Detailed information for compound 333645

Basic information

Technical information
  • TDR Targets ID: 333645
  • Name: 6-(furan-2-yl)-9-[(1S)-1-phenylethyl]purine
  • MW: 290.319 | Formula: C17H14N4O
  • H donors: 0 H acceptors: 3 LogP: 2.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H](n1cnc2c1ncnc2c1ccco1)c1ccccc1
  • InChi: 1S/C17H14N4O/c1-12(13-6-3-2-4-7-13)21-11-20-16-15(14-8-5-9-22-14)18-10-19-17(16)21/h2-12H,1H3/t12-/m0/s1
  • InChiKey: UOLSTMHRNKRFFR-LBPRGKRZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(2-furyl)-9-[(1S)-1-phenylethyl]purine
  • 6-furan-2-yl-9-[(1S)-1-phenylethyl]purine
  • 9H-Purine, 6-(2-furanyl)-9-[(1S)-1-phenylethyl]-
  • AIDS-174144
  • AIDS174144

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0213
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0263 0.1459
Echinococcus multilocularis dro:myosuppressin receptor 0.0132 0.3263 0.3263
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0079 0.1806 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0176 0.0974
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0142 0.5643
Brugia malayi Cathepsin L-like precursor 0.0023 0.0263 0.0807
Mycobacterium leprae putative cytochrome p450 0.0018 0.0142 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.2493 1
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.3263 0.3263
Echinococcus granulosus calcium activated potassium channel 0.0014 0.0027 0.0027
Brugia malayi AKH receptor 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0449 0.0545
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.01 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0222 0.0222
Echinococcus multilocularis zinc phosphodiesterase 0.0017 0.01 0.01
Brugia malayi laminin alpha chain 0.0025 0.0318 0.0975
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0017 0.01 0.0396
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.01 0.0556
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0023 0.0263 0.4673
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0256 0.6641 0.8059
Brugia malayi RNA, U transporter 1 0.0084 0.1934 0.5928
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Leishmania major GTP-binding protein, putative 0.0022 0.0237 0.1311
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0263 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0222 0.0269
Echinococcus granulosus neuropeptide receptor A26 0.0132 0.3263 0.3263
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0175 0.0437
Schistosoma mansoni biogenic amine receptor 0.0132 0.3263 0.3959
Brugia malayi hypothetical protein 0.0132 0.3263 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0222 0.068
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus granulosus somatostatin receptor 0.0132 0.3263 0.3263
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0175 0.0536
Echinococcus multilocularis g protein coupled receptor 0.0132 0.3263 0.3263
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0222 0.068
Echinococcus granulosus tachykinin peptides receptor 99D 0.0132 0.3263 0.3263
Echinococcus multilocularis 0.0018 0.0142 0.0142
Schistosoma mansoni neuropeptide receptor 0.0132 0.3263 0.3959
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.01 0.0171
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0263 0.0807
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0175 0.0968
Schistosoma mansoni hypothetical protein 0.0106 0.2535 0.3076
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.01 0.01
Echinococcus granulosus GPCR family 2 0.0017 0.01 0.01
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0132 0.3263 0.3959
Brugia malayi Melatonin receptor type 1A 0.0132 0.3263 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0373 0.7825
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0222 0.068
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0027 0.0373 0.0453
Echinococcus granulosus transient receptor potential cation channel 0.0174 0.441 0.441
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.01 0.0171
Schistosoma mansoni hypothetical protein 0.0043 0.0823 0.0998
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0176 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0176 0.0176
Entamoeba histolytica hypothetical protein 0.0024 0.0297 0.0979
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0222 0.0222
Brugia malayi Importin beta-1 subunit 0.0029 0.0449 0.1377
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0263 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0222 0.068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0142 0.5643
Schistosoma mansoni hypothetical protein 0.0315 0.8241 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0132 0.3263 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Plasmodium vivax vivapain-2 0.0023 0.0263 0.4673
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Leishmania major cytochrome p450-like protein 0.0018 0.0142 0.0789
Echinococcus granulosus Niemann Pick C1 protein 0.0149 0.3716 0.3716
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0132 0.3263 0.3263
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0142 0.0546
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.01 0.01
Brugia malayi hypothetical protein 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0122
Brugia malayi GnHR receptor homolog 0.0132 0.3263 1
Echinococcus granulosus dual specificity mitogen activated protein 0.0079 0.1806 0.1806
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Trypanosoma brucei glyoxalase II 0.0017 0.01 0.0396
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0222 0.0222
Echinococcus multilocularis pikachurin 0.0025 0.0318 0.0318
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0222 0.068
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.01 0.0556
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Schistosoma mansoni hypothetical protein 0.0043 0.0823 0.0998
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0142 0.5643
Echinococcus multilocularis transient receptor potential cation channel 0.0014 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0142 0.1258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0176 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0017 0.01 0.01
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0132 0.3263 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.01 0.0308
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1132 1
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.01 0.0122
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.01 0.0308
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0203 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0222 0.068
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.01 0.0556
Onchocerca volvulus 0.0132 0.3263 1
Leishmania major cysteine peptidase A (CPA) 0.0023 0.0263 0.1459
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.01 0.0556
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0318 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0222 0.0269
Echinococcus multilocularis fmrfamide receptor 0.0132 0.3263 0.3263
Brugia malayi follicle stimulating hormone receptor 0.0132 0.3263 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0222 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0176 0.0974
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0059 0.0071
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0222 0.0222
Echinococcus multilocularis allatostatin A receptor 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Brugia malayi Cytochrome P450 family protein 0.0045 0.0869 0.2664
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0237 0.0934
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0142 0.5643
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.063 0.1931
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0079 0.1806 0.5534
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0142 0.5643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0222 0.0269
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0025 0.0318 0.0975
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0017 0.01 0.0308
Loa Loa (eye worm) hypothetical protein 0.0045 0.0867 0.1052
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1132 0.6049
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Brugia malayi Cytochrome P450 family protein 0.0045 0.0869 0.2664
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0237 0.0237
Plasmodium vivax importin-beta 2, putative 0.0029 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Brugia malayi hypothetical protein 0.0132 0.3263 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0222 0.068
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1132 0.6269
Echinococcus granulosus ETHE1 protein 0.0017 0.01 0.01
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0023 0.0263 0.0263
Brugia malayi Cathepsin L-like precursor 0.0023 0.0263 0.0807
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0175 0.0968
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0017 0.01 0.0396
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0142 0.0546
Echinococcus multilocularis neuropeptide FF receptor 2 0.0132 0.3263 0.3263
Onchocerca volvulus 0.0132 0.3263 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0222 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0222 0.068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0222 0.0222
Echinococcus granulosus importin subunit beta 1 0.0029 0.0449 0.0449
Loa Loa (eye worm) hypothetical protein 0.0013 0.00000022964 0.00000027865
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0017 0.01 0.01
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0175 1
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.3263 0.3263
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1087 0.333
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1132 0.4465
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.01 0.0556
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0142 0.0789
Schistosoma mansoni hypothetical protein 0.0043 0.0823 0.0998
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0142 0.0546
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0176 0.0213
Loa Loa (eye worm) ctsf protein 0.0023 0.0263 0.032
Onchocerca volvulus 0.0132 0.3263 1
Schistosoma mansoni hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0176 0.0176
Brugia malayi Cathepsin L-like cysteine proteinase 0.0015 0.0059 0.018
Schistosoma mansoni hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0222 0.0222
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0297 0.1645
Echinococcus multilocularis transient receptor potential cation channel 0.0175 0.4424 0.4424
Echinococcus granulosus neuropeptide receptor 0.0132 0.3263 0.3263
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0142 0.0546
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0176 0.0213
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0176 0.0176
Entamoeba histolytica alkyl sulfatase, putative 0.0017 0.01 0.0171
Entamoeba histolytica Ran family GTPase 0.0022 0.0237 0.0731
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0176 0.0213
Brugia malayi Dopamine receptor 0.0132 0.3263 1
Schistosoma mansoni opsin-like receptor 0.0132 0.3263 0.3959
Brugia malayi larval opioid receptor 0.0132 0.3263 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0176 0.0176
Echinococcus multilocularis neuropeptide receptor 0.0132 0.3263 0.3263
Echinococcus multilocularis ankyrin repeat protein 0.0161 0.4055 0.4055
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0222 0.0269
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0234 0.6051 0.6051
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0263 0.0841
Echinococcus multilocularis transient receptor potential cation channel 0.0013 0.00000022964 0.00000022964
Loa Loa (eye worm) CYP4Cod1 0.0045 0.0869 0.1055
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0142 0.0546
Schistosoma mansoni ap endonuclease 0.0019 0.0175 0.0212
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.3263 0.3959
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0176 0.0539
Echinococcus granulosus hypothetical protein 0.0132 0.3263 0.3263
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0176 0.0213
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0449 0.397
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1087 0.1319
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1132 0.1132
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0263 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0222 0.068
Onchocerca volvulus 0.0132 0.3263 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0222 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.01 0.0122
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0142 0.0546
Echinococcus granulosus cathepsin l1 0.0015 0.0059 0.0059
Onchocerca volvulus 0.0132 0.3263 1
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.01 0.0556
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0132 0.3263 0.3959
Schistosoma mansoni zinc phosphodiesterase 0.0017 0.01 0.0122
Schistosoma mansoni opsin-like receptor 0.0132 0.3263 0.3959
Leishmania major hypothetical protein, conserved 0.0027 0.0373 0.2068
Brugia malayi hypothetical protein 0.0132 0.3263 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.3263 0.3959
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0132 0.3263 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0176 0.0539
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0132 0.3263 0.3959
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1132 0.6269
Brugia malayi ORL1-like opioid receptor 0.0132 0.3263 1
Onchocerca volvulus 0.0017 0.01 0.0308
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0176 0.0176
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0237 0.1311
Plasmodium vivax vivapain-2 0.0023 0.0263 0.4673
Brugia malayi ethe1-prov protein 0.0017 0.01 0.0308
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0132 0.3263 1
Echinococcus multilocularis dual specificity mitogen activated protein 0.0079 0.1806 0.1806
Loa Loa (eye worm) fibroinase 0.0023 0.0263 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Schistosoma mansoni amine GPCR 0.0132 0.3263 0.3959
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.3263 0.3959
Brugia malayi putative neuropeptide receptor 0.0132 0.3263 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0175 0.0477
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.2493 0.7641
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0237 0.3907
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1132 0.1373
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Onchocerca volvulus 0.0023 0.0263 0.0807
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0373 0.7825
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0176 0.0176
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0176 0.0213
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0132 0.3263 0.3959
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0234 0.6051 0.7342
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis g protein coupled receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0059 0.0325
Schistosoma mansoni opsin-like receptor 0.0132 0.3263 0.3959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.3099 0.376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Brugia malayi PXA domain containing protein 0.0019 0.0176 0.0539
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0017 0.01 0.0887
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0175 1
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Loa Loa (eye worm) hypothetical protein 0.0256 0.6641 0.8059
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.3263 0.3263
Entamoeba histolytica hypothetical protein 0.0019 0.0176 0.0481
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.3263 0.3959
Echinococcus granulosus expressed conserved protein 0.0098 0.232 0.232
Schistosoma mansoni neuropeptide receptor 0.0132 0.3263 0.3959
Schistosoma mansoni histamine h1 receptor 0.0132 0.3263 0.3959
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0867 0.0867
Brugia malayi olfactory channel protein osm-9 0.0014 0.0013 0.0041
Schistosoma mansoni ap endonuclease 0.0019 0.0175 0.0212
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Brugia malayi nuclear hormone receptor 0.0021 0.0222 0.068
Schistosoma mansoni amine GPCR 0.0132 0.3263 0.3959
Brugia malayi neuropeptide F receptor 0.0132 0.3263 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0203 0.0246
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0017 0.01 0.0122
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0025 0.0318 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0222 0.068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.3263 0.3263
Echinococcus granulosus 7tm_1 domain containing protein 0.0132 0.3263 0.3263
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0222 0.0269
Brugia malayi Cytochrome P450 family protein 0.0018 0.0142 0.0436
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0867 0.0867
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0017 0.01 0.0122
Entamoeba histolytica hypothetical protein 0.0019 0.0176 0.0481
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0142 0.0789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0222 0.0222
Onchocerca volvulus 0.0132 0.3263 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0132 0.3263 1
Echinococcus granulosus cathepsin l1 0.0023 0.0263 0.0263
Echinococcus multilocularis somatostatin receptor 0.0132 0.3263 0.3263
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0132 0.3263 0.3959
Echinococcus granulosus serotonin receptor 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0203 0.0246
Echinococcus granulosus peptide allatostatin:somatostatin 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus granulosus neuropeptide FF receptor 2 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0213
Schistosoma mansoni cell polarity protein 0.0025 0.0318 0.0386
Brugia malayi Dopamine receptor protein 1 0.0132 0.3263 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0373 0.2068
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0132 0.3263 0.3263
Brugia malayi hypothetical protein 0.0132 0.3263 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0263 0.0807
Brugia malayi Cathepsin L-like precursor 0.0023 0.0263 0.0807
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0386
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Brugia malayi hypothetical protein 0.0132 0.3263 1
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.3263 0.3263
Trypanosoma cruzi glyoxalase II 0.0017 0.01 0.0556
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0222 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0176 0.0974
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Schistosoma mansoni biogenic amine receptor 0.0132 0.3263 0.3959
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0142 0.5643
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0079 0.1806 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1132 0.6269
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.01 0.0556
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Trichomonas vaginalis STE family protein kinase 0.0079 0.1806 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0142 0.5643
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.3263 0.3263
Echinococcus granulosus cathepsin L cysteine proteinase 0.0023 0.0263 0.0263
Echinococcus multilocularis neuropeptide receptor 0.0132 0.3263 0.3263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0053 0.1087 0.1319
Brugia malayi sulfakinin receptor protein 0.0132 0.3263 1
Echinococcus multilocularis expressed protein 0.0379 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1132 0.6269
Leishmania major hypothetical protein, conserved 0.0017 0.01 0.0556
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0017 0.01 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Echinococcus multilocularis cysteine protease 0.0023 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0175 0.2133
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0017 0.01 0.0556
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Brugia malayi hypothetical protein 0.0019 0.0176 0.0539
Trichomonas vaginalis STE family protein kinase 0.0079 0.1806 1
Brugia malayi neuropeptide F receptor 0.0132 0.3263 1
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Toxoplasma gondii exonuclease III APE 0.0019 0.0175 0.1545
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0867 0.0867
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0071
Trichomonas vaginalis A-type flavoprotein 0.0017 0.01 0.0556
Brugia malayi PXA domain containing protein 0.0019 0.0176 0.0539
Leishmania major metallo-beta-lactamase family protein-like protein 0.0017 0.01 0.0556
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Schistosoma mansoni cytochrome P450 0.0018 0.0142 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0176 0.0213
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0263 0.032
Schistosoma mansoni adenoreceptor 0.0132 0.3263 0.3959
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0142 0.0546
Onchocerca volvulus 0.0023 0.0263 0.0807
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.3263 0.3959
Schistosoma mansoni neuropeptide f receptor 76f 0.0132 0.3263 0.3959
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0263 0.1459
Brugia malayi hypothetical protein 0.0017 0.0115 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0263 0.1459
Echinococcus multilocularis serotonin receptor 0.0256 0.6641 0.6641
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0142 0.0789
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.3263 0.3959
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0142 0.0546
Brugia malayi hypothetical protein 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0234 0.6051 0.7342
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0142 0.0546
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis serotonin receptor 0.0256 0.6641 0.6641
Brugia malayi G protein-coupled receptor 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0122
Echinococcus multilocularis ETHE1 protein 0.0017 0.01 0.01
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0132 0.3263 0.3263
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0297 0.1645
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0079 0.1806 0.7123
Echinococcus granulosus 7TM GPCR rhodopsin 0.0132 0.3263 0.3263
Brugia malayi steroid hormone receptor 0.0021 0.0222 0.068
Schistosoma mansoni growth hormone secretagogue receptor 0.0132 0.3263 0.3959
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0176 0.0213
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0297 0.1645
Echinococcus multilocularis protein dispatched 1 0.0051 0.1039 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis snurportin 1 0.0315 0.8241 0.8241
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.01 0.0171
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0263 0.0807
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Echinococcus multilocularis G-protein coupled receptor, putative 0.0132 0.3263 0.3263
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0023 0.0263 0.4673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0222 0.0269
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0175 0.0175
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0132 0.3263 0.3959
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.3263 0.3959
Echinococcus multilocularis g-protein coupled receptor 0.0132 0.3263 0.3263
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0132 0.3263 0.3959
Echinococcus multilocularis short transient receptor potential channel 6 0.0014 0.0013 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0142 0.5643
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.3263 0.3263
Schistosoma mansoni transient receptor potential channel 0.0014 0.0013 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.3263 0.3959
Echinococcus multilocularis protein patched 0.0045 0.0867 0.0867
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.3263 0.3959
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0176 0.0176
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0867 0.1052
Echinococcus granulosus biogenic amine 5HT receptor 0.0256 0.6641 0.6641
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0222 0.0222
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1132 0.6269
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0263 0.032
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0237 0.3907
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0017 0.01 0.0396
Trypanosoma brucei protein kinase, putative 0.0054 0.1132 0.4465
Echinococcus granulosus sex peptide receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus granulosus G protein coupled receptor 139 0.0132 0.3263 0.3263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.01 0.0308
Onchocerca volvulus 0.0132 0.3263 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Entamoeba histolytica type A flavoprotein, putative 0.0017 0.01 0.0171
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0449 0.1773
Schistosoma mansoni alpha-1 adrenergic receptor 0.0132 0.3263 0.3959
Schistosoma mansoni amine GPCR 0.0132 0.3263 0.3959
Echinococcus multilocularis G protein coupled receptor 139 0.0132 0.3263 0.3263
Brugia malayi Dopamine receptor protein 2 0.0132 0.3263 1
Brugia malayi MH2 domain containing protein 0.0126 0.3099 0.9497
Loa Loa (eye worm) hypothetical protein 0.0014 0.0013 0.0016
Onchocerca volvulus 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0213
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0132 0.3263 0.3959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0142 0.0546
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0017 0.01 0.01
Onchocerca volvulus Cathepsin L homolog 0.0023 0.0263 0.0807
Schistosoma mansoni ran 0.0022 0.0237 0.0287
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0222 0.0222
Brugia malayi putative neuropeptide receptor NPR1 0.0132 0.3263 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.0263 0.0807
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0222 0.0222
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.01 0.0556
Echinococcus granulosus pikachurin 0.0025 0.0318 0.0318
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1132 0.6269
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.3263 0.3263
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0176 0.0539
Echinococcus granulosus neuropeptide receptor 0.0132 0.3263 0.3263
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Onchocerca volvulus 0.0132 0.3263 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0449 0.0449
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0175 0.0968
Echinococcus granulosus g protein coupled receptor 0.0132 0.3263 0.3263
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0142 0.0546
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0222 0.0269
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0132 0.3263 0.3263
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0132 0.3263 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Entamoeba histolytica cysteine protease, putative 0.0023 0.0263 0.0841
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.01 0.0556
Echinococcus granulosus transient receptor potential cation channel 0.0013 0.00000022964 0.00000022964
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.01 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0122
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0132 0.3263 0.3263
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1132 0.6269
Brugia malayi hypothetical protein 0.0027 0.0373 0.1145
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Onchocerca volvulus 0.0015 0.0059 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0132 0.3263 0.3263
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0222 0.068
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0017 0.01 0.01
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.3263 0.3263
Echinococcus multilocularis cysteine protease 0.0023 0.0263 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0176 0.0213
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0079 0.1806 0.2191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0222 0.068
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0176 0.0974
Echinococcus granulosus leukotriene A 4 hydrolase 0.0234 0.6051 0.6051
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0175 0.0212
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1087 0.333
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0142 0.0546
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0017 0.01 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0222 0.0222
Brugia malayi Cytochrome P450 family protein 0.0059 0.1247 0.3821
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0045 0.0869 1
Loa Loa (eye worm) abnormal epIthelia family member 0.0025 0.0318 0.0386
Schistosoma mansoni myosin xvIII 0.0132 0.3263 0.3959
Trichomonas vaginalis ran, putative 0.0022 0.0237 0.1311
Onchocerca volvulus 0.0132 0.3263 1
Brugia malayi hypothetical protein 0.0132 0.3263 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0132 0.3263 0.3959
Echinococcus multilocularis orexin receptor type 2 0.0132 0.3263 0.3263
Leishmania major cytochrome p450-like protein 0.0045 0.0869 0.4814
Echinococcus multilocularis calcium activated potassium channel 0.0014 0.0027 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.3263 0.3263
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0017 0.01 0.0887
Plasmodium falciparum importin beta, putative 0.0029 0.0449 1
Onchocerca volvulus 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0059 0.0325
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1132 0.1132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0176 0.0176
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus granulosus g protein coupled receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1132 0.6269
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0142 0.0546
Schistosoma mansoni protein kinase 0.0079 0.1806 0.2191
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Onchocerca volvulus 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.00000022964 0.00000027865
Brugia malayi CHE-14 protein 0.0045 0.0867 0.2656
Echinococcus granulosus short transient receptor potential channel 6 0.0014 0.0013 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0132 0.3263 0.3263
Toxoplasma gondii cathepsin CPL 0.0023 0.0263 0.2328
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0017 0.01 0.0122
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0017 0.01 0.0556
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.01 0.0171
Brugia malayi hypothetical protein 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0071
Schistosoma mansoni amine GPCR 0.0132 0.3263 0.3959
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0176 0.0213
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0142 0.5643
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0142 0.5643
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1132 0.1373
Schistosoma mansoni hypothetical protein 0.0018 0.0142 0.0173
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0222 0.068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0222 0.068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0222 0.0269
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0132 0.3263 0.3263
Brugia malayi Cathepsin L-like precursor 0.0015 0.0059 0.018
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0869 0.4814
Brugia malayi G-protein coupled receptor 0.0132 0.3263 1
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) hypothetical protein 0.0017 0.01 0.0122
Chlamydia trachomatis ribonuclease Z 0.0017 0.01 0.5
Brugia malayi RE15519p 0.0132 0.3263 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0176 0.0176
Onchocerca volvulus 0.0132 0.3263 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.01 0.0556
Loa Loa (eye worm) TYRA-2 protein 0.0132 0.3263 0.3959
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0175 0.0968
Echinococcus granulosus zinc phosphodiesterase 0.0017 0.01 0.01
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.3263 0.3959
Echinococcus multilocularis g protein coupled receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0263 0.1459
Schistosoma mansoni transient receptor potential channel 0.0013 0.00000022964 0.00000027865
Schistosoma mansoni hypothetical protein 0.0036 0.063 0.0765
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0222 0.0222
Echinococcus granulosus dro:myosuppressin receptor 0.0132 0.3263 0.3263
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0132 0.3263 0.3959
Onchocerca volvulus 0.0132 0.3263 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0142 0.0562
Onchocerca volvulus Neuropeptide F receptor homolog 0.0132 0.3263 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.063 0.0765
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0142 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0222 0.068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Trypanosoma brucei RNA helicase, putative 0.0106 0.2535 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0175 0.069
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0104 0.2493 0.3025
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0222 0.0269
Schistosoma mansoni importin beta-1 0.0029 0.0449 0.0545
Brugia malayi Tachykinin-like peptides receptor 99D 0.0132 0.3263 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0142 0.5643
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0142 0.5643
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0213
Onchocerca volvulus Putative hydrolase PNKD 0.0017 0.01 0.0308
Giardia lamblia Kinase, STE STE20 0.0079 0.1806 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0237 0.08
Echinococcus granulosus snurportin 1 0.0315 0.8241 0.8241
Brugia malayi hypothetical protein 0.0019 0.0176 0.0539
Echinococcus granulosus g-protein coupled receptor 0.0132 0.3263 0.3263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Schistosoma mansoni neuropeptide receptor 0.0132 0.3263 0.3959
Echinococcus granulosus transient receptor potential cation channel 0.0014 0.0013 0.0013
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0318 0.0386
Brugia malayi hypothetical protein 0.0132 0.3263 1
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1132 0.1132
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0222 0.0269
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0142 0.5643
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Brugia malayi Serotonin receptor 0.0132 0.3263 1
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0132 0.3263 0.3959
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0203 0.0246
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0017 0.01 0.0556
Brugia malayi laminin-like protein K08C7.3 precursor 0.0025 0.0318 0.0975
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.3263 0.3959
Brugia malayi cytochrome P450 0.0018 0.0142 0.0436
Onchocerca volvulus 0.0023 0.0263 0.0807
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0132 0.3263 0.3959
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.2493 0.2493
Leishmania major cytochrome p450-like protein 0.0018 0.0142 0.0789
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0176 0.0213
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0176 0.0974
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0222 0.068
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0176 0.0213
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0237 0.0237
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0176 0.0176
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0142 0.5643
Loa Loa (eye worm) hypothetical protein 0.0021 0.0222 0.0269
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0373 0.7825
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.8241 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0373 0.1473
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.3263 0.3263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Onchocerca volvulus 0.0132 0.3263 1
Schistosoma mansoni hypothetical protein 0.0132 0.3263 0.3959
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0867 0.48
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0237 0.0726
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0176 0.0213
Echinococcus granulosus orexin receptor type 2 0.0132 0.3263 0.3263
Echinococcus granulosus cathepsin l cysteine peptidase 0.0023 0.0263 0.0263
Onchocerca volvulus 0.0023 0.0263 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0015 0.0059 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.01 0.0556
Echinococcus multilocularis fmrfamide receptor 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0237 0.0287
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0176 0.0176
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0142 0.0546
Echinococcus granulosus fmrfamide receptor 0.0132 0.3263 0.3263
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.3263 0.3263
Echinococcus multilocularis GPCR, family 2 0.0017 0.01 0.01
Entamoeba histolytica hypothetical protein 0.0019 0.0176 0.0481
Brugia malayi EGF-like domain containing protein 0.0025 0.0318 0.0975
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0132 0.3263 0.3959
Onchocerca volvulus 0.0023 0.0263 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0176 0.0974
Onchocerca volvulus 0.0023 0.0263 0.0807
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0142 0.5643
Leishmania major cathepsin L-like protease 0.0023 0.0263 0.1459
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Echinococcus multilocularis sex peptide receptor 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0027 0.0371 0.045
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.01 0.0171
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0176 0.0974
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0213
Schistosoma mansoni hypothetical protein 0.0017 0.01 0.0122
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0176 0.0539
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0019 0.0176 0.0213
Onchocerca volvulus 0.0017 0.01 0.0308
Echinococcus granulosus slit 2 protein 0.0025 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0222 0.0222
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0222 0.0269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0222 0.0269
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0023 0.0263 0.032
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0222 0.0222
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0237 0.1311
Brugia malayi Cathepsin L-like precursor 0.0023 0.0263 0.0807
Schistosoma mansoni slit 0.0025 0.0318 0.0386
Schistosoma mansoni coup transcription factor 0.0021 0.0222 0.0269
Echinococcus multilocularis Niemann Pick C1 protein 0.0149 0.3716 0.3716
Onchocerca volvulus Cathepsin F homolog 0.0023 0.0263 0.0807
Trypanosoma brucei cytochrome P450, putative 0.0045 0.0869 0.3429
Trypanosoma cruzi glyoxalase II 0.0017 0.01 0.0556
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.3263 0.3263
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0142 0.0546
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.0263 0.1459
Leishmania major importin beta-1 subunit, putative 0.0024 0.0297 0.1645
Plasmodium falciparum cysteine proteinase falcipain 3 0.0023 0.0263 0.4673
Brugia malayi Serotonin receptor 0.0132 0.3263 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0256 0.6641 0.8059
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0142 0.5643
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0222 0.068
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0142 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.3099 0.376
Schistosoma mansoni hypothetical protein 0.0043 0.0823 0.0998
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0449 0.1773
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0203 0.0246
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0142 0.0546
Schistosoma mansoni neuropeptide receptor 0.0132 0.3263 0.3959
Loa Loa (eye worm) cytochrome P450 0.0018 0.0142 0.0173
Schistosoma mansoni patched 1 0.0045 0.0867 0.1052
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0222 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.01 0.0556
Echinococcus multilocularis neuropeptide receptor A26 0.0132 0.3263 0.3263
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0142 0.5643
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.3263 0.3263
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0222 0.068
Loa Loa (eye worm) hypothetical protein 0.0055 0.1142 0.1385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Brugia malayi metallo-beta-lactamase superfamily protein 0.0017 0.01 0.0308
Schistosoma mansoni transient receptor potential channel 0.0013 0.00000022964 0.00000027865
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0237 0.2092
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0222 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0142 0.5643
Entamoeba histolytica metallo-beta-lactamase family protein 0.0017 0.01 0.0171
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0175 0.0968
Trichomonas vaginalis STE family protein kinase 0.0079 0.1806 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0132 0.3263 0.3959
Schistosoma mansoni ran 0.0022 0.0237 0.0287
Brugia malayi MAP kinase sur-1 0.0054 0.1132 0.3469
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Trypanosoma cruzi cruzipain precursor, putative 0.0023 0.0263 0.1459
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0017 0.01 0.0556
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Loa Loa (eye worm) cysteine protease 0.0023 0.0263 0.032
Echinococcus granulosus allatostatin A receptor 0.0132 0.3263 0.3263
Brugia malayi cathepsin L-like precursor 0.0015 0.0059 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Brugia malayi Cathepsin L-like precursor 0.0015 0.0059 0.018
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0263 0.032
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0373 0.3299
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.3263 0.3263
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.01 0.0556
Brugia malayi nuclear receptor NHR-88 0.0021 0.0222 0.068
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0017 0.01 0.0308
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0175 0.0968
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0142 0.5643
Echinococcus granulosus ankyrin repeat protein 0.0161 0.4055 0.4055
Onchocerca volvulus 0.0021 0.0222 0.068
Echinococcus granulosus alpha 1A adrenergic receptor 0.0132 0.3263 0.3263
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0142 0.0546
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0222 0.0269
Loa Loa (eye worm) hypothetical protein 0.0023 0.0263 0.032
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0142 0.5643
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0176 0.0176
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0176 0.0213
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0161 0.4055 0.492
Onchocerca volvulus 0.0132 0.3263 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0263 0.1459
Onchocerca volvulus 0.0023 0.0263 0.0807
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0203 0.0621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0386
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0132 0.3263 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0142 0.0546
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.2493 0.2493
Brugia malayi hypothetical protein 0.0017 0.01 0.0308
Leishmania major metallo-beta-lactamase family-like protein 0.0017 0.01 0.0556
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Loa Loa (eye worm) melatonin receptor type 1A 0.0132 0.3263 0.3959
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0023 0.0263 0.1459
Echinococcus multilocularis expressed conserved protein 0.0098 0.232 0.232
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0175 0.2133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0017 0.01 0.0556
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Onchocerca volvulus 0.0132 0.3263 1
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.01 0.0556
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0142 0.0546
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0297 0.1645
Brugia malayi G-protein coupled receptor 0.0132 0.3263 1
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.01 0.0556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0023 0.0263 0.1459
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0203 0.0203
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0176 0.0539
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Echinococcus multilocularis slit 2 protein 0.0025 0.0318 0.0318
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1132 0.6269
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1132 0.6269
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0203 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.01 0.0556
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0132 0.3263 0.3263
Echinococcus multilocularis neuropeptide s receptor 0.0132 0.3263 0.3263
Trichomonas vaginalis beta lactamase domain, putative 0.0017 0.01 0.0556
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus granulosus neuropeptide s receptor 0.0132 0.3263 0.3263
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.3263 0.3959
Echinococcus multilocularis cathepsin L cysteine protease 0.0023 0.0263 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.0263 0.1039
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0142 0.0789
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0142 1
Echinococcus granulosus g protein coupled receptor 0.0132 0.3263 0.3263
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0132 0.3263 0.3263
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0373 0.2068
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0132 0.3263 0.3263
Schistosoma mansoni amine GPCR 0.0132 0.3263 0.3959
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0132 0.3263 0.3263
Brugia malayi hypothetical protein 0.0108 0.259 0.7937
Trypanosoma cruzi cytochrome P450, putative 0.0045 0.0869 0.4814
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.3263 0.3959
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0869 0.1055
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0106 0.2537 0.3079
Loa Loa (eye worm) hypothetical protein 0.0132 0.3263 0.3959
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.3263 0.3263
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0176 0.0213
Brugia malayi ecdysteroid receptor 0.0021 0.0222 0.068
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0869 0.1055
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.1247 0.1513
Schistosoma mansoni biogenic amine receptor 0.0132 0.3263 0.3959
Trypanosoma cruzi glyoxalase II 0.0017 0.01 0.0556

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 ug ml-1 Inhibitory concentration against cytotoxicity in VERO cell line; n.d.=not determined ChEMBL. 15801862
Inhibition (functional) = 100 % Tested for the inhibition of Mycobacterium tuberculosis growth at a dose of 6.25 ug/mL ChEMBL. 15801862
Inhibition (functional) = 100 % Tested for the inhibition of Mycobacterium tuberculosis growth at a dose of 6.25 ug/mL ChEMBL. 15801862
MIC (functional) = 12.5 ug ml-1 Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv ChEMBL. 15801862
MIC (functional) = 12.5 ug ml-1 Minimum inhibitory concentration of the compound against Mycobacterium tuberculosis H37Rv ChEMBL. 15801862
Selectivity index (functional) 0 Selectivity index (IC50:MIC) of the compound; n.d.=not determined ChEMBL. 15801862

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.