Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.3295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3295 | 0.3295 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.3295 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0146 | 0.3295 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3295 | 0.3295 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.3295 | 0.3295 |
Echinococcus granulosus | carboxylesterase 5A | 0.0146 | 0.3295 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 1 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0146 | 0.3295 | 0.3295 |
Brugia malayi | Carboxylesterase family protein | 0.0146 | 0.3295 | 0.3295 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.4615 | 0.4615 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | carboxylesterase | 0.0146 | 0.3295 | 0.3295 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0274 | 0.704 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0146 | 0.3295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0274 | 0.704 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0146 | 0.3295 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0146 | 0.3295 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40 uM | Inhibition of bacterial translation by blocking the function of the ribosomal GTPase center | ChEMBL. | 15863296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.