Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0395 | 0.0395 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0311 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0898 | 0.0898 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0031 | 0.0395 | 0.0687 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0898 | 0.0898 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0395 | 0.0395 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0047 | 0.383 |
Brugia malayi | steroid hormone receptor | 0.0031 | 0.0395 | 0.0687 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2783 | 0.4837 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0031 | 0.0395 | 0.0395 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0182 | 0.5753 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0408 | 0.0408 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0122 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0408 | 0.0408 |
Schistosoma mansoni | coup transcription factor | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1684 | 0.2927 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0408 | 0.0408 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0047 | 0.383 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0047 | 0.383 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0122 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2783 | 0.2783 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2783 | 0.4837 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0395 | 0.0687 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5231 | 0.5231 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0031 | 0.0395 | 0.0395 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0898 | 0.0898 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0898 | 0.0898 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0122 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0395 | 0.0395 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | ran | 0.0021 | 0.0047 | 0.0047 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0898 | 0.0898 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0311 | 0.0311 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0408 | 0.071 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0311 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0408 | 0.0408 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0898 | 0.0898 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0311 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0047 | 0.383 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0047 | 0.1497 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5231 | 0.5231 |
Echinococcus granulosus | geminin | 0.0167 | 0.5231 | 0.5231 |
Brugia malayi | ecdysteroid receptor | 0.0182 | 0.5753 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.5753 | 0.5753 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0408 | 0.071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0031 | 0.0395 | 0.0687 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0031 | 0.0395 | 0.0687 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2783 | 0.2783 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0408 | 0.0408 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0031 | 0.0395 | 0.0395 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0122 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0898 | 0.0898 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.2157 | 0.3749 |
Schistosoma mansoni | ran | 0.0021 | 0.0047 | 0.0047 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0031 | 0.0395 | 0.0395 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0047 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0031 | 0.0395 | 0.0687 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0047 | 0.383 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0031 | 0.0395 | 0.0395 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0047 | 0.0047 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0898 | 0.1561 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0395 | 0.0687 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0408 | 0.0408 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0047 | 0.0047 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0301 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0031 | 0.0395 | 0.0687 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0031 | 0.0395 | 0.0687 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0047 | 0.1497 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0898 | 0.0898 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0408 | 0.0408 |
Echinococcus granulosus | FTZ F1 alpha | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1684 | 0.1684 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0031 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1684 | 0.1684 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Echinococcus multilocularis | snurportin 1 | 0.0301 | 1 | 1 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0047 | 0.1497 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0031 | 0.0395 | 0.0687 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0408 | 0.0408 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0047 | 0.0081 |
Schistosoma mansoni | thyroid hormone receptor | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0408 | 0.0408 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0031 | 0.0395 | 0.0687 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0311 | 0.054 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0031 | 0.0395 | 0.0395 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0311 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0031 | 0.0395 | 0.0395 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0311 | 0.0311 |
Echinococcus multilocularis | geminin | 0.0167 | 0.5231 | 0.5231 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0047 | 0.1497 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | nuclear receptor NHR-88 | 0.0031 | 0.0395 | 0.0687 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0311 | 0.0311 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0311 | 0.0311 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0047 | 0.0047 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0031 | 0.0395 | 0.0395 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0031 | 0.0395 | 0.0687 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0395 | 0.0395 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0408 | 0.0408 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | < 1 | Relative binding affinity(RBA) against Estrogen receptor using MCF-7 cells | ChEMBL. | 1573630 |
RBA (functional) | = 557 | Relative binding affinity(RBA) against AEBS(Antiestrogen binding site) using EL-4 cells | ChEMBL. | 1573630 |
RBA (binding) | < 1 | Relative binding affinity(RBA) against Estrogen receptor using MCF-7 cells | ChEMBL. | 1573630 |
RBA (functional) | = 557 | Relative binding affinity(RBA) against AEBS(Antiestrogen binding site) using EL-4 cells | ChEMBL. | 1573630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.