Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 13053 nM | Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay | ChEMBL. | 17944451 |
IC50 (functional) | = 13053 nM | Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay | ChEMBL. | 17944451 |
IC50 (functional) | = 32926 nM | Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay | ChEMBL. | 17944451 |
IC50 (functional) | = 32926 nM | Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay | ChEMBL. | 17944451 |
Inhibition (binding) | Binding affinity to Mycobacterium smegmatis mc2 155 EthR assessed as protein thermal unfolding at 20 uM by SYPRO Orange dye based thermal shift assay | ChEMBL. | 22738293 | |
Log PNalk | = -0.15 | Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system | ChEMBL. | 15857133 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17944451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.