TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 264.277 | Formula: C13H16N2O4
H donors: 4 H acceptors: 4 LogP: 0.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N[C@@H]([C@@H](O)C)C(=O)N[C@H]1Cc1ccc(cc1)O
InChi: 1S/C13H16N2O4/c1-7(16)11-13(19)14-10(12(18)15-11)6-8-2-4-9(17)5-3-8/h2-5,7,10-11,16-17H,6H2,1H3,(H,14,19)(H,15,18)/t7-,10-,11-/m0/s1
InChiKey: KVURITOIYMCUIA-SWPVVBRQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	acetylcholinesterase	0.0338	0.4223	0.6447
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0135	0.0207
Echinococcus granulosus	neuroligin	0.0057	0.0626	0.0956
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0309	0.1923
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0242	0.0369
Echinococcus multilocularis	lamin	0.0058	0.0641	0.0641
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0724	0.1714
Trichomonas vaginalis	ran, putative	0.0021	0.016	0.2547
Brugia malayi	hypothetical protein	0.052	0.6551	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0058	0.0641	0.0979
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0057	0.0626	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.016	0.0244
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0057	0.0626	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0989	0.1509
Brugia malayi	Carboxylesterase family protein	0.0057	0.0626	0.0956
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0443	0.0676
Echinococcus multilocularis	muscleblind protein	0.0163	0.1983	0.1983
Schistosoma mansoni	pyruvate kinase	0.0032	0.0309	0.0732
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0338	0.4223	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0186	0.2977
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0155	0.0236
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0108	0.0108
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0309	0.0472
Schistosoma mansoni	ran	0.0021	0.016	0.0378
Echinococcus granulosus	muscleblind protein	0.0163	0.1983	0.3027
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0135	0.0135
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0254	0.8229
Schistosoma mansoni	hypothetical protein	0.0025	0.0209	0.0496
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0309	0.1923
Mycobacterium ulcerans	pyruvate kinase	0.0032	0.0309	0.4935
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0032	0.0309	0.0472
Echinococcus granulosus	carboxylesterase 5A	0.0338	0.4223	0.6447
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0184	0.415
Treponema pallidum	hypothetical protein	0.0008	0	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0073	0.0827	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0338	0.4223	0.6447
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0163	0.0387
Brugia malayi	Intermediate filament tail domain containing protein	0.0058	0.0641	0.0979
Schistosoma mansoni	bromodomain containing protein	0.0077	0.0881	0.2086
Onchocerca volvulus		0.0057	0.0626	0.3896
Brugia malayi	Carboxylesterase family protein	0.0057	0.0626	0.0956
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0155	0.0367
Schistosoma mansoni	zinc finger protein	0.0018	0.0128	0.0303
Schistosoma mansoni	importin beta-1	0.0028	0.0254	0.0602
Echinococcus granulosus	intermediate filament protein	0.0058	0.0641	0.0979
Echinococcus granulosus	lamin	0.0058	0.0641	0.0979
Onchocerca volvulus		0.0057	0.0626	0.3896
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0414	0.0632
Plasmodium falciparum	pyruvate kinase 2	0.0017	0.0108	0.3481
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0479	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Brugia malayi	Carboxylesterase family protein	0.0057	0.0626	0.0956
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.016	0.0244
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Brugia malayi	Carboxylesterase family protein	0.0057	0.0626	0.0956
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.016	0.5161
Chlamydia trachomatis	pyruvate kinase	0.0032	0.0309	1
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0209	0.032
Echinococcus granulosus	zinc finger protein	0.0025	0.0216	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1608	0.2454
Schistosoma mansoni	pyruvate kinase	0.0017	0.0108	0.0255
Treponema pallidum	cation-transporting ATPase, P-type	0.0008	0	0.5
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.001	0.002	0.0031
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0286	0.0436
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0032	0.0309	1
Schistosoma mansoni	intermediate filament proteins	0.0058	0.0641	0.1519
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0163	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0128	0.4143
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1983	0.3027
Entamoeba histolytica	hypothetical protein	0.0023	0.0186	0.4208
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0057	0.0626	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0207
Echinococcus granulosus	lamin dm0	0.0058	0.0641	0.0979
Brugia malayi	hypothetical protein	0.0057	0.0626	0.0956
Onchocerca volvulus		0.0057	0.0626	0.3896
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0135	0.0207
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0309	0.1923
Brugia malayi	hypothetical protein	0.0085	0.0989	0.1509
Onchocerca volvulus		0.0031	0.0286	0.1778
Loa Loa (eye worm)	carboxylesterase	0.0338	0.4223	0.6447
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0641	0.0979
Echinococcus granulosus	cpg binding protein	0.0035	0.0337	0.0515
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0032	0.0309	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0972	0.1484
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0186	0.2977
Brugia malayi	Carboxylesterase family protein	0.0338	0.4223	0.6447
Echinococcus granulosus	pyruvate kinase	0.0032	0.0309	0.0472
Loa Loa (eye worm)	acetylcholinesterase 1	0.0338	0.4223	0.6447
Echinococcus multilocularis	snurportin 1	0.03	0.3731	0.3731
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0163	0.0249
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0135	0.0135
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0309	0.0472
Trypanosoma brucei	pyruvate kinase 1, putative	0.0032	0.0309	1
Loa Loa (eye worm)	intermediate filament protein	0.0058	0.0641	0.0979
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.016	0.5161
Schistosoma mansoni	hypothetical protein	0.0019	0.0135	0.032
Leishmania major	pyruvate kinase	0.0032	0.0309	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0186	0.6031
Loa Loa (eye worm)	carboxylesterase	0.0057	0.0626	0.0956
Echinococcus multilocularis	neuroligin	0.0057	0.0626	0.0626
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0135	0.0207
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0057	0.0626	0.1483
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Brugia malayi	Bromodomain containing protein	0.0091	0.106	0.1617
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0135	0.0207
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0442	0.0675
Echinococcus granulosus	GPCR family 2	0.0019	0.0135	0.0207
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0671	1
Brugia malayi	Bromodomain containing protein	0.0046	0.0478	0.073
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0254	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0989	0.1509
Giardia lamblia	Pyruvate kinase	0.0032	0.0309	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0155	0.0367
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.016	0.5161
Brugia malayi	PHD-finger family protein	0.0031	0.0297	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Schistosoma mansoni	hypothetical protein	0.0019	0.0135	0.032
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0309	0.0309
Trichomonas vaginalis	pyruvate kinase, putative	0.0032	0.0309	0.4935
Echinococcus multilocularis	acetylcholinesterase	0.0338	0.4223	0.4223
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0255	0.0255
Schistosoma mansoni	BC026374 protein (S09 family)	0.0057	0.0626	0.1483
Schistosoma mansoni	ran	0.0021	0.016	0.0378
Trypanosoma brucei	pyruvate kinase 1	0.0032	0.0309	1
Leishmania major	pyruvate kinase	0.0032	0.0309	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0059	0.0654	0.0999
Schistosoma mansoni	lamin	0.0058	0.0641	0.1519
Echinococcus multilocularis	acetylcholinesterase	0.0338	0.4223	0.4223
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.3731	0.5695
Leishmania major	GTP-binding protein, putative	0.0021	0.016	0.5161
Echinococcus multilocularis	musashi	0.0058	0.0641	0.0641
Echinococcus granulosus	acetylcholinesterase	0.0338	0.4223	0.6447
Onchocerca volvulus		0.0057	0.0626	0.3896
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0254	0.8229
Leishmania major	hypothetical protein, conserved	0.0018	0.0128	0.4143
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0309	0.0472
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.016	0.0244
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0059	0.0654	0.0999
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.016	0.5161
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0073	0.0827	0.1262
Entamoeba histolytica	hypothetical protein	0.0043	0.0443	1
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0108	0.0108
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0295	0.045
Echinococcus multilocularis	muscleblind protein 1	0.0163	0.1983	0.1983
Giardia lamblia	Pyruvate kinase	0.0017	0.0108	0.3481
Brugia malayi	hypothetical protein	0.0134	0.1608	0.2454
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0443	0.0443
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0059	0.0654	0.0999
Trichomonas vaginalis	spcc417.12 protein, putative	0.0057	0.0626	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0135	0.0207
Echinococcus granulosus	survival motor neuron protein 1	0.052	0.6551	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.016	0.5161
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0108	0.0108
Onchocerca volvulus		0.0058	0.0641	0.399
Brugia malayi	RNA, U transporter 1	0.008	0.0917	0.14
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0016	0.0016
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0057	0.0626	0.1483
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0057	0.0626	0.0626
Loa Loa (eye worm)	carboxylesterase	0.0057	0.0626	0.0956
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0032	0.0309	1
Echinococcus granulosus	pyruvate kinase	0.0017	0.0108	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0184	0.0281
Plasmodium falciparum	pyruvate kinase	0.0032	0.0309	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0128	0.0303
Schistosoma mansoni	eyes absent homolog	0.0085	0.0989	0.2342
Entamoeba histolytica	Ran family GTPase	0.0021	0.016	0.3601
Schistosoma mansoni	hypothetical protein	0.0106	0.1253	0.2966
Mycobacterium ulcerans	carboxylesterase, LipT	0.0057	0.0626	1
Plasmodium vivax	pyruvate kinase 2, putative	0.0017	0.0108	0.3481
Schistosoma mansoni	cpg binding protein	0.0031	0.0286	0.0677
Echinococcus granulosus	fetal alzheimer antigen falz	0.0029	0.0261	0.0398
Brugia malayi	intermediate filament protein	0.0058	0.0641	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0254	0.0388
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0057	0.0626	1
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0032	0.0309	0.4935
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0044	0.0066
Echinococcus granulosus	pyruvate kinase	0.0032	0.0309	0.0472
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0309	0.0309
Echinococcus granulosus	para nitrobenzyl esterase	0.0057	0.0626	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0516	0.0787
Schistosoma mansoni	acetylcholinesterase	0.0057	0.0626	0.1483
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0222	0.0222
Brugia malayi	Carboxylesterase family protein	0.0338	0.4223	0.6447
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0184	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0654	0.0999
Schistosoma mansoni	zinc finger protein	0.0025	0.0216	0.051
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0032	0.0309	0.0472
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0057	0.0626	0.1483
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.016	0.2376
Echinococcus multilocularis	carboxylesterase 5A	0.0338	0.4223	0.4223
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0155	0.0155
Brugia malayi	Muscleblind-like protein	0.0163	0.1983	0.3027
Schistosoma mansoni	pyruvate kinase	0.0032	0.0309	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0338	0.4223	0.6447
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1608	0.2454
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0186	0.2977
Onchocerca volvulus		0.0057	0.0626	0.3896
Trichomonas vaginalis	pyruvate kinase, putative	0.0032	0.0309	0.4935
Echinococcus granulosus	BC026374 protein S09 family	0.0057	0.0626	0.0956
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0029	0.0261	0.0261
Schistosoma mansoni	cpg binding protein	0.0035	0.0337	0.0798
Echinococcus multilocularis	survival motor neuron protein 1	0.052	0.6551	0.6551
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0286	0.0436
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0254	0.3789
Echinococcus multilocularis	lamin dm0	0.0058	0.0641	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0242	0.0369
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0255	0.039
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0295	0.045
Plasmodium falciparum	importin beta, putative	0.0028	0.0254	0.8229
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0628	0.0958
Onchocerca volvulus		0.0058	0.0641	0.399
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0626	0.0956
Schistosoma mansoni	hypothetical protein	0.0041	0.0414	0.0981
Schistosoma mansoni	hypothetical protein	0.0043	0.0443	0.1049
Echinococcus multilocularis	cpg binding protein	0.0035	0.0337	0.0337
Onchocerca volvulus	Huntingtin homolog	0.0134	0.1608	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0135	0.032
Schistosoma mansoni	gliotactin	0.0057	0.0626	0.1483
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0164	0.0251
Onchocerca volvulus		0.0106	0.1253	0.7792
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0414	0.0632
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0106	0.1253	0.1912
Echinococcus multilocularis	para nitrobenzyl esterase	0.0057	0.0626	0.0626
Toxoplasma gondii	pyruvate kinase PyK1	0.0032	0.0309	0.4604
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0057	0.0626	0.0956
Schistosoma mansoni	lamin	0.0058	0.0641	0.1519
Echinococcus granulosus	pyruvate kinase	0.0017	0.0108	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0567	0.0865
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0029	0.0261	0.0617
Brugia malayi	hypothetical protein	0.0043	0.0443	0.0676
Brugia malayi	Importin beta-1 subunit	0.0028	0.0254	0.0388
Schistosoma mansoni	survival motor neuron protein	0.0106	0.1253	0.2966
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0016	0.0024
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.016	0.5161
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0255	0.039
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1983	0.3027
Toxoplasma gondii	pyruvate kinase PyKII	0.0017	0.0108	0.1603
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.052	0.6551	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0186	0.6031
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0442	0.0442
Echinococcus granulosus	pyruvate kinase	0.0017	0.0108	0.0164
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0135	0.0135
Trypanosoma brucei	ISWI complex protein	0.0018	0.0128	0.4143
Schistosoma mansoni	hypothetical protein	0.03	0.3731	0.8834
Plasmodium vivax	pyruvate kinase, putative	0.0032	0.0309	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0254	0.8229
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0057	0.0626	1
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0128	0.4143
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0309	0.0472
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.0163	0.0249
Schistosoma mansoni	hypothetical protein	0.0019	0.0135	0.032
Schistosoma mansoni	cpg binding protein	0.0035	0.0337	0.0798
Onchocerca volvulus	Huntingtin homolog	0.0134	0.1608	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0057	0.0626	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0443	0.1049
Echinococcus granulosus	snurportin 1	0.03	0.3731	0.5695
Echinococcus multilocularis	zinc finger protein	0.0025	0.0216	0.0216

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 0 %	Percent inhibition of human calpain 1 at 580 uM; Inhibition within 110%	ChEMBL.	15896956
Inhibition (binding)	= 0 %	Percent inhibition of human calpain 1 at 580 uM; Inhibition within 110%	ChEMBL.	15896956

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 334748