Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0179 | 0.0594 | 0.1282 |
Onchocerca volvulus | 0.0025 | 0.0027 | 0.5 | |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1067 | 0.3865 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2732 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0.0027 | 0.0023 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0025 | 0.0027 | 0.0023 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2732 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0025 | 0.0027 | 0.0027 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0113 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0025 | 0.0027 | 0.0023 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1067 | 0.3865 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1067 | 0.3865 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.1067 | 0.3865 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0025 | 0.0027 | 0.0023 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2732 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1067 | 0.3865 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0027 | 0.0023 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2732 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2732 | 1 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0004 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.1067 | 0.3865 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0027 | 0.0023 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0025 | 0.0027 | 0.0023 |
Leishmania major | dihydroorotate dehydrogenase | 0.2732 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1067 | 0.3865 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0025 | 0.0027 | 0.0023 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2732 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2732 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2732 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2732 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2732 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0027 | 0.2138 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0025 | 0.0027 | 0.0027 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.1067 | 0.3865 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.1067 | 0.3865 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0027 | 0.2138 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1067 | 0.3865 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2732 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0027 | 0.2138 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0594 | 0.0487 |
Echinococcus multilocularis | geminin | 0.0179 | 0.0594 | 0.1282 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2732 | 1 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.1067 | 0.3865 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0113 | 0.0086 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0004 | 0.0004 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2732 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0179 | 0.0594 | 0.0487 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.1067 | 0.3865 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
C50 (binding) | = 159 nM | Concentration at which the fluorescence of an ethidium-DNA complex was reduced by 50% | ChEMBL. | 3806584 |
ID50 (functional) | = 0.000000041 M | Inhibitory effect of the compound against L1210 leukemia in tissue culture | ChEMBL. | 3806584 |
ID50 (functional) | = 0.000000041 M | Inhibitory effect of the compound against L1210 leukemia in tissue culture | ChEMBL. | 3806584 |
ID50 (functional) | = 0.0000005 M | Inhibitory effect of the compound against HCT8 Human colon adenocarcinoma | ChEMBL. | 3806584 |
ID50 (functional) | = 0.0000005 M | Inhibitory effect of the compound against HCT8 Human colon adenocarcinoma | ChEMBL. | 3806584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.