Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0067 | 0.0396 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0067 | 0.0396 | 0.0396 |
Onchocerca volvulus | 0.0067 | 0.0396 | 1 | |
Brugia malayi | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus multilocularis | acetylcholinesterase | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0067 | 0.0396 | 0.0031 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0396 | 0.0031 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.0396 | 0.0031 |
Loa Loa (eye worm) | carboxylesterase | 0.0399 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0367 | 0.0367 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0396 | 0.0031 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0067 | 0.0396 | 0.0396 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0066 | 0.0367 | 0.0367 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0066 | 0.0367 | 0.0367 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0067 | 0.0396 | 0.0396 |
Schistosoma mansoni | gliotactin | 0.0067 | 0.0396 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0067 | 0.0396 | 0.0396 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0396 | 0.0031 |
Onchocerca volvulus | 0.0067 | 0.0396 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0396 | 0.0031 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0066 | 0.0367 | 0.0367 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.0396 | 0.0031 |
Brugia malayi | Carboxylesterase family protein | 0.0399 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0399 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0066 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0367 | 0.0367 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0066 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0399 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0067 | 0.0396 | 0.5 |
Onchocerca volvulus | 0.0067 | 0.0396 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0399 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0067 | 0.0396 | 0.0396 |
Onchocerca volvulus | 0.0067 | 0.0396 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0399 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0067 | 0.0396 | 0.0396 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0066 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0067 | 0.0396 | 0.5 |
Onchocerca volvulus | 0.0067 | 0.0396 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0067 | 0.0396 | 0.0031 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0067 | 0.0396 | 0.5 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0066 | 0.0367 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0067 | 0.0396 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0399 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0399 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0067 | 0.0396 | 0.0031 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0399 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0066 | 0.0367 | 0.0367 |
Echinococcus granulosus | carboxylesterase 5A | 0.0399 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0067 | 0.0396 | 0.0396 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.0396 | 0.0031 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0067 | 0.0396 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0067 | 0.0396 | 0.0396 |
Echinococcus granulosus | acetylcholinesterase | 0.0399 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0066 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0396 | 0.0031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cells | ChEMBL. | 15828827 |
IC50 (binding) | = 1.1 uM | Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cells | ChEMBL. | 15828827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.