca volvulus 0.0018 0.0072 0.008
Echinococcus multilocularis neural cell expressed, developmentally 0.0018 0.0072 0.0117
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0043 0.0275 0.0971
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0018 0.0072 0.0117
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0072 0.0119
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0043 0.0275 0.0971
Schistosoma mansoni synaptotagmin 0.0018 0.0072 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Brugia malayi Synapse defective protein 1 0.0018 0.0072 0.0119
Schistosoma mansoni otoferlin 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0221
Brugia malayi Pre-SET motif family protein 0.0215 0.1712 0.2836
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0031 0.0157
Loa Loa (eye worm) AGC/AKT protein kinase 0.0202 0.1603 0.1603
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0043 0.0275 0.0971
Entamoeba histolytica Rap/Ran GTPase activating protein, putative 0.0018 0.0072 0.0244
Schistosoma mansoni hypothetical protein 0.0337 0.2734 0.4475
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0218 0.3319
Entamoeba histolytica protein kinase, putative 0.0202 0.1603 0.5446
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0043 0.0275 0.0971
Echinococcus multilocularis son of sevenless 1 0.0013 0.0031 0.0051
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1603 0.2624
Mycobacterium leprae Possible regulatory protein 0.0012 0.0024 0.0135
Brugia malayi Synaptotagmin protein 3 0.0018 0.0072 0.0119
Trichomonas vaginalis ion channel nompc, putative 0.0018 0.0072 0.0366
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0656 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0043 0.0275 0.0971
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1603 0.2624
Mycobacterium ulcerans hypothetical protein 0.0036 0.0221 0.078
Mycobacterium tuberculosis Conserved protein 0.0036 0.0221 0.078
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0218 0.3319
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0242 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0221 0.113
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0242 0.3684
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1262 0.2065
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0018 0.0072 0.0117
Echinococcus multilocularis active breakpoint cluster region 0.0018 0.0072 0.0117
Entamoeba histolytica hypothetical protein 0.0018 0.0072 0.0244
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0083 0.1268
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0175 0.0617
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0043 0.0275 0.0971
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Loa Loa (eye worm) hypothetical protein 0.0036 0.0219 0.0219
Echinococcus granulosus NEDD4 E3 ubiquitin protein ligase WWP1 0.0018 0.0072 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1603 0.2624
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0242 0.1233
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0083 0.0138
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0013 0.0031 0.0159
Schistosoma mansoni hypothetical protein 0.0043 0.0275 0.0451
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.001 0.0007 0.0023
Echinococcus multilocularis serine:threonine protein kinase N2 0.0202 0.1603 0.2624
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0083 0.2851
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0043 0.0275 0.0971
Echinococcus granulosus bloom syndrome protein 0.002 0.0083 0.0136
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0218 0.1111
Leishmania major copine i-like protein 0.0018 0.0072 0.1093
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0575 0.8764
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0003 0.0048
Echinococcus granulosus son of sevenless 1 0.0013 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Brugia malayi Cytochrome P450 family protein 0.0099 0.0749 0.124
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0202 0.1603 0.2624
Treponema pallidum NADH oxidase 0.0031 0.0175 0.7205
Loa Loa (eye worm) hypothetical protein 0.1006 0.8317 0.8317
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0043 0.0275 0.0971
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0072 0.0366
Schistosoma mansoni mctp-related 0.0018 0.0072 0.0117
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1846 0.6507
Schistosoma mansoni protein kinase C mu 0.0155 0.1216 0.1991
Brugia malayi Variant SH3 domain containing protein 0.0155 0.1216 0.2014
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0043 0.0275 0.4198
Plasmodium vivax glutathione reductase, putative 0.0088 0.0656 1
Schistosoma mansoni synaptotagmin 0.0018 0.0072 0.0117
Echinococcus multilocularis protein kinase c epsilon type 0.0733 0.6038 0.9884
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0202 0.1603 0.2624
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0018 0.0072 0.0117
Echinococcus granulosus Immunoglobulin E set 0.0018 0.0072 0.0117
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.016 0.1252 0.205
Onchocerca volvulus 0.0036 0.0221 0.0246
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0278
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0221 0.078
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0004
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0043 0.0275 0.0971
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0175 0.0893
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0656 1
Schistosoma mansoni hypothetical protein 0.0403 0.3288 0.5382
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.0072 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0123
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Echinococcus granulosus synaptotagmin 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0037 0.0226 0.0226
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0003 0.0048
Plasmodium falciparum ferlin, putative 0.0018 0.0072 0.1093
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0043 0.0275 0.0971
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0004
Trichomonas vaginalis Proline-rich protein, putative 0.0018 0.0072 0.0366
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0173 0.1368 0.2239
Brugia malayi RasGEF domain containing protein 0.0265 0.2128 0.3524
Trypanosoma brucei trypanothione reductase 0.0088 0.0656 0.409
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.001 0.0007 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Leishmania major cytochrome p450-like protein 0.0078 0.0575 0.8764
Echinococcus multilocularis copine 9 0.0018 0.0072 0.0117
Entamoeba histolytica recQ family DNA helicase 0.001 0.0003 0.0011
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0013 0.0031 0.0051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0031 0.0105
Toxoplasma gondii C2 domain-containing protein 0.0018 0.0072 0.0447
Loa Loa (eye worm) AGC/PKN protein kinase 0.0202 0.1603 0.1603
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0226 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Onchocerca volvulus 0.0155 0.1216 0.1352
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Brugia malayi beta-lactamase 0.0036 0.0221 0.0367
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Plasmodium falciparum glutathione reductase 0.0088 0.0656 1
Echinococcus granulosus protein kinase c eta type 0.0155 0.1216 0.1991
Echinococcus granulosus cpg binding protein 0.003 0.017 0.0278
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0175 0.1091
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0043 0.0275 0.0971
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0389 0.3166 0.3166
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0218 0.1111
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0024 0.0123
Trypanosoma brucei cytochrome P450, putative 0.0078 0.0575 0.3585
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0043 0.0275 0.0971
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0175 0.2667
Echinococcus multilocularis protein kinase c iota type 0.0357 0.2899 0.4746
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0173 0.1368 0.2239
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0018 0.0072 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0181 0.0297
Echinococcus multilocularis unc 13 (munc13) 0.0173 0.1368 0.2239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Trypanosoma brucei glucosidase, putative 0.0036 0.0218 0.1358
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0218 0.0356
Entamoeba histolytica protein kinase, putative 0.0202 0.1603 0.5446
Loa Loa (eye worm) CAMK/PKD protein kinase 0.016 0.1252 0.1252
Echinococcus granulosus extended synaptotagmin 2 0.0018 0.0072 0.0117
Mycobacterium leprae putative cytochrome p450 0.0043 0.0275 0.1542
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0018 0.0072 0.0117
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0165 0.1299 0.2126
Echinococcus granulosus multiple C2 and transmembrane domain containing protein 0.0018 0.0072 0.0117
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0201 0.1598 0.8951
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus multilocularis RNA directed DNA polymerase 0.0366 0.2978 0.4875
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0175 0.0286
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0175 0.0286
Entamoeba histolytica hypothetical protein 0.0018 0.0072 0.0244
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0013 0.0031 0.0035
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0226 0.0371
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.0072 0.0244
Echinococcus granulosus myoferlin 0.0018 0.0072 0.0117
Mycobacterium ulcerans arylsulfatase AtsB 0.001 0.0007 0.0023
Schistosoma mansoni single-minded 0.0048 0.0321 0.0525
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0031 0.047
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.016 0.1252 0.205
Brugia malayi Cytochrome P450 family protein 0.0043 0.0275 0.0456
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0297 0.0486
Toxoplasma gondii Sma protein 0.0018 0.0072 0.0447
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0242 0.8284
Brugia malayi RhoGEF domain containing protein 0.0155 0.1216 0.2014
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0043 0.0275 0.0971
Loa Loa (eye worm) C2 domain-containing protein 0.0018 0.0072 0.0072
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0242 0.3684
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0297 0.0486
Mycobacterium ulcerans arylsulfatase, AslA 0.001 0.0007 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0297 0.0486
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0242 0.1507
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Loa Loa (eye worm) hypothetical protein 0.1161 0.9613 0.9613
Schistosoma mansoni unc-13 (munc13) 0.0173 0.1368 0.2239
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.066 0.1081
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0221 0.078
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Schistosoma mansoni rho gtpase activating protein 0.0018 0.0072 0.0117
Echinococcus granulosus NDR protein kinase 0.0202 0.1603 0.2624
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.006 0.092
Schistosoma mansoni serine/threonine protein kinase 0.0741 0.6109 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0175 0.1091
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Schistosoma mansoni synaptotagmin 12 0.0018 0.0072 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0155 0.1216 0.1991
Loa Loa (eye worm) RasGEF domain-containing protein 0.042 0.3424 0.3424
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0083 0.0136
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0167 0.0273
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Onchocerca volvulus 0.1006 0.8317 0.9247
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Brugia malayi hypoxia-induced factor 1 0.0149 0.116 0.1921
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0018 0.0072 0.1093
Brugia malayi follicle stimulating hormone receptor 0.023 0.1839 0.3045
Schistosoma mansoni synaptotagmin-like protein 0.0018 0.0072 0.0117
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0733 0.6038 0.6038
Brugia malayi Ras association domain family 1 isoform A 0.0155 0.1216 0.2014
Plasmodium falciparum thioredoxin reductase 0.0031 0.0175 0.2667
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0072 0.0119
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Entamoeba histolytica protein kinase, putative 0.0202 0.1603 0.5446
Trypanosoma cruzi Coiled-coil and C2 domain-containing protein 0.0018 0.0072 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Brugia malayi calpain 5 0.0018 0.0072 0.0119
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0175 0.0617
Echinococcus granulosus Diacylglycerol kinase theta 0.0155 0.1216 0.1991
Schistosoma mansoni synaptotagmin 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Onchocerca volvulus 0.0018 0.0072 0.008
Trypanosoma cruzi cytochrome P450, putative 0.0078 0.0575 0.8764
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0216 0.0763
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.006 0.092
Echinococcus granulosus ras GTP exchange factor 0.0013 0.0031 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Onchocerca volvulus 0.0013 0.0031 0.0035
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1262 0.2065
Toxoplasma gondii hypothetical protein 0.0018 0.0072 0.0447
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0202 0.1603 0.2624
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Leishmania major cytochrome p450-like protein 0.0043 0.0275 0.4198
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0202 0.1603 0.2624
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0043 0.0275 0.0971
Echinococcus multilocularis myotubularin protein 13 0.0155 0.1216 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0221
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0003 0.0005
Onchocerca volvulus 0.0028 0.0156 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Plasmodium vivax hypothetical protein, conserved 0.001 0.0000046615 0.0001
Echinococcus granulosus Rac GTPase activating protein 1 0.0155 0.1216 0.1991
Entamoeba histolytica protein kinase, putative 0.0023 0.0108 0.0367
Entamoeba histolytica protein kinase, putative 0.0023 0.0108 0.0367
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0242 1
Echinococcus multilocularis Rac GTPase activating protein 1 0.0155 0.1216 0.1991
Loa Loa (eye worm) hydrolase 0.1077 0.8914 0.8914
Echinococcus multilocularis C2 calcium lipid binding region, CaLB 0.0018 0.0072 0.0117
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0221 0.0367
Brugia malayi Hr1 repeat family protein 0.0202 0.1603 0.2655
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0024 0.0123
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0072 0.0447
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0018 0.0072 0.1093
Trichomonas vaginalis esterase, putative 0.0036 0.0221 0.113
Loa Loa (eye worm) C2 domain-containing protein 0.0018 0.0072 0.0072
Leishmania major protein kinase, putative 0.0017 0.006 0.092
Mycobacterium tuberculosis Probable sulfatase 0.001 0.0007 0.0023
Echinococcus multilocularis serine:threonine protein kinase 38 0.0202 0.1603 0.2624
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0221 0.113
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0741 0.6109 1
Onchocerca volvulus 0.0018 0.0072 0.008
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0221 0.0362
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Plasmodium falciparum thioredoxin reductase 0.0088 0.0656 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0175 0.2667
Schistosoma mansoni rabphilin-3a 0.0018 0.0072 0.0117
Brugia malayi RasGEF domain containing protein 0.0013 0.0031 0.0051
Schistosoma mansoni fer-1-related 0.0018 0.0072 0.0117
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0043 0.0275 0.0971
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0155 0.1216 0.1216
Trypanosoma cruzi cytoskeleton associated protein, putative 0.0018 0.0072 0.1093
Entamoeba histolytica hypothetical protein 0.0018 0.0072 0.0244
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0181 0.0297
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0043 0.0275 0.0971
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0024 0.0123
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0157
Loa Loa (eye worm) CYP4Cod1 0.0078 0.0575 0.0575
Loa Loa (eye worm) acetyltransferase 0.0165 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0656 1
Echinococcus multilocularis synaptotagmin protein 4 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0201 0.1598 0.5635
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0175 0.0286
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0043 0.0275 0.0971
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0018 0.0072 0.0117
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0202 0.1603 0.1603
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0072 0.1093
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0024 0.0367
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Schistosoma mansoni unc-13 (munc13) 0.0173 0.1368 0.2239
Trypanosoma brucei C2 domain containing protein, putative 0.0018 0.0072 0.0447
Plasmodium vivax hypothetical protein, conserved 0.001 0.0000046615 0.0001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0083 0.0519
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1262 0.2065
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Loa Loa (eye worm) hypothetical protein 0.002 0.0083 0.0083
Loa Loa (eye worm) cytochrome P450 0.0043 0.0275 0.0275
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.1786 0.6296
Entamoeba histolytica diacylglycerol kinase, putative 0.0155 0.1216 0.4131
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0221 0.3376
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0175 0.5998
Trypanosoma cruzi synaptotagmin, putative 0.0018 0.0072 0.1093
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0175 0.1091
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0221 0.1381
Trichomonas vaginalis copine, putative 0.0018 0.0072 0.0366
Echinococcus multilocularis synaptotagmin 15 0.0018 0.0072 0.0117
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0018 0.0072 0.0366
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0218 0.074
Toxoplasma gondii thioredoxin reductase 0.0088 0.0656 0.409
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0024 0.0123
Echinococcus multilocularis cpg binding protein 0.003 0.017 0.0278
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.1087 0.8994 1
Echinococcus multilocularis calpain 5 0.0018 0.0072 0.0117
Echinococcus granulosus copine 9 0.0018 0.0072 0.0117
Onchocerca volvulus 0.0244 0.1959 0.2178
Brugia malayi Protein kinase domain containing protein 0.0202 0.1603 0.2655
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0221 0.124
Leishmania major protein kinase, putative 0.0017 0.006 0.092
Trypanosoma cruzi synaptotagmin, putative 0.0018 0.0072 0.1093
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0226 0.3451
Trichomonas vaginalis AGC family protein kinase 0.0202 0.1603 0.8183
Echinococcus multilocularis ras GTP exchange factor 0.0013 0.0031 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0218 0.0356
Echinococcus multilocularis serine threonine protein kinase 0.0586 0.4813 0.7878
Brugia malayi N-terminal motif family protein 0.0013 0.0031 0.0051
Schistosoma mansoni Mername-AA248 (C02 family) 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0221 0.078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Schistosoma mansoni synaptotagmin 12 0.0018 0.0072 0.0117
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Trichomonas vaginalis vab10 spectraplakin, putative 0.0018 0.0072 0.0366
Echinococcus multilocularis NEDD4 E3 ubiquitin protein ligase WWP1 0.0018 0.0072 0.0117
Mycobacterium leprae Conserved hypothetical protein 0.0043 0.0275 0.1542
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.006 0.092
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Onchocerca volvulus 0.0036 0.0216 0.0241
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0325 0.203
Entamoeba histolytica hypothetical protein 0.0018 0.0072 0.0244
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Echinococcus granulosus copine 9 0.0018 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0221
Onchocerca volvulus 0.0093 0.0696 0.0774
Trypanosoma brucei C2 domain containing protein, putative 0.0018 0.0072 0.0447
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Loa Loa (eye worm) hypothetical protein 0.0522 0.4274 0.4274
Echinococcus granulosus synaptotagmin 0.0018 0.0072 0.0117
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0165 0.1299 0.2126
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0006
Onchocerca volvulus 0.0018 0.0072 0.008
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0218 0.1111
Brugia malayi cytochrome P450 0.0043 0.0275 0.0456
Brugia malayi p70 ribosomal S6 kinase beta 0.0202 0.1603 0.2655
Giardia lamblia Hypothetical protein 0.001 0.0007 0.0221
Schistosoma mansoni DNA helicase recq5 0.002 0.0083 0.0136
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0226 0.037
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0083 0.0083
Brugia malayi Protein kinase domain containing protein 0.0202 0.1603 0.2655
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0202 0.1603 0.1603
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Toxoplasma gondii cytochrome p450 superfamily protein 0.0043 0.0275 0.1717
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0218 0.1111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0175 0.2667
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Schistosoma mansoni alpha-glucosidase 0.0138 0.1075 0.1759
Onchocerca volvulus 0.0173 0.1368 0.1521
Trichomonas vaginalis copine, putative 0.0018 0.0072 0.0366
Loa Loa (eye worm) hypothetical protein 0.0155 0.1216 0.1216
Loa Loa (eye worm) RecQ helicase 0.002 0.0083 0.0083
Loa Loa (eye worm) copine family protein 0.0018 0.0072 0.0072
Brugia malayi glutathione reductase 0.0088 0.0656 0.1086
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0024 0.0123
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Entamoeba histolytica C2 domain containing protein 0.0018 0.0072 0.0244
Trichomonas vaginalis synaptotagmin, putative 0.0018 0.0072 0.0366
Entamoeba histolytica protein kinase, putative 0.0202 0.1603 0.5446
Mycobacterium ulcerans hydrolase 0.001 0.0007 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0297 0.0297
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0221 0.3376
Leishmania major c2 domain protein, putative 0.0018 0.0072 0.1093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0181 0.0297
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0411 0.2565
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0013 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0013 0.0031 0.0474
Brugia malayi hypothetical protein 0.0347 0.2819 0.4668
Entamoeba histolytica diacylglycerol kinase, putative 0.0155 0.1216 0.4131
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0181 0.0297
Echinococcus multilocularis bloom syndrome protein 0.002 0.0083 0.0136
Loa Loa (eye worm) C2 domain-containing protein 0.0018 0.0072 0.0072
Trypanosoma brucei cAMP binding protein, putative 0.0018 0.0072 0.0447
Trypanosoma brucei C2 domain containing protein, putative 0.0018 0.0072 0.0447
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0242 0.04
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0226 0.1412
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.1093
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0221 0.0362
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0072 0.0366
Echinococcus granulosus unc 13 munc13 0.0173 0.1368 0.2239
Loa Loa (eye worm) RasGEF domain-containing protein 0.0013 0.0031 0.0031
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0226 0.037
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0083 0.0424
Onchocerca volvulus 0.0036 0.0221 0.0246
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0349 0.2836 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0043 0.0275 0.4198
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0327 0.0536
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0242 0.0821
Entamoeba histolytica DENN domain protein 0.0018 0.0072 0.0244
Echinococcus granulosus synaptotagmin 2 0.0018 0.0072 0.0117
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0013 0.0031 0.0106
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0292 0.0991
Trypanosoma brucei rac serine-threonine kinase, putative 0.0202 0.1603 1
Schistosoma mansoni rab3 interacting molecule (rim)-related 0.0018 0.0072 0.0117
Mycobacterium ulcerans lipase LipD 0.0036 0.0221 0.078
Echinococcus granulosus synaptotagmin 0.0018 0.0072 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0031 0.0157
Toxoplasma gondii hypothetical protein 0.0018 0.0072 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0226 0.1155
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0043 0.0275 0.0971
Plasmodium vivax ferlin, putative 0.0018 0.0072 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Leishmania major cytochrome p450-like protein 0.0043 0.0275 0.4198
Onchocerca volvulus 0.0018 0.0072 0.008
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0043 0.0275 0.4198
Brugia malayi C2 domain containing protein 0.0018 0.0072 0.0119
Echinococcus multilocularis synaptotagmin 0.0018 0.0072 0.0117
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0221 0.078
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0018 0.0072 0.0366
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0226 0.037
Trypanosoma cruzi hypothetical protein 0.0013 0.0031 0.0474
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0175 0.2668
Echinococcus granulosus protein kinase C gamma type 0.0586 0.4813 0.7878
Onchocerca volvulus Multiple C2 domain and transmembrane region protein homolog 0.0018 0.0072 0.008
Brugia malayi protein kinase C II. 0.0733 0.6038 1
Brugia malayi Thioredoxin reductase 0.0088 0.0656 0.1086
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0175 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0072 0.1093
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0155 0.1216 0.1991
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.001 0.0007 0.0023
Schistosoma mansoni glut4 vesicle protein-related 0.0018 0.0072 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Schistosoma mansoni E3 ubiquitin-protein ligase nedd-4 0.0018 0.0072 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0733 0.6038 0.9884
Brugia malayi diacylglycerol kinase 0.0155 0.1216 0.2014
Toxoplasma gondii ferlin family protein 0.0018 0.0072 0.0447
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0024 0.0123
Echinococcus granulosus single minded 2 0.0036 0.0216 0.0354
Loa Loa (eye worm) C2 domain-containing protein 0.0018 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0337 0.2734 0.4475
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0155 0.1216 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0007 0.0033
Loa Loa (eye worm) synaptotagmin-1 0.0018 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0297 0.0486
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0024
Toxoplasma gondii AGC kinase 0.0202 0.1603 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0083 0.1268
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0018 0.0072 0.1093
Echinococcus granulosus active breakpoint cluster region 0.0018 0.0072 0.0117
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0024 0.0367
Mycobacterium tuberculosis Probable reductase 0.0201 0.1598 0.5635
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0218 0.1111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0072 0.0072

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of MDA-MB-435 human breast cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of HOP-6 human lung cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of HCT-116 human colon cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of SF-539 human CNS cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of UACC-62 human melanoma cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of OVCAR-3 human ovarian cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of SN12C human renal cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of DU-145 human prostate cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of MDA-MB-435 human breast cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of HCT-116 human colon cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of SF-539 human CNS cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of UACC-62 human melanoma cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of OVCAR-3 human ovarian cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of SN12C human renal cancer cells by 50% ChEMBL. 16078843
GI50 (functional) < 0.01 uM Concentration of the compound required to inhibit the growth of DU-145 human prostate cancer cells by 50% ChEMBL. 16078843
GI50 (functional) = 0.07 uM Inhibition of the growth of human breast cancer MCF-7 cells done for 2 h at 37 degree C with compound ChEMBL. 16078843
GI50 (functional) = 0.07 uM Inhibition of the growth of human breast cancer MCF-7 cells done for 2 h at 37 degree C with compound ChEMBL. 16078843
IC50 (binding) = 1 uM Inhibitory concentration against steroid sulfatase in placental microsomes ChEMBL. 16078843
IC50 (binding) = 1 uM Inhibitory concentration against steroid sulfatase in placental microsomes ChEMBL. 16078843
MGM (functional) = 0.016 uM Mean graph midpoint (MGM) of the compound against a panel of human tumor cell lines ChEMBL. 16078843

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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