Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.4964 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0289 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0214 | 0.4964 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0141 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0214 | 0.4964 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0141 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0141 | 0 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0289 | 1 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0289 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Maximal induction of liver X receptor-beta receptor in transactivation assay; Not tested | ChEMBL. | 15911262 | |
Activity (binding) | 0 | Maximal induction of liver X receptor-alpha receptor in transactivation assay; Not tested | ChEMBL. | 15911262 |
Activity (binding) | 0 | Maximal induction of liver X receptor-beta receptor in transactivation assay; Not tested | ChEMBL. | 15911262 |
EC50 (binding) | nM | Effective concentration against liver X receptor-beta in HEK293 transactivation assay; Not tested | ChEMBL. | 15911262 |
EC50 (binding) | nM | Effective concentration for cofactor association with recombinant liver X receptor-beta; Not tested | ChEMBL. | 15911262 |
EC50 (binding) | 0 nM | Effective concentration for cofactor association with recombinant liver X receptor-alpha; Not tested | ChEMBL. | 15911262 |
EC50 (binding) | 0 nM | Effective concentration for cofactor association with recombinant liver X receptor-beta; Not tested | ChEMBL. | 15911262 |
EC50 (binding) | 0 nM | Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay; Not tested | ChEMBL. | 15911262 |
EC50 (binding) | 0 nM | Effective concentration against liver X receptor-beta in HEK293 transactivation assay; Not tested | ChEMBL. | 15911262 |
IC50 (binding) | = 29 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assay | ChEMBL. | 15911262 |
IC50 (binding) | = 29 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assay | ChEMBL. | 15911262 |
IC50 (binding) | = 90 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assay | ChEMBL. | 15911262 |
IC50 (binding) | = 90 nM | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assay | ChEMBL. | 15911262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.