Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0104 | 0.5127 | 0.9543 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.5127 | 0.9577 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0456 | 0.0742 |
Loa Loa (eye worm) | carboxylesterase | 0.0104 | 0.5127 | 0.9577 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0063 | 0.139 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3052 | 0.1757 |
Brugia malayi | Carboxylesterase family protein | 0.0104 | 0.5127 | 0.9543 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0046 | 0.167 | 0.3039 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3052 | 0.5303 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0063 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0104 | 0.5127 | 0.415 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3052 | 0.5652 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3052 | 0.1757 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0104 | 0.5127 | 0.9577 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0107 | 0.5351 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0153 | 0.8117 | 0.774 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0107 | 0.5351 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0107 | 0.5351 | 0.4418 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0109 | 0.545 | 0.4603 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0456 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3052 | 0.1658 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0456 | 0.0742 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0107 | 0.5351 | 0.4418 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0456 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0104 | 0.5127 | 0.415 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0456 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3052 | 0.1757 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0456 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3052 | 0.5303 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0456 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0101 | 0.496 | 0.3949 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0456 | 0.0742 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0104 | 0.5127 | 0.4219 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2293 | 0.4216 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3052 | 0.1757 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0456 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0046 | 0.167 | 0.2481 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0456 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3052 | 0.5303 |
Echinococcus multilocularis | acetylcholinesterase | 0.0104 | 0.5127 | 0.415 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3052 | 0.5652 |
Echinococcus multilocularis | acetylcholinesterase | 0.0104 | 0.5127 | 0.415 |
Onchocerca volvulus | 0.0026 | 0.0456 | 0.5 | |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0063 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0153 | 0.8117 | 0.774 |
Echinococcus multilocularis | protein dispatched 1 | 0.0053 | 0.2061 | 0.0469 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0456 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0456 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3052 | 0.1658 |
Schistosoma mansoni | patched 1 | 0.0046 | 0.167 | 0.0118 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0456 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0456 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0104 | 0.5127 | 0.415 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0063 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0101 | 0.496 | 0.3949 |
Echinococcus granulosus | acetylcholinesterase | 0.0104 | 0.5127 | 0.415 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.5127 | 0.9577 |
Echinococcus multilocularis | geminin | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3052 | 0.5652 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.5351 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3052 | 0.1757 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0456 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.167 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.167 | 0.3039 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -126.7 % | In vitro percent inhibition of LPS induced B-cell proliferation at the dose 100 ug/mL | ChEMBL. | 15908212 |
Inhibition (functional) | = -46.8 % | In vitro percent inhibition of ConA induced T-cell proliferation at the dose 1 ug/mL | ChEMBL. | 15908212 |
Inhibition (functional) | = -21.5 % | In vitro percent inhibition of ConA induced T-cell proliferation at the dose 10 ug/mL | ChEMBL. | 15908212 |
Inhibition (functional) | = 4 % | In vitro percent inhibition of LPS induced B-cell proliferation at the dose 1 ug/mL | ChEMBL. | 15908212 |
Inhibition (functional) | = 12.5 % | In vitro percent inhibition of LPS induced B-cell proliferation at the dose 10 ug/mL | ChEMBL. | 15908212 |
Inhibition (functional) | = 17.1 % | In vitro percent inhibition of ConA induced T-cell proliferation at the dose 100 ug/mL | ChEMBL. | 15908212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.