Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1393 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1393 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.1393 | 1 | 1 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0459 | 0.3171 | 0.312 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1393 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0544 | 0.3792 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1393 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1393 | 1 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0544 | 0.3792 | 0.3745 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Giardia lamblia | Aldose reductase | 0.0036 | 0.0075 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | hypothetical protein | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1393 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1393 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0544 | 0.3792 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1393 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0544 | 0.3792 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1393 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0544 | 0.3792 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0544 | 0.3792 | 0.3745 |
Echinococcus granulosus | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0036 | 0.0075 | 0.0075 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1393 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0544 | 0.3792 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.0036 | 0.0075 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1393 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1393 | 1 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.0075 | 0.5 | |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase | 0.0036 | 0.0075 | 0.0198 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0036 | 0.0075 | 0.0198 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0459 | 0.3171 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1393 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Accumulation (functional) | = 5 % | Maximum percent cAMP accumulation mediated by human melanocortin 3 receptor relative to alpha-MSH (1.1%) at 10 uM concentration | ChEMBL. | 15808454 |
Accumulation (functional) | = 54 % | Maximum percent cAMP accumulation mediated by human melanocortin 5 receptor relative to alpha-MSH (17%) at 10 uM concentration | ChEMBL. | 15808454 |
Accumulation (functional) | = 77 % | Maximum percent cAMP accumulation mediated by human melanocortin 4 receptor relative to alpha-MSH (1.9%) at 10 uM concentration | ChEMBL. | 15808454 |
EC50 (functional) | = 91 nM | Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 4 receptor | ChEMBL. | 15808454 |
EC50 (functional) | = 1000 nM | Concentration of compound at 50% maximum cAMP accumulation mediated by human melanocortin 5 receptor | ChEMBL. | 15808454 |
IC50 (binding) | = 29 nM | Inhibitory concentration to displace [125I]-NDP-alpha-MSH from human melanocortin 4 receptor expressed in CHO cells; Control 19 nM | ChEMBL. | 15808454 |
Selectivity (binding) | = 26 | Selectivity for human melanocortin 3 receptor over melanocortin 5 receptor expressed in CHO cells; control 6 nM | ChEMBL. | 15808454 |
Selectivity (binding) | = 48 | Selectivity for human melanocortin 3 receptor over melanocortin 4 receptor expressed in CHO cells; control 1 nM | ChEMBL. | 15808454 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.