Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein kinase shaggy | 0.0058 | 0.1952 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.1952 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 1 | 1 |
Echinococcus multilocularis | protein kinase shaggy | 0.0058 | 0.1952 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.1952 | 0.1952 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0.1952 | 0.5 |
Brugia malayi | intracellular kinase | 0.0058 | 0.1952 | 0.1952 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0058 | 0.1952 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0058 | 0.1952 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.1952 | 0.1952 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.1952 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 1 | 1 |
Onchocerca volvulus | 0.0058 | 0.1952 | 0.1952 | |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.1952 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.1952 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0.1952 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0.1952 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.1952 | 0.5 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0058 | 0.1952 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.1952 | 0.5 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0.1952 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0.1952 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.1952 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.1952 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 70 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRbeta (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 70 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRbeta (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 100 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 100 nM | Effective concentration for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha (Liver X receptor) | ChEMBL. | 16107141 |
EC50 (binding) | = 1.32 uM | Effective concentration in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay | ChEMBL. | 16107141 |
IC50 (binding) | > 5000 nM | Inhibition of human GSK-3beta | ChEMBL. | 16107141 |
IC50 (binding) | > 5000 nM | Inhibition of human GSK-3beta | ChEMBL. | 16107141 |
RE (binding) | = 0.3 | Relative efficacy for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha compared to GW3965 | ChEMBL. | 16107141 |
RE (binding) | = 0.5 | Relative efficacy for Steroid receptor coactivator-1 (SRC1) recruitment to human LXRalpha compared to GW3965 | ChEMBL. | 16107141 |
RE (binding) | = 0.6 | Relative efficacy in human ATP binding cassette transporter A1 (ABCA1) transcriptional activation assay compared to GW3965 | ChEMBL. | 16107141 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.