Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0115 | 0.0693 | 0.0679 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0308 | 0.0294 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0145 | 0.0899 | 0.3587 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0056 | 0.0281 | 0.0266 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0027 | 0.0085 | 0.0338 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0131 | 0.1204 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.0274 | 0.253 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0228 | 0.1475 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.016 | 0.1002 | 0.6736 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.109 | 0.6201 |
Giardia lamblia | Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit | 0.0034 | 0.0131 | 0.0269 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0306 | 0.2012 | 0.2421 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.016 | 0.1002 | 0.2492 |
Toxoplasma gondii | phosphofructokinase PFKII | 0.0034 | 0.0131 | 0.0665 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0056 | 0.0281 | 0.0266 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0055 | 0.0274 | 0.1704 |
Brugia malayi | RNase H family protein | 0.0278 | 0.1823 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0308 | 0.0294 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0085 | 0.0405 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0124 | 0.0757 | 0.5045 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1871 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0056 | 0.0281 | 0.1596 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0278 | 0.1823 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1063 | 0.6045 |
Trypanosoma brucei | SLACS retrotransposable element (part), putative | 0.0027 | 0.0085 | 0.0071 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0026 | 0.0076 | 0.0303 |
Echinococcus multilocularis | ribonuclease H1 | 0.0278 | 0.1823 | 0.7272 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0026 | 0.0076 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.109 | 0.6201 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0019 | 0.0027 | 0.0012 |
Leishmania major | trypanothione reductase | 0.0055 | 0.0274 | 0.064 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0228 | 0.1475 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.0274 | 0.253 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0017 | 0.0015 | 0.002 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0017 | 0.0015 | 0.006 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0111 | 0.0552 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0046 | 0.0108 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0111 | 0.0634 |
Trichomonas vaginalis | 6-phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0111 | 0.0097 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0017 | 0.0015 | 0.006 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0278 | 0.1823 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0027 | 0.0085 | 0.0338 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0061 | 0.032 | 0.1276 |
Brugia malayi | peptidase family M13 containing protein | 0.0056 | 0.0281 | 0.1486 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.1063 | 0.6045 |
Brugia malayi | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.4154 |
Giardia lamblia | Reverse transcriptase/endonuclease, putative | 0.0027 | 0.0085 | 0.015 |
Leishmania major | ATP-dependent phosphofructokinase | 0.0125 | 0.0764 | 0.1912 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0026 | 0.0076 | 0.0303 |
Trypanosoma cruzi | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0125 | 0.0764 | 0.1912 |
Schistosoma mansoni | lamin | 0.0031 | 0.0111 | 0.0097 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.0274 | 0.1556 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0044 | 0.0201 | 0.1202 |
Schistosoma mansoni | protein kinase | 0.0027 | 0.0085 | 0.007 |
Brugia malayi | Zinc knuckle family protein | 0.0027 | 0.0085 | 0.0405 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.1002 | 0.0989 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0046 | 0.005 |
Schistosoma mansoni | lamin | 0.0031 | 0.0111 | 0.0097 |
Giardia lamblia | Reverse transcriptase/endonuclease | 0.0027 | 0.0085 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1063 | 0.6045 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0019 | 0.0027 | 0.0107 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0145 | 0.0899 | 0.0886 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0085 | 0.0405 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0124 | 0.0757 | 0.5045 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.4346 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Trypanosoma brucei | SLACS reverse transcriptase, putative | 0.0027 | 0.0085 | 0.0071 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.0274 | 0.0301 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0027 | 0.0085 | 0.0338 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0228 | 0.1475 | 0.5883 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Schistosoma mansoni | phosphoglucomutase | 0.0278 | 0.1823 | 0.1811 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0308 | 0.0294 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0308 | 0.0294 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0046 | 0.005 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0278 | 0.1823 | 0.4659 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0046 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.109 | 0.6201 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1475 | 0.8389 |
Echinococcus multilocularis | NMDA receptor | 0.0017 | 0.0015 | 0.006 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0027 | 0.0085 | 0.0338 |
Brugia malayi | RNase H family protein | 0.0278 | 0.1823 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0138 | 0.0854 | 0.5708 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0111 | 0.0444 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0131 | 0.1063 |
Echinococcus granulosus | geminin | 0.0377 | 0.2508 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0111 | 0.0444 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0026 | 0.0076 | 0.0303 |
Brugia malayi | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.4154 |
Onchocerca volvulus | 0.0113 | 0.0678 | 0.3414 | |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0131 | 0.1063 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.016 | 0.1002 | 0.253 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.0693 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.109 | 0.6201 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Trichomonas vaginalis | NeSL-1_NeSL reverse transcriptases, putative | 0.0027 | 0.0085 | 0.015 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0025 | 0.0066 | 0.0103 |
Brugia malayi | RNase H family protein | 0.0278 | 0.1823 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0678 | 0.3858 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0027 | 0.0085 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0046 | 0.0031 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1871 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0228 | 0.1475 | 0.8078 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0019 | 0.0027 | 0.0094 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0017 | 0.0015 | 0.006 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0111 | 0.0634 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0044 | 0.0201 | 0.1784 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0138 | 0.0854 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1063 | 0.6045 |
Trypanosoma brucei | ATP-dependent 6-phosphofructokinase, glycosomal | 0.0125 | 0.0764 | 0.0899 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0308 | 0.0294 |
Brugia malayi | Zinc knuckle family protein | 0.0027 | 0.0085 | 0.0405 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0044 | 0.0201 | 0.1202 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0019 | 0.0027 | 0.0107 |
Brugia malayi | phosphofructokinase | 0.0125 | 0.0764 | 0.4154 |
Mycobacterium tuberculosis | Possible maturase | 0.0027 | 0.0085 | 0.0399 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0138 | 0.0854 | 0.5708 |
Brugia malayi | reverse transcriptase | 0.0027 | 0.0085 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1063 | 0.6045 |
Schistosoma mansoni | thymidylate kinase | 0.016 | 0.1002 | 0.0989 |
Chlamydia trachomatis | glutamine binding protein | 0.0044 | 0.0201 | 0.1784 |
Plasmodium vivax | thymidylate kinase, putative | 0.016 | 0.1002 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0115 | 0.0693 | 0.0679 |
Toxoplasma gondii | phosphofructokinase domain-containing protein | 0.0034 | 0.0131 | 0.0665 |
Schistosoma mansoni | hypothetical protein | 0.1203 | 0.8226 | 0.8223 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0115 | 0.0693 | 0.0679 |
Brugia malayi | Peptidase family M13 containing protein | 0.0228 | 0.1475 | 0.8078 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0027 | 0.0085 | 0.0338 |
Echinococcus granulosus | ribonuclease H1 | 0.0278 | 0.1823 | 0.7272 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.006 | 0.0308 | 0.0294 |
Schistosoma mansoni | phosphoglucomutase | 0.0278 | 0.1823 | 0.1811 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0046 | 0.0184 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.016 | 0.1002 | 0.6736 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1912 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0046 | 0.0184 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0031 | 0.0016 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0111 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0107 | 0.0611 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0027 | 0.0085 | 0.007 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0046 | 0.0134 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0138 | 0.0854 | 0.5708 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0046 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.109 | 0.6201 |
Loa Loa (eye worm) | RecQ helicase | 0.0025 | 0.0066 | 0.0378 |
Plasmodium vivax | 6-phosphofructokinase, putative | 0.0034 | 0.0131 | 0.1204 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0111 | 0.0444 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.0274 | 0.2648 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0027 | 0.0085 | 0.015 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.0274 | 0.1447 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) | 0.0125 | 0.0764 | 0.0093 |
Echinococcus granulosus | thymidylate kinase | 0.016 | 0.1002 | 0.3998 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0274 | 0.1091 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0228 | 0.1475 | 0.5883 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.0274 | 0.2648 |
Giardia lamblia | Reverse transcriptase/endonuclease, putative | 0.0027 | 0.0085 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0111 | 0.0634 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Echinococcus multilocularis | geminin | 0.0377 | 0.2508 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0046 | 0.02 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0111 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0032 | 0.0182 |
Echinococcus granulosus | bloom syndrome protein | 0.0025 | 0.0066 | 0.0265 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0278 | 0.1823 | 0.4659 |
Mycobacterium ulcerans | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.5091 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0085 | 0.0405 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0228 | 0.1475 | 0.1462 |
Trypanosoma brucei | thymidylate kinase, putative | 0.016 | 0.1002 | 0.119 |
Treponema pallidum | thymidylate kinase (tmk) | 0.016 | 0.1002 | 0.543 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0025 | 0.0066 | 0.0304 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0169 | 0.1063 | 0.6045 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0046 | 0.0192 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0046 | 0.005 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0269 | 0.1758 | 1 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0017 | 0.0015 | 0.0085 |
Toxoplasma gondii | thymidylate kinase | 0.016 | 0.1002 | 0.5473 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0124 | 0.0757 | 0.5045 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0306 | 0.2012 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0377 | 0.2508 | 0.2496 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0022 | 0.0046 | 0.0193 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0026 | 0.0076 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.0377 | 0.2508 | 0.2496 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.016 | 0.1002 | 0.119 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0278 | 0.1823 | 0.4659 |
Plasmodium falciparum | thymidylate kinase | 0.016 | 0.1002 | 1 |
Brugia malayi | reverse transcriptase | 0.0027 | 0.0085 | 0.0405 |
Trypanosoma brucei | thymidine kinase | 0.0576 | 0.3883 | 0.4703 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1912 |
Toxoplasma gondii | peptidase family M13 protein | 0.0228 | 0.1475 | 0.808 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.0265 | 0.1733 | 0.1721 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0017 | 0.0015 | 0.006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0027 | 0.0085 | 0.0338 |
Giardia lamblia | CDC8 | 0.016 | 0.1002 | 0.253 |
Giardia lamblia | Ribonuclease H | 0.0278 | 0.1823 | 0.4659 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0278 | 0.1823 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.0274 | 0.064 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.0063 | 0.033 | 0.0787 |
Echinococcus multilocularis | thymidylate kinase | 0.016 | 0.1002 | 0.3998 |
Onchocerca volvulus | 0.0031 | 0.0111 | 0.0154 | |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1912 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0027 | 0.0085 | 0.0338 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0056 | 0.0281 | 0.0266 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0027 | 0.0085 | 0.007 |
Trichomonas vaginalis | reverse transcriptases, putative | 0.0027 | 0.0085 | 0.015 |
Brugia malayi | follicle stimulating hormone receptor | 0.0269 | 0.1758 | 0.9642 |
Toxoplasma gondii | ribonuclease HI protein | 0.0278 | 0.1823 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0011 | 0.0065 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0027 | 0.0085 | 0.0338 |
Loa Loa (eye worm) | thymidylate kinase | 0.016 | 0.1002 | 0.5701 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.016 | 0.1002 | 0.3413 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.075 |
Giardia lamblia | Reverse transcriptase/endonuclease, putative | 0.0027 | 0.0085 | 0.015 |
Brugia malayi | thymidylate kinase | 0.016 | 0.1002 | 0.5469 |
Leishmania major | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Trichomonas vaginalis | reverse transcriptases, putative | 0.0027 | 0.0085 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.006 | 0.0308 | 0.0294 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0046 | 0.005 |
Loa Loa (eye worm) | 6-phosphofructokinase | 0.0125 | 0.0764 | 0.4346 |
Brugia malayi | reverse transcriptase | 0.0027 | 0.0085 | 0.0405 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.016 | 0.1002 | 0.253 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0017 | 0.0015 | 0.006 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0115 | 0.0693 | 0.0679 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0034 | 0.0131 | 0.0577 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0306 | 0.2012 | 0.2421 |
Giardia lamblia | Reverse transcriptase/endonuclease, putative | 0.0027 | 0.0085 | 0.015 |
Giardia lamblia | Thymidine kinase | 0.0576 | 0.3883 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0017 | 0.0015 | 0.0085 |
Chlamydia trachomatis | fructose-6-phosphate phosphotransferase | 0.0034 | 0.0131 | 0.1063 |
Onchocerca volvulus | 0.0031 | 0.0111 | 0.0154 | |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0046 | 0.005 |
Echinococcus multilocularis | bloom syndrome protein | 0.0025 | 0.0066 | 0.0265 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0061 | 0.032 | 0.1276 |
Schistosoma mansoni | phosphoglucomutase | 0.0278 | 0.1823 | 0.1811 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0019 | 0.0027 | 0.0158 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0034 | 0.0131 | 0.0269 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0046 | 0.0353 |
Brugia malayi | glutathione reductase | 0.0055 | 0.0274 | 0.1447 |
Mycobacterium tuberculosis | Probable reductase | 0.0124 | 0.0757 | 0.5045 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0017 | 0.0015 | 0.006 |
Trypanosoma brucei | ribonuclease H1 | 0.0278 | 0.1823 | 0.2191 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0017 | 0.0015 | 0.002 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0017 | 0.0015 | 0.006 |
Entamoeba histolytica | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1871 |
Trypanosoma brucei | Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative | 0.0027 | 0.0085 | 0.0071 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0056 | 0.0281 | 0.0266 |
Leishmania major | hypothetical protein, conserved | 0.0063 | 0.033 | 0.0787 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0046 | 0.0263 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.016 | 0.1002 | 0.253 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0019 | 0.0027 | 0.0094 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0044 | 0.0201 | 0.0969 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0046 | 0.0108 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.016 | 0.1002 | 0.253 |
Mycobacterium tuberculosis | Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) | 0.0125 | 0.0764 | 0.5091 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0085 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1475 | 0.8389 |
Schistosoma mansoni | thymidylate kinase | 0.016 | 0.1002 | 0.0989 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.016 | 0.1002 | 0.543 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0026 | 0.0076 | 0.0303 |
Echinococcus multilocularis | 6 phosphofructokinase | 0.0125 | 0.0764 | 0.3047 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0044 | 0.0201 | 0.0969 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0019 | 0.0027 | 0.0158 |
Toxoplasma gondii | 6-phosphofructokinase | 0.0034 | 0.0131 | 0.0665 |
Entamoeba histolytica | pyrophosphate-dependent phosphofructokinase | 0.0034 | 0.0131 | 0.022 |
Trypanosoma brucei | RNA helicase, putative | 0.1203 | 0.8226 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.0111 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1475 | 0.8389 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0124 | 0.0757 | 0.5045 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0056 | 0.0281 | 0.0266 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0046 | 0.0024 |
Treponema pallidum | diphosphate--fructose-6-phosphate 1-phosphotransferase | 0.0125 | 0.0764 | 0.4104 |
Echinococcus granulosus | 6 phosphofructokinase | 0.0125 | 0.0764 | 0.3047 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0046 | 0.0198 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0026 | 0.0076 | 0.0303 |
Chlamydia trachomatis | thymidylate kinase | 0.016 | 0.1002 | 1 |
Loa Loa (eye worm) | phosphofructokinase | 0.0125 | 0.0764 | 0.4346 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0145 | 0.0899 | 0.3587 |
Trichomonas vaginalis | reverse transcriptase [C. elegans], putative | 0.0027 | 0.0085 | 0.015 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0306 | 0.2012 | 0.2421 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0274 | 0.1091 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0085 | 0.007 |
Trypanosoma brucei | unspecified product | 0.0306 | 0.2012 | 0.2421 |
Leishmania major | thymidylate kinase-like protein | 0.016 | 0.1002 | 0.253 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.0063 | 0.033 | 0.0787 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0026 | 0.0076 | 0.0303 |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.0274 | 0.1556 |
Trichomonas vaginalis | phosphofructokinase, putative | 0.0125 | 0.0764 | 0.1912 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0061 | 0.032 | 0.1276 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0027 | 0.0085 | 0.0405 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0017 | 0.0015 | 0.006 |
Onchocerca volvulus | Putative thymidylate kinase | 0.016 | 0.1002 | 0.5278 |
Echinococcus granulosus | glutamate receptor 2 | 0.0026 | 0.0076 | 0.0303 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0228 | 0.1475 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0085 | 0.0405 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0027 | 0.0085 | 0.0338 |
Schistosoma mansoni | neprilysin | 0.006 | 0.0308 | 0.0294 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0111 | 0.0552 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0025 | 0.0066 | 0.0103 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0026 | 0.0076 | 0.0303 |
Leishmania major | ribonuclease H1, putative | 0.0278 | 0.1823 | 0.4659 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0056 | 0.0281 | 0.0266 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0046 | 0.005 |
Plasmodium falciparum | ATP-dependent 6-phosphofructokinase | 0.0034 | 0.0131 | 0.1063 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0124 | 0.0757 | 0.5045 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0576 | 0.3883 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.0274 | 0.1455 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0026 | 0.0076 | 0.0303 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.109 | 0.6201 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 60 uM | Inhibition of neutral endopeptidase in human umbilical vein endothelial cells | ChEMBL. | No reference |
IC50 (binding) | > 60 uM | Inhibition of neutral endopeptidase in human umbilical vein endothelial cells | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cells | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.