Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2267 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.2267 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0885 | 0.3455 | 0.2732 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.0784 | 0.7875 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.2267 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.2267 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2267 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.0995 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.2267 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0885 | 0.3455 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0885 | 0.3455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.0995 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.2267 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0885 | 0.3455 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.2267 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.2267 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0366 | 0.0995 | 0.0995 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.2267 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0885 | 0.3455 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.2267 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0885 | 0.3455 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.2267 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.2267 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Intrinsic activity (binding) | = 0.9 | Intrinsic activity for human 5-hydroxytryptamine 1D receptor | ChEMBL. | 16153839 |
Intrinsic activity (binding) | = 0.9 | Intrinsic activity for human 5-hydroxytryptamine 1B receptor | ChEMBL. | 16153839 |
Intrinsic activity (binding) | = 0.9 | Intrinsic activity for human 5-hydroxytryptamine 1B receptor | ChEMBL. | 16153839 |
Intrinsic activity (binding) | = 0.9 | Intrinsic activity for human 5-hydroxytryptamine 1D receptor | ChEMBL. | 16153839 |
Ki (binding) | = -8.7 | Binding affinity against cloned human 5-hydroxytryptamine 1B receptor | ChEMBL. | 16153839 |
Ki (binding) | = -7.9 | Binding affinity against cloned human 5-hydroxytryptamine 1A receptor | ChEMBL. | 16153839 |
Ki (binding) | = -7.6 | Binding affinity against cloned human 5-hydroxytryptamine 1D receptor | ChEMBL. | 16153839 |
Log Ki (binding) | = 7.6 | Binding affinity against cloned human 5-hydroxytryptamine 1D receptor | ChEMBL. | 16153839 |
Log Ki (binding) | = 7.9 | Binding affinity against cloned human 5-hydroxytryptamine 1A receptor | ChEMBL. | 16153839 |
Log Ki (binding) | = 8.7 | Binding affinity against cloned human 5-hydroxytryptamine 1B receptor | ChEMBL. | 16153839 |
Selectivity (binding) | = 6 | Selectivity towards human 5-hydroxytryptamine 1B receptor to that of 5-hydroxytryptamine 1A receptor | ChEMBL. | 16153839 |
Selectivity (binding) | = 12 | Selectivity towards human 5-hydroxytryptamine 1B receptor to that of 5-hydroxytryptamine 1D receptor | ChEMBL. | 16153839 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.