Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1207 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1207 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1207 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1207 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1207 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1207 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0637 | 0.1071 | 0.1071 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1207 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1207 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1207 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1207 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0637 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1207 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1207 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1207 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1207 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1207 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1207 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0637 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.1207 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1207 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1207 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1207 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1207 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0637 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 alpha | 0.1207 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1207 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0637 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1207 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1207 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.1207 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1207 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1207 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1207 | 1 | 1 |
Onchocerca volvulus | 0.1207 | 1 | 1 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1207 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1207 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1207 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1207 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0637 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.1207 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1207 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1207 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0637 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0637 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1207 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1207 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1207 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.1071 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.6 | Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells | ChEMBL. | 15887956 |
Ki (binding) | = -6.5 | Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells | ChEMBL. | 15887956 |
Ki (binding) | = -6.4 | Displacement of [3H]-WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cells | ChEMBL. | 15887956 |
Log Ki (binding) | = 6.4 | Displacement of [3H]-WAY-100635 from human 5-hydroxytryptamine 1A receptor expressed in CHO cells | ChEMBL. | 15887956 |
Log Ki (binding) | = 6.5 | Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cells | ChEMBL. | 15887956 |
Log Ki (binding) | = 8.6 | Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cells | ChEMBL. | 15887956 |
Selectivity (binding) | = 126 | Selectivity for human 5-hydroxytryptamine 1D receptor over 5-hydroxytryptamine 1B receptor | ChEMBL. | 15887956 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.