Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.00654705 | 0.980922 | 0.5 |
Schistosoma mansoni | immunophilin | 0.00666094 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.00654705 | 0.980922 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.00654705 | 0.980922 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.00654705 | 0.980922 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.00654705 | 0.980922 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.00608336 | 0.903245 | 0.903245 |
Schistosoma mansoni | immunophilin | 0.00666094 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.00666094 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.00654705 | 0.980922 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.00654705 | 0.980922 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.00666094 | 1 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.00654705 | 0.980922 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.00654705 | 0.980922 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.00654705 | 0.980922 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.00654705 | 0.980922 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.00654705 | 0.980922 | 0.980922 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.00654705 | 0.980922 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.00654705 | 0.980922 | 0.802819 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.00654705 | 0.980922 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.00654705 | 0.980922 | 0.802819 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.00666094 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.00666094 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.01 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6) | ChEMBL. | 15828818 |
IC50 (functional) | = 0.01 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-sensitive strain (D6) | ChEMBL. | 15828818 |
IC50 (functional) | = 0.063 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2) | ChEMBL. | 15828818 |
IC50 (functional) | = 0.063 ng ml-1 | In vitro antimalarial activity of the compound against plasmodium falciparum chloroquine, DHFR wild-type pyrimethamine-resistant strain (W2) | ChEMBL. | 15828818 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 15828818 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.