Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | histone deacetylase 3 (HD3) | 0.0178 | 0.2434 | 0.2452 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0178 | 0.2434 | 0.181 |
Echinococcus granulosus | histone deacetylase | 0.0638 | 0.9925 | 0.9925 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0077 | 0.0778 | 0.0784 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0642 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0178 | 0.2434 | 0.2434 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0178 | 0.2434 | 0.2452 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0778 | 0.0784 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.2811 | 0.2833 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0178 | 0.2434 | 0.181 |
Plasmodium falciparum | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Leishmania major | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0638 | 0.9925 | 1 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0077 | 0.0778 | 0.0784 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0638 | 0.9925 | 0.9925 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2434 | 0.2452 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0178 | 0.2434 | 0.2452 |
Leishmania major | histone deacetylase, putative | 0.0178 | 0.2434 | 0.2155 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0272 | 0.3961 | 0.3961 |
Echinococcus granulosus | histone deacetylase 7 | 0.0638 | 0.9925 | 0.9925 |
Trypanosoma brucei | histone deacetylase 4 | 0.0638 | 0.9925 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0638 | 0.9925 | 0.9925 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0178 | 0.2434 | 0.2452 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0077 | 0.0778 | 0.0778 |
Brugia malayi | histone deacetylase 11 | 0.0077 | 0.0778 | 0.0784 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0178 | 0.2434 | 0.2452 |
Plasmodium falciparum | histone deacetylase 2 | 0.0638 | 0.9925 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0638 | 0.9925 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0178 | 0.2434 | 0.2434 |
Onchocerca volvulus | 0.0229 | 0.3265 | 1 | |
Schistosoma mansoni | histone deacetylase | 0.0178 | 0.2434 | 0.2434 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0178 | 0.2434 | 0.2452 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0178 | 0.2434 | 0.2452 |
Leishmania major | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0638 | 0.9925 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0077 | 0.0778 | 0.0778 |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 0.8677 | 0.8742 |
Trypanosoma brucei | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0258 | 0.3735 | 0.3735 |
Entamoeba histolytica | histone deacetylase, putative | 0.0178 | 0.2434 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.0178 | 0.2434 | 0.2434 |
Giardia lamblia | Histone deacetylase | 0.0178 | 0.2434 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0638 | 0.9925 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.2811 | 0.2833 |
Echinococcus granulosus | sodium channel protein | 0.0052 | 0.0376 | 0.0376 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0178 | 0.2434 | 0.2434 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0638 | 0.9925 | 0.9925 |
Plasmodium vivax | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0638 | 0.9925 | 0.9925 |
Echinococcus granulosus | histone deacetylase 6 | 0.0638 | 0.9925 | 0.9925 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0638 | 0.9925 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0272 | 0.3961 | 0.3961 |
Leishmania major | histone deacetylase, putative | 0.0178 | 0.2434 | 0.2155 |
Echinococcus granulosus | histone deacetylase 6 | 0.0638 | 0.9925 | 0.9925 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0077 | 0.0778 | 0.2382 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0178 | 0.2434 | 0.2434 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0052 | 0.0376 | 0.0376 |
Echinococcus granulosus | histone deacetylase 8 | 0.0077 | 0.0778 | 0.0778 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0638 | 0.9925 | 0.9925 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0077 | 0.0778 | 0.0778 |
Plasmodium vivax | histone deacetylase, putative | 0.0077 | 0.0778 | 0.0784 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0638 | 0.9925 | 0.9925 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0638 | 0.9925 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0638 | 0.9925 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0178 | 0.2434 | 0.181 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0178 | 0.2434 | 0.2452 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.3265 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0052 | 0.0376 | 0.0376 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0642 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0566 | 0.8752 | 0.8818 |
Brugia malayi | Histone deacetylase family protein | 0.0638 | 0.9925 | 1 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0077 | 0.0778 | 0.0784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Inhibition of kainate-induced currents of rat ionotropic glutamate receptor AMPA expressed in Xenopus laevis oocytes; not active | ChEMBL. | 15634001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.