Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0141 | 0.7436 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0141 | 0.7436 | 0.7436 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0141 | 0.7436 | 0.7436 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.017 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0141 | 0.7436 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0141 | 0.7436 | 0.7436 |
Entamoeba histolytica | adenosine deaminase, putative | 0.017 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.017 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.017 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.017 | 1 | 1 |
Plasmodium vivax | adenosine deaminase, putative | 0.017 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0141 | 0.7436 | 0.7436 |
Schistosoma mansoni | adenosine deaminase | 0.017 | 1 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.017 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.017 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0141 | 0.7436 | 0.7436 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0141 | 0.7436 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.276 | 0.276 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Schistosoma mansoni | adenosine deaminase-related | 0.017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.017 | 1 | 1 |
Brugia malayi | Adenosylhomocysteinase | 0.0141 | 0.7436 | 0.7436 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0141 | 0.7436 | 0.7436 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0141 | 0.7436 | 0.7436 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0141 | 0.7436 | 0.7436 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0141 | 0.7436 | 0.7436 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.276 | 0.276 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0141 | 0.7436 | 0.7436 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.276 | 0.276 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.017 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.017 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0087 | 0.276 | 0.276 |
Plasmodium falciparum | adenosine deaminase | 0.017 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5169 | 0.5169 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.017 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.017 | 1 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.017 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | In vitro minimum inhibitory concentration against Candida tropicalis Berkout KCCM 50662 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | > 25 ug ml-1 | In vitro minimum inhibitory concentration against Candida krusei Berkout KCCM 11655 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | = 25 ug ml-1 | In vitro minimum inhibitory concentration against Aspergillus niger KCTC 1231 strain at 37 degree C after 2 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | > 50 ug ml-1 | In vitro minimum inhibitory concentration against Candida albicans Berkout KCCM 50235 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
MIC (functional) | > 50 ug ml-1 | In vitro minimum inhibitory concentration against Candida albicans Berkout KCCM 50235 strain at 37 degree C after 1 day of treatment | ChEMBL. | 15863328 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.