Detailed information for compound 334863

Basic information

Technical information
  • TDR Targets ID: 334863
  • Name: (2R)-2-[4-[4-(2-benzyl-1-benzofuran-3-yl)phen yl]phenoxy]-2-phenylacetic acid
  • MW: 510.579 | Formula: C35H26O4
  • H donors: 1 H acceptors: 2 LogP: 8.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H](c1ccccc1)Oc1ccc(cc1)c1ccc(cc1)c1c(Cc2ccccc2)oc2c1cccc2
  • InChi: 1S/C35H26O4/c36-35(37)34(28-11-5-2-6-12-28)38-29-21-19-26(20-22-29)25-15-17-27(18-16-25)33-30-13-7-8-14-31(30)39-32(33)23-24-9-3-1-4-10-24/h1-22,34H,23H2,(H,36,37)/t34-/m1/s1
  • InChiKey: BBLLDEJAERDDDB-UUWRZZSWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-[4-[4-(2-benzylbenzofuran-3-yl)phenyl]phenoxy]-2-phenyl-acetic acid
  • (2R)-2-[4-[4-(2-benzyl-3-benzofuranyl)phenyl]phenoxy]-2-phenylacetic acid
  • (2R)-2-phenyl-2-[4-[4-[2-(phenylmethyl)-1-benzofuran-3-yl]phenyl]phenoxy]ethanoic acid
  • (2R)-2-phenyl-2-[4-[4-[2-(phenylmethyl)-1-benzofuran-3-yl]phenyl]phenoxy]acetic acid
  • (2R)-2-phenyl-2-[4-[4-[2-(phenylmethyl)benzofuran-3-yl]phenyl]phenoxy]acetic acid
  • (2R)-2-phenyl-2-[4-[4-[2-(phenylmethyl)-3-benzofuranyl]phenyl]phenoxy]acetic acid
  • (2R)-2-[4-[4-[2-(benzyl)benzofuran-3-yl]phenyl]phenoxy]-2-phenyl-acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative Get druggable targets OG5_133865 All targets in OG5_133865
Loa Loa (eye worm) protein-tyrosine phosphatase Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum expressed protein Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus granulosus tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Brugia malayi Protein-tyrosine phosphatase containing protein Get druggable targets OG5_133865 All targets in OG5_133865
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0066 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0407 0.0406
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.005 0.0058
Schistosoma mansoni smad1 5 8 and 0.0041 0.032 0.0319
Echinococcus granulosus lamin 0.0026 0.0145 0.0144
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0973 0.0973
Schistosoma mansoni hypothetical protein 0.004 0.0304 0.0303
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0228 0.0227
Brugia malayi Isocitrate dehydrogenase 0.0064 0.0591 0.0685
Brugia malayi jmjC domain containing protein 0.011 0.1127 0.1305
Echinococcus granulosus Smad4 0.0041 0.032 0.0319
Schistosoma mansoni chromobox protein 0.0068 0.0636 0.0635
Treponema pallidum ribonuclease H (rnhA) 0.0023 0.0099 0.5
Schistosoma mansoni phosphoglucomutase 0.0023 0.0099 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0176 0.0175
Onchocerca volvulus 0.0319 0.3597 0.4164
Echinococcus granulosus dual specificity 0.019 0.207 0.207
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1132 0.1132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0407 0.0406
Schistosoma mansoni single-minded 0.0049 0.0415 0.0414
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.013 0.1366 0.1611
Echinococcus multilocularis ribokinase 0.0081 0.0794 0.0793
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1366 0.1551
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0909 0.0908
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0066 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0064 0.0591 0.059
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0122 0.0099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.1127 0.1126
Echinococcus multilocularis smad 0.0041 0.032 0.0319
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0066 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0066 0.0076
Onchocerca volvulus 0.004 0.0307 0.0355
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.019 0.207 0.2468
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0337 0.0336
Loa Loa (eye worm) hypothetical protein 0.0165 0.1786 0.2067
Brugia malayi Gooseberry protein 0.0014 0.0001 0.0001
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0164 0.0187
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.1127 0.1126
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0024 0.0122 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0066 0.0065
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0382 0.0381
Echinococcus granulosus chromobox protein 1 0.0068 0.0636 0.0635
Entamoeba histolytica cell division protein kinase 2, putative 0.0091 0.0909 0.0903
Leishmania major adenosine kinase, putative 0.0715 0.8269 1
Brugia malayi hypothetical protein 0.011 0.1132 0.1311
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0066 0.0076
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0066 0.0065
Brugia malayi PHD-finger family protein 0.0029 0.017 0.0197
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0861 0.086
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0317 0.0886
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.2716 0.3277
Echinococcus multilocularis cyclin dependent kinase 5 0.0091 0.0909 0.0908
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0648 0.075
Onchocerca volvulus 0.0746 0.8635 1
Echinococcus granulosus zinc finger protein 0.0022 0.0098 0.0097
Schistosoma mansoni hypothetical protein 0.0047 0.0391 0.039
Loa Loa (eye worm) hypothetical protein 0.0187 0.2044 0.2366
Schistosoma mansoni Smad4 0.0018 0.005 0.005
Mycobacterium tuberculosis Ribokinase RbsK 0.0081 0.0794 0.1711
Brugia malayi vab-3 gene. 0.0014 0.0001 0.0001
Echinococcus granulosus chromobox protein 1 0.0068 0.0636 0.0635
Echinococcus multilocularis lamin dm0 0.0026 0.0145 0.0144
Echinococcus granulosus cyclin dependent kinase 0.0091 0.0909 0.0908
Onchocerca volvulus 0.0037 0.0263 0.0304
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.013 0.1366 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0642 0.0641
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Brugia malayi PAS domain containing protein 0.0049 0.0415 0.048
Loa Loa (eye worm) hypothetical protein 0.0255 0.2847 0.3296
Loa Loa (eye worm) hypothetical protein 0.0097 0.0976 0.1129
Echinococcus multilocularis chromobox protein 1 0.0068 0.0636 0.0635
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0533 0.6129 0.6129
Echinococcus multilocularis peregrin 0.0036 0.026 0.0259
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0138 0.0137
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.019 0.207 0.2397
Onchocerca volvulus 0.003 0.0185 0.0214
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0091 0.0909 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0066 0.0076
Brugia malayi hypothetical protein 0.0103 0.1045 0.121
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Echinococcus granulosus dihydrofolate reductase 0.034 0.3843 0.3842
Leishmania major adenosine kinase-like protein 0.0081 0.0794 0.0949
Brugia malayi 'Paired box' domain containing protein 0.0014 0.0001 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0991 0.099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0066 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0066 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0428 0.0495
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0533 0.6129 0.6129
Brugia malayi intermediate filament protein 0.0026 0.0145 0.0168
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0081 0.0794 0.1711
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0591 0.0603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0407 0.0406
Schistosoma mansoni smad 0.0041 0.032 0.0319
Schistosoma mansoni programmed cell death protein 0.0058 0.0522 0.0521
Onchocerca volvulus 0.0026 0.0145 0.0167
Echinococcus granulosus programmed cell death protein 4 0.0058 0.0522 0.0521
Schistosoma mansoni hypothetical protein 0.004 0.0304 0.0303
Schistosoma mansoni hypothetical protein 0.0861 1 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0973 0.1408
Schistosoma mansoni bromodomain containing protein 0.0073 0.069 0.0689
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0311 0.031
Toxoplasma gondii MA3 domain-containing protein 0.0058 0.0522 0.0518
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0091 0.0909 0.1052
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.032 0.0319
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0319 0.0319
Toxoplasma gondii kinase, pfkB family protein 0.0081 0.0794 0.085
Echinococcus granulosus peregrin 0.0036 0.026 0.0259
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0064 0.0591 0.349
Schistosoma mansoni smad1 5 8 and 0.0041 0.032 0.0319
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.4829 0.4829
Schistosoma mansoni zinc finger protein 0.0022 0.0098 0.0097
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0976 0.1426
Trypanosoma brucei PAB1-binding protein , putative 0.0103 0.1045 0.1221
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0072 0.0082
Loa Loa (eye worm) hypothetical protein 0.0089 0.0883 0.1021
Trypanosoma brucei ribonuclease H1 0.0023 0.0099 0.0072
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1132 0.1132
Trypanosoma brucei hypothetical protein, conserved 0.0244 0.2716 0.3253
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.019 0.207 0.2495
Brugia malayi Pax transcription factor protein 2 0.0746 0.8635 1
Brugia malayi hypothetical protein 0.0081 0.0794 0.0919
Trichomonas vaginalis ribokinase, putative 0.0081 0.0794 0.2825
Trypanosoma brucei adenosine kinase, putative 0.0715 0.8269 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0066 0.0076
Trypanosoma cruzi adenosine kinase, putative 0.0715 0.8269 1
Echinococcus granulosus cyclin dependent kinase 1 0.0091 0.0909 0.0908
Loa Loa (eye worm) hypothetical protein 0.0187 0.2044 0.2366
Brugia malayi ecdysteroid receptor 0.002 0.0066 0.0076
Loa Loa (eye worm) MH2 domain-containing protein 0.0607 0.6996 0.8102
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0066 0.0065
Echinococcus multilocularis cyclin dependent kinase 1 0.0091 0.0909 0.0908
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0066 0.0065
Schistosoma mansoni hypothetical protein 0.004 0.0304 0.0303
Schistosoma mansoni hypothetical protein 0.0861 1 1
Onchocerca volvulus Ribokinase homolog 0.0081 0.0794 0.0918
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0066 0.0065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0066 0.0065
Leishmania major ribokinase, putative 0.0081 0.0794 0.0949
Schistosoma mansoni hypothetical protein 0.011 0.1132 0.1132
Echinococcus granulosus lamin dm0 0.0026 0.0145 0.0144
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0145 0.0167
Leishmania major tagatose-6-phosphate kinase-like protein 0.0081 0.0794 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0322 0.0907
Schistosoma mansoni zinc finger protein 0.0018 0.004 0.0039
Onchocerca volvulus 0.0047 0.0391 0.0452
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1463 0.1462
Entamoeba histolytica protein kinase, putative 0.019 0.207 1
Leishmania major dihydrofolate reductase-thymidylate synthase 0.013 0.1366 0.1641
Trypanosoma cruzi cdc2-related kinase 1 0.0091 0.0909 0.1088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0591 0.059
Loa Loa (eye worm) nuclear factor I 0.0023 0.0102 0.0117
Brugia malayi 'Paired box' domain containing protein 0.0014 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0337 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0794 0.2825
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0322 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0066 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0066 0.0065
Schistosoma mansoni hypothetical protein 0.0071 0.0669 0.0668
Brugia malayi 'Paired box' domain containing protein 0.0014 0.0001 0.0001
Trypanosoma cruzi adenosine kinase, putative 0.0715 0.8269 1
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0112 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0151 0.0213
Echinococcus multilocularis dual specificity 0.019 0.207 0.207
Schistosoma mansoni hypothetical protein 0.0033 0.0228 0.0227
Trypanosoma brucei ribokinase, putative 0.0081 0.0794 0.0916
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2573 0.2572
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.1635 0.1892
Echinococcus granulosus smad 0.0041 0.032 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0066 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0066 0.0076
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.005 0.005
Plasmodium falciparum protein kinase 5 0.0091 0.0909 0.5987
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1366 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0352 0.0407
Brugia malayi RNase H family protein 0.0023 0.0099 0.0114
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.1045 0.7181
Brugia malayi hypothetical protein 0.0066 0.0615 0.0712
Brugia malayi Heterochromatin protein 1 0.0068 0.0636 0.0736
Loa Loa (eye worm) hypothetical protein 0.0104 0.1056 0.1222
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0097 0.0976 0.1129
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0228 0.0262
Brugia malayi hypoxia-induced factor 1 0.0153 0.1635 0.1893
Schistosoma mansoni hypothetical protein 0.0033 0.0219 0.0219
Toxoplasma gondii kinase, pfkB family protein 0.0715 0.8269 1
Loa Loa (eye worm) hypothetical protein 0.0255 0.2847 0.3296
Brugia malayi Pre-SET motif family protein 0.0029 0.0176 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.019 0.207 0.207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0642 0.0641
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1132 0.1132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0066 0.0076
Echinococcus multilocularis geminin 0.0861 1 1
Schistosoma mansoni phosphoglucomutase 0.0023 0.0099 0.0098
Echinococcus multilocularis ribonuclease H1 0.0023 0.0099 0.0098
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0039
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0145 0.0167
Giardia lamblia PHD finger protein 15 0.0033 0.0228 0.1588
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0057
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0122 0.0099
Echinococcus multilocularis Smad4 0.0041 0.032 0.0319
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.019 0.207 0.2495
Onchocerca volvulus Putative pyridoxal kinase 0.0081 0.0794 0.0918
Trypanosoma cruzi ISWI complex protein 0.0018 0.004 0.0036
Brugia malayi MH2 domain containing protein 0.0607 0.6996 0.8102
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0976 0.1426
Brugia malayi CHE-14 protein 0.0041 0.0322 0.0373
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.005 0.0057
Echinococcus multilocularis musashi 0.0026 0.0145 0.0144
Trypanosoma brucei unspecified product 0.0024 0.0122 0.0099
Loa Loa (eye worm) isocitrate dehydrogenase 0.0064 0.0591 0.0684
Loa Loa (eye worm) hypothetical protein 0.0026 0.0145 0.0167
Leishmania major hypothetical protein, conserved 0.0018 0.004 0.0036
Onchocerca volvulus Alhambra homolog 0.0033 0.0228 0.0262
Brugia malayi paired box protein 0.0014 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.019 0.207 0.2398
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0636 0.0735
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0066 0.0065
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0163 0.0162
Echinococcus multilocularis programmed cell death protein 4 0.0058 0.0522 0.0521
Entamoeba histolytica heat shock transcription factor, putative 0.0097 0.0976 0.1426
Brugia malayi Protein kinase domain containing protein 0.0091 0.0909 0.1053
Trypanosoma cruzi adenosine kinase, putative 0.0081 0.0794 0.0949
Schistosoma mansoni thyroid hormone receptor 0.002 0.0066 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0066 0.0075
Brugia malayi PHD-finger family protein 0.0033 0.0228 0.0263
Schistosoma mansoni smad1 5 8 and 0.0041 0.032 0.0319
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0066 0.0065
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.005 0.005
Entamoeba histolytica protein kinase, putative 0.019 0.207 1
Entamoeba histolytica hypothetical protein 0.011 0.1132 0.2653
Echinococcus granulosus single minded 2 0.0037 0.0263 0.0262
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.034 0.3843 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0033 0.0228 0.0262
Schistosoma mansoni hypothetical protein 0.0033 0.0219 0.0219
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0322 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0151 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0283 0.0747
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0973 0.1127
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0066 0.0076
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0322 0.0321
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.034 0.3843 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0794 0.0918
Echinococcus multilocularis isocitrate dehydrogenase 0.0064 0.0591 0.059
Schistosoma mansoni smad 0.0018 0.005 0.005
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0228 0.0157
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0407 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0428 0.0427
Schistosoma mansoni intermediate filament proteins 0.0026 0.0145 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0428 0.0427
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.013 0.1366 0.1641
Brugia malayi MH2 domain containing protein 0.0041 0.032 0.0371
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0219 0.0253
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0064 0.0591 0.0704
Schistosoma mansoni hypothetical protein 0.004 0.0304 0.0303
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.019 0.207 0.2495
Trypanosoma brucei cdc2-related kinase 3 0.0091 0.0909 0.1056
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0058 0.0522 0.2589
Leishmania major hypothetical protein, conserved 0.0103 0.1045 0.1253
Brugia malayi RNase H family protein 0.0023 0.0099 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0066 0.0076
Brugia malayi Adenosine kinase-like 0.0715 0.8269 0.9576
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0081 0.0794 0.1711
Brugia malayi dihydrofolate reductase family protein 0.034 0.3843 0.445
Loa Loa (eye worm) hypothetical protein 0.0026 0.0139 0.016
Trypanosoma brucei cdc2-related kinase 1 0.0091 0.0909 0.1056
Brugia malayi nuclear receptor NHR-88 0.002 0.0066 0.0076
Echinococcus multilocularis zinc finger protein 0.0022 0.0098 0.0097
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0071 0.0669 0.0774
Echinococcus granulosus adenosine kinase 0.0715 0.8269 0.8269
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0007 0.0006
Echinococcus multilocularis adenosine kinase 0.0715 0.8269 0.8269
Trypanosoma cruzi ISWI complex protein 0.0018 0.004 0.0036
Onchocerca volvulus 0.002 0.0066 0.0075
Leishmania major hypothetical protein, conserved 0.0244 0.2716 0.3277
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0337 0.0389
Onchocerca volvulus 0.0026 0.0145 0.0167
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.4829 0.4829
Brugia malayi MH2 domain containing protein 0.0018 0.005 0.0058
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0164 0.0187
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.9231 0.9231
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0066 0.0065
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0066 0.0065
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0099 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0428 0.0427
Brugia malayi chromobox protein homolog 3 0.0038 0.0283 0.0327
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1056 0.1222
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0066 0.0076
Trypanosoma cruzi ribonuclease H1, putative 0.0023 0.0099 0.0108
Brugia malayi Dihydrofolate reductase 0.034 0.3843 0.445
Loa Loa (eye worm) hypothetical protein 0.003 0.0185 0.0214
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.034 0.3843 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0432 0.0499
Echinococcus granulosus expressed conserved protein 0.0091 0.0904 0.0903
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0066 0.0076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0066 0.0075
Schistosoma mansoni ribokinase 0.0081 0.0794 0.0793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0428 0.0427
Brugia malayi Bromodomain containing protein 0.0086 0.0849 0.0983
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0164 0.0187
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0066 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0066 0.0076
Plasmodium vivax protein kinase Crk2 0.0091 0.0909 0.6161
Leishmania major adenosine kinase-like protein 0.0081 0.0794 0.0949
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0015 0.0007 0.0007
Brugia malayi steroid hormone receptor 0.002 0.0066 0.0076
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0145 0.0168
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0081 0.0794 0.0793
Mycobacterium ulcerans fructokinase, PfkB 0.0081 0.0794 0.1711
Schistosoma mansoni programmed cell death protein 0.0058 0.0522 0.0521
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0176 0.0094
Giardia lamblia Kinase, CMGC CDK 0.0091 0.0909 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0283 0.0326
Echinococcus granulosus intermediate filament protein 0.0026 0.0145 0.0144
Echinococcus multilocularis beta adrenergic receptor kinase 0.0015 0.0007 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0607 0.6996 0.8102
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0066 0.0065
Brugia malayi hypothetical protein 0.0232 0.2573 0.298
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0066 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0066 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0066 0.0065
Schistosoma mansoni adenosine kinase 0.0715 0.8269 0.8269
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0023 0.0099 0.5
Brugia malayi Pre-SET motif family protein 0.0203 0.2228 0.258
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0066 0.0065
Echinococcus multilocularis lamin 0.0026 0.0145 0.0144
Loa Loa (eye worm) hypothetical protein 0.0057 0.051 0.059
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0219 0.0219
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0228 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.2716 0.3277
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0382 0.0381
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0228 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.005 0.0057
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.005 0.005
Trypanosoma brucei RNA helicase, putative 0.0085 0.0832 0.0963
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.032 0.0319
Entamoeba histolytica hypothetical protein 0.019 0.207 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0063 0.0063
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0018 0.005 0.0057
Schistosoma mansoni Smad4 0.0018 0.005 0.005
Trypanosoma brucei ribokinase, putative 0.0081 0.0794 0.0916
Brugia malayi MH2 domain containing protein 0.0041 0.032 0.0371
Brugia malayi nuclear hormone receptor 0.002 0.0066 0.0076
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0428 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0066 0.0075
Leishmania major putative PfkB family sugar kinase 0.0081 0.0794 0.0949
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.032 0.037
Loa Loa (eye worm) hypothetical protein 0.0715 0.8269 0.9576
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0176 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0428 0.0427
Echinococcus granulosus FTZ F1 alpha 0.002 0.0066 0.0065
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0066 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0066 0.0065
Trypanosoma cruzi cdc2-related kinase 3 0.0091 0.0909 0.1088
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.1045 0.1253
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0337 0.0336
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0636 0.2183
Mycobacterium tuberculosis Adenosine kinase 0.0081 0.0794 0.1711
Onchocerca volvulus 0.0633 0.7308 0.8463
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0138 0.0137
Trypanosoma brucei ingi protein (ORF1) 0.0024 0.0122 0.0099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0066 0.0065
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0063 0.0063
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0091 0.0909 0.0991
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0909 0.3293
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0415 0.0414
Brugia malayi jmjC domain containing protein 0.0043 0.0337 0.039
Brugia malayi Cytochrome P450 family protein 0.0022 0.0093 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0066 0.0075
Brugia malayi MH1 domain containing protein 0.0041 0.032 0.0371
Entamoeba histolytica hypothetical protein 0.011 0.1132 0.2653
Toxoplasma gondii LsmAD domain-containing protein 0.0103 0.1045 0.1158
Leishmania major tagatose-6-phosphate kinase-like protein 0.0081 0.0794 0.0949
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0064 0.0591 0.059
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0091 0.0909 0.1088
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0317 0.0366
Schistosoma mansoni lamin 0.0026 0.0145 0.0144
Brugia malayi Smad1 0.0041 0.032 0.0371
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.4829 0.4829
Brugia malayi Ribokinase 0.0081 0.0794 0.0919
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0138 0.0137
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0591 0.0603
Brugia malayi MH1 domain containing protein 0.0023 0.0102 0.0118
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0091 0.0909 0.1052
Entamoeba histolytica protein kinase domain containing protein 0.019 0.207 1
Onchocerca volvulus 0.0081 0.0794 0.0918
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0066 0.0076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0081 0.0794 0.0918
Schistosoma mansoni hypothetical protein 0.0085 0.0832 0.0831
Trichomonas vaginalis ribokinase, putative 0.0081 0.0794 0.2825
Echinococcus multilocularis cyclin dependent kinase 0.0091 0.0909 0.0908
Loa Loa (eye worm) hypothetical protein 0.0097 0.0973 0.1126
Echinococcus multilocularis GPCR, family 2 0.0033 0.0219 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.4829 0.5593
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0322 0.0321
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0376 0.0375
Schistosoma mansoni hypothetical protein 0.0046 0.0376 0.0375
Loa Loa (eye worm) hypothetical protein 0.0033 0.0219 0.0253
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1463 0.1462
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0263 0.0269
Plasmodium vivax ataxin-2 like protein, putative 0.0103 0.1045 0.7304
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0591 0.0704
Echinococcus multilocularis dihydrofolate reductase 0.034 0.3843 0.3842
Brugia malayi HSF-type DNA-binding domain containing protein 0.0097 0.0976 0.113
Loa Loa (eye worm) dihydrofolate reductase 0.034 0.3843 0.445
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0091 0.0909 0.0908
Trypanosoma cruzi ribokinase, putative 0.0081 0.0794 0.0949
Echinococcus multilocularis protein patched 0.0041 0.0322 0.0321
Echinococcus granulosus ribonuclease H1 0.0023 0.0099 0.0098
Schistosoma mansoni patched 1 0.0041 0.0322 0.0321
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0066 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0066 0.0076
Giardia lamblia Kinase, CMGC CDK 0.0091 0.0909 1
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0909 0.3293
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0283 0.0747
Entamoeba histolytica hypothetical protein 0.011 0.1132 0.2653
Echinococcus granulosus beta-adrenergic receptor kinase 0.0015 0.0007 0.0006
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0228 0.0227
Trypanosoma brucei adenosine kinase, putative 0.0715 0.8269 1
Brugia malayi hypothetical protein 0.0319 0.3597 0.4165
Echinococcus multilocularis protein dispatched 1 0.0047 0.0391 0.039
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0391 0.0453
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0064 0.0591 0.3195
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0522 0.291
Loa Loa (eye worm) hypothetical protein 0.0319 0.3597 0.4164
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0591 0.059
Schistosoma mansoni hypothetical protein 0.0033 0.0219 0.0219
Entamoeba histolytica hypothetical protein 0.011 0.1132 0.2653
Brugia malayi hypothetical protein 0.0165 0.1786 0.2068
Onchocerca volvulus 0.0231 0.2559 0.2962
Onchocerca volvulus Ribonuclease H1 homolog 0.0023 0.0099 0.0113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0066 0.0076
Schistosoma mansoni coup transcription factor 0.002 0.0066 0.0065
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.005 0.005
Brugia malayi RNase H family protein 0.0023 0.0099 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0219 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0428 0.0427
Schistosoma mansoni phosphoglucomutase 0.0023 0.0099 0.0098
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0319 0.0319
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1056 0.1223
Trypanosoma cruzi cdc2-related kinase 1 0.0091 0.0909 0.1088
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0164 0.0164
Loa Loa (eye worm) Smad1 0.0041 0.032 0.037
Brugia malayi isocitrate dehydrogenase 0.0064 0.0591 0.0685
Loa Loa (eye worm) hypothetical protein 0.0081 0.0791 0.0915
Schistosoma mansoni thyroid hormone receptor 0.002 0.0066 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0669 0.0775
Trypanosoma cruzi cdc2-related kinase 3 0.0091 0.0909 0.1088
Schistosoma mansoni hypothetical protein 0.0024 0.0112 0.0111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0591 0.059
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2559 1
Schistosoma mansoni hypothetical protein 0.0033 0.0219 0.0219
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0066 0.0075
Schistosoma mansoni Smad4 0.0041 0.032 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0307 0.0306
Schistosoma mansoni dihydrofolate reductase 0.034 0.3843 0.3842
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0075
Schistosoma mansoni adenosine kinase 0.0715 0.8269 0.8269
Brugia malayi MH1 domain containing protein 0.0023 0.0102 0.0118
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0909 0.0908
Trypanosoma cruzi PAB1-binding protein , putative 0.0103 0.1045 0.1253
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0063 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0066 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.032 0.037
Schistosoma mansoni chromobox protein 0.0068 0.0636 0.0635
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0428 0.0427
Echinococcus multilocularis cyclin dependent kinase 1 0.0091 0.0909 0.0908
Loa Loa (eye worm) hypothetical protein 0.0047 0.0385 0.0444
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0326
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0533 0.6129 0.6129
Schistosoma mansoni nuclear hormone receptor 0.002 0.0066 0.0065
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0064 0.0591 0.059
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0263 0.0305
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0164 0.0267
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0909 0.3293
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0093 0.0106
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0091 0.0909 0.1052
Echinococcus granulosus GPCR family 2 0.0033 0.0219 0.0219
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0164 0.0164
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0591 0.067
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.032 0.0319
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0263 0.0262
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0317 0.0886
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1056 0.1223
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0591 0.0704
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.032 0.0319
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0064 0.0591 0.067
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0103 0.1045 0.1209
Leishmania major ribonuclease H1, putative 0.0023 0.0099 0.0108
Brugia malayi hypothetical protein 0.0255 0.2847 0.3297
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0064 0.0591 0.116
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0015 0.0007 0.0008
Schistosoma mansoni survival motor neuron protein 0.0047 0.0391 0.039
Echinococcus multilocularis expressed conserved protein 0.0091 0.0904 0.0903
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.032 0.0319
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.4829 0.5592
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0081 0.0794 0.0793
Giardia lamblia Ribokinase 0.0081 0.0794 0.8577
Loa Loa (eye worm) hypothetical protein 0.0049 0.041 0.0474
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0066 0.0075
Echinococcus granulosus ribokinase 0.0081 0.0794 0.0793
Brugia malayi Bromodomain containing protein 0.0036 0.026 0.0301
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0015 0.0007 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0636 0.2183
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2573 0.2572
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0219 0.0219
Entamoeba histolytica cell division protein kinase 2, putative 0.0091 0.0909 0.0903
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0219 0.0254
Brugia malayi paired box pox-meso protein 0.0014 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0103 0.1045 0.7181
Loa Loa (eye worm) hypothetical protein 0.0533 0.6129 0.7098
Trichomonas vaginalis ribokinase, putative 0.0081 0.0794 0.2825
Loa Loa (eye worm) hypothetical protein 0.0023 0.0102 0.0117
Loa Loa (eye worm) hypothetical protein 0.0041 0.0322 0.0372
Loa Loa (eye worm) hypothetical protein 0.0232 0.2573 0.2979
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0228 0.0434
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0376 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0007 0.0006
Brugia malayi Bromodomain containing protein 0.0044 0.0352 0.0407
Brugia malayi cell division control protein 2 homolog 0.0091 0.0909 0.1053
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0049 0.0407 0.047
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2228 0.2579
Schistosoma mansoni lamin 0.0026 0.0145 0.0144
Echinococcus multilocularis chromobox protein 1 0.0068 0.0636 0.0635
Brugia malayi MH1 domain containing protein 0.0041 0.032 0.0371
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0066 0.0065
Loa Loa (eye worm) pax transcription factor protein 2 0.0746 0.8635 1
Echinococcus granulosus cyclin dependent kinase 5 0.0091 0.0909 0.0908
Chlamydia trachomatis dihydrofolate reductase 0.034 0.3843 0.5
Trypanosoma cruzi adenosine kinase, putative 0.0081 0.0794 0.0949

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -0.39 Concentration required for 50% inhibition of tyrosine phosphatase 1B ChEMBL. 15537353
IC50 (binding) = 6.4 Binding affinity to human recombinant PTP1B ChEMBL. 20452766
IC50 (binding) = 0.4 uM In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B) ChEMBL. 10753467
Log IC50 (binding) = 0.39 Concentration required for 50% inhibition of tyrosine phosphatase 1B ChEMBL. 15537353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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