TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 537.312 | Formula: C16H21N5O12P2--
H donors: 4 H acceptors: 9 LogP: -5.99 Rotable bonds: 0
Rule of 5 violations (Lipinski): 2
SMILES: OC1C(O)[C@H]2O[C@H]1n1cnc3c(c1=N)ncn3[C@H]1O[C@@H](COP(=O)(CP(=O)(OC2)[O-])[O-])[C@H]([C@@H]1O)O
InChi: 1S/C16H23N5O12P2/c17-13-8-14-19-4-20(13)15-11(24)9(22)6(32-15)1-30-34(26,27)5-35(28,29)31-2-7-10(23)12(25)16(33-7)21(14)3-18-8/h3-4,6-7,9-12,15-17,22-25H,1-2,5H2,(H,26,27)(H,28,29)/p-2/t6-,7+,9?,10-,11?,12?,15-,16+/m0/s1
InChiKey: CDPSSJLWAWWPMC-OMPVKIFQSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	orphan nuclear receptor NR2E1	0.0053	0.0157	0.02
Brugia malayi	Cadherin domain containing protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Echinococcus multilocularis	tar DNA binding protein	0.007	0.0266	0.0277
Schistosoma mansoni	nuclear receptor nhr-48	0.0053	0.0157	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Brugia malayi	nuclear hormone receptor	0.0053	0.0157	0.02
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0113	0.0541	0.0687
Brugia malayi	Calcium binding EGF domain containing protein	0.0107	0.0503	0.0638
Brugia malayi	GCC2 and GCC3 family protein	0.0041	0.0077	0.0098
Echinococcus multilocularis	FTZ F1 alpha	0.0113	0.0541	0.0563
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Brugia malayi	hypothetical protein	0.0059	0.0198	0.0252
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0113	0.0541	0.0687
Schistosoma mansoni	coup transcription factor	0.0113	0.0541	0.0474
Schistosoma mansoni	RAR-like nuclear receptor	0.0113	0.0541	0.0474
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.0157	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0198	0.0252
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0041	0.0077	0.008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus multilocularis	Tolloid protein 1	0.0107	0.0503	0.0523
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0113	0.0541	0.0474
Brugia malayi	ecdysone receptor	0.0053	0.0157	0.02
Schistosoma mansoni	notch	0.0041	0.0077	0.0006
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0053	0.0157	0.0157
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0266	0.0197
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.0198	0.0252
Brugia malayi	RNA binding protein	0.007	0.0266	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0113	0.0541	0.0687
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0113	0.0541	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0503	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0198	0.0252
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0113	0.0541	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0198	0.0252
Echinococcus granulosus	FTZ F1 alpha	0.0113	0.0541	0.0541
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0113	0.0541	0.0687
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus granulosus	slit 2 protein	0.0041	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0198	0.0252
Echinococcus granulosus	neurogenic locus notch protein 4	0.0041	0.0077	0.0077
Echinococcus granulosus	ecdysone induced protein 78C	0.0113	0.0541	0.0541
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0035	0.0039	0.0769
Onchocerca volvulus		0.0053	0.0157	0.1729
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Brugia malayi	Nuclear hormone receptor E75	0.0053	0.0157	0.02
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0053	0.0157	0.0087
Loa Loa (eye worm)	nuclear hormone receptor	0.0053	0.0157	0.02
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0113	0.0541	0.0687
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.1248	0.7878	0.7863
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Brugia malayi	nuclear receptor NHR-67	0.0053	0.0157	0.02
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0141	0.0178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0113	0.0541	0.0687
Brugia malayi	ecdysteroid receptor	0.0113	0.0541	0.0687
Brugia malayi	tailless protein	0.0053	0.0157	0.02
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.1248	0.7878	0.8192
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0141	0.0178
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0053	0.0157	0.02
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0113	0.0541	0.0474
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0059	0.0198	0.0128
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0113	0.0541	0.0563
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.1248	0.7878	1
Echinococcus granulosus	dna polymerase eta	0.0049	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0134	0.017
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus multilocularis	dna polymerase eta	0.0049	0.0134	0.0139
Brugia malayi	hypothetical protein	0.0053	0.0157	0.02
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0107	0.0503	0.0638
Echinococcus multilocularis	neurogenic locus protein delta	0.0041	0.0077	0.008
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0059	0.0198	0.0128
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0053	0.0157	0.02
Echinococcus multilocularis	neurogenic locus notch protein	0.0041	0.0077	0.008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Schistosoma mansoni	nuclear receptor	0.0053	0.0157	0.0087
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0113	0.0541	0.0563
Loa Loa (eye worm)	Notch2	0.0041	0.0077	0.0098
Echinococcus granulosus	laminin	0.0107	0.0503	0.0503
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0107	0.0503	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1517	0.9616	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.1248	0.7878	1
Loa Loa (eye worm)	TAR-binding protein	0.007	0.0266	0.0338
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0141	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0503	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0198	0.0252
Echinococcus granulosus	nuclear receptor nhr 48	0.0053	0.0157	0.0157
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0107	0.0503	0.0638
Schistosoma mansoni	egf-like domain protein	0.0107	0.0503	0.0435
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.009
Brugia malayi	nuclear hormone receptor	0.0113	0.0541	0.0687
Brugia malayi	nuclear receptor RXR	0.0059	0.0198	0.0252
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0113	0.0541	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0503	0.0638
Brugia malayi	Cadherin domain containing protein	0.0041	0.0077	0.0098
Schistosoma mansoni	hypothetical protein	0.0352	0.2087	0.2031
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.1248	0.7878	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0113	0.0541	0.0563
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0113	0.0541	0.0541
Trypanosoma cruzi	DNA polymerase eta, putative	0.0035	0.0039	0.0049
Echinococcus multilocularis	neural cadherin	0.0041	0.0077	0.008
Echinococcus multilocularis	neurogenic locus notch protein	0.0041	0.0077	0.008
Leishmania major	DNA polymerase eta, putative	0.0049	0.0134	0.017
Brugia malayi	conserved hypotetical protein	0.0053	0.0157	0.02
Loa Loa (eye worm)	RNA binding protein	0.007	0.0266	0.0338
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0053	0.0157	0.0164
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.1248	0.7878	0.7878
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Echinococcus granulosus	neurogenic locus protein delta	0.0041	0.0077	0.0077
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0141	0.007
Onchocerca volvulus	Arrow homolog	0.0107	0.0503	0.9167
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Schistosoma mansoni	nuclear receptor	0.0053	0.0157	0.0087
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0266	0.0197
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0266	0.0197
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0041	0.0077	0.0006
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0053	0.0157	0.1729
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Echinococcus multilocularis	ecdysone induced protein 78C	0.0113	0.0541	0.0563
Schistosoma mansoni	hypothetical protein	0.0352	0.2087	0.2031
Echinococcus granulosus	thyroid hormone receptor alpha	0.0053	0.0157	0.0157
Brugia malayi	ImpB/MucB/SamB family protein	0.0049	0.0134	0.017
Brugia malayi	nuclear receptor NHR-88	0.0113	0.0541	0.0687
Echinococcus multilocularis	slit 2 protein	0.0041	0.0077	0.008
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0041	0.0077	0.008
Brugia malayi	Calcium binding EGF domain containing protein	0.0041	0.0077	0.0098
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1248	0.7878	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0053	0.0157	0.02
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0059	0.0198	0.0198
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0053	0.0157	0.0164
Echinococcus granulosus	tar DNA binding protein	0.007	0.0266	0.0266
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0113	0.0541	0.0541
Echinococcus multilocularis	geminin	0.0352	0.2087	0.2171
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0071	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0113	0.0541	0.0687
Echinococcus granulosus	notch	0.0041	0.0077	0.0077
Loa Loa (eye worm)	DR-78	0.0053	0.0157	0.02
Brugia malayi	nuclear receptor RXR	0.0053	0.0157	0.02
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Schistosoma mansoni	notch	0.0041	0.0077	0.0006
Echinococcus multilocularis	laminin	0.0107	0.0503	0.0523
Onchocerca volvulus	Bile acid receptor homolog	0.0113	0.0541	1
Schistosoma mansoni	notch	0.0041	0.0077	0.0006
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1248	0.7878	1
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0107	0.0503	0.0435
Echinococcus multilocularis	neurogenic locus protein delta	0.0041	0.0077	0.008
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0113	0.0541	0.0474
Onchocerca volvulus		0.0053	0.0157	0.1729
Schistosoma mansoni	slit	0.0041	0.0077	0.0006
Echinococcus granulosus	protein jagged 1	0.0041	0.0077	0.0077
Brugia malayi	Calcium binding EGF domain containing protein	0.0041	0.0077	0.0098
Toxoplasma gondii	EGF family domain-containing protein	0.0041	0.0077	0.153
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Brugia malayi	Delta serrate ligand family protein	0.0041	0.0077	0.0098
Echinococcus multilocularis	notch	0.0041	0.0077	0.008
Brugia malayi	Nuclear hormone receptor E75	0.0053	0.0157	0.02
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.1248	0.7878	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0049	0.0134	0.017
Trichomonas vaginalis	flap endonuclease-1, putative	0.0029	0	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0113	0.0541	0.0687
Brugia malayi	TAR-binding protein	0.007	0.0266	0.0338
Echinococcus granulosus	neurogenic locus notch protein	0.0041	0.0077	0.0077
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0113	0.0541	0.0541
Echinococcus multilocularis	fibrillin 1	0.0107	0.0503	0.0523
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0053	0.0157	0.02
Schistosoma mansoni	thyroid hormone receptor	0.0113	0.0541	0.0474
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0107	0.0503	0.0638
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0053	0.0157	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Schistosoma mansoni	zinc finger protein	0.0053	0.0157	0.0087
Brugia malayi	Calcium binding EGF domain containing protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0503	0.0638
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0113	0.0541	0.0687
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0113	0.0541	0.0687
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Brugia malayi	steroid hormone receptor	0.0113	0.0541	0.0687
Echinococcus granulosus	Tolloid protein 1	0.0107	0.0503	0.0503
Echinococcus granulosus	delta-like protein 1	0.0041	0.0077	0.0077
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0059	0.0198	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus granulosus	transcription factor Dp 1	0.0722	0.4482	0.4482
Echinococcus multilocularis	protein jagged 1	0.0041	0.0077	0.008
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Plasmodium vivax	flap endonuclease 1, putative	0.0029	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0053	0.0157	0.0164
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0113	0.0541	0.0474
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0266	0.0197
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0113	0.0541	0.0687
Loa Loa (eye worm)	steroid hormone receptor	0.0113	0.0541	0.0687
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0053	0.0157	0.0157
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1248	0.7878	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0053	0.0157	0.0157
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0113	0.0541	0.0541
Schistosoma mansoni	cell polarity protein	0.0041	0.0077	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.009
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0113	0.0541	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0053	0.0157	0.1729
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0107	0.0503	0.0638
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0113	0.0541	0.0563
Echinococcus granulosus	fibropellin Ia	0.0041	0.0077	0.0077
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0053	0.0157	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Schistosoma mansoni	nuclear hormone receptor	0.0113	0.0541	0.0474
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0107	0.0503	1
Plasmodium falciparum	flap endonuclease 1	0.0029	0	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0049	0.0134	0.017
Echinococcus multilocularis	protein jagged 2	0.0041	0.0077	0.008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Brugia malayi	photoreceptor-specific nuclear receptor	0.0113	0.0541	0.0687
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0053	0.0157	0.0157
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.0157	0.0087
Schistosoma mansoni	septate junction protein	0.0041	0.0077	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0503	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Onchocerca volvulus		0.0113	0.0541	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0141	0.0141
Onchocerca volvulus	Protein ultraspiracle homolog	0.0113	0.0541	1
Schistosoma mansoni	notch	0.0041	0.0077	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Leishmania major	DNA polymerase eta, putative	0.0035	0.0039	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.009
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0053	0.0157	0.02
Schistosoma mansoni	retinoic acid receptor RXR	0.1577	1	1
Giardia lamblia	High cysteine protein	0.0041	0.0077	1
Brugia malayi	notch-like transmembrane receptor	0.0041	0.0077	0.0098
Entamoeba histolytica	hypothetical protein	0.004	0.0071	0.009
Schistosoma mansoni	notch	0.0041	0.0077	0.0006
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0266	0.0197
Brugia malayi	Nuclear hormone receptor-like 1	0.0113	0.0541	0.0687
Schistosoma mansoni	DNA polymerase eta	0.0049	0.0134	0.0063
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0059	0.0198	0.0252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0141	0.007
Schistosoma mansoni	laminin gamma-3 chain	0.0041	0.0077	0.0006
Brugia malayi	hypothetical protein	0.0053	0.0157	0.02
Echinococcus granulosus	protein jagged 2	0.0041	0.0077	0.0077
Echinococcus multilocularis	protein jagged 1	0.0041	0.0077	0.008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0141	0.007
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0113	0.0541	0.0687
Brugia malayi	nuclear receptor NHR-88	0.0053	0.0157	0.02
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0113	0.0541	0.0563
Echinococcus granulosus	neurogenic locus notch protein	0.0041	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.0266	0.0338
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.0266	0.0338
Echinococcus multilocularis	fibropellin Ia	0.0041	0.0077	0.008
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0113	0.0541	0.0687
Echinococcus multilocularis	transcription factor Dp 1	0.0722	0.4482	0.4661
Brugia malayi	EGF-like domain containing protein	0.0041	0.0077	0.0098
Brugia malayi	Muscle positioning protein 4	0.0041	0.0077	0.0098
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0071	0.0074
Schistosoma mansoni	notch	0.0041	0.0077	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0077	0.0098
Echinococcus granulosus	protein jagged 2	0.0041	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0157	0.02
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0113	0.0541	0.0474
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.0198	0.0252
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0113	0.0541	0.0474
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0113	0.0541	0.0563
Echinococcus granulosus	neural cadherin	0.0041	0.0077	0.0077
Brugia malayi	hypothetical protein	0.004	0.0071	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0113	0.0541	0.0687
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Schistosoma mansoni	thyroid hormone receptor	0.0113	0.0541	0.0474
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0141	0.0146
Echinococcus granulosus	protein jagged 1	0.0041	0.0077	0.0077
Brugia malayi	hypothetical protein	0.0059	0.0198	0.0252
Echinococcus granulosus	geminin	0.0352	0.2087	0.2087
Echinococcus multilocularis	nuclear receptor nhr 48	0.0053	0.0157	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0541	0.0687
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0041	0.0077	0.0098
Loa Loa (eye worm)	notch protein	0.0041	0.0077	0.0098
Schistosoma mansoni	hypothetical protein	0.0041	0.0077	0.0006
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0113	0.0541	0.0541
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0113	0.0541	0.0687
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0113	0.0541	0.0687
Brugia malayi	Fibulin-1 precursor	0.0107	0.0503	0.0638
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0113	0.0541	0.0687

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 856 nM	Effectiveconcentration of the compound agaisnt release of [Ca2+] ions from sea urchin egg	ChEMBL.	15943490

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 423344

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 337474