TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.387 | Formula: C23H27Cl2N3
H donors: 0 H acceptors: 1 LogP: 7.01 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(N1CCc2c3c1cc(C)nc3cn2c1ccc(cc1Cl)Cl)CCC
InChi: 1S/C23H27Cl2N3/c1-4-6-17(7-5-2)27-11-10-21-23-19(26-15(3)12-22(23)27)14-28(21)20-9-8-16(24)13-18(20)25/h8-9,12-14,17H,4-7,10-11H2,1-3H3
InChiKey: VTKRRCWSAXOGFB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0172	0.8192	0.8192
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.339	0.2998
Brugia malayi	Tubulin alpha chain	0.008	0.339	0.339
Plasmodium falciparum	tubulin gamma chain	0.008	0.339	0.3186
Plasmodium falciparum	metacaspase-like protein	0.0026	0.0559	0.0268
Echinococcus multilocularis	beta tubulin	0.0207	1	1
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0038	0.1191	0.1191
Leishmania major	delta tubulin, putative	0.0035	0.1008	0.0731
Leishmania major	epsilon tubulin, putative	0.008	0.339	0.3186
Echinococcus granulosus	Tubulin beta 2C chain	0.0207	1	1
Trichomonas vaginalis	tubulin, putative	0.0045	0.1562	0.1062
Plasmodium vivax	delta tubulin, putative	0.0035	0.1008	0.0731
Echinococcus multilocularis	sentrin specific protease 8	0.0091	0.397	0.397
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0038	0.1191	0.0669
Leishmania major	beta tubulin	0.0207	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.008	0.339	0.2998
Trypanosoma brucei	alpha tubulin	0.008	0.339	0.3143
Plasmodium vivax	sentrin-specific protease 1, putative	0.0038	0.1191	0.092
Leishmania major	metacaspase, putative	0.0026	0.0559	0.0268
Echinococcus multilocularis	tubulin subunit TubB	0.008	0.339	0.339
Schistosoma mansoni	caspase-7 (C14 family)	0.0098	0.4336	0.4336
Loa Loa (eye worm)	tubulin alpha-2 chain	0.008	0.339	0.339
Echinococcus granulosus	tubulin subunit beta	0.0207	1	1
Leishmania major	beta tubulin	0.0207	1	1
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0091	0.397	0.3612
Plasmodium vivax	sentrin-specific protease 2, putative	0.0038	0.1191	0.092
Echinococcus granulosus	sentrin specific protease 1	0.0038	0.1191	0.1191
Echinococcus granulosus	caspase	0.0098	0.4336	0.4336
Trypanosoma cruzi	SUMO1/Ulp2, putative	0.0038	0.1191	0.0862
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0559	0.0207
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0091	0.397	0.397
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.177	0.177
Leishmania major	beta tubulin	0.0207	1	1
Echinococcus granulosus	beta tubulin	0.0207	1	1
Trypanosoma brucei	metacaspase	0.0026	0.0559	0.0207
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.1008	0.0476
Echinococcus multilocularis	peroxisome assembly protein 26	0.008	0.339	0.339
Trypanosoma cruzi	beta tubulin, putative	0.0207	1	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0026	0.0559	0.0559
Giardia lamblia	Sentrin specific protease, putative	0.0038	0.1191	0.0203
Trypanosoma brucei	tubulin delta chain	0.0035	0.1008	0.0673
Trichomonas vaginalis	tubulin alpha chain, putative	0.0207	1	1
Loa Loa (eye worm)	serine/threonine protein phosphatase 5	0.0021	0.0299	0.0299
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.049	0.0197
Trypanosoma brucei	alpha tubulin	0.008	0.339	0.3143
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0038	0.1191	0.1191
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.049	0.0135
Echinococcus multilocularis	tubulin gamma 1 chain	0.008	0.339	0.339
Schistosoma mansoni	tubulin subunit beta	0.0207	1	1
Schistosoma mansoni	tubulin subunit beta	0.0207	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0045	0.1562	0.1062
Echinococcus granulosus	Tubulin alpha 1 chain	0.008	0.339	0.339
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0559	0.0559
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.1191	0.0669
Echinococcus multilocularis	caspase	0.0098	0.4336	0.4336
Echinococcus granulosus	sentrin specific protease 7	0.0172	0.8192	0.8192
Loa Loa (eye worm)	BEN-1 protein	0.0207	1	1
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Trypanosoma brucei	epsilon tubulin	0.008	0.339	0.3143
Schistosoma mansoni	tubulin subunit beta	0.0207	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0207	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0207	1	1
Schistosoma mansoni	tubulin subunit beta	0.0207	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0035	0.1008	0.5
Trypanosoma cruzi	epsilon tubulin, putative	0.008	0.339	0.3143
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0035	0.1008	0.5
Echinococcus granulosus	tubulin beta 4A class IVa	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.339	0.339
Plasmodium vivax	tubulin alpha chain, putative	0.008	0.339	0.3186
Brugia malayi	Cell death protein 3 precursor	0.0026	0.0559	0.0559
Giardia lamblia	Alpha-tubulin	0.008	0.339	0.2648
Leishmania major	beta tubulin	0.0207	1	1
Brugia malayi	tubulin alpha chain - mouse	0.008	0.339	0.339
Echinococcus multilocularis	tubulin alpha	0.008	0.339	0.339
Echinococcus multilocularis	sentrin specific protease 1	0.0038	0.1191	0.1191
Echinococcus granulosus	tubulin alpha chain	0.008	0.339	0.339
Trypanosoma cruzi	hypothetical protein	0.0091	0.397	0.3745
Mycobacterium ulcerans	cell division protein FtsZ	0.0035	0.1008	0.5
Trypanosoma brucei	alpha tubulin	0.008	0.339	0.3143
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Leishmania major	beta tubulin	0.0207	1	1
Trypanosoma brucei	epsilon tubulin	0.008	0.339	0.3143
Loa Loa (eye worm)	tubulin beta chain	0.0035	0.1008	0.1008
Trichomonas vaginalis	tubulin gamma chain, putative	0.008	0.339	0.2998
Loa Loa (eye worm)	BEN-1 protein	0.0207	1	1
Echinococcus granulosus	tubulin alpha chain	0.008	0.339	0.339
Echinococcus multilocularis	tubulin alpha 3 chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0035	0.1008	0.0476
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.049	0.0135
Leishmania major	SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative	0.0038	0.1191	0.092
Loa Loa (eye worm)	hypothetical protein	0.0049	0.177	0.177
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.1008	0.0476
Trypanosoma brucei	SUMO1/Ulp2, putative	0.0038	0.1191	0.0862
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.339	0.2998
Trichomonas vaginalis	tubulin epsilon chain, putative	0.008	0.339	0.2998
Trypanosoma cruzi	zeta tubulin, putative	0.0035	0.1008	0.0673
Plasmodium vivax	metacaspase 1, putative	0.0026	0.0559	0.0268
Echinococcus multilocularis	tubulin alpha 1C chain	0.008	0.339	0.339
Brugia malayi	Tubulin alpha-2 chain	0.008	0.339	0.339
Chlamydia trachomatis	deubiquitinase/deneddylase Dub2	0.0038	0.1191	0.5
Echinococcus multilocularis	caspase 8	0.0026	0.0559	0.0559
Leishmania major	beta tubulin	0.0207	1	1
Trypanosoma brucei	metacaspase MCA3	0.0026	0.0559	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1191	0.1191
Trypanosoma brucei	epsilon tubulin	0.008	0.339	0.3143
Trichomonas vaginalis	tubulin, putative	0.0207	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.008	0.339	0.3186
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0038	0.1191	0.1191
Brugia malayi	alpha-tubulin	0.008	0.339	0.339
Trichomonas vaginalis	tubulin beta chain, putative	0.0207	1	1
Onchocerca volvulus		0.0038	0.1191	0.6298
Brugia malayi	tubulin alpha-2 chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin alpha chain, putative	0.0045	0.1562	0.1062
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0038	0.1191	0.092
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0559	0.0207
Toxoplasma gondii	beta tubulin	0.0207	1	1
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Echinococcus multilocularis	tubulin alpha chain	0.008	0.339	0.339
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Schistosoma mansoni	tubulin subunit alpha	0.0035	0.1008	0.1008
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0038	0.1191	0.0669
Echinococcus granulosus	tubulin alpha 1C chain	0.008	0.339	0.339
Echinococcus multilocularis	Tubulin beta 2C chain	0.0207	1	1
Plasmodium falciparum	tubulin delta chain, putative	0.0035	0.1008	0.0731
Echinococcus granulosus	Tubulin beta 2C chain	0.0207	1	1
Giardia lamblia	Alpha-tubulin	0.008	0.339	0.2648
Brugia malayi	Tubulin beta chain	0.0035	0.1008	0.1008
Leishmania major	hypothetical protein, conserved	0.0025	0.049	0.0197
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0098	0.4336	0.4336
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0559	0.0559
Echinococcus granulosus	tubulin alpha 3 chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin alpha chain, putative	0.0045	0.1562	0.1062
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0038	0.1191	0.0669
Toxoplasma gondii	beta-1 tubulin, putative	0.0207	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.008	0.339	0.339
Loa Loa (eye worm)	tubulin beta-2A chain	0.0207	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.008	0.339	0.339
Echinococcus multilocularis	Tubulin alpha 1 chain	0.008	0.339	0.339
Brugia malayi	hypothetical protein	0.0025	0.049	0.049
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0035	0.1008	0.0476
Trichomonas vaginalis	tubulin gamma chain, putative	0.0207	1	1
Leishmania major	beta tubulin	0.0207	1	1
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0098	0.4336	0.4336
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0035	0.1008	0.5
Schistosoma mansoni	caspase-3 (C14 family)	0.0098	0.4336	0.4336
Echinococcus multilocularis	hypothetical protein	0.008	0.339	0.339
Leishmania major	zeta tubulin, putative	0.0035	0.1008	0.0731
Trypanosoma cruzi	alpha tubulin, putative	0.008	0.339	0.3143
Trypanosoma cruzi	tubulin gamma chain	0.008	0.339	0.3143
Toxoplasma gondii	alpha-tubulin I, putative	0.008	0.339	0.3186
Trypanosoma cruzi	zeta tubulin, putative	0.0035	0.1008	0.0673
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0026	0.0559	0.0268
Toxoplasma gondii	alpha tubulin TUBA1	0.008	0.339	0.3186
Entamoeba histolytica	tubulin gamma chain	0.008	0.339	0.2496
Leishmania major	beta tubulin	0.0207	1	1
Leishmania major	beta tubulin	0.0207	1	1
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.008	0.339	0.3186
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0091	0.397	0.3612
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0207	1	1
Loa Loa (eye worm)	beta-tubulin	0.0207	1	1
Trypanosoma brucei	beta tubulin	0.008	0.339	0.3143
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0172	0.8192	0.7948
Schistosoma mansoni	tubulin subunit epsilon	0.008	0.339	0.339
Brugia malayi	Tubulin beta chain	0.0045	0.1562	0.1562
Brugia malayi	beta-tubulin, identical	0.0207	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.008	0.339	0.339
Schistosoma mansoni	tubulin subunit beta	0.0207	1	1
Schistosoma mansoni	tubulin subunit gamma	0.008	0.339	0.339
Loa Loa (eye worm)	tubulin alpha 2	0.0045	0.1562	0.1562
Trypanosoma brucei	beta tubulin	0.0207	1	1
Echinococcus granulosus	beta tubulin	0.0207	1	1
Plasmodium falciparum	alpha tubulin 1	0.008	0.339	0.3186
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.008	0.339	0.2998
Plasmodium vivax	tubulin gamma chain, putative	0.008	0.339	0.3186
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0559	0.0207
Trypanosoma brucei	Metacaspase-4	0.0026	0.0559	0.0207
Leishmania major	beta tubulin	0.0207	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0035	0.1008	0.0476
Echinococcus multilocularis	caspase 2	0.0026	0.0559	0.0559
Echinococcus granulosus	tubulin subunit TubB	0.008	0.339	0.339
Echinococcus multilocularis	tubulin epsilon chain	0.008	0.339	0.339
Loa Loa (eye worm)	Ulp1 protease	0.0091	0.397	0.397
Echinococcus granulosus	tubulin alpha 1C chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin gamma chain, putative	0.008	0.339	0.2998
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0038	0.1191	0.092
Trypanosoma cruzi	metacaspase 5, putative	0.0026	0.0559	0.0207
Trypanosoma brucei	alpha tubulin, putative	0.0045	0.1562	0.1248
Echinococcus multilocularis	tubulin alpha 3 chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.339	0.2998
Echinococcus multilocularis	caspase 3	0.0072	0.2958	0.2958
Echinococcus multilocularis	Tubulin alpha 1 chain	0.008	0.339	0.339
Echinococcus multilocularis	tubulin alpha chain	0.008	0.339	0.339
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0091	0.397	0.397
Brugia malayi	Cell division protein ftsZ	0.0035	0.1008	0.1008
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0038	0.1191	0.1191
Echinococcus granulosus	tubulin alpha chain	0.008	0.339	0.339
Echinococcus granulosus	expressed conserved protein	0.0134	0.6182	0.6182
Brugia malayi	Tubulin alpha chain	0.0035	0.1008	0.1008
Echinococcus multilocularis	tubulin alpha chain	0.008	0.339	0.339
Echinococcus multilocularis	tubulin beta 1 chain	0.0207	1	1
Leishmania major	gamma-tubulin	0.008	0.339	0.3186
Echinococcus multilocularis	Tubulin beta 2C chain	0.0207	1	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0045	0.1562	0.1562
Chlamydia trachomatis	deubiquitinase/deneddylase Dub1	0.0038	0.1191	0.5
Onchocerca volvulus		0.0045	0.1562	1
Leishmania major	beta tubulin	0.0207	1	1
Leishmania major	beta tubulin	0.0207	1	1
Giardia lamblia	Gamma tubulin	0.008	0.339	0.2648
Echinococcus multilocularis	sentrin specific protease 7	0.0172	0.8192	0.8192
Loa Loa (eye worm)	tubulin beta-1 chain	0.0207	1	1
Schistosoma mansoni	tubulin subunit beta	0.0207	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0035	0.1008	0.0731
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1008	0.1008
Trypanosoma cruzi	metacaspase 5, putative	0.0026	0.0559	0.0207
Trypanosoma brucei	alpha tubulin	0.008	0.339	0.3143
Loa Loa (eye worm)	alpha-tubulin	0.008	0.339	0.339
Loa Loa (eye worm)	tubulin gamma chain	0.008	0.339	0.339
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0026	0.0559	0.0268
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0091	0.397	0.3612
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.049	0.0135
Giardia lamblia	Beta tubulin	0.0207	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.008	0.339	0.2998
Trypanosoma cruzi	tubulin delta chain	0.0035	0.1008	0.0673
Plasmodium vivax	tubulin alpha chain, putative	0.008	0.339	0.3186
Schistosoma mansoni	tubulin subunit beta	0.0035	0.1008	0.1008
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0033	0.0883	0.0883
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Giardia lamblia	Beta tubulin	0.0207	1	1
Loa Loa (eye worm)	protein phosphatase 5	0.0021	0.0283	0.0283
Trichomonas vaginalis	tubulin beta chain, putative	0.0045	0.1562	0.1062
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.049	0.0197
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0033	0.0883	0.0883
Echinococcus granulosus	caspase 3	0.0072	0.2958	0.2958
Trichomonas vaginalis	sentrin/sumo-specific protease, senp8, putative	0.0038	0.1191	0.0669
Echinococcus granulosus	tubulin alpha chain	0.008	0.339	0.339
Echinococcus granulosus	tubulin delta chain	0.0035	0.1008	0.1008
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0026	0.0559	0.0268
Loa Loa (eye worm)	tubulin alpha 2	0.0045	0.1562	0.1562
Plasmodium falciparum	alpha tubulin 2	0.008	0.339	0.3186
Leishmania major	beta tubulin	0.0207	1	1
Loa Loa (eye worm)	alpha-tubulin	0.008	0.339	0.339
Echinococcus granulosus	tubulin alpha 3 chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0207	1	1
Trichomonas vaginalis	tubulin, putative	0.0035	0.1008	0.0476
Schistosoma mansoni	tubulin subunit alpha	0.008	0.339	0.339
Trypanosoma cruzi	tubulin delta chain	0.0035	0.1008	0.0673
Schistosoma mansoni	tubulin subunit delta	0.0035	0.1008	0.1008
Trypanosoma brucei	beta tubulin	0.0207	1	1
Plasmodium falciparum	metacaspase 1	0.0026	0.0559	0.0268
Entamoeba histolytica	tubulin family protein	0.0207	1	1
Trypanosoma brucei	tubulin gamma chain	0.008	0.339	0.3143
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0091	0.397	0.3612
Plasmodium falciparum	tubulin beta chain	0.0207	1	1
Toxoplasma gondii	beta-tubulin, putative	0.0207	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0045	0.1562	0.1062
Brugia malayi	Tubulin gamma chain	0.008	0.339	0.339
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.339	0.2998
Echinococcus multilocularis	Tubulin beta 2C chain	0.0207	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0207	1	1
Echinococcus granulosus	protein phosphatase 5	0.0021	0.0299	0.0299
Echinococcus multilocularis	expressed conserved protein	0.0134	0.6182	0.6182
Schistosoma mansoni	hypothetical protein	0.0034	0.0951	0.0951
Leishmania major	beta tubulin	0.0207	1	1
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0038	0.1191	0.0669
Echinococcus granulosus	peroxisome assembly protein 26	0.008	0.339	0.339
Trypanosoma cruzi	epsilon tubulin, putative	0.008	0.339	0.3143
Entamoeba histolytica	tubulin family protein	0.0207	1	1
Trichomonas vaginalis	tubulin, putative	0.0045	0.1562	0.1062
Trypanosoma cruzi	metacaspase, putative	0.0026	0.0559	0.0207
Trypanosoma brucei	zeta tubulin	0.0035	0.1008	0.0673
Trypanosoma brucei	metacaspase 5, putative	0.0026	0.0559	0.0207
Echinococcus multilocularis	tubulin alpha chain	0.008	0.339	0.339
Echinococcus granulosus	caspase 2	0.0026	0.0559	0.0559
Schistosoma mansoni	alpha tubulin	0.008	0.339	0.339
Echinococcus multilocularis	beta tubulin	0.0207	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0045	0.1562	0.1062
Echinococcus granulosus	Tubulin beta 2C chain	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1562	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0025	0.049	0.049
Schistosoma mansoni	SET domain protein	0.0033	0.0883	0.0883
Echinococcus multilocularis	tubulin alpha chain	0.008	0.339	0.339
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0035	0.1008	0.0476
Echinococcus granulosus	alpha tubulin	0.008	0.339	0.339
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C48, putative	0.0038	0.1191	0.0862
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0559	0.0268
Echinococcus granulosus	Tubulin beta 2C chain	0.0207	1	1
Echinococcus granulosus	sentrin specific protease 8	0.0091	0.397	0.397
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0026	0.0559	0.0559
Echinococcus granulosus	caspase 8	0.0026	0.0559	0.0559
Brugia malayi	serine/threonine protein phosphatase 5	0.0021	0.0299	0.0299
Trypanosoma brucei	zeta tubulin, putative	0.0035	0.1008	0.0673
Echinococcus multilocularis	Tubulin alpha 1 chain	0.008	0.339	0.339
Echinococcus granulosus	Tubulin alpha 1 chain	0.008	0.339	0.339
Schistosoma mansoni	alpha tubulin	0.008	0.339	0.339
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0038	0.1191	0.0669
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0026	0.0559	0.0559
Leishmania major	beta tubulin	0.0207	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.008	0.339	0.3186
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.339	0.2998
Plasmodium falciparum	sentrin-specific protease 1	0.0038	0.1191	0.092
Entamoeba histolytica	tubulin alpha chain, putative	0.008	0.339	0.2496
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.177	0.177
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0951	0.0951
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.049	0.0197
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Leishmania major	beta tubulin	0.0207	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0207	1	1
Brugia malayi	Tubulin alpha-2 chain	0.008	0.339	0.339
Trypanosoma brucei	beta tubulin	0.0207	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.008	0.339	0.339
Echinococcus granulosus	Tubulin beta 2C chain	0.0207	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.339	0.2998
Entamoeba histolytica	tubulin alpha-1 chain	0.008	0.339	0.2496
Trypanosoma brucei	beta tubulin	0.0207	1	1
Toxoplasma gondii	Ulp1 protease family, C-terminal catalytic domain-containing protein	0.0038	0.1191	0.092
Echinococcus multilocularis	tubulin subunit beta	0.0207	1	1
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0035	0.1008	0.0731
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0035	0.1008	0.1008
Leishmania major	beta tubulin	0.0207	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0207	1	1
Echinococcus granulosus	tubulin alpha chain	0.008	0.339	0.339
Loa Loa (eye worm)	Ulp1 protease	0.0038	0.1191	0.1191
Echinococcus multilocularis	tubulin delta chain	0.0035	0.1008	0.1008
Echinococcus granulosus	Tubulin alpha 1 chain	0.008	0.339	0.339
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0207	1	1
Echinococcus multilocularis	protein phosphatase 5	0.0021	0.0299	0.0299
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0038	0.1191	0.0669
Echinococcus granulosus	tubulin epsilon chain	0.008	0.339	0.339
Trypanosoma brucei	metacaspase MCA2	0.0026	0.0559	0.0207
Giardia lamblia	Beta tubulin	0.0207	1	1
Schistosoma mansoni	tubulin subunit alpha	0.008	0.339	0.339
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.177	0.177
Echinococcus multilocularis	Tubulin beta 2C chain	0.0207	1	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1191	0.1191
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0091	0.397	0.3154
Brugia malayi	hypothetical protein	0.0016	0.0026	0.0026
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0951	0.0951
Schistosoma mansoni	protein phosphatase-5	0.0023	0.0359	0.0359
Echinococcus granulosus	tubulin alpha	0.008	0.339	0.339
Treponema pallidum	cell division protein FtsZ	0.0035	0.1008	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1191	0.1191
Leishmania major	alpha tubulin	0.008	0.339	0.3186
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0038	0.1191	0.1191
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.049	0.0197
Leishmania major	beta tubulin	0.0207	1	1
Schistosoma mansoni	alpha tubulin	0.008	0.339	0.339
Schistosoma mansoni	tubulin subunit alpha	0.008	0.339	0.339

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	NA 0 nM	Inhibition of [125I]-sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cells; Not active (<30% inhibition at 10 uM)	ChEMBL.	15943483

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 337318