Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | chemokine (C-X-C motif) receptor 4 | 356 aa | 332 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carboxylesterase 5A | 0.061 | 0.4443 | 1 |
Plasmodium vivax | cytochrome c, putative | 0.0103 | 0.0526 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.061 | 0.4443 | 1 |
Onchocerca volvulus | 0.0103 | 0.0528 | 0.0235 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0103 | 0.0528 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0103 | 0.0528 | 0.055 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.0528 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Loa Loa (eye worm) | carboxylesterase | 0.0103 | 0.0528 | 0.055 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.0528 | 0.055 |
Schistosoma mansoni | cytochrome c | 0.0103 | 0.0526 | 0.0545 |
Loa Loa (eye worm) | hypothetical protein | 0.061 | 0.4443 | 1 |
Loa Loa (eye worm) | cytochrome c type-1 | 0.0103 | 0.0526 | 0.0545 |
Brugia malayi | hypothetical protein | 0.0103 | 0.0528 | 0.0331 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0103 | 0.0528 | 0.0005 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0103 | 0.0528 | 0.0005 |
Onchocerca volvulus | 0.0103 | 0.0528 | 0.0235 | |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0363 | 0.2536 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0967 | 0.7195 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0363 | 0.2536 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0528 | 0.0331 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0103 | 0.0528 | 0.0005 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0103 | 0.0528 | 0.055 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0103 | 0.0528 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c2 | 0.0103 | 0.0526 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0103 | 0.0528 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.061 | 0.4443 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0103 | 0.0528 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.061 | 0.4443 | 0.6009 |
Brugia malayi | Cytochrome c type-1 | 0.0103 | 0.0526 | 0.0328 |
Echinococcus granulosus | acetylcholinesterase | 0.061 | 0.4443 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0103 | 0.0528 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0528 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0103 | 0.0528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.061 | 0.4443 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0363 | 0.2536 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.061 | 0.4443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0363 | 0.2536 | 1 |
Onchocerca volvulus | 0.0103 | 0.0528 | 0.0235 | |
Schistosoma mansoni | acetylcholinesterase | 0.0103 | 0.0528 | 0.055 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0528 | 0.0331 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0363 | 0.2536 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0103 | 0.0528 | 0.0331 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0103 | 0.0528 | 0.0005 |
Echinococcus granulosus | neuroligin | 0.0103 | 0.0528 | 0.0005 |
Toxoplasma gondii | cytochrome c, putative | 0.0103 | 0.0526 | 0.2073 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Onchocerca volvulus | 0.0103 | 0.0528 | 0.0235 | |
Onchocerca volvulus | 0.0103 | 0.0528 | 0.0235 | |
Brugia malayi | Carboxylesterase family protein | 0.061 | 0.4443 | 0.6009 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0363 | 0.2536 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.061 | 0.4443 | 1 |
Echinococcus multilocularis | neuroligin | 0.0103 | 0.0528 | 0.0005 |
Loa Loa (eye worm) | carboxylesterase | 0.0103 | 0.0528 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0103 | 0.0528 | 0.0005 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0103 | 0.0528 | 0.0005 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0103 | 0.0528 | 0.055 |
Mycobacterium leprae | Probable Ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0103 | 0.0528 | 0.055 |
Echinococcus multilocularis | acetylcholinesterase | 0.061 | 0.4443 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.061 | 0.4443 | 1 |
Plasmodium falciparum | cytochrome c, putative | 0.0103 | 0.0526 | 0.2073 |
Giardia lamblia | Telomerase catalytic subunit | 0.0363 | 0.2536 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0528 | 0.055 |
Echinococcus granulosus | acetylcholinesterase | 0.061 | 0.4443 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0363 | 0.2536 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibition of [125I]-SDF-1 binding to C-X-C chemokine receptor type 4 (CXCR4) expressed in CHO cells | ChEMBL. | 15857134 |
IC50 (binding) | = 1 uM | Inhibition of [125I]-SDF-1 binding to C-X-C chemokine receptor type 4 (CXCR4) expressed in CHO cells | ChEMBL. | 15857134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.