Detailed information for compound 337120

Basic information

Technical information
  • TDR Targets ID: 337120
  • Name: 1-[5-(2,4-dichlorophenyl)-3-phenyl-3,4-dihydr opyrazol-2-yl]ethanone
  • MW: 333.212 | Formula: C17H14Cl2N2O
  • H donors: 0 H acceptors: 1 LogP: 3.96 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)C1=NN(C(C1)c1ccccc1)C(=O)C
  • InChi: 1S/C17H14Cl2N2O/c1-11(22)21-17(12-5-3-2-4-6-12)10-16(20-21)14-8-7-13(18)9-15(14)19/h2-9,17H,10H2,1H3
  • InChiKey: SFJHXFNZSVVYBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-(2,4-dichlorophenyl)-5-phenyl-2-pyrazolin-1-yl]ethanone
  • 1-[3-(2,4-dichlorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl]ethanone
  • AN-806/14214181

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Trypanosoma cruzi epsilon tubulin, putative 0.006 0.1939 0.2648
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0621 0.0763
Echinococcus granulosus tubulin beta 4A class IVa 0.0154 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0541 0.0541
Echinococcus granulosus dna polymerase kappa 0.0041 0.1088 0.1729
Brugia malayi tubulin alpha-2 chain 0.006 0.1939 0.1939
Trichomonas vaginalis tubulin gamma chain, putative 0.0154 0.6292 1
Trichomonas vaginalis tubulin beta chain, putative 0.006 0.1939 0.2648
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0314 0.0499
Toxoplasma gondii alpha-tubulin I, putative 0.006 0.1939 0.2648
Trichomonas vaginalis tubulin epsilon chain, putative 0.006 0.1939 0.2648
Trichomonas vaginalis tubulin, putative 0.0034 0.0736 0.0616
Leishmania major beta tubulin 0.0154 0.6292 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Leishmania major beta tubulin 0.0154 0.6292 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.006 0.1939 0.2648
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0025 0.0314 0.0499
Plasmodium vivax tubulin alpha chain, putative 0.006 0.1939 0.2648
Echinococcus multilocularis Tubulin beta 2C chain 0.0154 0.6292 1
Trichomonas vaginalis tubulin beta chain, putative 0.006 0.1939 0.2648
Echinococcus granulosus alpha tubulin 0.006 0.1939 0.3082
Giardia lamblia Beta tubulin 0.0154 0.6292 1
Echinococcus granulosus tubulin alpha chain 0.006 0.1939 0.3082
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Giardia lamblia Delta tubulin 0.0026 0.0371 0.0355
Schistosoma mansoni alpha tubulin 0.006 0.1939 0.3082
Schistosoma mansoni tyrosine kinase 0.0036 0.0855 0.1359
Trypanosoma brucei epsilon tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) hypothetical protein 0.0034 0.0736 0.0736
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0025 0.0314 0.0499
Trypanosoma cruzi alpha tubulin, putative 0.006 0.1939 0.2648
Schistosoma mansoni roundabout 0.0025 0.0314 0.0499
Trichomonas vaginalis tubulin gamma chain, putative 0.006 0.1939 0.2648
Loa Loa (eye worm) tubulin beta chain 0.0026 0.0371 0.0371
Trypanosoma brucei alpha tubulin 0.006 0.1939 0.2909
Echinococcus multilocularis Tubulin beta 2C chain 0.0154 0.6292 1
Schistosoma mansoni septate junction protein 0.0025 0.0314 0.0499
Loa Loa (eye worm) tubulin alpha 2 0.0034 0.0736 0.0736
Brugia malayi Tubulin beta chain 0.0034 0.0736 0.0736
Trypanosoma brucei tubulin gamma chain 0.006 0.1939 0.2909
Echinococcus multilocularis tubulin epsilon chain 0.006 0.1939 0.3082
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.078 0.1021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Leishmania major beta tubulin 0.0154 0.6292 1
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Echinococcus multilocularis peroxisome assembly protein 26 0.006 0.1939 0.3082
Echinococcus multilocularis tubulin subunit beta 0.0154 0.6292 1
Loa Loa (eye worm) BEN-1 protein 0.0154 0.6292 0.6292
Brugia malayi Tubulin beta-1 chain 0.0154 0.6292 0.6292
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.1088 0.1211
Leishmania major gamma-tubulin 0.006 0.1939 0.2909
Giardia lamblia Gamma tubulin 0.006 0.1939 0.2909
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.1088 1
Schistosoma mansoni tubulin subunit beta 0.0154 0.6292 1
Trypanosoma brucei beta tubulin 0.0154 0.6292 1
Schistosoma mansoni alpha tubulin 0.006 0.1939 0.3082
Loa Loa (eye worm) tubulin beta-4 chain 0.0154 0.6292 0.6292
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Toxoplasma gondii beta-tubulin, putative 0.0154 0.6292 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) hypothetical protein 0.0026 0.0371 0.0371
Loa Loa (eye worm) tubulin alpha chain 0.006 0.1939 0.1939
Loa Loa (eye worm) hypothetical protein 0.0067 0.2277 0.2277
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.2277 0.2277
Schistosoma mansoni nephrin 0.0025 0.0314 0.0499
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.003 0.0541 0.0859
Trichomonas vaginalis tubulin gamma chain, putative 0.006 0.1939 0.2648
Brugia malayi Tubulin alpha-2 chain 0.006 0.1939 0.1939
Echinococcus granulosus twitchin 0.0085 0.3109 0.4942
Brugia malayi Peroxidasin 0.0025 0.0314 0.0314
Echinococcus multilocularis roundabout 2 0.0025 0.0314 0.0499
Brugia malayi Tubulin beta chain 0.0026 0.0371 0.0371
Loa Loa (eye worm) BEN-1 protein 0.0154 0.6292 0.6292
Loa Loa (eye worm) alpha-tubulin 0.006 0.1939 0.1939
Trichomonas vaginalis tubulin, putative 0.0154 0.6292 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.1088 0.1211
Echinococcus granulosus Tubulin alpha 1 chain 0.006 0.1939 0.3082
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Echinococcus multilocularis tyrosine protein kinase otk 0.0025 0.0314 0.0499
Giardia lamblia Beta tubulin 0.0154 0.6292 1
Schistosoma mansoni cell adhesion molecule 0.0025 0.0314 0.0499
Trichomonas vaginalis tubulin beta chain, putative 0.006 0.1939 0.2648
Plasmodium falciparum alpha tubulin 2 0.006 0.1939 0.2648
Echinococcus granulosus tubulin alpha 1C chain 0.006 0.1939 0.3082
Trypanosoma brucei tubulin delta chain 0.0026 0.0371 0.0355
Echinococcus granulosus neuroglian 0.0085 0.3109 0.4942
Leishmania major beta tubulin 0.0154 0.6292 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.3132 0.3132
Mycobacterium tuberculosis Cell division protein FtsZ 0.0026 0.0371 1
Echinococcus multilocularis tubulin alpha 3 chain 0.006 0.1939 0.3082
Echinococcus granulosus tubulin delta chain 0.0026 0.0371 0.0589
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Echinococcus multilocularis Tubulin alpha 1 chain 0.006 0.1939 0.3082
Echinococcus multilocularis tubulin alpha 3 chain 0.006 0.1939 0.3082
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Trypanosoma brucei beta tubulin 0.0154 0.6292 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0154 0.6292 1
Brugia malayi tubulin alpha chain - mouse 0.006 0.1939 0.1939
Loa Loa (eye worm) alpha-tubulin 0.006 0.1939 0.1939
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Echinococcus granulosus defective proboscis extension response 0.0067 0.2277 0.3619
Loa Loa (eye worm) TK protein kinase 0.003 0.0541 0.0541
Echinococcus granulosus Immunoglobulin 0.0067 0.2277 0.3619
Leishmania major beta tubulin 0.0154 0.6292 1
Echinococcus granulosus Tubulin beta 2C chain 0.0154 0.6292 1
Echinococcus multilocularis neuroglian 0.0085 0.3109 0.4942
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0621 0.0763
Echinococcus multilocularis Tubulin beta 2C chain 0.0154 0.6292 1
Brugia malayi alpha-tubulin 0.006 0.1939 0.1939
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0067 0.2277 0.3619
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.1088 0.1211
Trypanosoma brucei zeta tubulin, putative 0.0026 0.0371 0.0355
Echinococcus granulosus Tubulin beta 2C chain 0.0154 0.6292 1
Schistosoma mansoni septate junction protein 0.0025 0.0314 0.0499
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0314 0.0499
Giardia lamblia Beta tubulin 0.0154 0.6292 1
Echinococcus granulosus tubulin alpha 3 chain 0.006 0.1939 0.3082
Brugia malayi polk-prov protein 0.0031 0.0621 0.0621
Echinococcus granulosus tubulin alpha chain 0.006 0.1939 0.3082
Loa Loa (eye worm) hypothetical protein 0.0092 0.3424 0.3424
Echinococcus multilocularis tubulin alpha 1C chain 0.006 0.1939 0.3082
Leishmania major beta tubulin 0.0154 0.6292 1
Echinococcus granulosus tyrosine protein kinase otk 0.0025 0.0314 0.0499
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.006 0.1939 0.2648
Leishmania major zeta tubulin, putative 0.0026 0.0371 0.0355
Echinococcus multilocularis tubulin alpha chain 0.006 0.1939 0.3082
Trypanosoma brucei alpha tubulin, putative 0.0034 0.0736 0.0949
Brugia malayi Fibronectin type III domain containing protein 0.0067 0.2277 0.2277
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0025 0.0314 0.0499
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.1088 0.1211
Loa Loa (eye worm) tubulin beta chain 0.0154 0.6292 0.6292
Echinococcus granulosus tubulin gamma 1 chain 0.006 0.1939 0.3082
Entamoeba histolytica tubulin family protein 0.0154 0.6292 1
Trichomonas vaginalis tubulin, putative 0.0034 0.0736 0.0616
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0034 0.0736 0.0616
Schistosoma mansoni alpha tubulin 0.006 0.1939 0.3082
Trypanosoma brucei alpha tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) hypothetical protein 0.0067 0.2277 0.2277
Schistosoma mansoni nephrin 0.0085 0.3109 0.4942
Echinococcus granulosus roundabout 2 0.0025 0.0314 0.0499
Schistosoma mansoni tubulin subunit beta 0.0154 0.6292 1
Echinococcus multilocularis beta tubulin 0.0154 0.6292 1
Schistosoma mansoni tubulin subunit alpha 0.0026 0.0371 0.0589
Leishmania major beta tubulin 0.0154 0.6292 1
Trichomonas vaginalis tubulin beta chain, putative 0.006 0.1939 0.2648
Loa Loa (eye worm) tubulin beta-1 chain 0.0154 0.6292 0.6292
Treponema pallidum cell division protein FtsZ 0.0026 0.0371 0.5
Brugia malayi Tubulin gamma chain 0.006 0.1939 0.1939
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0314 0.0314
Schistosoma mansoni tubulin subunit alpha 0.006 0.1939 0.3082
Echinococcus multilocularis Immunoglobulin 0.0067 0.2277 0.3619
Trypanosoma cruzi epsilon tubulin, putative 0.006 0.1939 0.2648
Toxoplasma gondii beta tubulin 0.0154 0.6292 1
Trichomonas vaginalis tubulin beta chain, putative 0.006 0.1939 0.2648
Echinococcus granulosus Tubulin alpha 1 chain 0.006 0.1939 0.3082
Trypanosoma brucei unspecified product 0.0035 0.078 0.1021
Brugia malayi Cell division protein ftsZ 0.0026 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0067 0.2277 0.2277
Brugia malayi Tubulin alpha chain 0.006 0.1939 0.1939
Plasmodium vivax tubulin alpha chain, putative 0.006 0.1939 0.2648
Toxoplasma gondii beta-1 tubulin, putative 0.0154 0.6292 1
Mycobacterium leprae cell division protein FtsZ 0.0026 0.0371 0.5
Echinococcus granulosus peroxidasin 0.0025 0.0314 0.0499
Brugia malayi Tubulin alpha-2 chain 0.006 0.1939 0.1939
Echinococcus granulosus tubulin alpha chain 0.006 0.1939 0.3082
Echinococcus granulosus Tubulin beta 2C chain 0.0154 0.6292 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0025 0.0314 0.0499
Loa Loa (eye worm) hypothetical protein 0.0031 0.0621 0.0621
Plasmodium vivax tubulin gamma chain, putative 0.006 0.1939 0.2648
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.1088 0.1211
Echinococcus granulosus Tubulin beta 2C chain 0.0154 0.6292 1
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0085 0.3132 0.3132
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0736 0.0616
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Trypanosoma cruzi tubulin gamma chain 0.006 0.1939 0.2648
Echinococcus multilocularis beta tubulin 0.0154 0.6292 1
Leishmania major beta tubulin 0.0154 0.6292 1
Leishmania major beta tubulin 0.0154 0.6292 1
Echinococcus multilocularis tubulin alpha 0.006 0.1939 0.3082
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.1088 1
Brugia malayi hypothetical protein 0.0067 0.2277 0.2277
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0025 0.0314 0.0499
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Schistosoma mansoni cell adhesion molecule 0.0074 0.2591 0.4118
Trypanosoma brucei beta tubulin 0.0154 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Brugia malayi Prion-like- 0.0025 0.0314 0.0314
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Plasmodium falciparum alpha tubulin 1 0.006 0.1939 0.2648
Trypanosoma brucei beta tubulin 0.006 0.1939 0.2909
Schistosoma mansoni cell adhesion molecule 0.0025 0.0314 0.0499
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.1088 0.1523
Echinococcus multilocularis tubulin subunit TubB 0.006 0.1939 0.3082
Echinococcus multilocularis tubulin beta 1 chain 0.0154 0.6292 1
Trypanosoma brucei epsilon tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0034 0.0736 0.0736
Giardia lamblia Alpha-tubulin 0.006 0.1939 0.2909
Echinococcus granulosus hemicentin 1 0.0025 0.0314 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Trichomonas vaginalis tubulin epsilon chain, putative 0.0154 0.6292 1
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0026 0.0371 0.5
Echinococcus granulosus roundabout 2 0.0025 0.0314 0.0499
Echinococcus granulosus tubulin alpha 0.006 0.1939 0.3082
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Echinococcus granulosus beta tubulin 0.0154 0.6292 1
Loa Loa (eye worm) tubulin alpha chain 0.006 0.1939 0.1939
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Trichomonas vaginalis tubulin epsilon chain, putative 0.0154 0.6292 1
Loa Loa (eye worm) tubulin gamma chain 0.006 0.1939 0.1939
Echinococcus multilocularis peroxidasin 0.0025 0.0314 0.0499
Echinococcus granulosus lachesin 0.0025 0.0314 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.2277 0.2277
Echinococcus granulosus beta tubulin 0.0154 0.6292 1
Trypanosoma brucei epsilon tubulin 0.006 0.1939 0.2909
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0034 0.0736 0.0616
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0074 0.2591 0.4118
Leishmania major beta tubulin 0.0154 0.6292 1
Schistosoma mansoni tubulin subunit epsilon 0.006 0.1939 0.3082
Loa Loa (eye worm) hypothetical protein 0.006 0.1939 0.1939
Echinococcus multilocularis hemicentin 1 0.0025 0.0314 0.0499
Echinococcus multilocularis hypothetical protein 0.006 0.1939 0.3082
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0541 0.0541
Onchocerca volvulus Tyrosine kinase homolog 0.003 0.0541 0.7351
Echinococcus granulosus neuroglian 0.0025 0.0314 0.0499
Trichomonas vaginalis tubulin beta chain, putative 0.0034 0.0736 0.0616
Trichomonas vaginalis tubulin alpha chain, putative 0.0154 0.6292 1
Toxoplasma gondii alpha tubulin TUBA1 0.006 0.1939 0.2648
Echinococcus multilocularis Tubulin alpha 1 chain 0.006 0.1939 0.3082
Echinococcus granulosus contactin 0.0025 0.0314 0.0499
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0025 0.0314 0.4272
Echinococcus granulosus tubulin alpha chain 0.006 0.1939 0.3082
Schistosoma mansoni tubulin subunit beta 0.0154 0.6292 1
Echinococcus granulosus tubulin subunit beta 0.0154 0.6292 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.006 0.1939 0.3082
Plasmodium falciparum tubulin gamma chain 0.006 0.1939 0.2648
Schistosoma mansoni tubulin subunit beta 0.0154 0.6292 1
Trypanosoma cruzi beta tubulin, putative 0.0154 0.6292 1
Schistosoma mansoni tubulin subunit alpha 0.006 0.1939 0.3082
Trichomonas vaginalis tubulin beta chain, putative 0.006 0.1939 0.2648
Plasmodium falciparum tubulin epsilon chain, putative 0.006 0.1939 0.2648
Leishmania major beta tubulin 0.0154 0.6292 1
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.003 0.0541 0.0859
Brugia malayi Tubulin alpha chain 0.0026 0.0371 0.0371
Echinococcus multilocularis tubulin alpha chain 0.006 0.1939 0.3082
Leishmania major delta tubulin, putative 0.0026 0.0371 0.0355
Leishmania major beta tubulin 0.0154 0.6292 1
Entamoeba histolytica tubulin family protein 0.0154 0.6292 1
Onchocerca volvulus 0.0034 0.0736 1
Echinococcus multilocularis neuroglian 0.0025 0.0314 0.0499
Echinococcus multilocularis tubulin alpha chain 0.006 0.1939 0.3082
Trypanosoma brucei beta tubulin 0.0154 0.6292 1
Leishmania major beta tubulin 0.0154 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.2277 0.2277
Loa Loa (eye worm) tubulin alpha 2 0.0034 0.0736 0.0736
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.1088 0.1523
Echinococcus multilocularis roundabout 2 0.0092 0.3424 0.5441
Loa Loa (eye worm) hypothetical protein 0.0067 0.2277 0.2277
Leishmania major beta tubulin 0.0154 0.6292 1
Echinococcus granulosus Tubulin beta 2C chain 0.0154 0.6292 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Loa Loa (eye worm) beta-tubulin 0.0154 0.6292 0.6292
Schistosoma mansoni tubulin subunit beta 0.0154 0.6292 1
Schistosoma mansoni tubulin subunit beta 0.0026 0.0371 0.0589
Trypanosoma brucei zeta tubulin 0.0026 0.0371 0.0355
Echinococcus granulosus tubulin subunit TubB 0.006 0.1939 0.3082
Echinococcus multilocularis roundabout 2 0.0025 0.0314 0.0499
Schistosoma mansoni titin 0.0025 0.0314 0.0499
Schistosoma mansoni tubulin subunit beta 0.0154 0.6292 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0067 0.2277 0.3619
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Giardia lamblia Alpha-tubulin 0.006 0.1939 0.2909
Echinococcus granulosus tubulin alpha chain 0.006 0.1939 0.3082
Loa Loa (eye worm) tubulin alpha-3 chain 0.0026 0.0371 0.0371
Echinococcus multilocularis tubulin gamma 1 chain 0.006 0.1939 0.3082
Echinococcus granulosus tubulin epsilon chain 0.006 0.1939 0.3082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0314 0.0314
Leishmania major alpha tubulin 0.006 0.1939 0.2909
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0025 0.0314 0.0314
Trypanosoma brucei alpha tubulin 0.006 0.1939 0.2909
Echinococcus multilocularis Immunoglobulin 0.0067 0.2277 0.3619
Echinococcus multilocularis dna polymerase kappa 0.0041 0.1088 0.1729
Schistosoma mansoni neuroglian 0.0025 0.0314 0.0499
Echinococcus granulosus tubulin alpha 3 chain 0.006 0.1939 0.3082
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0067 0.2277 0.3619
Schistosoma mansoni tubulin subunit alpha 0.006 0.1939 0.3082
Echinococcus multilocularis tubulin delta chain 0.0026 0.0371 0.0589
Loa Loa (eye worm) hypothetical protein 0.0074 0.2591 0.2591
Echinococcus granulosus tubulin alpha 1C chain 0.006 0.1939 0.3082
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0736 0.0616
Loa Loa (eye worm) tubulin alpha-2 chain 0.006 0.1939 0.1939
Loa Loa (eye worm) hypothetical protein 0.0092 0.3424 0.3424
Giardia lamblia Epsilon tubulin 0.0026 0.0371 0.0355
Loa Loa (eye worm) tubulin beta-2A chain 0.0154 0.6292 0.6292
Echinococcus multilocularis tubulin alpha chain 0.006 0.1939 0.3082
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0154 0.6292 1
Leishmania major epsilon tubulin, putative 0.006 0.1939 0.2909
Schistosoma mansoni vesicular amine transporter 0.0067 0.2277 0.3619
Leishmania major beta tubulin 0.0154 0.6292 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.1088 0.1211
Leishmania major beta tubulin 0.0154 0.6292 1
Plasmodium falciparum tubulin beta chain 0.0154 0.6292 1
Echinococcus granulosus tubulin beta 1 chain 0.0154 0.6292 1
Schistosoma mansoni tubulin subunit gamma 0.006 0.1939 0.3082
Trichomonas vaginalis tubulin epsilon chain, putative 0.006 0.1939 0.2648
Echinococcus multilocularis tubulin alpha chain 0.006 0.1939 0.3082
Echinococcus multilocularis hemicentin 1 0.0025 0.0314 0.0499
Echinococcus granulosus roundabout 2 0.0092 0.3424 0.5441
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Leishmania major beta tubulin 0.0154 0.6292 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Brugia malayi beta-tubulin, identical 0.0154 0.6292 0.6292
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Plasmodium vivax tubulin epsilon chain, putative 0.006 0.1939 0.2648
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.0314 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1088 0.1523
Schistosoma mansoni cell adhesion molecule 0.0025 0.0314 0.0499
Schistosoma mansoni tubulin subunit delta 0.0026 0.0371 0.0589
Trichomonas vaginalis tubulin alpha chain, putative 0.0034 0.0736 0.0616
Echinococcus granulosus peroxisome assembly protein 26 0.006 0.1939 0.3082
Trypanosoma brucei alpha tubulin 0.006 0.1939 0.2909
Echinococcus multilocularis tubulin alpha 1C chain 0.006 0.1939 0.3082
Plasmodium vivax tubulin beta chain, putative 0.0154 0.6292 1
Echinococcus granulosus Tubulin alpha 1 chain 0.006 0.1939 0.3082
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.0314 0.0314
Echinococcus multilocularis Tubulin beta 2C chain 0.0154 0.6292 1
Trichomonas vaginalis tubulin alpha chain, putative 0.006 0.1939 0.2648
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0314 0.0314
Echinococcus multilocularis lachesin 0.0025 0.0314 0.0499
Trichomonas vaginalis tubulin beta chain, putative 0.0154 0.6292 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0314 0.0314
Leishmania major beta tubulin 0.0154 0.6292 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 37600 nM In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay (n=3) ChEMBL. 15808464
IC50 (binding) = 37600 nM In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay (n=3) ChEMBL. 15808464

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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