Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.1337 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.0326 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | TK/FAK protein kinase | 0.0535 | 0.3883 | 0.4039 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0028 | 0.0021 | 0.1335 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.0326 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Plasmodium falciparum | flap endonuclease 1 | 0.0028 | 0.0021 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.015 | 0.013 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0095 | 0.0535 | 0.0535 |
Schistosoma mansoni | thyroid hormone receptor | 0.0095 | 0.0535 | 0.0535 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0095 | 0.0535 | 0.0515 |
Brugia malayi | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0102 | 0.0102 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1143 | 0.1143 |
Brugia malayi | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0174 | 0.0168 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.005 | 0.0191 | 0.0186 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.1197 | 0.1197 |
Brugia malayi | ecdysteroid receptor | 0.0095 | 0.0535 | 0.0544 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0326 | 0.0326 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0028 | 0.0021 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0535 | 0.3883 | 0.4039 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Brugia malayi | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.005 | 0.0191 | 0.0191 |
Onchocerca volvulus | 0.0095 | 0.0535 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0095 | 0.0535 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0095 | 0.0535 | 0.0535 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.0326 | 0.0307 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.0326 | 0.0327 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0045 | 0.015 | 0.0135 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0175 | 0.1143 | 0.1124 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0095 | 0.0535 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0095 | 0.0535 | 0.0536 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0028 | 0.0021 | 0.0007 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.036 | 0.2554 | 0.2539 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0045 | 0.015 | 0.015 |
Brugia malayi | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | steroid hormone receptor | 0.0095 | 0.0535 | 0.0544 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0095 | 0.0535 | 0.0515 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1284 | 0.9592 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0095 | 0.0535 | 0.0536 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0045 | 0.015 | 0.0143 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0095 | 0.0535 | 0.0536 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0045 | 0.015 | 0.0143 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 0.0174 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1143 | 0.1143 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0045 | 0.015 | 0.013 |
Brugia malayi | nuclear receptor NHR-67 | 0.0045 | 0.015 | 0.0143 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.015 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0739 | 0.5439 | 0.5665 |
Schistosoma mansoni | nuclear receptor | 0.0045 | 0.015 | 0.015 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0095 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Brugia malayi | nuclear receptor RXR | 0.005 | 0.0191 | 0.0186 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0182 | 0.0162 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.0326 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0191 | 0.0186 |
Echinococcus multilocularis | geminin | 0.0182 | 0.1197 | 0.1226 |
Brugia malayi | nuclear hormone receptor | 0.0045 | 0.015 | 0.0143 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0095 | 0.0535 | 0.0535 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.0065 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0326 | 0.0326 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0175 | 0.1143 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0175 | 0.1143 | 0.1179 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.1284 | 0.9592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.1284 | 0.9592 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0554 | 0.4028 | 0.4191 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0102 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Schistosoma mansoni | zinc finger protein | 0.0045 | 0.015 | 0.015 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0045 | 0.015 | 0.015 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0182 | 0.0168 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0045 | 0.015 | 0.0135 |
Echinococcus granulosus | geminin | 0.0182 | 0.1197 | 0.1178 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | nuclear hormone receptor | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | tailless protein | 0.0045 | 0.015 | 0.0143 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0743 | 0.5471 | 0.5462 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0182 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0095 | 0.0535 | 0.0535 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0102 | 0.0085 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0095 | 0.0535 | 0.0535 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0045 | 0.015 | 0.015 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.005 | 0.0191 | 0.0178 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.1284 | 0.9592 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.0021 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.2692 | 0.2797 |
Brugia malayi | ecdysone receptor | 0.0045 | 0.015 | 0.0143 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 0.0174 | 0.0168 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0028 | 0.0021 | 0.5 |
Echinococcus multilocularis | protein tyrosine kinase | 0.0529 | 0.3835 | 0.3976 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.1284 | 0.9592 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.036 | 0.2554 | 0.264 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0095 | 0.0535 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0045 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0048 | 0.0174 | 0.0168 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0095 | 0.0535 | 0.0536 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0095 | 0.0535 | 0.0535 |
Brugia malayi | nuclear receptor RXR | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1143 | 0.1179 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.0326 | 0.0319 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.005 | 0.0191 | 0.0191 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.0065 | 0.0054 |
Echinococcus multilocularis | GPCR, family 2 | 0.0175 | 0.1143 | 0.1169 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0095 | 0.0535 | 0.0544 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0095 | 0.0535 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0095 | 0.0535 | 0.0544 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0102 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0326 | 0.0326 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0102 | 0.0092 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0095 | 0.0535 | 0.0544 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0095 | 0.0535 | 0.0544 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0182 | 0.0182 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.005 | 0.0191 | 0.0171 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0045 | 0.015 | 0.013 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.015 | 0.015 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0182 | 0.0176 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.1197 | 0.1197 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 0.0174 | 0.016 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 0.0174 | 0.0174 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0326 | 0.0326 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.1284 | 0.9592 | 0.9592 |
Brugia malayi | nuclear receptor NHR-88 | 0.0095 | 0.0535 | 0.0544 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0095 | 0.0535 | 0.0515 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0095 | 0.0535 | 0.0544 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.1284 | 0.9592 | 0.9976 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0095 | 0.0535 | 0.0515 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.1284 | 0.9592 | 0.9591 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0102 | 0.0082 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.0021 | 0.0007 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0175 | 0.1143 | 0.1169 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0095 | 0.0535 | 0.0536 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0095 | 0.0535 | 0.0515 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0095 | 0.0535 | 0.0544 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0095 | 0.0535 | 0.0536 |
Echinococcus granulosus | GPCR family 2 | 0.0175 | 0.1143 | 0.1124 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0028 | 0.0021 | 0.0007 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0095 | 0.0535 | 0.0544 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0102 | 0.0102 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0095 | 0.0535 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0175 | 0.1143 | 0.1179 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1284 | 0.9592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0535 | 0.0544 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0045 | 0.015 | 0.013 |
Schistosoma mansoni | nuclear hormone receptor | 0.0095 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.0326 | 0.0327 |
Echinococcus granulosus | protein tyrosine kinase | 0.0529 | 0.3835 | 0.3823 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 0.0174 | 0.0168 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.005 | 0.0191 | 0.0186 |
Brugia malayi | conserved hypotetical protein | 0.0045 | 0.015 | 0.0143 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0743 | 0.5471 | 0.5681 |
Schistosoma mansoni | thyroid hormone receptor | 0.0095 | 0.0535 | 0.0535 |
Brugia malayi | Flap endonuclease-1 | 0.0028 | 0.0021 | 0.0007 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0102 | 0.0085 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 0.0174 | 0.0154 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0045 | 0.015 | 0.0143 |
Brugia malayi | RNA binding protein | 0.0068 | 0.0326 | 0.0327 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0095 | 0.0535 | 0.0515 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0102 | 0.0085 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0045 | 0.015 | 0.0135 |
Schistosoma mansoni | hypothetical protein | 0.0379 | 0.2692 | 0.2692 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0028 | 0.0021 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0379 | 0.2692 | 0.2797 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0554 | 0.4028 | 0.4191 |
Loa Loa (eye worm) | DR-78 | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0095 | 0.0535 | 0.0544 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0095 | 0.0535 | 0.0544 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0182 | 0.0162 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0045 | 0.015 | 0.0143 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0045 | 0.015 | 0.013 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0095 | 0.0535 | 0.0536 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0182 | 0.0182 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0095 | 0.0535 | 0.0535 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.005 | 0.0191 | 0.0186 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0095 | 0.0535 | 0.0544 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0045 | 0.015 | 0.013 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0739 | 0.5439 | 0.5665 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0045 | 0.015 | 0.0143 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.0065 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1287 | 0.9616 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0095 | 0.0535 | 0.0515 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0045 | 0.015 | 0.0135 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0182 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.015 | 0.0143 |
Echinococcus granulosus | FTZ F1 alpha | 0.0095 | 0.0535 | 0.0515 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0095 | 0.0535 | 0.0544 |
Schistosoma mansoni | coup transcription factor | 0.0095 | 0.0535 | 0.0535 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.1284 | 0.9592 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0529 | 0.3835 | 0.3835 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 91 nM | Inhibition of corticotropin releasing factor stimulated cAMP production in rat pituitary assay | ChEMBL. | 15743196 |
Ki (binding) | = 6.3 nM | Inhibition of [125I]-[Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells | ChEMBL. | 15743196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.