Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin B | 0.0073 | 0.1584 | 0.1163 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0301 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.0073 | 0.1584 | 0.1163 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0073 | 0.1584 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0073 | 0.1584 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Trichomonas vaginalis | cyclins, putative | 0.0073 | 0.1584 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0476 | 0.078 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0.0769 | 0.322 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Trichomonas vaginalis | cyclin B, putative | 0.0073 | 0.1584 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0301 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0051 | 0.0769 | 0.0308 |
Trichomonas vaginalis | cyclin D, putative | 0.0043 | 0.0476 | 0.078 |
Trichomonas vaginalis | cyclin B, putative | 0.0073 | 0.1584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1584 | 0.1584 |
Trypanosoma cruzi | cyclin, putative | 0.0073 | 0.1584 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Leishmania major | cyclin | 0.0073 | 0.1584 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0177 | 0.544 | 0.544 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0073 | 0.1584 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0476 | 0.078 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0.0769 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0073 | 0.1584 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.0769 | 0.0769 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.0769 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0226 | 0.7258 | 0.7029 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0051 | 0.0769 | 0.0308 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0301 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0073 | 0.1584 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0073 | 0.1584 | 1 |
Schistosoma mansoni | gliotactin | 0.0051 | 0.0769 | 0.0308 |
Loa Loa (eye worm) | carboxylesterase | 0.0301 | 1 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0073 | 0.1584 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Onchocerca volvulus | 0.0073 | 0.1584 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1584 | 0.1584 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0476 | 0.078 |
Schistosoma mansoni | cyclin B3 | 0.0177 | 0.544 | 0.5212 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0177 | 0.544 | 0.506 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0051 | 0.0769 | 0.0308 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0.0769 | 0.322 |
Trichomonas vaginalis | cyclins, putative | 0.0073 | 0.1584 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.0769 | 0.5 |
Plasmodium falciparum | cyclin | 0.0043 | 0.0476 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0051 | 0.0769 | 0.0308 |
Trichomonas vaginalis | cyclin D, putative | 0.0043 | 0.0476 | 0.078 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0769 | 0.0769 |
Trichomonas vaginalis | cyclins, putative | 0.0073 | 0.1584 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0073 | 0.1584 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0043 | 0.0476 | 0.078 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0177 | 0.544 | 0.5212 |
Echinococcus granulosus | acetylcholinesterase | 0.0301 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0073 | 0.1584 | 0.0883 |
Echinococcus multilocularis | cyclin B | 0.0073 | 0.1584 | 0.1163 |
Echinococcus multilocularis | acetylcholinesterase | 0.0301 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0073 | 0.1584 | 0.0883 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0051 | 0.0769 | 0.0308 |
Echinococcus granulosus | carboxylesterase 5A | 0.0301 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0301 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0051 | 0.0769 | 0.0308 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0051 | 0.0769 | 0.0308 |
Echinococcus multilocularis | neuroligin | 0.0051 | 0.0769 | 0.0308 |
Trypanosoma cruzi | cyclin, putative | 0.0073 | 0.1584 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0.0769 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0177 | 0.544 | 0.5212 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 0.7258 | 0.7258 |
Trypanosoma cruzi | cyclin 6, putative | 0.0073 | 0.1584 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.0073 | 0.1584 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0033 | 0.0094 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0032 uM | Inhibition of Cyclin B-cyclin-dependent kinase 1 | ChEMBL. | 15974571 |
IC50 (binding) | = 0.0032 uM | Inhibition of Cyclin B-cyclin-dependent kinase 1 | ChEMBL. | 15974571 |
IC50 (functional) | = 0.13 uM | In vitro inhibitory concentrationagainst cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells | ChEMBL. | 15974571 |
IC50 (functional) | = 0.13 uM | In vitro inhibitory concentrationagainst cell proliferation in human HeLa (cervical adenocarcinoma) tumor cells | ChEMBL. | 15974571 |
IC50 (functional) | = 0.91 uM | In vitro inhibitory concentration against cell proliferation in human HCT-116 (colon carcinoma) tumor cells | ChEMBL. | 15974571 |
IC50 (functional) | = 0.91 uM | In vitro inhibitory concentration against cell proliferation in human HCT-116 (colon carcinoma) tumor cells | ChEMBL. | 15974571 |
IC50 (functional) | = 0.97 uM | In vitro inhibitory concentration against cell proliferation in human A375 (malignant melanoma),tumor cells | ChEMBL. | 15974571 |
IC50 (functional) | = 0.97 uM | In vitro inhibitory concentration against cell proliferation in human A375 (malignant melanoma),tumor cells | ChEMBL. | 15974571 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15974571 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.