Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0023 | 0.023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Onchocerca volvulus | 0.0023 | 0.023 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.5425 | 0.5425 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0023 | 0.023 | 0.0423 |
Schistosoma mansoni | gliotactin | 0.0023 | 0.023 | 0.0423 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0023 | 0.023 | 0.0423 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.5425 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.023 | 0.023 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.023 | 0.023 |
Onchocerca volvulus | 0.0023 | 0.023 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0023 | 0.023 | 0.0423 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0023 | 0.023 | 0.0423 |
Loa Loa (eye worm) | carboxylesterase | 0.0138 | 0.5425 | 0.5425 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.023 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Onchocerca volvulus | 0.0023 | 0.023 | 1 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0023 | 0.023 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.023 | 0.023 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.023 | 0.0423 |
Echinococcus granulosus | carboxylesterase 5A | 0.0138 | 0.5425 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0138 | 0.5425 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0239 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0023 | 0.023 | 0.023 |
Echinococcus multilocularis | acetylcholinesterase | 0.0138 | 0.5425 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0023 | 0.023 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0138 | 0.5425 | 0.5425 |
Echinococcus multilocularis | neuroligin | 0.0023 | 0.023 | 0.0423 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0023 | 0.023 | 0.0423 |
Schistosoma mansoni | acetylcholinesterase | 0.0023 | 0.023 | 0.0423 |
Onchocerca volvulus | 0.0023 | 0.023 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0023 | 0.023 | 0.0423 |
Onchocerca volvulus | 0.0023 | 0.023 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0138 | 0.5425 | 0.5425 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0023 | 0.023 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.5425 | 0.5425 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0138 | 0.5425 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0023 | 0.023 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0023 | 0.023 | 0.0423 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0023 | 0.023 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.5425 | 0.5425 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.5425 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0023 | 0.023 | 0.0423 |
Echinococcus granulosus | acetylcholinesterase | 0.0138 | 0.5425 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.023 | 0.023 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0023 | 0.023 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.023 | 0.023 |
Loa Loa (eye worm) | carboxylesterase | 0.0023 | 0.023 | 0.023 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 89 uM | Inhibition of Mycobacterium tuberculosis recombinant TMPK | ChEMBL. | 18467107 |
Ki (binding) | = 110 uM | Binding affinity towards mycobacterium tuberculosis thymidine monophosphate kinase | ChEMBL. | 15801836 |
Ki (binding) | = 110 uM | Inhibition of Mycobacterium tuberculosis TMPK using dTMP substrate and NADH by pyruvate kinase/lactate dehydrogenase coupling system based spectrophotometric assay | ChEMBL. | No reference |
Ki (binding) | = 110 uM | Binding affinity towards mycobacterium tuberculosis thymidine monophosphate kinase | ChEMBL. | 15801836 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.