Detailed information for compound 337646

Basic information

Technical information
  • TDR Targets ID: 337646
  • Name: (Z)-2-benzamido-3-[6-(2-chlorophenyl)pyridin- 2-yl]prop-2-enoic acid
  • MW: 378.808 | Formula: C21H15ClN2O3
  • H donors: 2 H acceptors: 4 LogP: 4.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C(=C/c1cccc(n1)c1ccccc1Cl)/NC(=O)c1ccccc1
  • InChi: 1S/C21H15ClN2O3/c22-17-11-5-4-10-16(17)18-12-6-9-15(23-18)13-19(21(26)27)24-20(25)14-7-2-1-3-8-14/h1-13H,(H,24,25)(H,26,27)/b19-13-
  • InChiKey: BCAQVLVQQUXMFV-UYRXBGFRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (Z)-2-benzamido-3-[6-(2-chlorophenyl)-2-pyridyl]prop-2-enoic acid
  • (Z)-2-benzamido-3-[6-(2-chlorophenyl)-2-pyridyl]-2-propenoic acid
  • (Z)-2-benzamido-3-[6-(2-chlorophenyl)-2-pyridyl]acrylic acid
  • AIDS326358
  • 2-Benzoylamino-3-[6-(2-chloro-phenyl)-pyridin-2-yl]-acrylic acid
  • AIDS-326358

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS5B RNA-dependent RNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica DNA repair and recombination protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus granulosus ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus multilocularis ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma mansoni hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to PIF1 DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma japonicum ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Giardia lamblia Rrm3p helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.0043 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.1643 1 1
Brugia malayi nuclear receptor RXR 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0117 0.0561 0.0561
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi hypothetical protein 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0062 0.0218 0.0254
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0117 0.0561 0.0544
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.0086
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0062 0.0218 0.0218
Loa Loa (eye worm) DR-78 0.0055 0.0177 0.0204
Plasmodium falciparum flap endonuclease 1 0.003 0.0018 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.0561 0.0675
Echinococcus granulosus thyroid hormone receptor alpha 0.0055 0.0177 0.016
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0149 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0117 0.0561 0.0544
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0062 0.0218 0.0254
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0056 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0117 0.0561 0.0675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0177 0.0166
Echinococcus multilocularis nuclear receptor nhr 48 0.0055 0.0177 0.0166
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0177 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0117 0.0561 0.0675
Echinococcus multilocularis thyroid hormone receptor alpha 0.0117 0.0561 0.0566
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0034 0.0043 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0117 0.0561 0.0675
Brugia malayi hypothetical protein 0.0062 0.0218 0.0254
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0218 0.0254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0156 0.0144
Brugia malayi nuclear receptor NHR-67 0.0055 0.0177 0.0204
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0056 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0218 0.0218
Schistosoma mansoni nuclear hormone receptor 0.0117 0.0561 0.0561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0156 0.0156
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0117 0.0561 0.0566
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0279 0.0329
Schistosoma mansoni hypothetical protein 0.0041 0.0087 0.0087
Brugia malayi Steroid receptor seven-up type 2 0.0117 0.0561 0.0675
Echinococcus granulosus tar DNA binding protein 0.0072 0.0279 0.0262
Leishmania major DNA polymerase eta, putative 0.0051 0.0149 0.0169
Brugia malayi RNA binding protein 0.0072 0.0279 0.0329
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0062 0.0218 0.0254
Echinococcus multilocularis ecdysone induced protein 78C 0.0117 0.0561 0.0566
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0117 0.0561 0.0566
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1343 0.8142 1
Brugia malayi tailless protein 0.0055 0.0177 0.0204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0156 0.0144
Onchocerca volvulus 0.0117 0.0561 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0177 0.016
Echinococcus granulosus dna polymerase eta 0.0051 0.0149 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0156 0.0156
Echinococcus granulosus FTZ F1 alpha 0.0117 0.0561 0.0544
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0087 0.0073
Echinococcus granulosus geminin 0.0365 0.2094 0.208
Loa Loa (eye worm) hypothetical protein 0.0051 0.0149 0.0169
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0156 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0149 0.0169
Schistosoma mansoni nuclear receptor 0.0055 0.0177 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0117 0.0561 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0117 0.0561 0.0675
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Brugia malayi hypothetical protein 0.0062 0.0218 0.0254
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0043 0.0031
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1343 0.8142 1
Schistosoma mansoni hypothetical protein 0.0365 0.2094 0.2094
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0117 0.0561 0.0544
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0117 0.0561 0.0544
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.1343 0.8142 0.8138
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0177 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0117 0.0561 0.0675
Echinococcus granulosus nuclear receptor nhr 48 0.0055 0.0177 0.016
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.0043 0.0038
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0087 0.007
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0177 0.0177
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0177 0.0166
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0117 0.0561 0.0675
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0279 0.0329
Brugia malayi nuclear receptor RXR 0.0062 0.0218 0.0254
Loa Loa (eye worm) RNA binding protein 0.0072 0.0279 0.0329
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0156 0.0177
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.0086
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0177 0.016
Echinococcus multilocularis transcription factor Dp 1 0.0777 0.4643 0.4819
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0117 0.0561 0.0544
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0018 0.0007
Brugia malayi steroid hormone receptor 0.0117 0.0561 0.0675
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0034 0.0043 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0117 0.0561 0.0566
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.1343 0.8142 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Entamoeba histolytica hypothetical protein 0.0041 0.0087 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0117 0.0561 0.0675
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0034 0.0043 0.0038
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0055 0.0177 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.1343 0.8142 0.8142
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0062 0.0218 0.0201
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0177 0.016
Brugia malayi nuclear hormone receptor 0.0117 0.0561 0.0675
Leishmania major DNA polymerase eta, putative 0.0036 0.0056 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0062 0.0218 0.0254
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0055 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 0.0561 0.0675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0156 0.0138
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.0043 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0117 0.0561 0.0561
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0117 0.0561 0.0675
Brugia malayi orphan nuclear receptor NR2E1 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0117 0.0561 0.0561
Schistosoma mansoni steroid hormone receptor ad4bp 0.0117 0.0561 0.0561
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0279 0.0279
Schistosoma mansoni zinc finger protein 0.0055 0.0177 0.0177
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0218 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0117 0.0561 0.0675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0156 0.0156
Brugia malayi photoreceptor-specific nuclear receptor 0.0117 0.0561 0.0675
Brugia malayi Flap endonuclease-1 0.003 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0218 0.0254
Loa Loa (eye worm) nuclear receptor NHR-67 0.0055 0.0177 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0156 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0117 0.0561 0.0675
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0062 0.0218 0.0209
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi nuclear hormone receptor family member odr-7 0.0055 0.0177 0.0204
Schistosoma mansoni DNA polymerase eta 0.0051 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi hypothetical protein 0.0041 0.0087 0.0093
Brugia malayi ecdysone receptor 0.0055 0.0177 0.0204
Schistosoma mansoni nuclear receptor nhr-48 0.0055 0.0177 0.0177
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0055 0.0177 0.016
Loa Loa (eye worm) steroid hormone receptor 0.0117 0.0561 0.0675
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0279 0.0279
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.1343 0.8142 1
Schistosoma mansoni coup transcription factor 0.0117 0.0561 0.0561
Entamoeba histolytica DNA repair and recombination protein, putative 0.0034 0.0043 0.0031
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0279 0.0329
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0018 0.0007
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.1343 0.8142 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.1343 0.8142 0.8463
Schistosoma mansoni RAR-like nuclear receptor 0.0117 0.0561 0.0561
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0117 0.0561 0.0561
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0117 0.0561 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0279 0.0279
Brugia malayi nuclear receptor NHR-88 0.0117 0.0561 0.0675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0117 0.0561 0.0675
Schistosoma mansoni thyroid hormone receptor 0.0117 0.0561 0.0561
Brugia malayi ecdysteroid receptor 0.0117 0.0561 0.0675
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0279 0.0279
Echinococcus multilocularis FTZ F1 alpha 0.0117 0.0561 0.0566
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0018 0.1335
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0117 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0117 0.0561 0.0566
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.1343 0.8142 1
Echinococcus multilocularis dna polymerase eta 0.0051 0.0149 0.0137
Loa Loa (eye worm) hypothetical protein 0.0062 0.0218 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0117 0.0561 0.0675
Brugia malayi nuclear hormone receptor 0.0055 0.0177 0.0204
Onchocerca volvulus Bile acid receptor homolog 0.0117 0.0561 1
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0177 0.0177
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.0043 0.0038
Echinococcus granulosus transcription factor Dp 1 0.0777 0.4643 0.4634
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0177 0.0204
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0055 0.0177 0.0166
Echinococcus granulosus ecdysone induced protein 78C 0.0117 0.0561 0.0544
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0018 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 1
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0018 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0055 0.0177 0.0204
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0117 0.0561 0.0544
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0034 0.0043 0.0038
Schistosoma mansoni nuclear receptor 0.0055 0.0177 0.0177
Echinococcus multilocularis geminin 0.0365 0.2094 0.2163
Loa Loa (eye worm) hypothetical protein 0.0117 0.0561 0.0675
Brugia malayi TAR-binding protein 0.0072 0.0279 0.0329
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0087 0.0087
Giardia lamblia Rrm3p helicase 0.0034 0.0043 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0055 0.0177 0.0204
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0117 0.0561 0.0561
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0117 0.0561 0.0566
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Brugia malayi nuclear receptor NHR-88 0.0055 0.0177 0.0204
Schistosoma mansoni hypothetical protein 0.0365 0.2094 0.2094
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0149 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0279 0.0279
Schistosoma mansoni hypothetical protein 0.0034 0.0043 0.0043
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1581 0.9617 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0117 0.0561 0.0566
Loa Loa (eye worm) hypothetical protein 0.0055 0.0177 0.0204
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0279 0.0272
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.0561 0.0561
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0034 0.0043 0.0025
Brugia malayi conserved hypotetical protein 0.0055 0.0177 0.0204
Onchocerca volvulus Protein ultraspiracle homolog 0.0117 0.0561 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0117 0.0561 0.0675
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1343 0.8142 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11 uM Inhibitory concentration against Hepatitis C virus NS5B polymerase ChEMBL. 15863301
IC50 (binding) = 11 uM Inhibitory concentration against Hepatitis C virus NS5B polymerase ChEMBL. 15863301

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.