Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.5 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 20 uM | Antiproliferative effect against RH7777 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer DU-145 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer PC-3 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer LNCaP Cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer PPC-1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer TSU-Pr1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer DU-145 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer PC-3 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer LNCaP Cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer PPC-1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
IC50 (functional) | > 20 uM | Antiproliferative activity against prostate cancer TSU-Pr1 cell line using sulforhodamine B(SRB) assay | ChEMBL. | 15801848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.