Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Echinococcus granulosus | protein jagged 1 | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0026 | 0.2184 | 0.2184 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0024 | 0.1875 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.007 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Schistosoma mansoni | septate junction protein | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | notch | 0.0014 | 0.0067 | 0.0067 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0024 | 0.1875 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0024 | 0.1875 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | Cadherin domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0042 | 0.4943 | 0.4943 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.007 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.007 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.007 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | GCC2 and GCC3 family protein | 0.004 | 0.4684 | 0.4684 |
Brugia malayi | Delta serrate ligand family protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | slit 2 protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0024 | 0.1875 | 0.5 |
Echinococcus granulosus | protein jagged 2 | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | Peroxidasin homolog | 0.0042 | 0.4943 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | slit | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0018 | 0.0732 | 0.0732 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | Animal haem peroxidase family protein | 0.0042 | 0.4943 | 0.4943 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | Peroxidasin | 0.0045 | 0.5541 | 0.5541 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Plasmodium falciparum | glutathione reductase | 0.007 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Trypanosoma brucei | trypanothione reductase | 0.007 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | Sushi domain | 0.0026 | 0.2184 | 0.2184 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0026 | 0.2184 | 0.2131 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Plasmodium vivax | glutathione reductase, putative | 0.007 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0039 | 0.4474 | 0.9039 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0039 | 0.4474 | 0.9039 | |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0026 | 0.2184 | 0.2184 |
Echinococcus granulosus | protein jagged 2 | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | protein jagged 1 | 0.0014 | 0.0067 | 0.0067 |
Plasmodium falciparum | apical sushi protein | 0.0026 | 0.2184 | 0.0379 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0039 | 0.4474 | 0.9039 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Schistosoma mansoni | peroxidasin | 0.0042 | 0.5072 | 0.5072 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.2702 | 0.2702 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0469 | 0.0469 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Schistosoma mansoni | notch | 0.0014 | 0.0067 | 0.0067 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0026 | 0.2184 | 0.2131 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0026 | 0.2184 | 0.2131 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | notch protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Schistosoma mansoni | peroxidasin | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0469 | 0.0469 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Plasmodium vivax | apical sushi protein, putative | 0.0026 | 0.2184 | 0.0379 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0024 | 0.1875 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0039 | 0.4474 | 0.9039 |
Onchocerca volvulus | Peroxidase homolog | 0.0039 | 0.4474 | 0.9039 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Echinococcus granulosus | neural cadherin | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | roundabout 2 | 0.0016 | 0.0469 | 0.0469 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.007 | 1 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | Notch2 | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | Dual oxidase homolog | 0.0039 | 0.4474 | 0.9039 |
Echinococcus granulosus | notch | 0.0014 | 0.0067 | 0.0067 |
Treponema pallidum | NADH oxidase | 0.0024 | 0.1875 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | notch | 0.0014 | 0.0067 | 0.0067 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0024 | 0.1875 | 0.1821 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.1875 |
Echinococcus multilocularis | roundabout 2 | 0.0016 | 0.0469 | 0.0404 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.1875 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.0026 | 0.2184 | 0.2184 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0018 | 0.0732 | 0.0732 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.5541 | 0.5541 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Schistosoma mansoni | notch | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | peroxidasin | 0.0045 | 0.5541 | 0.5541 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0026 | 0.2184 | 0.2184 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | thioredoxin reductase | 0.007 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0026 | 0.2184 | 0.2184 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.1821 |
Brugia malayi | Animal haem peroxidase family protein | 0.0039 | 0.4474 | 0.4474 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0024 | 0.1875 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Schistosoma mansoni | notch | 0.0014 | 0.0067 | 0.0067 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0024 | 0.1875 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | notch | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0014 | 0.0067 | 0.0067 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0024 | 0.1875 | 0.1821 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | Thioredoxin reductase | 0.007 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Brugia malayi | Animal haem peroxidase family protein | 0.0039 | 0.4474 | 0.4474 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0024 | 0.1875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | Animal haem peroxidase family protein | 0.0039 | 0.4474 | 0.4474 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Brugia malayi | Muscle positioning protein 4 | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | fibropellin Ia | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | Peroxidasin homolog | 0.0042 | 0.4943 | 1 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0026 | 0.2184 | 0.2131 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4474 | 0.4474 |
Onchocerca volvulus | 0.0039 | 0.4474 | 0.9039 | |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4684 | 0.4684 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0024 | 0.1875 | 0.1875 |
Echinococcus multilocularis | peroxidasin | 0.0045 | 0.5541 | 0.5511 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Echinococcus granulosus | delta-like protein 1 | 0.0014 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0067 | 0.0067 |
Brugia malayi | hypothetical protein | 0.0026 | 0.2184 | 0.2184 |
Brugia malayi | EGF-like domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.0026 | 0.2184 | 0.4341 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0014 | 0.0067 | 0.0067 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 28 % | Percent displacement of [3H]-CGS-21,680 binding to adenosine A2A receptors of bovine striatal membranes at 0.00005 M | ChEMBL. | 15743197 |
Ki (binding) | = 30 nM | Displacement of [3H]-DPCPX binding to adenosine A1 receptors of bovine cortical membranes | ChEMBL. | 15743197 |
Ki (binding) | = 2560 nM | Displacement of [125I]-AB-MECA from adenosine A3 receptors in bovine cortical membranes | ChEMBL. | 15743197 |
Ratio (binding) | > 3.9 | Relative affinities for adenosine A2A and A3 receptors (ratio of KiA2A/KiA3) | ChEMBL. | 15743197 |
Ratio (binding) | = 85.3 | Relative affinities for adenosine A3 and A1 receptors (ratio of KiA3/KiA1) | ChEMBL. | 15743197 |
Ratio (binding) | > 333 | Relative affinities against adenosine A2A and A1 receptors (ratio of KiA2A/KiA1) | ChEMBL. | 15743197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.