Detailed information for compound 33450

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 425.486 | Formula: C24H23N7O
  • H donors: 1 H acceptors: 5 LogP: 3.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1cc2ncn(c2c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C
  • InChi: 1S/C24H23N7O/c1-3-6-18-13-21-22(30(2)15-25-21)24(32)31(18)14-16-9-11-17(12-10-16)19-7-4-5-8-20(19)23-26-28-29-27-23/h4-5,7-13,15H,3,6,14H2,1-2H3,(H,26,27,28,29)
  • InChiKey: VXJNVRGDVLNHRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0034 0.1416
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0203 0.2476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0349
Loa Loa (eye worm) hypothetical protein 0.0026 0.0068 0.0827
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0019 0.0114
Schistosoma mansoni hypothetical protein 0.0034 0.0096 0.0592
Echinococcus granulosus phd:f box containing protein 0.0017 0.0034 0.021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0203 0.2476
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0016 0.0101
Loa Loa (eye worm) hypothetical protein 0.005 0.0154 0.1873
Schistosoma mansoni cpg binding protein 0.0033 0.0093 0.0575
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0072 0.3016
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.1255
Entamoeba histolytica hypothetical protein 0.0073 0.024 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0177
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0216 0.8981
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0034 0.021
Brugia malayi isocitrate dehydrogenase 0.0016 0.0029 0.035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.1255
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0034 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.024 1
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0016 0.0662
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0072 0.3016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0019 0.0226
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0034 0.1416
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0204
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0882
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0034 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0216 0.02
Echinococcus granulosus transcription factor btf3 0.0073 0.024 0.1482
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.004 0.0117 0.4868
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0029 0.0177
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0029 0.0349
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.004 0.0117 0.4868
Brugia malayi jmjC domain containing protein 0.0066 0.0215 0.2613
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.019 0.7921
Brugia malayi Cytochrome P450 family protein 0.0012 0.0016 0.0194
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0029 0.0029
Schistosoma mansoni transcription factor btf3 0.0073 0.024 0.1482
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0034 0.021
Schistosoma mansoni cpg binding protein 0.0031 0.0087 0.0534
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0216 0.1331
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0414
Echinococcus granulosus cpg binding protein 0.0033 0.0093 0.0575
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0041 0.0251
Brugia malayi CXXC zinc finger family protein 0.0031 0.0087 0.1054
Brugia malayi intermediate filament protein 0.0027 0.007 0.085
Plasmodium vivax basic transcription factor 3b, putative 0.0073 0.024 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.1255
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0072 0.3016
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0177
Schistosoma mansoni hypothetical protein 0.0353 0.1277 0.7876
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0034 0.021
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0016 0.0662
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0116 0.0714
Treponema pallidum cysteinyl-tRNA synthetase 0.004 0.0117 1
Leishmania major hypothetical protein, conserved 0.0017 0.0034 0.1416
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0029 0.1197
Echinococcus granulosus intermediate filament protein 0.0027 0.007 0.043
Echinococcus granulosus leucyl tRNA synthetase 0.004 0.0117 0.0721
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.0822 1
Echinococcus multilocularis lamin 0.0027 0.007 0.043
Brugia malayi jmjC domain containing protein 0.0017 0.0034 0.0414
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0177
Echinococcus granulosus lamin dm0 0.0027 0.007 0.043
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0029 0.1197
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0116 0.4816
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0116 0.4816
Schistosoma mansoni retinoic acid receptor RXR 0.0105 0.0361 0.2225
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0177
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0007 0.0041
Echinococcus multilocularis cpg binding protein 0.0033 0.0093 0.0575
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.004 0.0117 0.4868
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0116 0.4816
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0116 0.4816
Echinococcus granulosus lamin 0.0027 0.007 0.043
Schistosoma mansoni ap endonuclease 0.0039 0.0116 0.0714
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0087 0.1054
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0024 0.029
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0208 0.1283
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.1197
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0116 0.9893
Loa Loa (eye worm) intermediate filament protein 0.0027 0.007 0.085
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0029 0.0349
Echinococcus multilocularis cysteinyl tRNA synthetase 0.004 0.0117 0.0721
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0177
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0016 0.0194
Brugia malayi RNA binding protein 0.0063 0.0203 0.2476
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0034 0.021
Brugia malayi hypothetical protein 0.0018 0.0036 0.0443
Plasmodium falciparum cysteine--tRNA ligase 0.004 0.0117 0.4868
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0217 0.1336
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0072 0.3016
Brugia malayi TAR-binding protein 0.0063 0.0203 0.2476
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0208 0.1283
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.024 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0029 0.1197
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0072 0.3016
Loa Loa (eye worm) hypothetical protein 0.0027 0.007 0.085
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0016 0.0194
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.1255
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.024 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0215 0.1324
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0029 0.0177
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.004 0.0117 0.1424
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0216 0.8981
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0029 0.035
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0016 0.0101
Echinococcus multilocularis transcription factor btf3 0.0073 0.024 0.1482
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0029 0.0177
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.1197
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0034 0.021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0029 0.1197
Onchocerca volvulus 0.004 0.0117 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0116 0.1408
Brugia malayi cysteinyl tRNA synthetase protein 1 0.004 0.0117 0.1424
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0116 0.0116
Schistosoma mansoni cysteinyl-tRNA synthetase 0.004 0.0117 0.0721
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.024 1
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.004 0.0117 0.4868
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0072 0.3016
Echinococcus multilocularis lamin dm0 0.0027 0.007 0.043
Trypanosoma cruzi transcription factor btf3, putative 0.0073 0.024 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0116 0.9893
Loa Loa (eye worm) hypothetical protein 0.004 0.0117 0.1424
Plasmodium vivax JmjC domain containing protein 0.0017 0.0034 0.1416
Leishmania major hypothetical protein, conserved 0.0028 0.0072 0.3016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0216 0.0216
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0216 0.1331
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.004 0.0117 0.0101
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.004 0.0117 0.4868
Plasmodium vivax cysteine--tRNA ligase, putative 0.004 0.0117 0.4868
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2711 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0024 0.029
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0154 0.1873
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0116 0.4816
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0034 0.0414
Schistosoma mansoni intermediate filament proteins 0.0027 0.007 0.043
Toxoplasma gondii exonuclease III APE 0.0039 0.0116 0.4816
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0034 0.021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0029 0.0177
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0414
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.007 0.085
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0019 0.0114
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0116 0.1408
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0034 0.1416
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0116 0.01
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0029 0.0177
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0072 0.3016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0101 0.0346 0.2134
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0154 0.1873
Schistosoma mansoni lamin 0.0027 0.007 0.043
Giardia lamblia Cysteinyl-tRNA synthetase 0.004 0.0117 1
Leishmania major cytochrome p450-like protein 0.0012 0.0016 0.0662
Echinococcus multilocularis musashi 0.0027 0.007 0.043
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0203 0.1255
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0116 0.0714
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.1622 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0034 0.021
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0203 0.1255
Schistosoma mansoni hypothetical protein 0.0446 0.1622 1
Echinococcus granulosus geminin 0.0353 0.1277 0.7876
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0006 0.0075
Brugia malayi jmjC domain containing protein 0.0017 0.0034 0.0414
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0216 0.02
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0216 0.1331
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0116 0.4816
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0215 0.1324
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0216 0.1331
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0177
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.007 0.085
Echinococcus granulosus dnaJ subfamily B 0.0446 0.1622 1
Onchocerca volvulus 0.0027 0.007 0.5967
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0034 0.0414
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0029 0.0177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0105 0.0361 0.2225
Chlamydia trachomatis cysteine--tRNA ligase 0.004 0.0117 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0029 0.0177
Plasmodium falciparum basic transcription factor 3b, putative 0.0073 0.024 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.0203 0.2476
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0016 0.0194
Loa Loa (eye worm) ICD-1 protein 0.0073 0.024 0.2925
Schistosoma mansoni hypothetical protein 0.0016 0.0029 0.0177
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0034 0.1416
Echinococcus granulosus cysteinyl tRNA synthetase 0.004 0.0117 0.0721
Brugia malayi jmjC domain containing protein 0.0017 0.0034 0.0414
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0116 0.4816
Brugia malayi follicle stimulating hormone receptor 0.023 0.0822 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0034 0.021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0208 0.1283
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0203 0.2476
Brugia malayi hypothetical protein 0.0028 0.0072 0.0882
Schistosoma mansoni lamin 0.0027 0.007 0.043
Onchocerca volvulus 0.0031 0.0087 0.7407
Schistosoma mansoni ap endonuclease 0.0039 0.0116 0.0714
Toxoplasma gondii NAC domain-containing protein 0.0073 0.024 1
Schistosoma mansoni cysteinyl-tRNA synthetase 0.004 0.0117 0.0721
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0034 0.021
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0016 0.0662
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0034 0.021
Schistosoma mansoni cpg binding protein 0.0033 0.0093 0.0575
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0034 0.1416
Schistosoma mansoni hypothetical protein 0.0353 0.1277 0.7876
Leishmania major basic transcription factor 3a, putative 0.0073 0.024 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0034 0.1416
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0029 0.035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0204
Brugia malayi jmjC domain containing protein 0.0017 0.0034 0.0414
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0029 0.0177
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0116 0.4816
Loa Loa (eye worm) histone methyltransferase 0.001 0.0007 0.008
Brugia malayi beta-NAC-like protein 0.0073 0.024 0.2925
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0034 0.021
Echinococcus granulosus tar DNA binding protein 0.0063 0.0203 0.1255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0216 0.02
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0414
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0029 0.0349
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0215 0.1324
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2711 1 1
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.004 0.0117 0.4868
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0154 0.1873
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0096 0.1167
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0208 0.1283
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0029 0.1197
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.004 0.0117 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0116 0.4816
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0041 0.0251
Onchocerca volvulus 0.0027 0.007 0.5967
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0029 0.1197
Brugia malayi Cytochrome P450 family protein 0.0012 0.0016 0.0194
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0007 0.0041
Echinococcus multilocularis GPCR, family 2 0.0016 0.0029 0.0177
Brugia malayi jmjC domain containing protein 0.0064 0.0208 0.2533
Echinococcus multilocularis geminin 0.0353 0.1277 0.7876
Echinococcus granulosus GPCR family 2 0.0016 0.0029 0.0177
Plasmodium falciparum cysteine--tRNA ligase 0.004 0.0117 0.4868
Leishmania major cysteinyl-tRNA synthetase, putative 0.004 0.0117 0.4868
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0029 0.1197
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0215 0.2613
Trypanosoma brucei transcription factor BTF3, putative 0.0073 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0096 0.1167
Entamoeba histolytica transcription factor BTF3, putative 0.0073 0.024 1

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) < 0.3 mg kg-1 In vivo potency determined as dose of the compound given iv to produce reduction in angiotensin II pressor response in normotensive rats ChEMBL. No reference
Inhibition (functional) > 50 % Tested for in vitro inhibition of specific binding of [125I]-AII for bolus injection of 0.3 mg/kg lasting up to 90 min post dose ChEMBL. No reference
pKB (functional) = 10.2 In vitro functional antagonistic affinity measured against angiotensin II receptor in paired rings of rabbit aorta ChEMBL. No reference
pKB (functional) = 10.2 In vitro functional antagonistic affinity measured against angiotensin II receptor in paired rings of rabbit aorta ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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