Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.026 | 0.8695 | 0.8695 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0271 | 0.9116 | 0.9116 |
Plasmodium falciparum | transporter, putative | 0.005 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 1 | 1 | |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.005 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 1 | 1 |
Plasmodium vivax | amine transporter, putative | 0.005 | 0 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.005 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0 | 0.5 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 1 | 1 |
Plasmodium falciparum | amino acid transporter, putative | 0.005 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0271 | 0.9116 | 0.9116 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.61 nM | Inhibition of [3H]-WIN- 35,428 binding to rat striatal dopamine transporter | ChEMBL. | 15916437 |
IC50 (binding) | = 5.61 nM | Inhibition of [3H]-WIN- 35,428 binding to rat striatal dopamine transporter | ChEMBL. | 15916437 |
IC50 (binding) | = 6.3 nM | Inhibition of [3H]-nisoxetine binding to rat cerebral cortex norepinephrine transporter | ChEMBL. | 15916437 |
IC50 (binding) | = 6.3 nM | Inhibition of [3H]-nisoxetine binding to rat cerebral cortex norepinephrine transporter | ChEMBL. | 15916437 |
IC50 (binding) | = 226 nM | Inhibition of [3H]-paroxetine binding to rat cortex serotonin transporter | ChEMBL. | 15916437 |
IC50 (binding) | = 226 nM | Inhibition of [3H]-paroxetine binding to rat cortex serotonin transporter | ChEMBL. | 15916437 |
Ki (binding) | = 2.6 nM | Displacement of [3H]-nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex | ChEMBL. | 15916437 |
Ki (binding) | = 2.6 nM | Displacement of [3H]-nisoxetine from norepinephrine transporter (NET) of rat cerebral cortex | ChEMBL. | 15916437 |
Ki (binding) | = 55.3 nM | Displacement of [3H]-paroxetine from serotonin transporter (5-HT) of rat cerebral cortex | ChEMBL. | 15916437 |
Ki (binding) | = 55.3 nM | Displacement of [3H]-paroxetine from serotonin transporter (5-HT) of rat cerebral cortex | ChEMBL. | 15916437 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.