Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | unspecified product | 0.0112 | 0.3016 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0023 | 0.0186 | 0.0617 |
Plasmodium vivax | plasmepsin IV, putative | 0.0074 | 0.18 | 0.5967 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0023 | 0.0186 | 0.1034 |
Plasmodium vivax | unspecified product | 0.0105 | 0.2779 | 0.9213 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0023 | 0.0186 | 0.0617 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0308 | 0.9257 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0074 | 0.18 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0074 | 0.18 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0074 | 0.18 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0186 | 0.0617 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0074 | 0.18 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0023 | 0.0186 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0186 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0186 | 0.1034 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0023 | 0.0186 | 0.1034 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0186 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0186 | 0.1034 |
Plasmodium falciparum | plasmepsin IV | 0.0074 | 0.18 | 0.5967 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0074 | 0.18 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0023 | 0.0186 | 0.0617 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0074 | 0.18 | 1 |
Schistosoma mansoni | amine oxidase | 0.0023 | 0.0186 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0186 | 0.1034 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0023 | 0.0186 | 0.1034 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0023 | 0.0186 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0186 | 0.1034 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0074 | 0.18 | 1 |
Onchocerca volvulus | 0.0023 | 0.0186 | 1 | |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0023 | 0.0186 | 0.0617 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0074 | 0.18 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0023 | 0.0186 | 0.1034 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0023 | 0.0186 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0112 | 0.3016 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0074 | 0.18 | 0.5967 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0023 | 0.0186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0186 | 0.1034 |
Plasmodium falciparum | plasmepsin II | 0.0074 | 0.18 | 0.5967 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0074 | 0.18 | 0.5967 |
Plasmodium vivax | vivapain-1 | 0.0112 | 0.3016 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0023 | 0.0186 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0332 | 1 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0023 | 0.0186 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0074 | 0.18 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0074 | 0.18 | 0.5967 |
Leishmania major | UDP-galactopyranose mutase | 0.0023 | 0.0186 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0023 | 0.0186 | 0.1034 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.18 | 1 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0186 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0023 | 0.0186 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 100 uM | Concentration required to reduce the viability of mock-infected cells by 50%; determined by MTT method. | ChEMBL. | 15974590 |
CC50 (functional) | > 100 uM | Concentration required to reduce the viability of mock-infected cells by 50%; determined by MTT method. | ChEMBL. | 15974590 |
EC50 (functional) | = 5 uM | Concentration required to protect MT-4 cells from HIV-1 induced cytopathogenicity by 50%; determined by MTT method | ChEMBL. | 15974590 |
EC50 (functional) | = 5 uM | Concentration required to protect MT-4 cells from HIV-1 induced cytopathogenicity by 50%; determined by MTT method | ChEMBL. | 15974590 |
SI (functional) | > 20 | Selective index as the ratio of CC50 and EC50 | ChEMBL. | 15974590 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15974590 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.