Detailed information for compound 335364

Basic information

Technical information
  • TDR Targets ID: 335364
  • Name: methyl 2-[[(2S)-1-amino-1-oxopropan-2-yl]carb amoyl]-2-benzylazetidine-1-carboxylate
  • MW: 319.356 | Formula: C16H21N3O4
  • H donors: 2 H acceptors: 3 LogP: 0.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)N1CCC1(Cc1ccccc1)C(=O)N[C@H](C(=O)N)C
  • InChi: 1S/C16H21N3O4/c1-11(13(17)20)18-14(21)16(8-9-19(16)15(22)23-2)10-12-6-4-3-5-7-12/h3-7,11H,8-10H2,1-2H3,(H2,17,20)(H,18,21)/t11-,16?/m0/s1
  • InChiKey: NSCBPMOBROYTEG-CHPOKUKFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 2-[[(1S)-2-amino-1-methyl-2-oxo-ethyl]carbamoyl]-2-benzyl-azetidine-1-carboxylate
  • 2-[[[(1S)-2-amino-1-methyl-2-oxoethyl]amino]-oxomethyl]-2-benzyl-1-azetidinecarboxylic acid methyl ester
  • methyl 2-[[(2S)-1-azanyl-1-oxo-propan-2-yl]carbamoyl]-2-(phenylmethyl)azetidine-1-carboxylate
  • 2-[[(1S)-2-amino-2-keto-1-methyl-ethyl]carbamoyl]-2-benzyl-azetidine-1-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1051 0.3936
Entamoeba histolytica protein kinase, putative 0.0101 0.1051 1
Leishmania major cytochrome p450-like protein 0.0016 0.012 0.0166
Schistosoma mansoni netrin receptor unc5 0.0016 0.0123 0.0459
Echinococcus multilocularis lamin dm0 0.003 0.0279 0.0226
Loa Loa (eye worm) D-ets-2 protein 0.0012 0.0075 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.012 0.0105
Brugia malayi Cytochrome P450 family protein 0.0026 0.0229 0.0643
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0858 0.4036
Brugia malayi follicle stimulating hormone receptor 0.0261 0.2816 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0356 0.0799
Brugia malayi Protein kinase domain containing protein 0.0101 0.1051 0.3617
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.012 0.0105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0315 0.0262
Brugia malayi Protein kinase domain containing protein 0.0017 0.0128 0.028
Chlamydia trachomatis methylated-DNA protein-cysteine methyltransferase 0.02 0.2145 0.5
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0123 0.0347
Schistosoma mansoni lamin 0.003 0.0279 0.1044
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.012 0.0105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0279 0.0596
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0315 0.0262
Echinococcus granulosus death domain containing protein 0.0016 0.0123 0.0347
Brugia malayi transcription factor E74 isoform 0.0012 0.0075 0.0086
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.02 0.2145 1
Brugia malayi cytochrome P450 0.0016 0.012 0.025
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.0192
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0101 0.1051 0.4687
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.012 0.0105
Leishmania major cytochrome p450-like protein 0.0026 0.0229 0.0693
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0842 0.2068
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.012 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.012 0.0105
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0014 0.01 0.0128
Schistosoma mansoni gabp alpha 0.0082 0.0842 0.3154
Loa Loa (eye worm) hypothetical protein 0.01 0.1045 0.2598
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.012 0.0166
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.012 0.3811
Schistosoma mansoni elf1 0.0012 0.0075 0.0279
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0209 0.0156
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0075 0.0086
Schistosoma mansoni DNA helicase recq5 0.001 0.0054 0.0201
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.001
Onchocerca volvulus 0.0267 0.2883 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0062
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0123 0.0254
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.001
Brugia malayi Death domain containing protein 0.0016 0.0123 0.026
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0229 0.0464
Loa Loa (eye worm) hypothetical protein 0.007 0.0712 0.1728
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.012 0.0105
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.012 0.0105
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.1703
Echinococcus granulosus protein C ets 2 0.0012 0.0075 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.012 0.0105
Trichomonas vaginalis methylated-DNA--protein-cysteine methyltransferase, putative 0.02 0.2145 0.7398
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0054 0.1703
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0839 0.7807
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0858 0.0808
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.012 0.0166
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0229 0.0464
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.012 0.0105
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0229 0.1479
Echinococcus multilocularis lamin 0.003 0.0279 0.0226
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.012 0.0105
Schistosoma mansoni intermediate filament proteins 0.003 0.0279 0.1044
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.1051 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.012 0.0105
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.012 0.0105
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0153 0.0574
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0086 0.0815
Brugia malayi hypothetical protein 0.0137 0.1454 0.5073
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0177 1
Schistosoma mansoni cytochrome P450 0.0016 0.012 0.0449
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0315 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0315 0.0954
Schistosoma mansoni hypothetical protein 0.0016 0.0123 0.0459
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0155 0.0273
Loa Loa (eye worm) fli-1 protein 0.0248 0.2671 0.6845
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.012 0.0105
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0075 0.0021
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.1051 0.4687
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.012 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0315 0.1178
Schistosoma mansoni DNA helicase recq1 0.001 0.0054 0.0201
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0301 0.1242
Mycobacterium ulcerans DNA-methyltransferase (modification methylase) 0.0081 0.0839 0.1198
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0121 0.3851
Brugia malayi intermediate filament protein 0.003 0.0279 0.0824
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0075 0.0106
Brugia malayi Ets-domain containing protein 0.0082 0.0842 0.2862
Loa Loa (eye worm) hypothetical protein 0.0358 0.3878 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0123 0.019
Onchocerca volvulus 0.003 0.0279 0.0805
Echinococcus granulosus lamin 0.003 0.0279 0.113
Loa Loa (eye worm) hypothetical protein 0.0014 0.01 0.0128
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.2816 0.7226
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0075 0.0021
Loa Loa (eye worm) ets-domain-containing protein 0.0012 0.0075 0.0062
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.012 0.0105
Echinococcus multilocularis 0.0016 0.012 0.0067
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0101 0.1051 1
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0086 0.0123
Echinococcus granulosus lamin dm0 0.003 0.0279 0.113
Loa Loa (eye worm) hypothetical protein 0.0016 0.0123 0.0188
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0101 0.1051 0.2613
Onchocerca volvulus 0.003 0.0279 0.0805
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.012 0.0105
Schistosoma mansoni hypothetical protein 0.0191 0.2046 0.766
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.012 0.0105
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0075 0.0021
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0229 0.0464
Mycobacterium tuberculosis Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra 0.0608 0.6634 1
Onchocerca volvulus 0.0034 0.0315 0.0931
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.012 0.0333
Schistosoma mansoni hypothetical protein 0.0191 0.2046 0.766
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.012 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0229 0.0693
Echinococcus multilocularis Ankyrin 0.0016 0.0124 0.0071
Brugia malayi Uncoordinated protein 44 0.0016 0.0123 0.026
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0006
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0075 0.0021
Schistosoma mansoni ets 0.0012 0.0075 0.0279
Echinococcus granulosus geminin 0.0191 0.2046 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.012 0.0105
Schistosoma mansoni hypothetical protein 0.0016 0.012 0.0449
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0123 0.0188
Loa Loa (eye worm) RecQ helicase 0.0024 0.0209 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0315 0.1178
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0054 0.0007
Echinococcus granulosus Ankyrin 0.0016 0.0124 0.0354
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0123 0.0069
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0012 0.0075 0.0062
Schistosoma mansoni ets-related 0.0012 0.0075 0.0279
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0075 0.0021
Brugia malayi Pre-SET motif family protein 0.0235 0.2525 0.8947
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.012 0.0105
Echinococcus multilocularis ets variant gene 4 0.0012 0.0075 0.0021
Schistosoma mansoni hypothetical protein 0.0012 0.0075 0.0279
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0075 0.0106
Brugia malayi Ets-domain containing protein 0.0082 0.0842 0.2862
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.012 0.0105
Entamoeba histolytica protein kinase, putative 0.0101 0.1051 1
Echinococcus granulosus dual specificity 0.0101 0.1051 0.5007
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.02 0.2145 1
Schistosoma mansoni ets-related 0.0248 0.2671 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1045 0.2598
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0229 0.027
Brugia malayi Cytochrome P450 family protein 0.0026 0.0229 0.0643
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0124 0.0465
Loa Loa (eye worm) hypothetical protein 0.0034 0.0315 0.0689
Loa Loa (eye worm) hypothetical protein 0.0012 0.0075 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.012 0.0105
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.012 0.0105
Plasmodium vivax SET domain protein, putative 0.0034 0.0315 1
Schistosoma mansoni hypothetical protein 0.0012 0.0075 0.0279
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.012 0.0105
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0075 0.0106
Echinococcus multilocularis geminin 0.0191 0.2046 0.2003
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.012 0.0105
Brugia malayi Cytochrome P450 family protein 0.0016 0.012 0.025
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0209 0.0559
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0123 0.0347
Mycobacterium ulcerans methylated-DNA--protein-cysteine methyltransferase Ogt 0.0608 0.6634 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.012 0.0105
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.012 0.0105
Echinococcus granulosus bloom syndrome protein 0.0024 0.0209 0.078
Brugia malayi Ets-domain containing protein 0.0012 0.0075 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0315 0.131
Mycobacterium leprae PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA 0.0608 0.6634 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.012 0.0166
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.012 0.0105
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0106 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0315 0.1178
Echinococcus multilocularis dual specificity 0.0101 0.1051 0.1003
Schistosoma mansoni lamin 0.003 0.0279 0.1044
Loa Loa (eye worm) cytochrome P450 0.0016 0.012 0.0181
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.012 0.0105
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0101 0.1051 0.4687
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0209 0.0572
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.012 0.0105
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0106 0.0052
Echinococcus multilocularis protein C ets 2 0.0012 0.0075 0.0021
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0123 0.0459
Trichomonas vaginalis set domain proteins, putative 0.0267 0.2882 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0123 0.0263
Leishmania major cytochrome p450-like protein 0.0016 0.012 0.0166
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0075 0.0106
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0229 0.0693
Brugia malayi Cytochrome P450 family protein 0.0037 0.0356 0.1105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.2525 0.6465
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.012 0.0105
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.012 0.0166
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0842 0.396
Loa Loa (eye worm) hypothetical protein 0.001 0.0054 0.0007
Entamoeba histolytica hypothetical protein 0.0101 0.1051 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0279 0.0596
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.012 0.0105
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0209 0.0559
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0842 0.0793
Echinococcus multilocularis musashi 0.003 0.0279 0.0226
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0123 0.0069
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.012 0.0105
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0075 0.0106
Brugia malayi Fli-1 protein 0.0248 0.2671 0.9473
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0054 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0012 0.0075 0.0062
Echinococcus granulosus intermediate filament protein 0.003 0.0279 0.113
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0075 0.0106
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0075 0.0021
Treponema pallidum methylated-DNA-protein-cysteine S-methyltransferase (dat) 0.02 0.2145 0.5
Leishmania major hypothetical protein, conserved 0.02 0.2145 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0106 0.0144
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0123 0.026
Loa Loa (eye worm) intermediate filament protein 0.003 0.0279 0.0596
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0315 0.1178
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.012 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.012 0.0105
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0075 0.0279
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0279 0.0824
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.012 0.0354
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.058

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 200 uM Cytotoxic concentration required to reduce HEL cell growth ChEMBL. 15801851
CC50 (functional) > 200 uM Cytotoxic concentration required to reduce HEL cell growth ChEMBL. 15801851
EC50 (functional) = 346 uM Effective concentration required to reduce varicella-zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line ChEMBL. 15801851
EC50 (functional) = 346 uM Effective concentration required to reduce varicella-zoster virus 07/1(TK-) plaque formation after 5 days in HEL fibroblast cell line ChEMBL. 15801851
EC50 (functional) > 400 uM Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection ChEMBL. 15801851
EC50 (functional) > 400 uM Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection ChEMBL. 15801851
EC50 (functional) > 400 uM Effective concentration required to reduce varicella-zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line ChEMBL. 15801851
EC50 (functional) > 400 uM Effective concentration required to inhibit human cytomegalo virus AD-169 induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection ChEMBL. 15801851
EC50 (functional) > 400 uM Effective concentration required to inhibit human cytomegalo virus Davis induced cytopathicity in HEL fibroblast cell line after 7 days of postinfection ChEMBL. 15801851
EC50 (functional) > 400 uM Effective concentration required to reduce varicella-zoster virus OKA(TK) plaque formation after 5 days in HEL fibroblast cell line ChEMBL. 15801851
MCC (functional) > 400 uM Minimum cytotoxic concentration required to cause a microscopically visible alteration of HEL fibroblast cell morphology ChEMBL. 15801851
MCC (functional) > 400 uM Minimum cytotoxic concentration required to cause a microscopically visible alteration of HEL fibroblast cell morphology ChEMBL. 15801851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.