TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.34 | Formula: C21H26BrFNO-
H donors: 1 H acceptors: 1 LogP: 6.28 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCN([C@@H]1Cc2c([C@@H]1c1ccccc1)cc(c(c2)O)F)CCC.[Br-]
InChi: 1S/C21H26FNO.BrH/c1-3-10-23(11-4-2)19-12-16-13-20(24)18(22)14-17(16)21(19)15-8-6-5-7-9-15;/h5-9,13-14,19,21,24H,3-4,10-12H2,1-2H3;1H/p-1/t19-,21-;/m1./s1
InChiKey: VKGHTYOTBXYAKV-GNGUGDOWSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.1155	1	1
Schistosoma mansoni	hypothetical protein	0.0166	0.1239	0.1239
Mycobacterium ulcerans	beta-lactamase	0.0107	0.0714	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0107	0.0714	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1155	1	1
Brugia malayi	beta-lactamase family protein	0.0107	0.0714	0.0714
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.1155	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.1155	1	1
Onchocerca volvulus	Huntingtin homolog	0.0119	0.082	0.082
Echinococcus multilocularis	nuclear receptor nhr 48	0.0545	0.4595	0.4595
Mycobacterium ulcerans	hypothetical protein	0.0107	0.0714	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.202	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.1155	1	1
Schistosoma mansoni	hypothetical protein	0.0166	0.1239	0.1239
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.1155	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0321	0.0321
Brugia malayi	hypothetical protein	0.061	0.5174	0.5174
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0321	0.0321
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0545	0.4595	0.4595
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0061	0.0061
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0107	0.0714	0.0714
Schistosoma mansoni	RAR-like nuclear receptor	0.1155	1	1
Echinococcus multilocularis	FTZ F1 alpha	0.1155	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.1155	1	1
Brugia malayi	nuclear receptor NHR-67	0.0545	0.4595	0.4595
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0714	0.0714
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0545	0.4595	0.4595
Brugia malayi	nuclear receptor RXR	0.0545	0.4595	0.4595
Onchocerca volvulus		0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0446	0.3716	0.3716
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.1155	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.061	0.5174	0.5174
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.061	0.5174	0.5174
Brugia malayi	conserved hypotetical protein	0.0545	0.4595	0.4595
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.1155	1	1
Echinococcus multilocularis	geminin	0.0166	0.1239	0.1239
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0545	0.4595	0.4595
Brugia malayi	orphan nuclear receptor NR2E1	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Toxoplasma gondii	ABC1 family protein	0.0107	0.0714	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.202	1
Onchocerca volvulus		0.0107	0.0714	0.0714
Schistosoma mansoni	coup transcription factor	0.1155	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.1155	1	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0061	0.0061
Onchocerca volvulus	Glucosylceramidase homolog	0.0167	0.1246	0.1246
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0714	0.0714
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.061	0.5174	0.5174
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.1155	1	1
Leishmania major	hypothetical protein, conserved	0.0107	0.0714	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1325	0.4682
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.1155	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0161	0.0161
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.1155	1	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0321	0.0321
Onchocerca volvulus		0.0107	0.0714	0.0714
Onchocerca volvulus		0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.061	0.5174	0.5174
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0196	0.0196
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.061	0.5174	0.5174
Schistosoma mansoni	nuclear hormone receptor	0.1155	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0714	0.0714
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0107	0.0714	0.0714
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0254	0.202	0.202
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.1155	1	1
Brugia malayi	tailless protein	0.0545	0.4595	0.4595
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0545	0.4595	0.4595
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0545	0.4595	0.4595
Brugia malayi	Nuclear hormone receptor E75	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Brugia malayi	nuclear hormone receptor	0.1155	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0107	0.0714	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0161	0.0161
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.1155	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.1155	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0545	0.4595	0.4595
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.0714	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0545	0.4595	0.4595
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0714	0.0714
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.1325	0.4682
Brugia malayi	hypothetical protein	0.0545	0.4595	0.4595
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.1155	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.1155	1	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0107	0.0714	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0161	0.0161
Brugia malayi	nuclear hormone receptor	0.0545	0.4595	0.4595
Onchocerca volvulus		0.0545	0.4595	0.4595
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0321	0.0321
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0545	0.4595	0.4595
Echinococcus granulosus	geminin	0.0166	0.1239	0.1239
Echinococcus granulosus	muscleblind protein	0.0446	0.3716	0.3716
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0714	0.0714
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0161	0.0161
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0545	0.4595	0.4595
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.1155	1	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.061	0.5174	0.5174
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0321	0.0321
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.1155	1	1
Schistosoma mansoni	nuclear receptor	0.0545	0.4595	0.4595
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0545	0.4595	0.4595
Schistosoma mansoni	zinc finger protein	0.0545	0.4595	0.4595
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.1155	1	1
Mycobacterium leprae	conserved hypothetical protein	0.0107	0.0714	0.5
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0161	0.0161
Mycobacterium ulcerans	lipase LipD	0.0107	0.0714	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0682	0.5806	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0196	0.0196
Loa Loa (eye worm)	nuclear hormone receptor	0.0545	0.4595	0.4595
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.082	0.082
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0545	0.4595	0.4595
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.202	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.1155	1	1
Brugia malayi	beta-lactamase	0.0107	0.0714	0.0714
Schistosoma mansoni	nuclear receptor	0.0545	0.4595	0.4595
Echinococcus granulosus	nuclear receptor nhr 48	0.0545	0.4595	0.4595
Echinococcus multilocularis	ecdysone induced protein 78C	0.1155	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.061	0.5174	0.5174
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0545	0.4595	0.4595
Brugia malayi	nuclear receptor RXR	0.061	0.5174	0.5174
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.1155	1	1
Mycobacterium leprae	Probable lipase LipE	0.0107	0.0714	0.5
Brugia malayi	steroid hormone receptor	0.1155	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0321	0.0321
Schistosoma mansoni	thyroid hormone receptor	0.1155	1	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.1155	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.1155	1	1
Schistosoma mansoni	thyroid hormone receptor	0.1155	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0161	0.0161
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.0714	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0321	0.0321
Schistosoma mansoni	nuclear receptor nhr-48	0.0545	0.4595	0.4595
Onchocerca volvulus	Bile acid receptor homolog	0.1155	1	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0254	0.202	0.202
Brugia malayi	nuclear receptor NHR-88	0.1155	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0321	0.0321
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.1155	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.0714	0.0714
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.0714	0.0714
Loa Loa (eye worm)	DR-78	0.0545	0.4595	0.4595
Echinococcus granulosus	beta LACTamase domain containing family member	0.0107	0.0714	0.0714
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.1155	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0446	0.3716	0.3716
Loa Loa (eye worm)	hypothetical protein	0.061	0.5174	0.5174
Echinococcus granulosus	thyroid hormone receptor alpha	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Brugia malayi	TAR-binding protein	0.0062	0.0321	0.0321
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Brugia malayi	Steroid receptor seven-up type 2	0.1155	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.1155	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.1155	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0714	0.0714
Brugia malayi	Muscleblind-like protein	0.0446	0.3716	0.3716
Brugia malayi	beta-lactamase family protein	0.0107	0.0714	0.0714
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0321	0.0321
Onchocerca volvulus	Protein ultraspiracle homolog	0.1155	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Brugia malayi	Nuclear hormone receptor-like 1	0.061	0.5174	0.5174
Brugia malayi	ecdysone receptor	0.0545	0.4595	0.4595
Schistosoma mansoni	nuclear hormone receptor	0.0545	0.4595	0.4595
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.1155	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.082	0.082
Loa Loa (eye worm)	beta-lactamase	0.0107	0.0714	0.0714
Brugia malayi	photoreceptor-specific nuclear receptor	0.1155	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.061	0.5174	0.5174
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.202	1
Brugia malayi	Nuclear hormone receptor-like 1	0.061	0.5174	0.5174
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0321	0.0321
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0545	0.4595	0.4595
Echinococcus multilocularis	muscleblind protein 1	0.0446	0.3716	0.3716
Brugia malayi	RNA binding protein	0.0062	0.0321	0.0321
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0545	0.4595	0.4595
Brugia malayi	hypothetical protein	0.0119	0.082	0.082
Brugia malayi	Nuclear hormone receptor E75	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Onchocerca volvulus	Huntingtin homolog	0.0119	0.082	0.082
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.1155	1	1
Brugia malayi	hypothetical protein	0.0545	0.4595	0.4595
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.1246	0.4073
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.1155	1	1
Onchocerca volvulus		0.0107	0.0714	0.0714
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.202	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0254	0.202	1
Brugia malayi	nuclear receptor NHR-88	0.0545	0.4595	0.4595
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.1155	1	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0545	0.4595	0.4595
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Echinococcus multilocularis	muscleblind protein	0.0446	0.3716	0.3716
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0107	0.0714	0.0714
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.0714	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0161	0.0161
Schistosoma mansoni	retinoic acid receptor RXR	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0196	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.1155	1	1
Echinococcus granulosus	FTZ F1 alpha	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.0545	0.4595	0.4595
Brugia malayi	hypothetical protein	0.061	0.5174	0.5174
Loa Loa (eye worm)	hypothetical protein	0.061	0.5174	0.5174
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0061	0.0061
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0545	0.4595	0.4595
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.1155	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0321	0.0321
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.1155	1	1
Loa Loa (eye worm)	hypothetical protein	0.1155	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 12 uM	Inhibitory constant for [3H]-YM-09151-2 binding to Dopamine receptor D2-like in porcine striatal membranes	ChEMBL.	15801855
Ki (binding)	= 54 uM	Inhibitory constant for [3H]-SCH-23,390 binding to Dopamine receptor D1-like of porcine striatal membranes	ChEMBL.	15801855

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 420618

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 333630