Detailed information for compound 333853

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.387 | Formula: C26H24Cl2N2O2
  • H donors: 0 H acceptors: 2 LogP: 7.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N1N(c2ccc(cc2)Cl)C(=O)C(C1=O)CCCCCc1ccccc1
  • InChi: 1S/C26H24Cl2N2O2/c27-20-11-15-22(16-12-20)29-25(31)24(10-6-2-5-9-19-7-3-1-4-8-19)26(32)30(29)23-17-13-21(28)14-18-23/h1,3-4,7-8,11-18,24H,2,5-6,9-10H2
  • InChiKey: QBZJPHFDLWJYLM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylenolpyruvoylglucosamine reductase Get druggable targets OG5_131886 All targets in OG5_131886
Mycobacterium leprae PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) Get druggable targets OG5_131886 All targets in OG5_131886
Chlamydia trachomatis UDP-N-acetylenolpyruvoylglucosamine reductase Get druggable targets OG5_131886 All targets in OG5_131886
Mycobacterium tuberculosis Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase) Get druggable targets OG5_131886 All targets in OG5_131886
Mycobacterium ulcerans UDP-N-acetylenolpyruvoylglucosamine reductase Get druggable targets OG5_131886 All targets in OG5_131886
Treponema pallidum UDP-N-acetylenolpyruvoylglucosamine reductase Get druggable targets OG5_131886 All targets in OG5_131886
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0737 0.5084 0.5084
Mycobacterium ulcerans UDP-N-acetylenolpyruvoylglucosamine reductase 0.1286 0.9182 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1396 1 1
Schistosoma mansoni nuclear hormone receptor 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor family member nhr-3 0.1396 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0658 0.4494 0.4494
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 0.5355 0.5584
Onchocerca volvulus 0.0658 0.4494 0.4494
Brugia malayi nuclear receptor NHR-88 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0218 0.1207 0.1127
Echinococcus granulosus geminin 0.0175 0.0888 0.0888
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 0.5355 0.5743
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.1396 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.1396 1 1
Treponema pallidum UDP-N-acetylenolpyruvoylglucosamine reductase 0.1286 0.9182 1
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Onchocerca volvulus 0.0658 0.4494 0.4494
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0556 0.3726 0.3704
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0261 0.153 0.1169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1396 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0257 0.1494 0.1494
Onchocerca volvulus 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0658 0.4494 0.4494
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0637 0.4332 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0257 0.1494 0.1494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.1396 1 1
Mycobacterium tuberculosis Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase) 0.1286 0.9182 1
Brugia malayi nuclear hormone receptor 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.0257 0.1494 0.1494
Schistosoma mansoni nuclear hormone receptor 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor E75 0.0658 0.4494 0.4494
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.1396 1 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0637 0.4332 0.4332
Schistosoma mansoni thyroid hormone receptor 0.1396 1 1
Brugia malayi ecdysone receptor 0.0658 0.4494 0.4494
Echinococcus multilocularis nuclear receptor nhr 48 0.0658 0.4494 0.4494
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0658 0.4494 0.4494
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Brugia malayi photoreceptor-specific nuclear receptor 0.1396 1 1
Brugia malayi nuclear receptor NHR-67 0.0658 0.4494 0.4494
Schistosoma mansoni hypothetical protein 0.0175 0.0888 0.0888
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0261 0.153 0.1169
Brugia malayi hypothetical protein 0.0737 0.5084 0.5084
Brugia malayi nuclear hormone receptor 0.1396 1 1
Schistosoma mansoni nuclear receptor 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0737 0.5084 0.5084
Schistosoma mansoni carbonic anhydrase-related 0.0257 0.1494 0.1494
Plasmodium falciparum carbonic anhydrase 0.0257 0.1494 0.9766
Brugia malayi nuclear hormone receptor family member nhr-6 0.0658 0.4494 0.4494
Echinococcus granulosus carbonic anhydrase 0.0257 0.1494 0.1494
Schistosoma mansoni hypothetical protein 0.0257 0.1494 0.1494
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1396 1 1
Brugia malayi nuclear receptor RXR 0.0737 0.5084 0.5084
Brugia malayi orphan nuclear receptor NR2E1 0.0658 0.4494 0.4494
Echinococcus granulosus thyroid hormone receptor alpha 0.0658 0.4494 0.4494
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 0.5355 0.5584
Echinococcus granulosus Nuclear hormone receptor HR96 0.0658 0.4494 0.4494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.1396 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0737 0.5084 0.5084
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0774 0.5355 0.5584
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0257 0.1494 0.1494
Echinococcus multilocularis carbonic anhydrase 0.0257 0.1494 0.1494
Plasmodium vivax DNA gyrase subunit B, putative 0.0126 0.0517 0.3378
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.1396 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.1396 1 1
Chlamydia trachomatis UDP-N-acetylenolpyruvoylglucosamine reductase 0.1286 0.9182 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0737 0.5084 0.5084
Echinococcus multilocularis carbonic anhydrase II 0.0637 0.4332 0.4332
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0658 0.4494 0.4494
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0737 0.5084 0.5084
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.1396 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.0737 0.5084 0.5084
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.1494 0.1494
Schistosoma mansoni nuclear receptor nhr-48 0.0658 0.4494 0.4494
Brugia malayi nuclear receptor NHR-88 0.0658 0.4494 0.4494
Loa Loa (eye worm) nuclear hormone receptor 0.0658 0.4494 0.4494
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0261 0.153 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0637 0.4332 1
Onchocerca volvulus Protein ultraspiracle homolog 0.1396 1 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0637 0.4332 0.4332
Echinococcus granulosus nuclear receptor nhr 48 0.0658 0.4494 0.4494
Schistosoma mansoni Tr4/Tr2 (homologue) 0.1396 1 1
Brugia malayi Steroid receptor seven-up type 2 0.1396 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0257 0.1494 0.1494
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0658 0.4494 0.4494
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0257 0.1494 0.1494
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor family member nhr-31 0.1396 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.1396 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0737 0.5084 0.5084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.1396 1 1
Mycobacterium ulcerans DNA gyrase subunit A 0.0261 0.153 0.1169
Schistosoma mansoni carbonic anhydrase-related 0.0257 0.1494 0.1494
Brugia malayi hypothetical protein 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Brugia malayi nuclear receptor RXR 0.0658 0.4494 0.4494
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0218 0.1207 0.0805
Schistosoma mansoni coup transcription factor 0.1396 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0257 0.1494 0.1494
Echinococcus granulosus carbonic anhydrase 0.0257 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Plasmodium vivax DNA gyrase subunit A, putative 0.0261 0.153 1
Echinococcus multilocularis FTZ F1 alpha 0.1396 1 1
Brugia malayi Nuclear hormone receptor E75 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor family member nhr-1 0.1396 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0658 0.4494 0.4494
Onchocerca volvulus Bile acid receptor homolog 0.1396 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0658 0.4494 0.4494
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Brugia malayi hypothetical protein 0.0658 0.4494 0.4494
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0637 0.4332 0.4332
Schistosoma mansoni thyroid hormone receptor 0.1396 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.1396 1 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0218 0.1207 0.7889
Schistosoma mansoni retinoic acid receptor RXR 0.1396 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0658 0.4494 0.4494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1396 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0261 0.153 0.1169
Brugia malayi tailless protein 0.0658 0.4494 0.4494
Brugia malayi nuclear hormone receptor family member odr-7 0.0658 0.4494 0.4494
Schistosoma mansoni steroid hormone receptor ad4bp 0.1396 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.1396 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0737 0.5084 0.5084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.1396 1 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINE REDUCTASE MURB (UDP-N-ACETYLMURAMATE DEHYDROGENASE) 0.1286 0.9182 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Echinococcus granulosus carbonic anhydrase 0.0257 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0737 0.5084 0.5084
Loa Loa (eye worm) hypothetical protein 0.0737 0.5084 0.5084
Loa Loa (eye worm) DR-78 0.0658 0.4494 0.4494
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.1396 1 1
Brugia malayi hypothetical protein 0.0737 0.5084 0.5084
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.1396 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0658 0.4494 0.4494
Plasmodium falciparum DNA gyrase subunit B 0.0126 0.0517 0.3378
Schistosoma mansoni nuclear hormone receptor 0.1396 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0637 0.4332 0.4332
Schistosoma mansoni hypothetical protein 0.0175 0.0888 0.0888
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0637 0.4332 0.4332
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylenolpyruvoylglucosamine reductase 0.1286 0.9182 1
Leishmania major carbonic anhydrase-like protein 0.0637 0.4332 1
Echinococcus granulosus ecdysone induced protein 78C 0.1396 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1396 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0637 0.4332 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.1396 1 1
Schistosoma mansoni carbonic anhydrase 0.0257 0.1494 0.1494
Schistosoma mansoni nuclear receptor 0.0658 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.0737 0.5084 0.5084
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor-like 1 0.1396 1 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0556 0.3726 0.371
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1396 1 1
Plasmodium falciparum DNA gyrase subunit A 0.0261 0.153 1
Loa Loa (eye worm) hypothetical protein 0.0257 0.1494 0.1494
Echinococcus multilocularis carbonic anhydrase 0.0257 0.1494 0.1494
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.1396 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0257 0.1494 0.1494
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1396 1 1
Loa Loa (eye worm) steroid hormone receptor 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor family member nhr-14 0.1396 1 1
Echinococcus multilocularis geminin 0.0175 0.0888 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-41 0.1396 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0126 0.0517 0.036
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0073 0.0121 0.0788
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0637 0.4332 0.4332
Brugia malayi conserved hypotetical protein 0.0658 0.4494 0.4494
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1396 1 1
Echinococcus granulosus FTZ F1 alpha 0.1396 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.1396 1 1
Schistosoma mansoni zinc finger protein 0.0658 0.4494 0.4494
Trichomonas vaginalis DNA topoisomerase II, putative 0.0057 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Echinococcus granulosus carbonic anhydrase II 0.0637 0.4332 0.4332
Entamoeba histolytica DNA topoisomerase II, putative 0.0057 0 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0658 0.4494 0.4494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.1396 1 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.5084 0.5084
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0218 0.1207 0.0796
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Brugia malayi steroid hormone receptor 0.1396 1 1
Chlamydia trachomatis DNA gyrase subunit A 0.0261 0.153 0.1486
Loa Loa (eye worm) hypothetical protein 0.0658 0.4494 0.4494
Toxoplasma gondii hypothetical protein 0.0257 0.1494 0.9766
Schistosoma mansoni retinoid-x-receptor (RXR) 0.1396 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.1396 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1396 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1396 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.1396 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1396 1 1
Echinococcus multilocularis carbonic anhydrase 0.0257 0.1494 0.1494

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 uM Inhibitory concentration against MurB enzyme in Escherichia coli ChEMBL. 15863310
IC50 (binding) = 10 uM Inhibitory concentration against MurB enzyme in Escherichia coli ChEMBL. 15863310
IC50 (binding) = 32 uM Inhibitory concentration against MurB enzyme in Staphylococcus aureus ChEMBL. 15863310
IC50 (binding) = 32 uM Inhibitory concentration against MurB enzyme in Staphylococcus aureus ChEMBL. 15863310
IC50 (binding) = 42.3 uM Inhibitory concentration against MurA enzyme in Escherichia coli ChEMBL. 15863310
IC50 (binding) = 42.3 uM Inhibitory concentration against MurA enzyme in Escherichia coli ChEMBL. 15863310
MIC (functional) = 25 uM Minimum inhibitory concentration against cell wall biosynthesis of penicillin resistant Streptococcus pneumoniae GC 1894 (PRSP) ChEMBL. 15863310
MIC (functional) = 100 uM Minimum inhibitory concentration against cell wall biosynthesis of methicillin susceptible Staphylococcus aureus GC 4543 ChEMBL. 15863310
MIC (functional) = 100 uM Minimum inhibitory concentration against cell wall biosynthesis of vancomycin susceptible (ATCC) Enterococcus faecalis GC 4555 ChEMBL. 15863310
MIC (functional) = 200 uM Minimum inhibitory concentration against cell wall biosynthesis of methicillin resistant Staphylococcus aureus GC 1131 ChEMBL. 15863310
MIC (functional) = 200 uM Minimum inhibitory concentration against cell wall biosynthesis of vancomycin resistant Enterococcus faecalis GC 2242 (VRE) ChEMBL. 15863310
MIC (functional) > 200 uM Minimum inhibitory concentration against cell wall biosynthesis of penicillin resistant Streptococcus pneumoniae GC 1894 (PRSP) in the presence of 4% bovine serum albumin ChEMBL. 15863310
MIC (functional) > 200 uM Minimum inhibitory concentration against cell wall biosynthesis of methicillin-susceptible Coagulase negative staphylococcus GC 646 (MSCNS) ChEMBL. 15863310
MIC (functional) > 200 uM Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4559 ChEMBL. 15863310
MIC (functional) > 200 uM Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4560 ChEMBL. 15863310
MIC (functional) > 200 uM Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4559 ChEMBL. 15863310
MIC (functional) > 200 uM Minimum inhibitory concentration against cell wall biosynthesis of Escherichia coli GC 4560 ChEMBL. 15863310

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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