Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0459 | 0.3171 | 0.312 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1393 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1393 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Echinococcus granulosus | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1393 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0544 | 0.3792 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1393 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Giardia lamblia | Aldose reductase | 0.0036 | 0.0075 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1393 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0036 | 0.0075 | 0.0075 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1393 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0544 | 0.3792 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1393 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0544 | 0.3792 | 0.3745 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0459 | 0.3171 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0544 | 0.3792 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Giardia lamblia | Aldose reductase | 0.0036 | 0.0075 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1393 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1393 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1393 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1393 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1393 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1393 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 0.3745 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1393 | 1 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0544 | 0.3792 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Accumulation (functional) | = 4 % | Maximum percent cAMP accumulation mediated by human melanocortin 3 receptor relative to alpha-MSH (1.1%) at 10 uM concentration | ChEMBL. | 15808454 |
Accumulation (functional) | = 10 % | Maximum percent cAMP accumulation mediated by human melanocortin 5 receptor relative to alpha-MSH (17%) at 10 uM concentration | ChEMBL. | 15808454 |
Accumulation (functional) | = 92 % | Maximum percent cAMP accumulation mediated by human melanocortin 4 receptor relative to alpha-MSH (1.9%) at 10 uM concentration | ChEMBL. | 15808454 |
Activity (functional) | = 216 | Covalent binding to rat microsomal proteins after 30 min of incubation with [3H]-compound in the presence of NADPH (n=3) | ChEMBL. | 15808454 |
EC50 (functional) | = 18 nM | Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptor | ChEMBL. | 15808454 |
IC50 (binding) | = 11 nM | Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nM | ChEMBL. | 15808454 |
Selectivity (binding) | = 81 | Selectivity for human melanocortin 3 receptor over melanocortin 4 receptor expressed in CHO cells; control 1 nM | ChEMBL. | 15808454 |
Selectivity (binding) | = 105 | Selectivity for human melanocortin 3 receptor over melanocortin 5 receptor expressed in CHO cells; control 6 nM | ChEMBL. | 15808454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.