Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.8662 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1202 | 0.0628 | 0.0647 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0148 | 0.0062 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.8106 | 0.9702 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1202 | 0.0628 | 0.0647 |
Loa Loa (eye worm) | thymidylate synthase | 1.8106 | 0.9702 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0148 | 0.0062 | 0.0064 |
Mycobacterium ulcerans | thymidylate synthase | 1.8106 | 0.9702 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1202 | 0.0628 | 0.5 |
Brugia malayi | thymidylate synthase | 1.8106 | 0.9702 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.8662 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.8106 | 0.9702 | 1 |
Echinococcus multilocularis | thymidylate synthase | 1.8106 | 0.9702 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.8662 | 1 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0148 | 0.0062 | 0.0064 |
Echinococcus granulosus | thymidylate synthase | 1.8106 | 0.9702 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.878 | 0.4696 | 0.5 |
Onchocerca volvulus | 1.8106 | 0.9702 | 1 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.878 | 0.4696 | 0.484 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.8662 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.878 | 0.4696 | 0.4483 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1202 | 0.0628 | 0.0647 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.8662 | 1 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.8106 | 0.9702 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 18.6 mg kg-1 | Effective dose required for antagonist activity against strychnine induced seizures in mice when administered intraperitoneally | ChEMBL. | 8289185 |
ED50 (functional) | = 18.6 mg kg-1 | Effective dose required for antagonist activity against strychnine induced seizures in mice when administered intraperitoneally | ChEMBL. | 8289185 |
ED50 (functional) | = 100 mg kg-1 | Effective dose required for antagonist activity against pentylenetetrazole-induced seizures in mice when administered intraperitoneally; Range is 50-100 | ChEMBL. | 8289185 |
ED50 (functional) | = 100 mg kg-1 | Effective dose required for antagonist activity against pentylenetetrazole-induced seizures in mice when administered intraperitoneally; Range is 50-100 | ChEMBL. | 8289185 |
ED50 (functional) | = 200 mg kg-1 | Effective dose required for antagonist activity against maximal electroshock induced seizures in mice when administered intraperitoneally; Range is 100-200 | ChEMBL. | 8289185 |
ED50 (functional) | > 200 mg kg-1 | Effective dose required for antagonist activity against 3-mercaptopropionic-acid induced seizures in mice when administered intraperitoneally | ChEMBL. | 8289185 |
ED50 (functional) | = 200 mg kg-1 | Effective dose required for antagonist activity against maximal electroshock induced seizures in mice when administered intraperitoneally; Range is 100-200 | ChEMBL. | 8289185 |
ED50 (functional) | > 200 mg kg-1 | Effective dose required for antagonist activity against 3-mercaptopropionic-acid induced seizures in mice when administered intraperitoneally | ChEMBL. | 8289185 |
LD50 (ADMET) | = 800 mg kg-1 | Dose encompassing the 50% lethal effect was recorded when administered intraperitoneally in mice; Range is 400-800 | ChEMBL. | 8289185 |
LD50 (ADMET) | = 800 mg kg-1 | Dose encompassing the 50% lethal effect was recorded when administered intraperitoneally in mice; Range is 400-800 | ChEMBL. | 8289185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.