Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, alpha | 451 aa | 372 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0176 | 0.1523 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0301 | 0.9282 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0176 | 0.1523 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.7 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
IC50 (binding) | = 5.24 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
IC50 (binding) | = 5.24 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
IC50 (binding) | uM | Inhibitory activity of the compound against human TRAFbeta; Not tested | ChEMBL. | 15857115 |
IC50 (binding) | 0 uM | Inhibitory activity of the compound against human TRAFalpha; Not tested | ChEMBL. | 15857115 |
IC50 (binding) | 0 uM | Inhibitory activity of the compound against human TRAFbeta; Not tested | ChEMBL. | 15857115 |
IC50 (binding) | = 5.7 uM | Inhibitory activity against human Thyroid hormone receptor beta | ChEMBL. | 15857115 |
IC50 (binding) | = 5.7 uM | Inhibitory activity against human Thyroid hormone receptor beta | ChEMBL. | 15857115 |
IC50 (binding) | = 20 uM | Inhibitory activity against human Thyroid hormone receptor alpha | ChEMBL. | 15857115 |
IC50 (binding) | = 20 uM | Inhibitory activity against human Thyroid hormone receptor alpha | ChEMBL. | 15857115 |
Log IC50 (binding) | = 4.7 | Inhibition of thyroid hormone receptor alpha (unknown origin) | ChEMBL. | 17467994 |
Log IC50 (binding) | = 5.24 | Inhibition of human thyroid hormone receptor beta 1 | ChEMBL. | 17524652 |
Log IC50 (binding) | = 5.24 | Inhibition of thyroid hormone receptor beta (unknown origin) | ChEMBL. | 17467994 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.