Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cytochrome c | 0.0032 | 0.2662 | 0.2662 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | semaphorin 1A | 0.003 | 0.2348 | 0.2348 |
Trypanosoma brucei | cytochrome c | 0.0032 | 0.2662 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.7274 | 0.7274 |
Leishmania major | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Echinococcus multilocularis | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Onchocerca volvulus | 0.0072 | 0.8169 | 1 | |
Loa Loa (eye worm) | sema domain-containing protein | 0.003 | 0.2348 | 0.2348 |
Schistosoma mansoni | semaphorin 5-related | 0.003 | 0.2348 | 0.2874 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.7274 | 0.7274 |
Echinococcus multilocularis | cytochrome c | 0.0032 | 0.2662 | 0.2662 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.2348 | 0.2874 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0013 | 0 | 0.5 |
Brugia malayi | Sema domain containing protein | 0.003 | 0.2348 | 0.2348 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0018 | 0.0681 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0013 | 0 | 0.5 |
Plasmodium vivax | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Schistosoma mansoni | cytochrome c | 0.0032 | 0.2662 | 0.3259 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.7274 | 0.8904 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.7274 | 0.7274 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.7274 | 0.7274 |
Echinococcus granulosus | semaphorin 5B | 0.003 | 0.2348 | 0.2348 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.7274 | 0.7274 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.7274 | 0.7274 |
Schistosoma mansoni | plexin | 0.0072 | 0.8169 | 1 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0032 | 0.2662 | 0.2662 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.3991 | 0.4885 |
Toxoplasma gondii | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.2348 | 0.2874 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3991 | 0.3991 |
Brugia malayi | Plexin repeat family protein | 0.0072 | 0.8169 | 0.8169 |
Loa Loa (eye worm) | sema domain-containing protein | 0.003 | 0.2348 | 0.2348 |
Leishmania major | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0085 | 1 | 1 |
Trypanosoma cruzi | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Schistosoma mansoni | plexin | 0.0042 | 0.3991 | 0.4885 |
Brugia malayi | Sema domain containing protein | 0.003 | 0.2348 | 0.2348 |
Brugia malayi | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.7274 | 0.7274 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.7274 | 0.7274 |
Brugia malayi | Cytochrome c type-1 | 0.0032 | 0.2662 | 0.2662 |
Trypanosoma cruzi | cytochrome c, putative | 0.0032 | 0.2662 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0032 | 0.2662 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.7274 | 0.7274 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.7274 | 0.7274 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.7274 | 0.7274 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.7274 | 0.7274 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0018 | 0.0681 | 1 |
Echinococcus multilocularis | semaphorin 5B | 0.003 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | plexin A | 0.0085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.8169 | 0.8169 |
Echinococcus granulosus | plexin a4 | 0.0085 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.2348 | 0.2348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 2490 uM | Inhibition of [3H]-Leucine uptake into CHO cells | ChEMBL. | 15828841 |
IC50 (functional) | > 8300 uM | Inhibition of [3H]-Leucine uptake into CHO cells | ChEMBL. | 15828841 |
Ki (binding) | = 0.037 uM | Equilibrium dissociation constant for Voltage-gated calcium channel alpha2-delta subunit as inhibition of [3H]-gabapentin binding to pig brain membranes | ChEMBL. | 15828841 |
Ki (binding) | = 0.33 uM | Equilibrium dissociation constant for Voltage-gated calcium channel alpha2-delta subunit as inhibition of [3H]-gabapentin binding to pig brain membranes | ChEMBL. | 15828841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.