Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0065 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0065 | 1 | 1 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Trypanosoma brucei | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0065 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0065 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0065 | 1 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0024 | 0.2671 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0024 | 0.2671 | 0.2671 |
Trypanosoma brucei | cytochrome P450, putative | 0.0065 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0024 | 0.2671 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0065 | 1 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0065 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0024 | 0.2671 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Loa Loa (eye worm) | tubulin beta chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0065 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0065 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Loa Loa (eye worm) | BEN-1 protein | 0.0024 | 0.2671 | 0.2671 |
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0065 | 1 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0024 | 0.2671 | 0.2671 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Toxoplasma gondii | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Entamoeba histolytica | tubulin family protein | 0.0024 | 0.2671 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0065 | 1 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0065 | 1 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0024 | 0.2671 | 1 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0065 | 1 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0065 | 1 | 1 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0024 | 0.2671 | 0.2671 |
Schistosoma mansoni | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Schistosoma mansoni | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Schistosoma mansoni | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | 0.0065 | 1 | 1 | |
Leishmania major | cytochrome p450-like protein | 0.0065 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0024 | 0.2671 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0024 | 0.2671 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0024 | 0.2671 | 0.2671 |
Brugia malayi | Tubulin beta-1 chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Trypanosoma brucei | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0065 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0065 | 1 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0024 | 0.2671 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0024 | 0.2671 | 0.2671 |
Brugia malayi | cytochrome P450 | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0065 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0065 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0065 | 1 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0065 | 1 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0024 | 0.2671 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0065 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0024 | 0.2671 | 0.2671 |
Schistosoma mansoni | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0065 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0065 | 1 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0065 | 1 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Giardia lamblia | Beta tubulin | 0.0024 | 0.2671 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0065 | 1 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0024 | 0.2671 | 1 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Echinococcus granulosus | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | tubulin subunit beta | 0.0024 | 0.2671 | 0.2671 |
Brugia malayi | beta-tubulin, identical | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0065 | 1 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0024 | 0.2671 | 0.2671 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0024 | 0.2671 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0065 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Echinococcus multilocularis | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0065 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0065 | 1 | 0.5 |
Leishmania major | beta tubulin | 0.0024 | 0.2671 | 0.2671 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0065 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0065 | 1 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0065 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0065 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0065 | 1 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0024 | 0.2671 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 23.5 uM | Inhibitory concentration of the compound against HeLa cell line | ChEMBL. | 15828838 |
IC50 (functional) | = 23.5 uM | Inhibitory concentration of the compound against HeLa cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against COLO 320 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against H522 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against HT-29 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against MiaPaca cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against HepG2 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against COLO 320 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against H522 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against HT-29 cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against MiaPaca cell line | ChEMBL. | 15828838 |
IC50 (functional) | > 30 uM | Inhibitory concentration of the compound against HepG2 cell line | ChEMBL. | 15828838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.