Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transient receptor potential cation channel, subfamily V, member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0052 | 0.000000057511 | 0.000000057511 |
Brugia malayi | Blistered cuticle protein 3 | 0.0402 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0402 | 1 | 1 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0402 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0402 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0402 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.000000057511 | 0.000000057511 |
Onchocerca volvulus | Peroxidasin homolog | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0402 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0052 | 0.000000057511 | 0.000000057511 |
Brugia malayi | Animal haem peroxidase family protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Onchocerca volvulus | Dual oxidase homolog | 0.0402 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0052 | 0.000000057511 | 0.000000057511 |
Brugia malayi | Animal haem peroxidase family protein | 0.0402 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0402 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0052 | 0 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0052 | 0.000000057511 | 0.000000057511 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0402 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0402 | 1 | 1 |
Onchocerca volvulus | 0.0402 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0052 | 0.000000057511 | 0.000000057511 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0052 | 0.000000057511 | 0.000000057511 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.119 10^-6M | Inhibition of rat human chimera TRPV1 channel expressed in CHO cells | ChEMBL. | 17948977 |
IC50 (functional) | = 44 nM | Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
IC50 (functional) | = 44 nM | Inhibition of capsaicin-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
IC50 (functional) | = 660 nM | Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
IC50 (functional) | = 660 nM | Inhibition of pH-induced calcium uptake by transient receptor potential vanilloid type 1 expressed in CHO cells | ChEMBL. | 15634002 |
Log IC50 (binding) | = 6.92 | Inhibition of rat human chimera TRPV1 channel expressed in CHO cells | ChEMBL. | 17948977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.