Detailed information for compound 333564

Basic information

Technical information
  • TDR Targets ID: 333564
  • Name: (3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hyd roxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,1 5,16,17-tetradecahydrocyclopenta[a]phenanthre n-11-one
  • MW: 332.477 | Formula: C21H32O3
  • H donors: 1 H acceptors: 3 LogP: 3.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]1CC[C@]2([C@H](C1)CC[C@@H]1[C@@H]2C(=O)C[C@]2([C@H]1CC[C@@H]2C(=O)C)C)C
  • InChi: 1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1
  • InChiKey: DUHUCHOQIDJXAT-OLVMNOGESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,5S,8S,9S,10S,13S,14S,17S)-17-ethanoyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one
  • alphaxalone
  • 23930-19-0
  • Lopac0_000929
  • SMR000058494
  • MLS000069684
  • Prestwick1_001002
  • 3-Hydroxy-5alpha-pregnane-11,20-dione
  • P5052_SIGMA
  • SPBio_003004
  • Prestwick0_001002
  • BPBio1_001237
  • Prestwick2_001002
  • Prestwick3_001002
  • ZINC04081122
  • (3alpha,5alpha)-3-hydroxypregnane-11,20-dione
  • EU-0100929
  • GR 2/234
  • (3-alpha,5-alpha)-3-Hydroxypregnane-11,20-dione
  • 3-Hydroxypregnane-11,20-dione
  • 3-alpha-Hydroxy-5-alpha-pregnane-11,20-dione
  • 3alpha-Hydroxy-5alpha-pregnan-11,20-dion
  • 3alpha-Hydroxy-5alpha-pregnane-11,20-dione
  • 4-08-00-02091 (Beilstein Handbook Reference)
  • 5-alpha-Pregnane-11,20-dione, 3-alpha-hydroxy-
  • 5alpha-Pregnan-3alpha-ol-11,20-dione
  • Alfaxalona [INN-Spanish]
  • Alfaxalone
  • Alfaxalone [DCF:INN:JAN]
  • Alfaxalonum [INN-Latin]
  • BRN 3217240
  • BSPBio_001123
  • Pregnane-11,20-dione, 3-hydroxy-, (3-alpha,5-alpha)- (9CI)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 References
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, alpha 2 Starlite/ChEMBL References
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens gamma-aminobutyric acid (GABA) A receptor, gamma 2 References
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Rattus norvegicus GABA-A receptor; anion channel Starlite/ChEMBL References
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129441 All targets in OG5_129441
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129441 All targets in OG5_129441
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor Get druggable targets OG5_129441 All targets in OG5_129441
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131775 All targets in OG5_131775
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 494 aa 25.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative GABA-A receptor; anion channel   467 aa 384 aa 19.5 %
Brugia malayi hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Muscarinic acetylcholine receptor M1   460 aa 462 aa 23.4 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Echinococcus multilocularis serotonin receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 468 aa 28.6 %
Echinococcus granulosus biogenic amine 5HT receptor Muscarinic acetylcholine receptor M1   460 aa 432 aa 26.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Loa Loa (eye worm) hypothetical protein Muscarinic acetylcholine receptor M1   460 aa 425 aa 22.1 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 454 aa 29.5 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein gamma-aminobutyric acid (GABA) A receptor, gamma 2 467 aa 449 aa 27.6 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 434 aa 26.7 %
Echinococcus granulosus glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 435 aa 29.7 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 441 aa 33.8 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein GABA-A receptor; anion channel   467 aa 375 aa 21.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Eukaryotic initiation factor 4A-III homolog GABA-A receptor; anion channel   467 aa 453 aa 26.9 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 446 aa 28.0 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Onchocerca volvulus Gamma-aminobutyric acid receptor subunit beta homolog GABA-A receptor; anion channel   467 aa 433 aa 34.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Echinococcus granulosus glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 439 aa 29.6 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein gamma-aminobutyric acid (GABA) A receptor, alpha 2 451 aa 393 aa 25.9 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Schistosoma mansoni Cys-loop ligand gated ion channel subunit GABA-A receptor; anion channel   467 aa 479 aa 29.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Brugia malayi Cation transporter family protein GABA-A receptor; anion channel   467 aa 453 aa 28.5 %
Onchocerca volvulus Large subunit GTPase 1 homolog GABA-A receptor; anion channel   467 aa 496 aa 26.0 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 447 aa 25.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 446 aa 29.1 %
Echinococcus multilocularis glycine receptor subunit alpha 1 GABA-A receptor; anion channel   467 aa 430 aa 32.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Schistosoma mansoni amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Onchocerca volvulus GABA-A receptor; anion channel   467 aa 454 aa 30.4 %
Echinococcus multilocularis glycine receptor subunit beta GABA-A receptor; anion channel   467 aa 478 aa 28.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Loa Loa (eye worm) hypothetical protein GABA-A receptor; anion channel   467 aa 461 aa 27.8 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit GABA-A receptor; anion channel   467 aa 379 aa 19.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog GABA-A receptor; anion channel   467 aa 418 aa 19.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium and chloride dependent glycine 0.026 0.0747 0.1601
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0068 0.0058
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0138 0.0376 0.0367
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0042 0.007
Schistosoma mansoni notch 0.0021 0.0019 0.0022
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0331 0.07
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0064
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0038 0.0072 0.0156
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0135 0.0365 0.43
Plasmodium vivax phosphodiesterase gamma, putative 0.0138 0.0376 0.3649
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0098 0.0254 0.072
Onchocerca volvulus 0.0117 0.0311 0.064
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0016 0.0012
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0565 0.1206
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0045 0.0091 0.0198
Brugia malayi glutathione reductase 0.0057 0.0129 0.028
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0129 0.048
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.0365 0.43
Onchocerca volvulus 0.0037 0.0068 0.0111
Schistosoma mansoni cpg binding protein 0.0037 0.0067 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.0861
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0119 0.02
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0174 0.2829
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.008
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0345 0.1002 0.3975
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0044 0.0076
Onchocerca volvulus 0.0021 0.002 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0736 0.2908
Toxoplasma gondii microneme protein, putative 0.0029 0.0044 0.0103
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Echinococcus granulosus protein jagged 2 0.0021 0.0019 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Loa Loa (eye worm) TK/ROR protein kinase 0.0117 0.0311 0.0655
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0345 0.1002 0.2924
Schistosoma mansoni hypothetical protein 0.0067 0.016 0.0327
Onchocerca volvulus Neurogenic locus notch homolog 0.0021 0.0019 0.0006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0398 0.1556
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0083 0.0207 0.043
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0116 0.0427
Leishmania major C-8 sterol isomerase-like protein 0.0841 0.2508 1
Onchocerca volvulus Slit protein homolog 0.0021 0.0019 0.0006
Leishmania major hypothetical protein, conserved 0.0138 0.0376 0.1467
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Leishmania major DNA polymerase eta, putative 0.0021 0.002 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.0376 0.1499
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0376 0.1467
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.015 0.0412 0.4882
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0077 0.0191 0.0331
Brugia malayi ecdysteroid receptor 0.002 0.0017 0.0036
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0019 0.001
Brugia malayi Trypsin family protein 0.0214 0.0605 0.131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0007
Echinococcus granulosus lamin dm0 0.0026 0.0035 0.0056
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.089 0.3525
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.002 0.0032
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0016 0.002
Schistosoma mansoni intermediate filament proteins 0.0026 0.0035 0.0056
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Plasmodium falciparum thioredoxin reductase 0.0057 0.0129 0.1148
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0017 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0174 0.03
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0034 0.0059 0.0107
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0017 0.0007
Onchocerca volvulus 0.0035 0.0061 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0068 0.0127
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0138 0.0376 0.0797
Brugia malayi steroid hormone receptor 0.002 0.0017 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0019 0.0021
Echinococcus granulosus protein jagged 1 0.0021 0.0019 0.0021
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.026 0.0747 0.1601
Entamoeba histolytica hypothetical protein 0.0112 0.0295 0.5059
Brugia malayi hypothetical protein 0.0038 0.0072 0.0156
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0043
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0019
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0077 0.0191 0.0331
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.005 0.0089
Leishmania major hypothetical protein, conserved 0.0117 0.0311 0.1206
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.026 0.0747 0.1602
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0351 0.0624
Brugia malayi glucose-6-phosphate dehydrogenase 0.015 0.0412 0.0892
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0046 0.0066
Loa Loa (eye worm) hypothetical protein 0.0186 0.052 0.111
Echinococcus multilocularis Mastin 0.0034 0.0059 0.0049
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Onchocerca volvulus 0.0045 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0131 0.0354 0.0748
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0254 0.055
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0089
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0141 0.0285
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0295 0.0622
Loa Loa (eye worm) hypothetical protein 0.0054 0.0119 0.0238
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0138 0.0376 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0038 0.0072 0.0136
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0064
Schistosoma mansoni hypothetical protein 0.0083 0.0208 0.0431
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.002 0.0019
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0345 0.1002 0.1812
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0174 0.0659
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0083 0.0207 0.043
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0044 0.0103
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0017 0.0015
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0039 0.0087
Brugia malayi N-terminal motif family protein 0.0186 0.052 0.1128
Onchocerca volvulus 0.0072 0.0174 0.0342
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0107
Loa Loa (eye worm) oxidoreductase 0.0021 0.002 0.0023
Onchocerca volvulus 0.0083 0.0207 0.0415
Loa Loa (eye worm) hypothetical protein 0.1137 0.3406 0.7377
Loa Loa (eye worm) hypothetical protein 0.0098 0.0254 0.0531
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0138 0.0376 0.0815
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.3649
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.015 0.0412 0.4012
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0007
Loa Loa (eye worm) serotonin transporter b 0.1534 0.4614 1
Echinococcus multilocularis notch 0.0021 0.0019 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0072 0.0156
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0083 0.0207 0.043
Echinococcus granulosus Tolloid protein 1 0.0027 0.0039 0.0064
Onchocerca volvulus 0.0021 0.0019 0.0006
Schistosoma mansoni hypothetical protein 0.0494 0.1455 0.3141
Onchocerca volvulus Huntingtin homolog 0.0131 0.0354 0.0733
Schistosoma mansoni neurotransmitter gated ion channel 0.0038 0.0072 0.0136
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0206 0.0428
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0138 0.0376 0.0367
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0016 0.0035
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0077 0.0191 0.3143
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Echinococcus granulosus glycine receptor subunit alpha 1 0.0083 0.0207 0.043
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.0826 0.0817
Brugia malayi Pre-SET motif family protein 0.0037 0.0068 0.0147
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0042 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0242 0.0233
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1137 0.3406 0.7378
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Schistosoma mansoni notch 0.0021 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0068 0.0127
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0059 0.0108
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0062 0.0146 0.0296
Loa Loa (eye worm) hypothetical protein 0.0214 0.0605 0.1293
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0046 0.0079
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Onchocerca volvulus 0.0029 0.0044 0.006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0083 0.0207 0.0198
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0083 0.0207 0.043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1137 0.3406 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.002 0.001
Echinococcus multilocularis GPCR, family 2 0.0031 0.005 0.0041
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0138 0.0376 0.1467
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0119 0.1042
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0083 0.0207 0.043
Onchocerca volvulus 0.0034 0.0059 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0017 0.0016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0016 0.0064
Brugia malayi Trypsin-like protease protein 5 0.0034 0.0059 0.0127
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0217 0.0451
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.002 0.0019
Echinococcus granulosus enteropeptidase 0.0034 0.0059 0.0107
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Loa Loa (eye worm) glutathione reductase 0.0057 0.0129 0.026
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0135 0.0365 0.1422
Brugia malayi CHE-14 protein 0.0086 0.0217 0.047
Loa Loa (eye worm) Notch2 0.0021 0.0019 0.0021
Loa Loa (eye worm) LGC-31 protein 0.0083 0.0207 0.043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.011 0.0183
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0042
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Brugia malayi Pre-SET motif family protein 0.0252 0.0721 0.1563
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0841 0.2508 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0138 0.0376 0.0797
Brugia malayi Cytochrome P450 family protein 0.0018 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0998 0.2986 0.6465
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0329 0.0695
Echinococcus granulosus protein jagged 2 0.0021 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0058 0.0133 0.0269
Brugia malayi hypothetical protein 0.0038 0.0072 0.0156
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0214 0.0605 0.1293
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0016 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Schistosoma mansoni protein kinase 0.0111 0.0294 0.0619
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.014 0.0381 0.4497
Loa Loa (eye worm) hypothetical protein 0.0286 0.0823 0.1767
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0214 0.0605 0.1293
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Echinococcus granulosus glycine receptor subunit beta 0.0083 0.0207 0.043
Mycobacterium tuberculosis Probable conserved exported protein 0.0077 0.0191 0.0331
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0119 0.1407
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0091 0.0198
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni cpg binding protein 0.0035 0.0061 0.0113
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0043
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0038 0.0072 0.0063
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0083 0.0207 0.043
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0017 0.0016
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0998 0.2986 0.298
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0242 0.0506
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Loa Loa (eye worm) hypothetical protein 0.0043 0.0088 0.017
Onchocerca volvulus 0.0026 0.0035 0.004
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0395 0.0704
Brugia malayi Trypsin family protein 0.0034 0.0059 0.0127
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.015 0.0412 0.0874
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0138 0.0376 0.3649
Brugia malayi cytochrome P450 0.0018 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0841 0.2508 0.5426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0017 0.0015
Loa Loa (eye worm) STE/STE7/MEK7 protein kinase 0.0111 0.0294 0.0619
Echinococcus multilocularis transmembrane protease serine 3 0.0034 0.0059 0.0049
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0138 0.0376 0.0796
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0083 0.0207 0.0198
Echinococcus granulosus uncharacterized sodium dependent transporter 0.026 0.0747 0.1601
Mycobacterium tuberculosis Probable reductase 0.013 0.0351 0.0624
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0083 0.0207 0.0198
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1137 0.3406 0.7377
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0174 0.0377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0242 0.0506
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0083 0.0207 0.043
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0083 0.0207 0.0198
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0019 0.0021
Toxoplasma gondii melibiase subfamily protein 0.0124 0.0331 0.0949
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0045 0.0091 0.0198
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0072 0.0156
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0448 0.08
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0064
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0077 0.0191 0.0331
Brugia malayi Cytochrome P450 family protein 0.006 0.0137 0.0297
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0398 0.1587
Echinococcus granulosus tissue type plasminogen activator 0.0117 0.0311 0.0655
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Mycobacterium ulcerans hypothetical protein 0.0077 0.0191 0.0331
Echinococcus granulosus laminin 0.0027 0.0039 0.0064
Schistosoma mansoni lamin 0.0026 0.0035 0.0056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0129 0.0219
Schistosoma mansoni cpg binding protein 0.0037 0.0067 0.0126
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0345 0.1002 0.2173
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0059 0.0108
Brugia malayi hypothetical protein 0.0112 0.0295 0.064
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0138 0.0376 0.0796
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Onchocerca volvulus 0.0021 0.0019 0.0006
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0072 0.0063
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.1534 0.4614 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.089 0.3525
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0207 0.0449
Onchocerca volvulus 0.0021 0.0019 0.0006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0331 0.07
Loa Loa (eye worm) hypothetical protein 0.0279 0.0803 0.1723
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Mycobacterium ulcerans hypothetical protein 0.0077 0.0191 0.0331
Brugia malayi Muscle positioning protein 4 0.0021 0.0019 0.0041
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0059 0.0108
Schistosoma mansoni acetylcholine receptor subunit beta 0.0038 0.0072 0.0136
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0376 0.1467
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0137 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0072 0.0174 0.0357
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1455 0.314
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0016 0.0012
Echinococcus granulosus GPCR family 2 0.0031 0.005 0.0089
Echinococcus multilocularis dna polymerase eta 0.0021 0.002 0.001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.002 0.0019
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0351 0.0624
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.002 0.0019
Onchocerca volvulus 0.0034 0.0059 0.0092
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0159 0.0443
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0027 0.0039 0.0064
Onchocerca volvulus 0.026 0.0747 0.1588
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.002 0.0019
Onchocerca volvulus 0.0083 0.0207 0.0415
Schistosoma mansoni thyroid hormone receptor 0.002 0.0017 0.0016
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.3649
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0044 0.0103
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0039 0.0087
Onchocerca volvulus 0.0029 0.0044 0.006
Onchocerca volvulus 0.0045 0.0091 0.0163
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0138 0.0376 0.0796
Schistosoma mansoni hypothetical protein 0.0043 0.0088 0.017
Brugia malayi excitatory GABA receptor EXP-1A 0.0083 0.0207 0.0449
Toxoplasma gondii kringle domain-containing protein 0.0117 0.0311 0.0888
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Loa Loa (eye worm) hypothetical protein 0.0138 0.0376 0.0796
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.016 0.0346
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0068 0.0127
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.002 0.0019
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0083 0.0207 0.043
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.1403 0.4215 0.9132
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0138 0.0376 0.1467
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0083 0.0207 0.043
Onchocerca volvulus 0.018 0.0502 0.1056
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Schistosoma mansoni hypothetical protein 0.0034 0.0059 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0087 0.0312
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0398 0.1556
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Echinococcus granulosus delta-like protein 1 0.0021 0.0019 0.0021
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0217 0.0208
Loa Loa (eye worm) hypothetical protein 0.0453 0.1332 0.2872
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.015 0.0412 0.0874
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi hypothetical protein 0.0038 0.0072 0.0156
Toxoplasma gondii microneme protein MIC17B 0.0029 0.0044 0.0103
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0206 0.0428
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0207 0.0449
Onchocerca volvulus 0.0026 0.0035 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Echinococcus multilocularis glycoprotein Antigen 5 0.0034 0.0059 0.0049
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0046 0.0367
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.002 0.0019
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0044 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0141 0.0286
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0174 0.03
Loa Loa (eye worm) norepinephrine transporter 0.1534 0.4614 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0207 0.0449
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.005 0.0109
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0376 0.1467
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.0088 0.0231
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0138 0.0376 0.1499
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni nAChR subunit 0.0038 0.0072 0.0136
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Echinococcus multilocularis fibropellin Ia 0.0021 0.0019 0.001
Brugia malayi Thioredoxin reductase 0.0057 0.0129 0.028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0035 0.0056
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.002 0.008
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0048 0.0103 0.0373
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0141 0.024
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.026 0.0747 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0138 0.0376 0.0815
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0059 0.0108
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.026 0.0747 0.1602
Onchocerca volvulus 0.0025 0.0031 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0721 0.1546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0083 0.0207 0.043
Brugia malayi Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.1618
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Mycobacterium tuberculosis Conserved protein 0.0077 0.0191 0.0331
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.014 0.0381 0.0806
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0034 0.0059 0.0127
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Echinococcus multilocularis S formylglutathione hydrolase 0.0077 0.0191 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0119 0.0238
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.1823 0.549 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0017 0.0015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0133 0.0288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Echinococcus multilocularis protein jagged 1 0.0021 0.0019 0.001
Brugia malayi Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.1618
Brugia malayi GCC2 and GCC3 family protein 0.0021 0.0019 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0295 0.0286
Schistosoma mansoni hypothetical protein 0.0117 0.0311 0.0655
Brugia malayi Trypsin family protein 0.0034 0.0059 0.0127
Mycobacterium ulcerans hypothetical protein 0.0077 0.0191 0.0331
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Mycobacterium ulcerans hypothetical protein 0.0034 0.0059 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0174 0.03
Loa Loa (eye worm) hypothetical protein 0.0138 0.0376 0.0796
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Onchocerca volvulus 0.0021 0.0019 0.0006
Echinococcus multilocularis protein patched 0.0086 0.0217 0.0208
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0376 0.1467
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Onchocerca volvulus 0.026 0.0747 0.1588
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0077 0.0191 0.0331
Schistosoma mansoni DNA polymerase eta 0.0021 0.002 0.0023
Brugia malayi Cation transporter family protein 0.0083 0.0207 0.0449
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0138 0.0376 0.444
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.002 0.004
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0279 0.0803 0.1739
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.014 0.0381 0.0371
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0998 0.2986 0.6472
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0083 0.0207 0.0198
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0017 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Echinococcus multilocularis protein jagged 2 0.0021 0.0019 0.001
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0841 0.2508 0.5435
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0072 0.0156
Loa Loa (eye worm) hypothetical protein 0.0072 0.0174 0.0357
Echinococcus granulosus glycine receptor subunit alpha 1 0.0083 0.0207 0.043
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0019 0.0021
Schistosoma mansoni notch 0.0021 0.0019 0.0022
Schistosoma mansoni sodium/chloride dependent transporter 0.0261 0.0748 0.1604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0242 0.0506
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0038 0.0072 0.0156
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.0574 0.1227
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0138 0.0376 0.444
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0087 0.0312
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Onchocerca volvulus 0.026 0.0747 0.1588
Onchocerca volvulus 0.0029 0.0044 0.006
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.0331 0.0322
Schistosoma mansoni lamin 0.0026 0.0035 0.0056
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.002 0.0043
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0565 0.0556
Brugia malayi CXXC zinc finger family protein 0.0035 0.0061 0.0133
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0138 0.0376 0.0367
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0061 0.0113
Plasmodium falciparum glutathione reductase 0.0057 0.0129 0.1148
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0043
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.002 0.0049
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0034 0.0059 0.0049
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.0365 0.43
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0138 0.0376 0.1467
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.1823 0.549 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Mycobacterium ulcerans hypothetical protein 0.0072 0.0174 0.03
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0207 0.0449
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.026 0.0747 0.1618
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.015 0.0412 0.4882
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.002 0.0042
Loa Loa (eye worm) hypothetical protein 0.1534 0.4614 1
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0083 0.0207 0.043
Toxoplasma gondii hypothetical protein 0.0029 0.0044 0.0103
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.1167
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0016 0.0026
Leishmania major hypothetical protein, conserved 0.0138 0.0376 0.1467
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Plasmodium falciparum amino acid transporter, putative 0.026 0.0747 0.7407
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1534 0.4614 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0345 0.1002 0.2173
Brugia malayi hypothetical protein 0.0034 0.0059 0.0127
Loa Loa (eye worm) solute carrier family 6 member 4 0.1534 0.4614 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.1499
Schistosoma mansoni hypothetical protein 0.0083 0.0208 0.0431
Echinococcus granulosus uncharacterized sodium dependent transporter 0.026 0.0747 0.1601
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.015 0.0412 0.4882
Loa Loa (eye worm) hypothetical protein 0.0054 0.0119 0.0238
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0083 0.0207 0.0449
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Brugia malayi Cytochrome P450 family protein 0.0028 0.0042 0.009
Loa Loa (eye worm) hypothetical protein 0.0241 0.0687 0.1471
Onchocerca volvulus 0.0038 0.0072 0.012
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.0826 0.1773
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.014 0.0381 0.0371
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0017 0.0015
Brugia malayi Cadherin domain containing protein 0.0021 0.0019 0.0041
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0083 0.0207 0.0198
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0395 0.0704
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0395 0.0704
Echinococcus multilocularis nAChR subunit 0.0083 0.0207 0.0198
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Onchocerca volvulus 0.0287 0.0827 0.1762
Plasmodium falciparum dihydroorotate dehydrogenase 0.0345 0.1002 1
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.2171
Echinococcus granulosus glycoprotein Antigen 5 0.0034 0.0059 0.0107
Onchocerca volvulus 0.0029 0.0044 0.006
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0079
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0016 0.0012
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0138 0.0376 0.0815
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.005 0.0089
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0138 0.0376 0.0367
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.026 0.0747 0.1602
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0091 0.0179
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.3649
Brugia malayi Cation transporter family protein 0.0083 0.0207 0.0449
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Brugia malayi nuclear receptor NHR-88 0.002 0.0017 0.0036
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0135 0.0365 0.43
Schistosoma mansoni laminin gamma-3 chain 0.0021 0.0019 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0351 0.0624
Entamoeba histolytica hypothetical protein 0.0112 0.0295 0.5059
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0023
Echinococcus granulosus nAChR subunit 0.0045 0.0091 0.0178
Echinococcus granulosus S formylglutathione hydrolase 0.0077 0.0191 0.0394
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Leishmania major trypanothione reductase 0.0057 0.0129 0.048
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0038 0.0072 0.0136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0254 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0017 0.0015
Brugia malayi hypothetical protein 0.026 0.0747 0.1618
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0131 0.0354 0.0748
Brugia malayi Melibiase family protein 0.0082 0.0206 0.0447
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.002 0.0023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0017 0.0036
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0091 0.0179
Brugia malayi intermediate filament protein 0.0026 0.0035 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.015 0.0412 0.161
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Loa Loa (eye worm) GABA receptor subunit 0.0045 0.0091 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Schistosoma mansoni cytochrome P450 0.0018 0.0009 0.0001
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0345 0.1002 0.3975
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0376 0.1467
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Echinococcus multilocularis serotonin transporter 0.1534 0.4614 0.4609
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0088 0.0725
Echinococcus multilocularis dual specificity mitogen activated protein 0.0111 0.0294 0.0285
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni septate junction protein 0.0021 0.0019 0.0022
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.0331 0.0322
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.026 0.0747 0.0738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0017 0.0015
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.002 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.002 0.0043
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0083 0.0207 0.043
Toxoplasma gondii EGF family domain-containing protein 0.0021 0.0019 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0017 0.0036
Onchocerca volvulus Arrow homolog 0.0027 0.0039 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0141 0.0526
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0042 0.0129
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0174 0.03
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0138 0.0376 0.3649
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0174 0.03
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0119 0.1042
Toxoplasma gondii hypothetical protein 0.0029 0.0044 0.0103
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0242 0.0506
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0138 0.0376 0.0815
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.3649
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0039 0.0084
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0087 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0376 0.444
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0064
Schistosoma mansoni slit 0.0021 0.0019 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.005 0.0041
Trypanosoma brucei trypanothione reductase 0.0057 0.0129 0.0516
Onchocerca volvulus 0.0029 0.0044 0.006
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Giardia lamblia High cysteine protein 0.0021 0.0019 0.0009
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0042
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Onchocerca volvulus 0.0214 0.0605 0.1279
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0059 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0376 0.444
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0083 0.0207 0.0449
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0017 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Loa Loa (eye worm) hypothetical protein 0.0054 0.0119 0.0238
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Schistosoma mansoni hypothetical protein 0.0031 0.005 0.0089
Schistosoma mansoni hypothetical protein 0.0031 0.005 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0174 0.03
Loa Loa (eye worm) hypothetical protein 0.0117 0.0311 0.0655
Brugia malayi Fibulin-1 precursor 0.0027 0.0039 0.0084
Schistosoma mansoni hypothetical protein 0.0083 0.0208 0.0431
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1137 0.3406 0.34
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0376 0.1467
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0174 0.03
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.0019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.015 0.0412 0.161
Brugia malayi hypothetical protein 0.0039 0.0075 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi MH2 domain containing protein 0.0123 0.0329 0.0713
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0017 0.0007
Toxoplasma gondii microneme protein MIC17C 0.0029 0.0044 0.0103
Toxoplasma gondii microneme protein MIC17A 0.0029 0.0044 0.0103
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0046 0.0145
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0174 0.03
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0242 0.0506
Leishmania major cytochrome p450-like protein 0.0028 0.0042 0.0129
Loa Loa (eye worm) hypothetical protein 0.043 0.126 0.2716
Entamoeba histolytica hypothetical protein 0.0045 0.0091 0.1313
Schistosoma mansoni sodium/chloride dependent transporter 0.1534 0.4614 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0129 0.026
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0083 0.0207 0.0198
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0019 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0376 0.444
Echinococcus multilocularis cpg binding protein 0.0037 0.0067 0.0058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0174 0.03
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.011 0.0183
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.002 0.0049
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0141 0.0132
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0072 0.0136
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0088 0.019
Schistosoma mansoni dihydroorotate dehydrogenase 0.0345 0.1002 0.2157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Schistosoma mansoni hypothetical protein 0.0112 0.0295 0.0622
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.002 0.0019
Echinococcus multilocularis Tolloid protein 1 0.0027 0.0039 0.0029
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0017 0.0015
Brugia malayi Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.1618
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0345 0.1002 0.1812
Toxoplasma gondii microneme protein MIC4 0.0029 0.0044 0.0103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0345 0.1002 0.3997
Echinococcus granulosus fibropellin Ia 0.0021 0.0019 0.0021
Onchocerca volvulus 0.0029 0.0044 0.006
Echinococcus granulosus notch 0.0021 0.0019 0.0021
Brugia malayi Cytochrome P450 family protein 0.0028 0.0042 0.009
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0138 0.0376 0.0367
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0174 0.0377
Treponema pallidum sodium- and chloride- dependent transporter 0.1534 0.4614 1
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0088 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0015
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.0874
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0083 0.0207 0.0449
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0138 0.0376 0.0796
Echinococcus multilocularis dna polymerase kappa 0.0021 0.002 0.001
Plasmodium falciparum phosphodiesterase delta, putative 0.0138 0.0376 0.3649
Loa Loa (eye worm) hypothetical protein 0.02 0.0565 0.1206
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.026 0.0747 0.1601
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.002 0.0042
Echinococcus multilocularis laminin 0.0027 0.0039 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0064
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0019 0.0041
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0083 0.0207 0.043
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.002 0.0002
Echinococcus granulosus protein jagged 1 0.0021 0.0019 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0019 0.0041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi Esterase D 0.0077 0.0191 0.0414
Echinococcus multilocularis slit 2 protein 0.0021 0.0019 0.001
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.002 0.0043
Onchocerca volvulus 0.0021 0.0019 0.0006
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Brugia malayi Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED- 0.0111 0.0294 0.0638
Echinococcus multilocularis musashi 0.0026 0.0035 0.0026
Onchocerca volvulus 0.0058 0.0133 0.0253
Toxoplasma gondii subtilisin SUB12 0.0029 0.0044 0.0103
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.089 0.355
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0017 0.0016
Onchocerca volvulus 0.0029 0.0044 0.006
Onchocerca volvulus 0.0021 0.002 0.0007
Brugia malayi notch-like transmembrane receptor 0.0021 0.0019 0.0041
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.002 0.0023
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0044 0.0076
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0207 0.0449
Brugia malayi Delta serrate ligand family protein 0.0021 0.0019 0.0041
Echinococcus multilocularis glycine receptor subunit beta 0.0083 0.0207 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0376 0.1467
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0138 0.0376 0.1499
Loa Loa (eye worm) hypothetical protein 0.0138 0.0376 0.0796
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Loa Loa (eye worm) trypsin family protein 0.0034 0.0059 0.0107
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0042 0.007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.0331 0.0699
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0046 0.0066
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0042 0.0166
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0351 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0083 0.0207 0.0449
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0565 0.1223
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0019 0.0021
Echinococcus granulosus slit 2 protein 0.0021 0.0019 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0141 0.024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.011 0.0183
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Plasmodium vivax glutathione reductase, putative 0.0057 0.0129 0.1148
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Loa Loa (eye worm) ACC-1 protein 0.0083 0.0207 0.043
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0138 0.0376 0.1499
Echinococcus granulosus neural cadherin 0.0021 0.0019 0.0021
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.002 0.0023
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0059 0.0049
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0016 0.0026
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0021 0.0019 0.0006
Mycobacterium ulcerans hypothetical protein 0.003 0.0046 0.0066
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0083 0.0207 0.043
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0395 0.0704
Toxoplasma gondii propionate-CoA ligase 0.0021 0.002 0.0032
Giardia lamblia hypothetical protein 0.0138 0.0376 0.1062
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Loa Loa (eye worm) acetylcholine receptor protein 0.0038 0.0072 0.0136
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0107
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0017 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0174 0.0659
Loa Loa (eye worm) hypothetical protein 0.0082 0.0206 0.0428
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0119 0.02
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0083 0.0207 0.0449
Echinococcus granulosus glycine receptor subunit alpha 1 0.0083 0.0207 0.043
Leishmania major cAMP-specific phosphodiesterase, putative 0.0138 0.0376 0.1467
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0083 0.0207 0.0198
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0174 0.2829
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0035 0.0076
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0138 0.0376 0.0815
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Onchocerca volvulus 0.0029 0.0044 0.006
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.1601
Loa Loa (eye worm) hypothetical protein 0.0214 0.0605 0.1293
Loa Loa (eye worm) ACC-1 protein 0.0083 0.0207 0.043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0017 0.0016
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0038 0.0072 0.0063
Schistosoma mansoni notch 0.0021 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.0178
Onchocerca volvulus 0.0034 0.0059 0.0092
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0138 0.0376 0.0796
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0141 0.024
Loa Loa (eye worm) STE/STE7/MEK7 protein kinase 0.0111 0.0294 0.0619
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0045 0.0091 0.0179
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.002 0.0019
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0998 0.2986 0.6465
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Echinococcus granulosus expressed conserved protein 0.0188 0.0528 0.1126
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0029 0.0044 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0376 0.1467
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0138 0.0376 0.0367
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0027 0.0039 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0017 0.0036
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0017 0.0016
Echinococcus multilocularis protein jagged 1 0.0021 0.0019 0.001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.026 0.0747 0.1602
Loa Loa (eye worm) hypothetical protein 0.026 0.0747 0.1601
Brugia malayi hypothetical protein 0.0131 0.0354 0.0767
Echinococcus multilocularis enteropeptidase 0.0034 0.0059 0.0049
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0046 0.0145
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.002 0.004
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.002 0.0019
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.1642
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0331 0.07
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.2171
Trypanosoma cruzi hypothetical protein, conserved 0.0117 0.0311 0.1206
Echinococcus granulosus tumor protein p63 0.0679 0.2017 0.4361
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.0736 0.2934
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.002 0.0023
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.0734
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.014 0.0381 0.4497
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0138 0.0376 0.1499
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0016 0.0026
Brugia malayi Trypsin family protein 0.0034 0.0059 0.0127
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.002 0.0019
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0016 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.002 0.0042
Onchocerca volvulus 0.0038 0.0072 0.012
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0009 0.0038
Schistosoma mansoni notch 0.0021 0.0019 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0017 0.0036
Trypanosoma brucei unspecified product 0.0021 0.002 0.0079
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1534 0.4614 1
Onchocerca volvulus 0.0099 0.0258 0.0524
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0183 0.0378
Loa Loa (eye worm) hypothetical protein 0.0037 0.0068 0.0127
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0016 0.0064
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0345 0.1002 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0034 0.0059 0.0108
Mycobacterium ulcerans hypothetical protein 0.0077 0.0191 0.0331
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0052
Schistosoma mansoni acetylcholine receptor-related 0.0038 0.0072 0.0136
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.002 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.002 0.0023
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.052 0.1096
Onchocerca volvulus 0.0083 0.0207 0.0415
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.014 0.0381 0.6621
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0083 0.0207 0.043
Schistosoma mansoni nAChR subunit 0.0038 0.0072 0.0136
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0098 0.0254 0.0446
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0072 0.0136
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0138 0.0376 0.0796
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1455 0.1447
Echinococcus multilocularis expressed conserved protein 0.0188 0.0528 0.0519
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Schistosoma mansoni hypothetical protein 0.0083 0.0208 0.0431
Onchocerca volvulus 0.0029 0.0044 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0017 0.0036
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0083 0.0207 0.0449
Schistosoma mansoni neurotransmitter gated ion channel 0.0038 0.0072 0.0136
Onchocerca volvulus 0.0083 0.0207 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0017 0.0036
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0027 0.0039 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0017 0.0007
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0077 0.0191 0.0331
Loa Loa (eye worm) hypothetical protein 0.0067 0.016 0.0326
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0345 0.1002 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Loa Loa (eye worm) hypothetical protein 0.0034 0.0059 0.0107
Plasmodium falciparum phosphodiesterase gamma, putative 0.0138 0.0376 0.3649
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0052 0.0114 0.0191
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.002 0.0023
Echinococcus multilocularis lamin 0.0026 0.0035 0.0026
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0044 0.0103
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Loa Loa (eye worm) hypothetical protein 0.0105 0.0276 0.0579
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0174 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0017 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0242 0.0233
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.002 0.0019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.015 0.0412 0.0403
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0077 0.0191 0.0331
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0329 0.0695
Giardia lamblia DINP protein human, muc B family 0.0021 0.002 0.0011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0129 0.012
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0011 0.0003
Loa Loa (eye worm) hypothetical protein 0.0086 0.0217 0.0451
Echinococcus multilocularis glycine receptor subunit beta 0.0083 0.0207 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0068 0.0127
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0056
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0077 0.0191 0.0331
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.026 0.0747 0.1602
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.002 0.0047
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Plasmodium falciparum cysteine repeat modular protein 1 0.0117 0.0311 0.2988
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Plasmodium vivax SET domain protein, putative 0.0037 0.0068 0.0524
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0138 0.0376 0.1467
Mycobacterium ulcerans hypothetical protein 0.0162 0.0448 0.08
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0016 0.0026
Echinococcus multilocularis sodium and chloride dependent glycine 0.026 0.0747 0.0738
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0077 0.0191 0.0331
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.0019
Echinococcus granulosus FTZ F1 alpha 0.002 0.0017 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.089 0.3525
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0138 0.0376 0.0797
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0254 0.055
Brugia malayi Latrophilin receptor protein 2 0.0031 0.005 0.0109
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Toxoplasma gondii thioredoxin reductase 0.0057 0.0129 0.0354
Echinococcus multilocularis lamin dm0 0.0026 0.0035 0.0026
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.3649
Echinococcus granulosus lamin 0.0026 0.0035 0.0056
Onchocerca volvulus 0.0083 0.0207 0.0415
Toxoplasma gondii hypothetical protein 0.005 0.0107 0.0287
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0046 0.0066
Onchocerca volvulus 0.0021 0.002 0.0007
Brugia malayi Zinc finger, C2H2 type family protein 0.0135 0.0365 0.079
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0016 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0242 0.0525
Echinococcus granulosus cpg binding protein 0.0037 0.0067 0.0126
Brugia malayi Kringle domain containing protein 0.0117 0.0311 0.0673
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0295 0.0621
Echinococcus multilocularis tumor protein p63 0.0679 0.2017 0.201
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0017 0.0007
Loa Loa (eye worm) PDE1B protein 0.0138 0.0376 0.0796
Onchocerca volvulus Huntingtin homolog 0.0131 0.0354 0.0733
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.002 0.0047
Plasmodium vivax amine transporter, putative 0.026 0.0747 0.7407
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Onchocerca volvulus 0.0038 0.0072 0.012
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.002 0.0079
Giardia lamblia Hypothetical protein 0.0138 0.0376 0.1062
Echinococcus multilocularis tissue type plasminogen activator 0.0117 0.0311 0.0302
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0141 0.0286
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0077 0.0191 0.0331
Brugia malayi Protein kinase domain containing protein 0.0117 0.0311 0.0673
Echinococcus granulosus dna polymerase kappa 0.0021 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.1534 0.4614 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0174 0.2829
Schistosoma mansoni notch 0.0021 0.0019 0.0022
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0088 0.019
Brugia malayi EGF-like domain containing protein 0.0021 0.0019 0.0041
Onchocerca volvulus 0.1534 0.4614 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0141 0.024
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.002 0.0019
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0091 0.0198
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0079
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.002 0.0042
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0016 0.0064
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0823 0.0814
Loa Loa (eye worm) hypothetical protein 0.0054 0.0119 0.0238
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.002 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0017 0.0036
Echinococcus multilocularis protein dispatched 1 0.0098 0.0254 0.0245
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.002 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0017 0.0036
Entamoeba histolytica hypothetical protein 0.0112 0.0295 0.5059
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0823 0.1767
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0021 0.0019 0.0022
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0019 0.001
Echinococcus granulosus glycine receptor subunit beta 0.0083 0.0207 0.043
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0042 0.0129
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0017 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0061 0.0113
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.002 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0016 0.0012
Leishmania major hypothetical protein, conserved 0.0257 0.0736 0.2908
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.026 0.0747 0.0738
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0068 0.0172
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0019 0.0041
Mycobacterium tuberculosis Conserved protein 0.003 0.0046 0.0066
Loa Loa (eye worm) esterase D 0.0077 0.0191 0.0394
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0345 0.1002 0.1812
Brugia malayi hypothetical protein 0.0039 0.0075 0.0162
Loa Loa (eye worm) notch protein 0.0021 0.0019 0.0021
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Schistosoma mansoni nAChR subunit 0.0083 0.0207 0.043
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Entamoeba histolytica hypothetical protein 0.0112 0.0295 0.5059
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0083 0.0207 0.043
Brugia malayi nuclear hormone receptor 0.002 0.0017 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0174 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0217 0.2481
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.002 0.0079
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0376 0.1467
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0001
Schistosoma mansoni sodium/chloride dependent transporter 0.026 0.0747 0.1602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi hypothetical protein 0.0038 0.0072 0.0156
Loa Loa (eye worm) hypothetical protein 0.0099 0.0258 0.0539
Brugia malayi hypothetical protein 0.0286 0.0823 0.1783
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0345 0.1002 0.3975
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0044 0.0103
Schistosoma mansoni nuclear hormone receptor 0.002 0.0017 0.0016
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0038 0.0072 0.0156
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0117 0.0311 0.2988
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0076
Loa Loa (eye worm) hypothetical protein 0.1403 0.4215 0.9132
Onchocerca volvulus 0.0029 0.0044 0.006
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0141 0.0388
Schistosoma mansoni patched 1 0.0086 0.0217 0.0452
Schistosoma mansoni egf-like domain protein 0.0027 0.0039 0.0064
Schistosoma mansoni hypothetical protein 0.0034 0.0059 0.0108
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0129 0.026
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0044 0.0076
Toxoplasma gondii PAN/Apple domain-containing protein 0.0029 0.0044 0.0103
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0044 0.0103
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0046 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0017 0.0015
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0083 0.0207 0.0449
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0068 0.0127
Mycobacterium tuberculosis Possible conserved membrane protein 0.0077 0.0191 0.0331
Mycobacterium ulcerans hypothetical protein 0.003 0.0046 0.0066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0017 0.0007
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1137 0.3406 0.7377
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0016 0.0064
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0019 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0242 0.0506
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.0019
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.014 0.0381 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0017 0.0036
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.026 0.0747 0.0738
Echinococcus granulosus transmembrane protease serine 3 0.0034 0.0059 0.0107
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.1601
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0129 0.1148
Echinococcus granulosus dual specificity mitogen activated protein 0.0111 0.0294 0.0619
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0016 0.002
Schistosoma mansoni hypothetical protein 0.0031 0.005 0.0089
Loa Loa (eye worm) hypothetical protein 0.0083 0.0207 0.043
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0083 0.0207 0.043
Trypanosoma brucei C-8 sterol isomerase, putative 0.0841 0.2508 1
Echinococcus multilocularis nAChR subunit 0.0045 0.0091 0.0082
Toxoplasma gondii PAN domain-containing protein 0.0029 0.0044 0.0103
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0138 0.0376 0.0797
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.1499
Echinococcus granulosus Mastin 0.0034 0.0059 0.0107
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0009 0.0001
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Echinococcus multilocularis sodium and chloride dependent glycine 0.026 0.0747 0.0738
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0351 0.0624
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Onchocerca volvulus 0.0083 0.0207 0.0415
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1137 0.3406 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.005 0.0041
Onchocerca volvulus 0.0034 0.0059 0.0092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0017 0.0016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0068 0.0058
Onchocerca volvulus 0.0034 0.0059 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0015
Schistosoma mansoni hypothetical protein 0.0031 0.005 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0023
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0087 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0034 0.0059 0.0108
Echinococcus granulosus nAChR subunit 0.0083 0.0207 0.043
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0088 0.019
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0039 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0174 0.03
Loa Loa (eye worm) PAN domain-containing protein 0.0029 0.0044 0.0076
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0042 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.002 0.0042
Leishmania major DNA polymerase kappa, putative 0.0021 0.002 0.0042
Toxoplasma gondii hypothetical protein 0.026 0.0747 0.2171
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0138 0.0376 0.444
Toxoplasma gondii hypothetical protein 0.026 0.0747 0.2171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0174 0.03
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0217 0.0451
Schistosoma mansoni cell polarity protein 0.0021 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0021
Brugia malayi Cadherin domain containing protein 0.0021 0.0019 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.005 0.0089
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0083 0.0207 0.0198
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.1823 0.549 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0351 0.0624
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0217 0.0451
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.005 0.0107 0.0391
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.026 0.0747 0.1602
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.026 0.0747 0.1602
Echinococcus multilocularis fibrillin 1 0.0027 0.0039 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0017 0.0036
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0258 0.054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0072 0.0136
Onchocerca volvulus Putative cubilin 0.0021 0.0019 0.0006
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.002 0.0042
Schistosoma mansoni thyroid hormone receptor 0.002 0.0017 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0083 0.0207 0.0449
Brugia malayi Cation transporter family protein 0.0083 0.0207 0.0449
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.011 0.0183
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.0736 0.2908
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0017 0.0016
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0015
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.002 0.0011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0083 0.0207 0.043
Loa Loa (eye worm) hypothetical protein 0.0072 0.0174 0.0357
Echinococcus granulosus dna polymerase eta 0.0021 0.002 0.0023
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0035 0.0056
Echinococcus multilocularis neural cadherin 0.0021 0.0019 0.001
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0827 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.002 0.0019
Echinococcus granulosus intermediate filament protein 0.0026 0.0035 0.0056
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0019 0.0041
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.026 0.0747 0.1602
Onchocerca volvulus Putative nachr subunit 0.0083 0.0207 0.0415
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0034 0.0059 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0083 0.0207 0.0449
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0206 0.2348
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0138 0.0376 0.1467
Plasmodium vivax hypothetical protein, conserved 0.026 0.0747 0.7407
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0083 0.0207 0.043
Echinococcus granulosus serotonin transporter 0.1534 0.4614 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0017 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.002 0.0079
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0017 0.0015
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0046 0.0145
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.015 0.0412 0.4012
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.5416
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0016 0.0015
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0088 0.0725
Echinococcus granulosus sodium and chloride dependent glycine 0.026 0.0747 0.1601
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0083 0.0207 0.0198
Schistosoma mansoni coup transcription factor 0.002 0.0017 0.0016
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0083 0.0207 0.043
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0083 0.0207 0.0449
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.002 0.0042
Schistosoma mansoni sodium-dependent amino acid transporter 0.026 0.0747 0.1602
Onchocerca volvulus 0.0029 0.0044 0.006
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.002 0.0032
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0138 0.0376 0.0815
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1137 0.3406 0.34
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.002 0.0019
Brugia malayi hypothetical protein 0.0038 0.0072 0.0156
Brugia malayi PAN domain containing protein 0.0029 0.0044 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.002 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0021 0.002 0.0043
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0046 0.0066
Leishmania major dihydroorotate dehydrogenase 0.0345 0.1002 0.3975
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0138 0.0376 0.444
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0138 0.0376 0.1467
Schistosoma mansoni survival motor neuron protein 0.0058 0.0133 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0138 0.0376 0.108
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.002 0.0042
Schistosoma mansoni hypothetical protein 0.0021 0.0019 0.0022
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.015 0.0412 0.1185
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.026 0.0747 0.2171
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0017 0.0016
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.0331 0.07
Plasmodium falciparum transporter, putative 0.026 0.0747 0.7407

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 2 uM Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
EC50 (binding) = 2 uM Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
HD50 (functional) = 6.3 uM kg-1 Hyponotic dose required to cause a loss of righting reflex for a minimum period of 30 s in 50 percent of treated mice after intravenous administration. ChEMBL. 11063608
HD50 (functional) = 6.3 uM kg-1 Hypnotic dose was determined by observing loss of righting reflex for a minimum period of 30 sec in 50% of treated mice after i.v. administration. ChEMBL. 9171876
IC50 (binding) = 423 nM Inhibition of binding of tert-butyl bicyclophosphorothionate ([35 S]TBPS) at Gamma-aminobutyric-acid A receptor from rat whole brain membranes ChEMBL. 11063608
IC50 (binding) = 538 nM The concentration of the compound required to inhibit 50% of binding of [35S]-TBPS to Gamma-aminobutyric-acid A receptor to rat whole brain membranes. ChEMBL. 9171876
IC50 (binding) = 0.3 uM Inhibition of [35S]-TBPS binding to GABA-A receptor in rat cerebral cortex. ChEMBL. 9599235
Maximal efficacy (binding) = 322 % Maximal efficacy for GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
Maximal efficacy (binding) = 322 % Maximal efficacy for GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes ChEMBL. 15801854
POT (functional) = 700 nM Concentration required to potentiate GABA-evoked currents in voltage-clamped bovine chromaffin cells by 300% ChEMBL. 9171876
Potency (functional) 0.0224 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 6.4241 uM PUBCHEM_BIOASSAY: S16 Schwann cell PMP22 intronic element firefly luciferase assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.4852 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493163, AID504444, AID504648] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 20.5962 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7083 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen for APE1 Inhibitors: qHTS Validation Assay for Inhibitors of Endonuclease IV. (Class of assay: confirmatory) [Related pubchem assays: 1705, 1707 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
SD (functional) = 1.7 min Effect on interval between loss of righting reflex and return to righting reflex (sleep duration) was measured at a dose twice that of hypnotic dose. ChEMBL. 9171876
Time (functional) = 1 min Anesthetic effect in mouse assessed as time taken for recovery of righting effect and walking at 16 mg/kg, iv ChEMBL. 21504158
Time (functional) = 4 min Anesthetic effect in mouse assessed as duration of loss of righting reflex at 16 mg/kg, iv ChEMBL. 21504158
Time (functional) = 4 min Anesthetic effect in mouse assessed as duration of loss of righting reflex at 16 mg/kg, iv ChEMBL. 24328079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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