Detailed information for compound 33564

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.505 | Formula: C21H36O10
  • H donors: 5 H acceptors: 7 LogP: 1.08 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(C(=O)O)CCCCCCOC1CCCCC1OC1OC(C)C(C(C1O)O)O
  • InChi: 1S/C21H36O10/c1-12-16(22)17(23)18(24)21(30-12)31-15-10-6-5-9-14(15)29-11-7-3-2-4-8-13(19(25)26)20(27)28/h12-18,21-24H,2-11H2,1H3,(H,25,26)(H,27,28)
  • InChiKey: VXMMQQMYEMUEHF-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0036 0.0036 0.031
Brugia malayi G protein-coupled receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0068 0.0123
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.0319 0.1556
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.114 0.2014 1
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0036 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0151 0.0151
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.114 0.2014 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0045 0.0045
Leishmania major trypanothione reductase 0.0041 0.0046 0.0081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0068 0.0123
Schistosoma mansoni smad1 5 8 and 0.0018 0.0004 0.0004
Leishmania major basic transcription factor 3a, putative 0.0038 0.0041 0.007
Schistosoma mansoni hypothetical protein 0.0052 0.0065 0.0065
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0495 0.0859 0.0859
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0007 0.0007
Echinococcus granulosus fmrfamide receptor 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0036 0.0036 0.031
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0046 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0007 0.0007
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0079 0.0143
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0036 0.0036
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0496 0.086 0.086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0036 0.0036
Leishmania major DNA polymerase kappa, putative 0.0045 0.0053 0.0094
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0734 0.1287 0.2465
Echinococcus granulosus sex peptide receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0036 0.0036
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0036 0.0036
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0123 0.0193 0.0193
Schistosoma mansoni wnt related 0.0016 0.000000000005955 0.000000000005955
Onchocerca volvulus 0.0036 0.0036 0.031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0044 0.0186
Toxoplasma gondii isocitrate dehydrogenase 0.0069 0.0096 0.0176
Brugia malayi MH2 domain containing protein 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0331 0.0564 0.0564
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0495 0.0859 0.0859
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.0266 0.0266
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0331 0.0564 0.0564
Echinococcus granulosus neuropeptide receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0036 0.0036
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0007 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0046 0.0046
Brugia malayi hypothetical protein 0.0134 0.0211 0.0211
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.2924 0.5207 1
Leishmania major C-8 sterol isomerase-like protein 0.1329 0.2351 0.4511
Brugia malayi Dopamine receptor 0.0036 0.0036 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0069 0.0096 0.0176
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0312 0.0531 0.0496
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0036 0.0036 0.0036
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0496 0.086 0.1622
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.0036 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0036 0.0036
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0238 0.0398 0.195
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2111 0.3753 0.3753
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0036 0.0036
Schistosoma mansoni protein farnesyltransferase subunit beta 0.114 0.2014 0.2014
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0041 0.007
Schistosoma mansoni neuropeptide receptor 0.0036 0.0036 0.0036
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0586 0.1021 0.1021
Brugia malayi RE15519p 0.0036 0.0036 0.0036
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0069 0.0096 0.0096
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.004 0.004
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.0068 0.0068
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0007 0.0007
Trypanosoma brucei trypanothione reductase 0.0041 0.0046 0.0052
Brugia malayi Protein kinase domain containing protein 0.0019 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0033 0.0032 0.0032
Echinococcus granulosus GPCR family 2 0.0052 0.0065 0.0065
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0141 0.0105
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0036
Toxoplasma gondii thioredoxin reductase 0.0041 0.0046 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.0036 0.0036
Echinococcus granulosus dna polymerase eta 0.0068 0.0093 0.0093
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0007 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0069 0.0096 0.0176
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0007 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0534 0.0929 0.0929
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Schistosoma mansoni cpg binding protein 0.0031 0.0028 0.0028
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0007 0.0007
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0495 0.0859 0.0859
Loa Loa (eye worm) hypothetical protein 0.0112 0.0173 0.0173
Schistosoma mansoni opsin-like receptor 0.0036 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0036 0.0036 0.0036
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0496 0.086 0.1622
Entamoeba histolytica hypothetical protein 0.0118 0.0183 0.0881
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0036
Echinococcus granulosus expressed protein 0.0379 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.0232 0.0388 0.0388
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0734 0.1287 0.6377
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis orexin receptor type 2 0.0036 0.0036 0.0036
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0587 0.1024 0.0991
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0371 0.0636 0.0636
Leishmania major dihydrofolate reductase-thymidylate synthase 0.2924 0.5207 1
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.004 0.0166
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0004 0.0004
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Echinococcus granulosus g protein coupled receptor 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.0319 0.1556
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0007 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.0092 0.0048
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0019 0.0007 0.0007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0036 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0036 0.0036
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0134 0.0212 0.0176
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0054 0.0068 0.0068
Schistosoma mansoni biogenic amine receptor 0.0036 0.0036 0.0036
Schistosoma mansoni cpg binding protein 0.0033 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0169
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0007 0.0007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.0036 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0036 0.0036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0036 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.004 0.0004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0004 0.0004
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.005
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.0036 0.0036
Echinococcus multilocularis Smad4 0.0018 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.006 0.0079 0.0144
Onchocerca volvulus 0.0036 0.0036 0.031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Loa Loa (eye worm) hypothetical protein 0.0134 0.0211 0.0211
Schistosoma mansoni histamine h1 receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0015 0.0015
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1329 0.2351 0.2351
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0496 0.086 0.086
Schistosoma mansoni peptidylglycine monooxygenase 0.0123 0.0193 0.0193
Echinococcus multilocularis dihydrofolate reductase 0.56 1 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni opsin-like receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis transcription factor btf3 0.0038 0.0041 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0036 0.0036
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.0077
Onchocerca volvulus 0.0036 0.0036 0.031
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0587 0.1024 0.0991
Brugia malayi neuropeptide F receptor 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0045 0.005
Echinococcus granulosus tm gpcr rhodopsin 0.2111 0.3753 0.3753
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0044 0.0186
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0036 0.0036
Schistosoma mansoni inositol monophosphatase 0.004 0.0044 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Leishmania major lanosterol synthase, putative 0.0917 0.1615 0.3095
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0053 0.0017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0141 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus granulosus hypothetical protein 0.0036 0.0036 0.0036
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0079 0.036
Onchocerca volvulus 0.0036 0.0036 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Plasmodium vivax farnesyltransferase beta subunit, putative 0.114 0.2014 0.3862
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0496 0.086 0.1646
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0449 0.0775 0.0775
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0069 0.0096 0.0176
Onchocerca volvulus 0.0053 0.0066 0.0608
Schistosoma mansoni Smad4 0.0018 0.0004 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi Dihydrofolate reductase 0.56 1 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0495 0.0859 0.0859
Onchocerca volvulus Huntingtin homolog 0.0134 0.0211 0.203
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0065 0.0065
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0095 0.0141 0.0105
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0036 0.0036
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0007 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0069 0.0096 0.0096
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0063 0.0084 0.0084
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0331 0.0564 0.1051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.0092 0.0141
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.0319 0.1556
Loa Loa (eye worm) Smad1 0.0018 0.0004 0.0004
Onchocerca volvulus 0.0054 0.0068 0.0631
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0232 0.0388 0.0388
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0036 0.0036
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.114 0.2014 1
Brugia malayi MH1 domain containing protein 0.0018 0.0004 0.0004
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0495 0.0859 0.4244
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.0036 0.0036
Brugia malayi beta-NAC-like protein 0.0038 0.0041 0.0041
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0069 0.0096 0.0176
Giardia lamblia Prenyltransferase 0.114 0.2014 1
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0194 0.0319 0.3088
Schistosoma mansoni DNA polymerase eta 0.0068 0.0093 0.0093
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.016 0.0124
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0169
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0044 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.0036 0.0036
Plasmodium vivax geranylgeranyltransferase, putative 0.0331 0.0564 0.1076
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0496 0.086 0.8396
Loa Loa (eye worm) thymidylate synthase 0.0587 0.1024 0.1024
Echinococcus multilocularis thymidylate synthase 0.0587 0.1024 0.1024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0092 0.0169
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0734 0.1287 0.6377
Echinococcus multilocularis geminin 0.0371 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0173 0.0173
Echinococcus granulosus serotonin receptor 0.0036 0.0036 0.0036
Schistosoma mansoni dihydrofolate reductase 0.56 1 1
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0232 0.0388 0.0388
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.0238 0.0398 0.0757
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0036 0.0036
Giardia lamblia Rab geranylgeranyltransferase 0.0496 0.086 0.4117
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0041 0.007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0036 0.0036
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0041 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0036 0.0036
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0202 0.0334 0.0633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0092 0.0169
Echinococcus multilocularis microtubule associated protein 2 0.0757 0.1327 0.1327
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0167 0.0271 0.0271
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.56 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0639 0.1117 0.5425
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0194 0.0319 0.1356
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0007 0.0007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.2924 0.5207 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.2924 0.5207 1
Brugia malayi PXA domain containing protein 0.0019 0.0007 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.0036 0.0036
Treponema pallidum fructose-bisphosphate aldolase 0.0639 0.1117 0.5
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0007 0.0007
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0279 0.0472 0.09
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0036 0.0036
Trypanosoma brucei lanosterol synthase 0.1248 0.2207 0.4217
Brugia malayi hypothetical protein 0.0279 0.0472 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.0036 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0262 0.0441 0.0441
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0496 0.086 0.1646
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0004 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0036 0.0036
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0734 0.1287 0.1287
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Echinococcus granulosus thymidylate synthase 0.0587 0.1024 0.1024
Echinococcus multilocularis cpg binding protein 0.0033 0.0032 0.0032
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0041 0.007
Echinococcus granulosus g protein coupled receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0164 0.0266 0.0266
Mycobacterium ulcerans thymidylate synthase 0.0587 0.1024 0.0984
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0331 0.0564 0.0564
Echinococcus multilocularis smad 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.016 0.0124
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.0036 0.0036
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0079 0.036
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0496 0.086 0.1646
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi putative neuropeptide receptor 0.0036 0.0036 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0068 0.0123
Toxoplasma gondii hypothetical protein 0.0496 0.086 0.1646
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.0036 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0141 0.0105
Brugia malayi hypothetical protein 0.0118 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0036 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Trypanosoma brucei protein farnesyltransferase beta subunit 0.114 0.2014 0.3845
Loa Loa (eye worm) inositol-1 0.004 0.0044 0.0044
Leishmania major DNA polymerase eta, putative 0.0068 0.0093 0.0171
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0496 0.086 0.4253
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Brugia malayi thymidylate synthase 0.0587 0.1024 0.1024
Brugia malayi MH1 domain containing protein 0.0018 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0069 0.0096 0.0096
Brugia malayi Isocitrate dehydrogenase 0.0069 0.0096 0.0096
Schistosoma mansoni amine GPCR 0.0036 0.0036 0.0036
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis serotonin receptor 0.0036 0.0036 0.0036
Schistosoma mansoni survival motor neuron protein 0.0053 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0371 0.0636 0.0636
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.0036 0.0036
Schistosoma mansoni biogenic amine receptor 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0052 0.0065 0.0065
Schistosoma mansoni inositol monophosphatase 0.004 0.0044 0.0044
Onchocerca volvulus 0.0036 0.0036 0.031
Loa Loa (eye worm) hypothetical protein 0.0123 0.0193 0.0193
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0495 0.0859 0.0859
Plasmodium falciparum protein farnesyltransferase subunit beta 0.114 0.2014 0.3862
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0069 0.0096 0.0148
Schistosoma mansoni hypothetical protein 0.0118 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.1248 0.2207 0.2178
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0007 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0047 0.0047
Echinococcus granulosus g-protein coupled receptor 0.0036 0.0036 0.0036
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Brugia malayi Dopamine receptor protein 2 0.0036 0.0036 0.0036
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0194 0.0319 0.0319
Entamoeba histolytica hypothetical protein 0.0118 0.0183 0.0881
Echinococcus granulosus transcription factor btf3 0.0038 0.0041 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0036 0.0036
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0312 0.0531 0.0496
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0052 0.0065 0.0065
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0587 0.1024 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Loa Loa (eye worm) transcription factor SMAD2 0.0262 0.0441 0.0441
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0331 0.0564 0.0564
Schistosoma mansoni microtubule-associated protein tau 0.0757 0.1327 0.1327
Echinococcus granulosus allatostatin A receptor 0.0036 0.0036 0.0036
Schistosoma mansoni dopamine-beta-monooxygenase 0.0123 0.0193 0.0193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus granulosus dihydrofolate reductase 0.56 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.0036 0.0036
Brugia malayi G-protein coupled receptor 0.0036 0.0036 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0093 0.0093
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0036 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.0092 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0496 0.086 0.4253
Entamoeba histolytica hypothetical protein 0.0118 0.0183 0.0881
Giardia lamblia Rab geranylgeranyltransferase 0.0331 0.0564 0.2607
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0036 0.0036 0.031
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0496 0.086 0.086
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.2924 0.5207 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0044 0.0044
Brugia malayi GnHR receptor homolog 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0068 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0007 0.0007
Mycobacterium tuberculosis Hypothetical protein 0.0279 0.0472 0.0437
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0036 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0066 0.0066
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0151 0.0151
Echinococcus multilocularis expressed protein 0.0379 0.065 0.065
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0495 0.0859 0.4244
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0151 0.0151
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0809 0.1421 0.2724
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0053 0.0094
Brugia malayi larval opioid receptor 0.0036 0.0036 0.0036
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.0092 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0151 0.0151
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0496 0.086 0.086
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0068 0.0094
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0036 0.0036
Brugia malayi Zinc finger, C2H2 type family protein 0.0358 0.0613 0.0613
Echinococcus multilocularis sex peptide receptor 0.0036 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.0564 0.1076
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0151 0.0151
Entamoeba histolytica hypothetical protein 0.0038 0.0041 0.0169
Brugia malayi polk-prov protein 0.0041 0.0045 0.0045
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0068 0.0068
Brugia malayi Serotonin receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis tumor protein p63 0.0368 0.0632 0.0632
Schistosoma mansoni myosin xvIII 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0093 0.0143
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0734 0.1287 0.1287
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.0183 0.0183
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0041 0.0169
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0036 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0079 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.0036 0.0036
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.114 0.2014 1
Trichomonas vaginalis conserved hypothetical protein 0.0279 0.0472 0.232
Schistosoma mansoni tyrosine kinase 0.0164 0.0266 0.0266
Chlamydia trachomatis dihydrofolate reductase 0.56 1 0.5
Echinococcus granulosus smad 0.0018 0.0004 0.0004
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.006 0.0079 0.0116
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0734 0.1287 0.1287
Plasmodium falciparum thioredoxin reductase 0.0041 0.0046 0.0081
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0092 0.0092
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0036 0.0036
Echinococcus granulosus orexin receptor type 2 0.0036 0.0036 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Giardia lamblia Rab geranylgeranyltransferase 0.0734 0.1287 0.6291
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0015 0.0015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.0183 0.0183
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi glutathione reductase 0.0041 0.0046 0.0046
Brugia malayi neuropeptide F receptor 0.0036 0.0036 0.0036
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0331 0.0564 0.2778
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Brugia malayi Thioredoxin reductase 0.0041 0.0046 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0496 0.086 0.1622
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi lanosterol synthase, putative 0.1248 0.2207 0.4234
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.0266 0.0266
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.114 0.2014 0.2014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0036 0.0036
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0194 0.0319 0.0319
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0194 0.0319 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0036 0.0036
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0093 0.0171
Echinococcus multilocularis survival motor neuron protein 1 0.0258 0.0434 0.0434
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0036 0.031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0047 0.0047
Schistosoma mansoni amine GPCR 0.0036 0.0036 0.0036
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0046 0.008
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0069 0.0096 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0496 0.086 0.1646
Echinococcus multilocularis GPCR, family 2 0.0052 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0331 0.0564 0.0564
Brugia malayi G-protein coupled receptor 0.0036 0.0036 0.0036
Brugia malayi Inositol-1 0.004 0.0044 0.0044
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0734 0.1287 0.1287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.114 0.2014 1
Brugia malayi follicle stimulating hormone receptor 0.0036 0.0036 0.0036
Echinococcus granulosus dna polymerase kappa 0.0067 0.0092 0.0092
Echinococcus multilocularis dna polymerase eta 0.0068 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0151 0.0151
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0069 0.0096 0.0148
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0046 0.0081
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.114 0.2014 0.2014
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.016 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0496 0.086 0.1646
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0331 0.0564 0.2778
Schistosoma mansoni smad1 5 8 and 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0068 0.0123
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.0319 0.1556
Onchocerca volvulus 0.0036 0.0036 0.031
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0068 0.0123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0052 0.0065 0.0065
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0331 0.0564 0.1076
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0312 0.0531 0.0489
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0036 0.0036
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0046 0.0081
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.56 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0036 0.0036
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0496 0.086 0.1646
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0052 0.0065 0.0065
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0331 0.0564 0.1076
Trichomonas vaginalis DNA polymerase eta, putative 0.0067 0.0092 0.0425
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0069 0.0096 0.006
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0036 0.0036
Trypanosoma cruzi lanosterol synthase, putative 0.1248 0.2207 0.4234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0151 0.0151
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0041 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0053 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0079 0.0144
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.0036 0.0036
Brugia malayi MH2 domain containing protein 0.0018 0.0004 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0065 0.0065
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.114 0.2014 1
Schistosoma mansoni hypothetical protein 0.0024 0.0015 0.0015
Onchocerca volvulus 0.0036 0.0036 0.031
Echinococcus granulosus somatostatin receptor 0.0036 0.0036 0.0036
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0331 0.0564 0.1076
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0036 0.0036
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.2924 0.5207 1
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0496 0.086 0.1646
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0092 0.0169
Brugia malayi AKH receptor 0.0036 0.0036 0.0036
Brugia malayi Serotonin receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0036 0.0036
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0036 0.0036
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0734 0.1287 0.1287
Schistosoma mansoni hypothetical protein 0.0112 0.0173 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0044 0.0077
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0036 0.031
Schistosoma mansoni hypothetical protein 0.0056 0.0073 0.0073
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0141 0.0105
Schistosoma mansoni smad1 5 8 and 0.0018 0.0004 0.0004
Onchocerca volvulus Huntingtin homolog 0.0134 0.0211 0.203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0331 0.0564 0.1076
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0007 0.0007
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0194 0.0319 0.1556
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Entamoeba histolytica hypothetical protein 0.0118 0.0183 0.0881
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0007 0.0007
Trypanosoma brucei C-8 sterol isomerase, putative 0.1329 0.2351 0.4496
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0167 0.0271 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0032 0.0025
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0036 0.0036 0.031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.004 0.004
Echinococcus multilocularis zinc finger transcription factor gli2 0.0358 0.0613 0.0613
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0007 0.0007
Schistosoma mansoni adenoreceptor 0.0036 0.0036 0.0036
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0007 0.0007
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1329 0.2351 0.4511
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.0077
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0004
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0069 0.0096 0.0176
Echinococcus granulosus neuropeptide receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis serotonin receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0036 0.0036 0.031
Loa Loa (eye worm) zinc finger protein 0.0358 0.0613 0.0613
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0496 0.086 0.1646
Schistosoma mansoni smad 0.0018 0.0004 0.0004
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.0319 0.1556
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0054 0.0068 0.0068
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0036 0.0036
Onchocerca volvulus 0.0031 0.0028 0.0237
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0734 0.1287 0.1287
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0061 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0007 0.0007
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0036 0.0036
Trypanosoma brucei unspecified product 0.006 0.0079 0.0116
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0232 0.0388 0.0388
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0036 0.0036
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.0036 0.0036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0069 0.0096 0.0096
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0007 0.0007
Echinococcus granulosus dnaJ subfamily B 0.0449 0.0775 0.0775
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0036 0.0036 0.0036
Echinococcus granulosus tumor protein p63 0.0368 0.0632 0.0632
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0079 0.0116
Echinococcus granulosus Smad4 0.0018 0.0004 0.0004
Trypanosoma cruzi protein farnesyltransferase, putative 0.114 0.2014 0.3862
Plasmodium falciparum glutathione reductase 0.0041 0.0046 0.0081
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0067 0.0092 0.0425
Loa Loa (eye worm) glutathione reductase 0.0041 0.0046 0.0046
Echinococcus multilocularis dna polymerase kappa 0.0067 0.0092 0.0092
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0065 0.0065
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0587 0.1024 0.1024
Mycobacterium tuberculosis Probable reductase 0.0095 0.0141 0.0105
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0496 0.086 0.1622
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.114 0.2014 0.2014
Echinococcus granulosus geminin 0.0371 0.0636 0.0636
Leishmania major farnesyltransferase beta subunit 0.114 0.2014 0.3862
Echinococcus granulosus zinc finger transcription factor gli2 0.0358 0.0613 0.0613
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0044 0.0186
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0007 0.0007
Echinococcus multilocularis sodium channel protein 0.0202 0.0334 0.0334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0639 0.1117 0.553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0036 0.031
Echinococcus granulosus sodium channel protein 0.0202 0.0334 0.0334
Echinococcus granulosus survival motor neuron protein 1 0.0258 0.0434 0.0434
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0194 0.0319 0.1556
Loa Loa (eye worm) hypothetical protein 0.0134 0.0211 0.0211
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.0564 0.1076
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.016 0.0124
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.004 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0068 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0054 0.0068 0.0123
Echinococcus granulosus g protein coupled receptor 0.0036 0.0036 0.0036
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0036 0.0036
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.114 0.2014 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.0266 0.0266
Schistosoma mansoni transcription factor btf3 0.0038 0.0041 0.0041
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0007 0.0007
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0151 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0069 0.0096 0.0096
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0331 0.0564 0.2778
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0053 0.0066 0.0066
Brugia malayi Smad1 0.0018 0.0004 0.0004
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0495 0.0859 0.0859
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0496 0.086 0.086
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0232 0.0388 0.0388
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Brugia malayi PXA domain containing protein 0.0019 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0036 0.031
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0069 0.0096 0.0096
Brugia malayi MH2 domain containing protein 0.0262 0.0441 0.0441
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.004 0.004
Brugia malayi hypothetical protein 0.0035 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0032 0.0025
Onchocerca volvulus 0.0036 0.0036 0.031
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0036 0.0036
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0007 0.0007
Leishmania major geranylgeranyltransferase, putative 0.0331 0.0564 0.1076
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0202 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Brugia malayi isocitrate dehydrogenase 0.0069 0.0096 0.0096
Brugia malayi Kringle domain containing protein 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0032 0.0025
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0496 0.086 0.086
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Trypanosoma cruzi protein farnesyltransferase, putative 0.114 0.2014 0.3862
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0044 0.0077
Echinococcus multilocularis isocitrate dehydrogenase 0.0069 0.0096 0.0096
Plasmodium falciparum geranylgeranyltransferase, putative 0.0331 0.0564 0.1076
Echinococcus granulosus protein farnesyltransferase subunit beta 0.114 0.2014 0.2014
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0044 0.0186
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) dihydrofolate reductase 0.56 1 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0007 0.0007
Brugia malayi sulfakinin receptor protein 0.0036 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0036 0.0036
Echinococcus multilocularis somatostatin receptor 0.0036 0.0036 0.0036
Schistosoma mansoni opsin-like receptor 0.0036 0.0036 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0036 0.0036
Echinococcus granulosus cpg binding protein 0.0033 0.0032 0.0032
Echinococcus granulosus microtubule associated protein 2 0.0757 0.1327 0.1327
Onchocerca volvulus 0.0036 0.0036 0.031
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0092 0.0169
Loa Loa (eye worm) TK/ROR protein kinase 0.0019 0.0006 0.0006
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.114 0.2014 0.3862
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.004 0.004
Brugia malayi hypothetical protein 0.0019 0.0007 0.0007
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0007 0.0007
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0036 0.0036
Leishmania major DNA polymerase eta, putative 0.0041 0.0046 0.008
Schistosoma mansoni biogenic amine receptor 0.0036 0.0036 0.0036
Plasmodium vivax glutathione reductase, putative 0.0041 0.0046 0.0081
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0007 0.0007
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0734 0.1287 0.6377
Brugia malayi CXXC zinc finger family protein 0.0031 0.0028 0.0028
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0046 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0258 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0036 0.0036 0.0036
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.56 1 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0734 0.1287 0.2465
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0041 0.0041
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0069 0.0096 0.0176
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0007 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0065 0.0065
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0041 0.007
Brugia malayi Dopamine receptor protein 1 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.1329 0.2351 0.2351
Onchocerca volvulus 0.0036 0.0036 0.031
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.0036 0.0036
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0734 0.1287 0.6377
Echinococcus granulosus neuropeptide s receptor 0.0036 0.0036 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0036 0.0036
Echinococcus multilocularis allatostatin A receptor 0.0036 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0258 0.0434 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0041 0.0169
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0036 0.0036
Brugia malayi ORL1-like opioid receptor 0.0036 0.0036 0.0036
Brugia malayi hypothetical protein 0.0036 0.0036 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0028 0.0028
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0004 0.0004
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.0319 0.1556
Brugia malayi Melatonin receptor type 1A 0.0036 0.0036 0.0036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0141 0.0105
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0044 0.0044
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0331 0.0564 0.1076

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 5 mM Tested for the inhibition of HL60 cell adhesion to recombinant E-selectin-IgG fusion protein measured by cell culture assay. ChEMBL. No reference
IC50 (functional) > 5 mM Tested for the inhibition of HL60 cell adhesion to recombinant P-selectin-IgG fusion protein measured by cell culture assay. ChEMBL. No reference
IC50 (functional) > 5 mM Tested for the inhibition of HL60 cell adhesion to recombinant E-selectin-IgG fusion protein measured by cell culture assay. ChEMBL. No reference
IC50 (functional) > 5 mM Tested for the inhibition of HL60 cell adhesion to recombinant P-selectin-IgG fusion protein measured by cell culture assay. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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