Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | adenosine kinase | 345 aa | 337 aa | 35.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Adenosine kinase | 0.0024 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0024 | 0 | 0.5 |
Giardia lamblia | Ribokinase | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.021 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0186 | 0.8714 | 1 | |
Entamoeba histolytica | kinase, PfkB family | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.021 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.02 | 0.9426 | 0.9426 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0024 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.021 | 1 | 1 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0024 | 0 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.021 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.02 | 0.9426 | 0.9426 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0024 | 0 | 0.5 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | ribokinase, putative | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.021 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.021 | 1 | 1 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.0024 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.021 | 1 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.021 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.021 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.021 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 183 nM | Inhibitory concentration against Adenosine Kinase (enzyme) | ChEMBL. | 15911258 |
IC50 (binding) | = 183 nM | Inhibitory concentration against Adenosine Kinase (enzyme) | ChEMBL. | 15911258 |
IC50 (binding) | = 367 nM | Inhibitory concentration against Adenosine Kinase (intact cells) | ChEMBL. | 15911258 |
IC50 (binding) | = 367 nM | Inhibitory concentration against Adenosine Kinase (intact cells) | ChEMBL. | 15911258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.